Professor John Storey

Professor John Storey
Professor John Storey
Professor John Storey

BSc, PhD (KC, London)

Chair in Pharmaceutical Industrial Chemistry

About
Email Address
j.storey@abdn.ac.uk
Telephone Number
+44 (0)1224 272926
Office Address
Meston Room G106
School/Department
School of Natural and Computing Sciences

External Memberships

Head Chemist for TauRx Therapeutics

Research

Research Overview

Free Radical Chemistry, Organic Methodology, Medicinal Chemistry

Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.

An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.

Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.

Current Research

Selected Current Projects

  • Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
  • A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
  • Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
  • New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
  • The use of organic molecules as asymmetric catalysts.

 

Teaching

Teaching Responsibilities

Professor Storey teaches in the following courses: 

  • CM1010
  • CM1011
  • CM4017/CM3024 Honours/Advanced Chemistry
  • CM5003 MChem Chemistry Applications

 

Publications

Page 12 of 16 Results 111 to 120 of 153

  • Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants

    Larch, C. P., Storey, J. M. D., Williamson, C., Marshall, C., Kemp, S. J.
    Patents: Patents
  • 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents
  • 3,6-Disubstituted xanthylium salts

    Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R., Wischik, C. M.
    Patents: Patents
  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.
    Patents: Patents
  • Ligands for aggregated tau molecules: WO2010034982

    Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S., Heinrich, T.
    Patents: Patents
  • Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

    Wischik, C. M., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
    Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.), pp. 210-232, 23 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • Therapeutic Use of Diaminophenothiazines: WO2009044127

    Wischik, C. M., Damon J., W., Storey, J. M. D., Harrington, C. R.
    Patents: Patents
  • Methods of synthesis and/or purification of diaminophenothiazinium compounds

    Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents
  • Investigation of Reactions Involving Radical Intermediates

    Aldabbagh, F., Bowman, W. R., Storey, J. M.
    The Investigation of Organic Reactions and Their Mechanisms. Maskill, H. (ed.). John Wiley and Sons, pp. 261-292, 32 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters
  • Synthesis using aromatic homolytic substitution: recent advances

    Bowman, W. R., Storey, J. M. D.
    Chemical Society Reviews, vol. 36, no. 11, pp. 1803-1822
    Contributions to Journals: Literature Reviews
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