Professor John Storey

Professor John Storey
Professor John Storey
Professor John Storey

BSc, PhD (KC, London)

Chair in Pharmaceutical Industrial Chemistry

About
Email Address
j.storey@abdn.ac.uk
Telephone Number
+44 (0)1224 272926
Office Address
Meston Room G106
School/Department
School of Natural and Computing Sciences

External Memberships

Head Chemist for TauRx Therapeutics

Research

Research Overview

Free Radical Chemistry, Organic Methodology, Medicinal Chemistry

Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.

An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.

Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.

Current Research

Selected Current Projects

  • Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
  • A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
  • Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
  • New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
  • The use of organic molecules as asymmetric catalysts.

 

Teaching

Teaching Responsibilities

Professor Storey teaches in the following courses: 

  • CM1010
  • CM1011
  • CM4017/CM3024 Honours/Advanced Chemistry
  • CM5003 MChem Chemistry Applications

 

Publications

Page 10 of 16 Results 91 to 100 of 153

  • Reversible Isothermal Twist-Bend Nematic-Nematic Phase Transition Driven by the Photoisomerization of an Azobenzene-Based Nonsymmetric Liquid Crystal Dimer

    Paterson, D. A., Xiang, J., Singh, G., Walker, R., Agra-Kooijman, D. M., Martinez-Felipe, A., Gao, M., Storey, J. M. D., Kumar, S., Lavrentovich, O. D., Imrie, C. T.
    Journal of the American Chemical Society, vol. 138, no. 16, pp. 5283-5289
    Contributions to Journals: Articles
  • Crystal structures of four indole derivatives with a phenyl substituent at the 2-position and a carbonyl group at the 3-position: the C(6) N-H⋯O chain remains the same, but the weak reinforcing inter-actions are different

    Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L., Harrison, W. T. A.
    Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 3, pp. 363-369
    Contributions to Journals: Articles
  • Investigations into the construction of the pentasubstituted ring C of Neosurugatoxin – a crystallographic study

    Jones, A. M., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 1, pp. 44-48
    Contributions to Journals: Articles
  • Ethyl 2-(5-bromo-2-iodo­anilino)cyclo­pent-1-ene-1-carboxyl­ate

    Barnes, P., Storey, J. M. D., Harrison, W. T. A.
    IUCrData, vol. 1, no. 1, pp. 1-7
    Contributions to Journals: Articles
  • Synthesis of a Thiosulfonic Acid by a step of Periodate Mediated Oxidative Coupling of a Thiosulfonic Acid with and Aniline

    Sinclair, J. P., Nicoll, S. L., Storey, J. M. D., Larch, C.
    Patents: Patents
  • Understanding the twist-bend nematic phase: the characterisation of 1-(4-cyanobiphenyl-4'-yloxy)-6-(4-cyanobiphenyl-4'-yl) hexane (CB6OCB) and comparison with CB7CB

    Paterson, D. A., Gao, M., Kim, Y., Jamali, A., Finley, K., Robles-Hernandez, B., Diez-Berat, S., Salud, J., de la Fuente, M. R., Timimi, B. A., Zimmermann, H., Greco, C., Ferrarini, A., Storey, J. M. D., Lopez, D. O., Lavrentovich, O. D., Luckhurst, G. R., Imrie, C. T.
    Soft matter, vol. 12, no. 32, pp. 6827-6840
    Contributions to Journals: Articles
  • Crystal structures of four indole derivatives as possible cannabinoid allosteric antagonists

    Kerr, J. R., Trembleau, L., Storey, J. M. D., Wardell, J. L., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 71, no. 6, pp. 654-659
    Contributions to Journals: Articles
  • Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

    Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.
    Behavioural Pharmacology, vol. 26, no. 4, pp. 353-368
    Contributions to Journals: Articles
  • Electrically Tunable Selective Reflection of Light from Ultraviolet to Visible and Infrared by Heliconical Cholesterics

    Xiang, J., Li, Y., Li, Q., Paterson, D. A., Storey, J. M. D., Imrie, C. T., Lavrentovich, O. D.
    Advanced Materials, vol. 27, no. 19, pp. 3014-3018
    Contributions to Journals: Articles
  • Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease

    Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M.
    The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875
    Contributions to Journals: Articles
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