![Professor Graeme MacLennan Professor Graeme MacLennan](/img/200x200/staffpages/uploads/sme312/Graeme_McLennan_002.jpg)
Director (CHaRT)
- About
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- Email Address
- g.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438147
- Office Address
Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT.
My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.
Qualifications
- BSc Mathematics1997 - University of Aberdeen
- MSc Applied Statistics2004 - Sheffield Hallam University
- Research
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Research Overview
The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester).
Research on making trials more efficient, collaborating with Trial Forge.
Current Research
A complete list of the CHaRT RCT portolio is available by clicking here
- Teaching
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Teaching Responsibilities
I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.
- Publications
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Page 1 of 5 Results 1 to 50 of 239
Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial
JAMA, vol. 332, no. 1, pp. 31-40Contributions to Journals: ArticlesEvaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study
Ophthalmology, vol. 131, no. 7, pp. 759-770Contributions to Journals: ArticlesThe mellow babies trial: a randomised controlled trial to assess the clinical and cost-effectiveness of the Mellow Babies programme for mothers experiencing psychosocial stress
Public Health ResearchContributions to Journals: ArticlesAssessment of depth of sedation using Bispectral Index™ monitoring in patients with severe traumatic brain injury in UK intensive care units
BJA Open, vol. 10, 100287Contributions to Journals: ArticlesLaparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT
Health Technology Assessment, vol. 28, no. 26, pp. 1-151Contributions to Journals: ArticlesBisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial
JAMAContributions to Journals: ArticlesResuscitative Endovascular Balloon Occlusion of the Aorta in Patients With Exsanguinating Hemorrhage-Reply
JAMA, vol. 331, no. 11, pp. 981-982Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1001/jama.2024.0285
Reply to Arnulf Stenzl, Morgan Rouprêt, J. Alfred Witjes, Paolo Gontero. High-quality Transurethral Resection of Bladder Tumour Needs Additional Forms of Tumour Delineation. Eur Urol 2023;83:193–4
European Urology, vol. 85, no. 3, pp. 309-312Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2023.05.040
- [ONLINE] View publication in Scopus
SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial
ERJ Open Research, vol. 10, no. 2, 00917-2023Contributions to Journals: ArticlesThree-year cost utility analysis of mini versus standard slings: A trial based economic evaluation
BJUI Compass, vol. 5, no. 2, pp. 230-239Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bco2.303
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22315/2/Kilonzo_etal_BJUIC_Three_Year_Cost_VoR.pdf
- [ONLINE] View publication in Scopus
Effects of socioeconomic status on baseline values and outcomes at 24 months in the Treatment of Advanced Glaucoma Study randomised controlled Trial
British Journal of Ophthalmology, vol. 108, no. 2, pp. 203-210Contributions to Journals: ArticlesEffectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial
BMJ, vol. 383, e075383Contributions to Journals: ArticlesCost-effectiveness of cognitive behavioural and personalised exercise interventions for reducing fatigue in inflammatory rheumatic diseases
Rheumatology, vol. 62, no. 12, pp. 3819-3827Contributions to Journals: ArticlesDevelopment of an intervention to manage benzodiazepine dependence and high-risk use in the context of escalating drug related deaths in Scotland: an application of the MRC framework
BMC Health Services Research, vol. 23, no. 1, 1205Contributions to Journals: ArticlesEmergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial
JAMA, vol. 330, no. 19, pp. 1862-1871Contributions to Journals: ArticlesCost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma
British Journal of Ophthalmology, vol. 107, no. 10, pp. 1452-1457Contributions to Journals: ArticlesPatient preferences for stress urinary incontinence treatments: a discrete choice experiment
BMJ Open, vol. 13, no. 8, pp. e066157Contributions to Journals: ArticlesPROSPECT: 4- and 6-year follow-up of a randomised trial of surgery for vaginal prolapse
International Urogynecology Journal, vol. 34, pp. 67-78Contributions to Journals: ArticlesCost utility analysis of shockwave lithotripsy versus ureteroscopic stone treatment in adults
BJU International, vol. 131, no. 2, pp. 253-261Contributions to Journals: ArticlesCorrection to: Pulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study (Pilot and Feasibility Studies, (2022), 8, 1, (77), 10.1186/s40814-022-01029-9)
Pilot and Feasibility Studies, vol. 8, 82Contributions to Journals: Comments and DebatesSingle-incision mini-slings versus standard synthetic mid-urethral slings for surgical treatment of stress urinary incontinence in women: The SIMS RCT
Health technology assessment (Winchester, England), vol. 26, no. 47, pp. 1-190Contributions to Journals: ArticlesDeveloping a Diagnostic Multivariable Prediction Model for Urinary Tract Cancer in Patients Referred with Haematuria: results from the IDENTIFY Collaborative Study
European Urology Focus, vol. 8, no. 6, pp. 1673-1682Contributions to Journals: ArticlesPhotodynamic versus white-light-guided resection of first-diagnosis non-muscle-invasive bladder cancer: PHOTO RCT
Health technology assessment (Winchester, England), vol. 26, no. 40, pp. 1-144Contributions to Journals: ArticlesA Randomized Trial of PHOTOdynamic Surgery in Non-Muscle-Invasive Bladder Cancer
NEJM evidence, vol. 1, no. 10, EVIDoa2200092Contributions to Journals: ArticlesThe Achieving Self-directed Integrated Cancer Aftercare Intervention for Detection of Recurrent and Second Primary Melanoma in Survivors of Melanoma: Pilot Randomized Controlled Trial
JMIR cancer, vol. 8, no. 3, e37539Contributions to Journals: ArticlesRandomised controlled trial comparing the clinical and cost-effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long-term catheters: study protocol for the CATHETER II study
Trials, vol. 23, no. 1, 630Contributions to Journals: ArticlesRemotely delivered cognitive behavioural and personalised exercise interventions for fatigue severity and impact in inflammatory rheumatic diseases: a multi-centre randomised controlled parallel open-label group trial (LIFT)
The Lancet Rheumatology, vol. 4, no. 8, pp. e534-e545Contributions to Journals: ArticlesSynthetic sling or artificial urinary sphincter for men with urodynamic stress incontinence after prostate surgery: the MASTER non-inferiority RCT
Health Technology Assessment, vol. 26, no. 36, 184Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/TBFZ0277
Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial
Trials, vol. 23, no. 1, 582Contributions to Journals: ArticlesReducing asthma attacks in children using exhaled nitric oxide (RAACENO) as a biomarker to inform treatment strategy: a multicentre, parallel, randomised, controlled, phase 3 trial
The Lancet. Respiratory medicine, vol. 10, no. 6, pp. 584-592Contributions to Journals: ArticlesTreatment guided by fractional exhaled nitric oxide in addition to standard care in 6- to 15-year-olds with asthma: the RAACENO RCT
Efficacy and Mechanism Evaluation, vol. 9, no. 4, pp. 1-153Contributions to Journals: ArticlesThe EMPOWER blended digital intervention for relapse prevention in schizophrenia: a feasibility cluster randomised controlled trial in Scotland and Australia
The Lancet Psychiatry, vol. 9, no. 6, pp. 477-486Contributions to Journals: ArticlesVisualising harms in publications of randomised controlled trials: consensus and recommendations
BMJ (Clinical research ed.), vol. 377, e068983Contributions to Journals: ArticlesThe effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial)
Trials, vol. 23, no. 1, 384Contributions to Journals: ArticlesDigital smartphone intervention to recognise and manage early warning signs in schizophrenia to prevent relapse: the EMPOWER feasibility cluster RCT
Health Technology Assessment, vol. 26, no. 27, pp. v-122Contributions to Journals: ArticlesScotCap - A large observational cohort study
Colorectal Disease, vol. 24, no. 4, pp. 411-421Contributions to Journals: ArticlesUse of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial. (BICS)
Trials, vol. 23, no. 1, 307Contributions to Journals: ArticlesThe development of theory-informed participant-centred interventions to maximise participant retention in randomised controlled trials
Trials, vol. 23, no. 1, 268Contributions to Journals: ArticlesPulpotomy for the Management of Irreversible Pulpitis in Mature Teeth (PIP): a feasibility study
Pilot and Feasibility Studies, vol. 8, 77Contributions to Journals: ArticlesSingle-Incision Mini-Slings for Stress Urinary Incontinence in Women
The New England Journal of Medicine, vol. 386, no. 13, pp. 1230-1243Contributions to Journals: ArticlesShockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones: the TISU non-inferiority RCT
Health technology assessment (Winchester, England), vol. 26, no. 19, pp. 1-70Contributions to Journals: ArticlesAssessing the feasibility, acceptability and accessibility of a peer-delivered intervention to reduce harm and improve the well-being of people who experience homelessness with problem substance use: the SHARPS study
Harm Reduction Journal, vol. 19, 10Contributions to Journals: ArticlesA peer-delivered intervention to reduce harm and improve the well-being of homeless people with problem substance use: the SHARPS feasibility mixed-methods study
Health technology assessment (Winchester, England), vol. 26, no. 14, pp. 1-128Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/WVVL4786
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/18607/1/Parkes_et_al_A_Peer_delivered_NIHR_vor.pdf
- [ONLINE] View publication in Scopus
The ALLEGRO trial: a placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery
Trials, vol. 23, no. 1, 84Contributions to Journals: ArticlesEye Movement Patterns Can Distinguish Schizophrenia From the Major Affective Disorders and Healthy Control Subjects
Schizophrenia Bulletin Open, vol. 3, no. 1, sgac032Contributions to Journals: ArticlesHow common are complications following polypropylene mesh, biological xenograft and native tissue surgery for pelvic organ prolapse?: A secondary analysis from the PROSPECT trial
BJOG: An International Journal of Obstetrics and Gynaecology, vol. 128, no. 13, pp. 2180-2189Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/1471-0528.16897
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17640/1/Reld_etal_BJOG_How_Common_Are_VoR.pdf
- [ONLINE] View publication in Scopus
Primary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT
Books and Reports: Other ReportsPrimary trabeculectomy versus primary glaucoma eye drops for newly diagnosed advanced glaucoma: TAGS RCT
Health Technology Assessment, vol. 25, no. 72, pp. i-158Contributions to Journals: ArticlesFemale Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study): a superiority randomised clinical trial to evaluate the effectiveness and cost-effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms
Trials, vol. 22, no. 1, 745Contributions to Journals: ArticlesA multicentre open label randomised clinical trial using exhaled nitric oxide in addition to standard care to reduce asthma attacks in children
Efficacy and Mechanism EvaluationContributions to Journals: Articles