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Professor Graeme MacLennan

Professor Graeme MacLennan
Professor Graeme MacLennan
Professor Graeme MacLennan

Director (CHaRT)

About
Email Address
g.maclennan@abdn.ac.uk
Telephone Number
+44 (0)1224 438147
Office Address

Health Services Research Unit
2nd Floor Health Sciences Building
Foresterhill
Aberdeen
AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I am currently Professor of Medical Statistics and the Director of the Centre for Health Care Randomised Trials (CHaRT) which is the Clinical Trials Unit embedded within the Health Services Research Unit. My overarching research interest is in designing fair tests of health care treatments and policies, with a specifc interest in evaluating surgical and complex interventions. I'm also interested in improving the design, conduct, and analysis and reporting of clinical trials through the development and application of methodological research to clinical trials from CHaRT. 

My undergrad degree is in Mathematics from the University of Aberdeen, graduating in 1997. After a year training as a Mathematics teacher I joined the Unit in September 1998 as a statistician. I studied part-time for an MSc in Applied Statistics with Sheffield Hallam University, graduating in 2004. In 2008 I was appointed Senior Statistican, and in 2016 was I Interim Programme Director for the Health Care Assessment Programme, until being appointment as CHaRT Director in April 2017.  

Qualifications

  • BSc Mathematics 
    1997 - University of Aberdeen 
  • MSc Applied Statistics 
    2004 - Sheffield Hallam University 
Research

Research Overview

The application of statistical methods to clinical trials. Recent example is JCE paper available here on using instrumental variables in a surgery trial to address non-compliance. Collaborators were Jonathan Cook (Oxford), Tom Palmer (Lancaster), and Richard Emesley (Manchester). 

Research on making trials more efficient, collaborating with Trial Forge. 

Current Research

A complete list of the CHaRT RCT portolio is available by clicking here

Teaching

Teaching Responsibilities

I teach on our MPH course module PU5031: EVIDENCE-BASED HEALTH.

Publications

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  • CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Young, A. J., Cotton, S., Norrie, J., MacLennan, G.
    BMJ Open
    Contributions to Journals: Articles

  • Laparoscopic cholecystectomy versus conservative management for uncomplicated symptomatic gallstones: economic evaluation based on the C-GALL trial

    Hernández, R. A., Ahmed, I., Edwards, K., Hudson, J., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J. M., Brazzelli, M., Cotton, S., Croal, B. L., MacLennan, G., Murchie, P., Ramsay, C.
    British Journal of Surgery
    Contributions to Journals: Articles

  • The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: The (UK-REBOA) multicentre RCT

    Jansen, J. O., Hudson, J., Kennedy, C., Cochran, C., Maclennan, G., Gillies, K., Lendrum, R., Sadek, S., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Cotton, S., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., UK-REBOA Study Group
    Health Technology Assessment, vol. 28, no. 54
    Contributions to Journals: Articles

  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    RCOG World Congress 2024
    Contributions to Conferences: Posters

  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    The International Continence Society
    Contributions to Conferences: Posters

  • Public perspective on potential treatment intervention harm in clinical trials-terminology and communication

    Phillips, R., Bi, D., Goulão, B., Miller, M., El-Askary, M., Fagbemi, O., Freeborn, C., Giammetta, M., El Masri, N., Flockhart, P., Kumar, M., Melvin, M., Murray, D., Myhill, A., Saeid, L., Thomas, S., MacLennan, G., Cornelius, V.
    Trials, vol. 25, no. 1, 573
    Contributions to Journals: Articles

  • Feasibility of in-home monitoring for people with glaucoma: the I-TRAC mixed-methods study

    Stewart, C., Wu, H., Alagappan, U., Azuara-Blanco, A., King, A. J., Tatham, A. J., Hernández, R., Lowe, B., Shotton, D., Appiah, N., Coffey, T., Vadiveloo, T., MacLennan, G., Gillies, K.
    Health technology assessment (Winchester, England), vol. 28, no. 44, pp. 1-163
    Contributions to Journals: Articles

  • Text Messages With Financial Incentives for Men With Obesity: A Randomized Clinical Trial

    Hoddinott, P., O'Dolan, C., Macaulay, L., Dombrowski, S. U., Swingler, J., Cotton, S., Avenell, A., Getaneh, A. M., Gray, C., Hunt, K., Kee, F., MacLean, A., McKinley, M., Torrens, C., Turner, K., van der Pol, M., MacLennan, G.
    JAMA, vol. 332, no. 1, pp. 31-40
    Contributions to Journals: Articles

  • Evaluating Primary Treatment for People with Advanced Glaucoma: Five-Year Results of the Treatment of Advanced Glaucoma Study

    King, A. J., Hudson, J., Azuara-Blanco, A., Burr, J., Kernohant, A., Homer, T., Shabaninejad, H., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., Davidson, T., Vale, L., MacLennan, G., TAGS Study Group
    Ophthalmology, vol. 131, no. 7, pp. 759-770
    Contributions to Journals: Articles

  • The mellow babies trial: a randomised controlled trial to assess the clinical and cost-effectiveness of the Mellow Babies programme for mothers experiencing psychosocial stress

    Thompson, L., Tanner, J., Breckons, M., Young, N., Ternent, L., Vadiveloo, T., Wilson, P., Wight, D., Marryat, L., McGowan, I., MacLennan, G., MacBeth, A., McTaggart, J., Allison, T., Norrie, J.
    Public Health Research
    Contributions to Journals: Articles

  • Assessment of depth of sedation using Bispectral Index™ monitoring in patients with severe traumatic brain injury in UK intensive care units

    Kaye, C., Rhodes, J., Austin, P., Casey, M., Gould, R., Sira, J., Treweek, S., MacLennan, G.
    BJA Open, vol. 10, 100287
    Contributions to Journals: Articles

  • Laparoscopic cholecystectomy versus conservative management for adults with uncomplicated symptomatic gallstones: the C-GALL RCT

    Innes, K., Ahmed, I., Hudson, J., Hernández, R. A., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J. M., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    Health Technology Assessment, vol. 28, no. 26, pp. 1-151
    Contributions to Journals: Articles

  • Bisoprolol in Patients With Chronic Obstructive Pulmonary Disease at High Risk of Exacerbation: The BICS Randomized Clinical Trial

    Devereux, G., Cotton, S., Nath, M., McMeekin, N., Campbell, K., Chaudhuri, R., Choudhury, G., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A. J., MacLennan, G., Morice, A., Norrie, J., Price, D., Short, P., Vestbo, J., Walker, P., Wedzicha, J., Wilson, A., Wu, O., Lipworth, B. J.
    JAMA, vol. 332, no. 6, pp. 462-470
    Contributions to Journals: Articles

  • Complexity of Trials on Pain Management in Acute Pancreatitis: An Ongoing Challenge

    Kamarajah, S. K., Maclennan, G., Pandanaboyana, S.
    Clinical Gastroenterology and Hepatology
    Contributions to Journals: Letters

  • Prevalence of urinary tract cancer in the Spanish cohort of the IDENTIFY study

    Toribio-Vázquez, C., Gómez Rivas, J., Amigo, F., Carrión, D. M., Yebes, , Alonso-Bartolomé, M., Ayllon, H., Aguilera, A., Martinez-Pineiro, L., Antón-Juanilla, M., Crespo-Atín, V., Otaola-Arca, H., Herranz-Yague, J. A., Munoz Rivero, M. V., MacKenzie, K. R., Shah, T. T., Gao, C., Zimmermann, E., Jefferies, M., Nambiar, A., Gallagher, K. M., Khadhouri, S., Kasivisvanathan, V., Moore, S., Zimmermann, E. F., Edison, E., Mannas, M. P., Lee, T., Marra, G., Lillaz, B., Olivier, J., Assmus, M. A., Uçar, T., Claps, F., Boltri, M., Burnhope, T., Nkwam, N., Tanasescu, G., Boxall, N. E., Downey, A. P., Ahmed Lal, A., Clarke, H., HW Lau, D., Gillams, K., Crockett, M., Nielsen, M., Takwoingi, Y., Chuchu, N., O'Rourke, J., MacLennan, G., IDENTIFY Study group
    Actas Urologicas Espanolas, vol. 48, no. 3, pp. 228-237
    Contributions to Journals: Articles

  • Resuscitative Endovascular Balloon Occlusion of the Aorta in Patients With Exsanguinating Hemorrhage-Reply

    Jansen, J. O., MacLennan, G. S., Campbell, M. K.
    JAMA, vol. 331, no. 11, pp. 981-982
    Contributions to Journals: Comments and Debates

  • Reply to Arnulf Stenzl, Morgan Rouprêt, J. Alfred Witjes, Paolo Gontero. High-quality Transurethral Resection of Bladder Tumour Needs Additional Forms of Tumour Delineation. Eur Urol 2023;83:193–4

    Heer, R., Tan, W. S., Gravestock, P., Vadiveloo, T., Lewis, R., Penegar, S., Vale, L., MacLennan, G., Hall, E., PHOTO Trial Team
    European Urology, vol. 85, no. 3, pp. 309-312
    Contributions to Journals: Comments and Debates

  • SFX-01 in hospitalised patients with community-acquired pneumonia during the COVID-19 pandemic: a double-blind, randomised, placebo-controlled trial

    Long, M. B., Abo-Leyah, H., Giam, Y. H., Vadiveloo, T., Hull, R. C., Keir, H. R., Pembridge, T., De Lima, D. A., Delgado, L., Inglis, S. K., Hughes, C., Gilmour, A., Gierlinski, M., New, B. J., Maclennan, G., Dinkova-Kostova, A. T., Chalmers, J. D.
    ERJ Open Research, vol. 10, no. 2, 00917-2023
    Contributions to Journals: Articles

  • Three-year cost utility analysis of mini versus standard slings: A trial based economic evaluation

    Kilonzo, M., Boyers, D., Cooper, D., Davidson, T., Bhal, K., N'Dow, J., MacLennan, G., Norrie, J., Abdel-Fattah, M.
    BJUI Compass, vol. 5, no. 2, pp. 230-239
    Contributions to Journals: Articles

  • Effects of socioeconomic status on baseline values and outcomes at 24 months in the Treatment of Advanced Glaucoma Study randomised controlled Trial

    King, A. J., Hudson, J., Azuara-Blanco, A., Kirwan, J. F., Goyal, S., Lim, K. S., Maclennan, G., TAGS Research Group
    British Journal of Ophthalmology, vol. 108, no. 2, pp. 203-210
    Contributions to Journals: Articles

  • How surgical Trainee Research Collaboratives achieve success: a mixed methods study to develop trainee engagement strategies

    Clement, C., Coulman, K., Heywood, N., Pinkney, T., Blazeby, J., Blencowe, N. S., Cook, J. A., Bulbulia, R., Arenas-Pinto, A., Snowdon, C., Hilton, Z., Magill, L., MacLennan, G., Glasbey, J., Nepogodiev, D., Hardy, V., Lane, J. A.
    BMJ Open, vol. 13, no. 12, e072851
    Contributions to Journals: Articles

  • Effectiveness of conservative management versus laparoscopic cholecystectomy in the prevention of recurrent symptoms and complications in adults with uncomplicated symptomatic gallstone disease (C-GALL trial): pragmatic, multicentre randomised controlled trial

    Ahmed, I., Hudson, J., Innes, K., Hernández, R., Gillies, K., Bruce, R., Bell, V., Avenell, A., Blazeby, J., Brazzelli, M., Cotton, S., Croal, B., Forrest, M., MacLennan, G., Murchie, P., Wileman, S., Ramsay, C.
    BMJ, vol. 383, e075383
    Contributions to Journals: Articles

  • Cost-effectiveness of cognitive behavioural and personalised exercise interventions for reducing fatigue in inflammatory rheumatic diseases

    Chong, H. Y., McNamee, P., Bachmair, E., Martin, K., Aucott, L., Dhaun, N., Dures, E., Emsley, R., Gray, S. R., Kidd, E., Kumar, V., Lovell, K., MacLennan, G., Norrie, J., Paul, L., Packham, J., Ralston, S. H., Siebert, S., Wearden, A., Macfarlane, G., Basu, N., LIFT study group
    Rheumatology, vol. 62, no. 12, pp. 3819-3827
    Contributions to Journals: Articles

  • Development of an intervention to manage benzodiazepine dependence and high-risk use in the context of escalating drug related deaths in Scotland: an application of the MRC framework

    Berry, K., Matheson, C., Schofield, J., Dumbrell, J., Parkes, T., Hill, D., Kilonzo, M., MacLennan, G., Stewart, D., Ritchie, T., Turner, M.
    BMC Health Services Research, vol. 23, no. 1, 1205
    Contributions to Journals: Articles

  • Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients with Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial

    Jansen, J. O., Hudson, J., Cochran, C., MacLennan, G., Lendrum, R., Sadek, S., Gillies, K., Cotton, S., Kennedy, C., Boyers, D., Ferry, G., Lawrie, L., Nath, M., Wileman, S., Forrest, M., Brohi, K., Harris, T., Lecky, F., Moran, C., Morrison, J. J., Norrie, J., Paterson, A., Tai, N., Welch, N., Campbell, M. K., Aylwin, C., Bew, D., Brooks, A., Chinery, J., Cowlam, T., Frith, D., George, A., Hudson, A., Johnstone, P., Mahmood, A., Novak, A., O'Meara, M., Reid, S., Sattout, A., Smith, C., Stansfield, T., Thompson, J., UK-REBOA Study Group
    JAMA, vol. 330, no. 19, pp. 1862-1871
    Contributions to Journals: Articles
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