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The School of Natural and Computing Sciences

Professor John Storey

Professor John Storey
Professor John Storey
Professor John Storey

BSc, PhD (KC, London)

Chair in Pharmaceutical Industrial Chemistry

About
Email Address
j.storey@abdn.ac.uk
Telephone Number
+44 (0)1224 272926
Office Address
Meston Room G106
School/Department
School of Natural and Computing Sciences

External Memberships

Head Chemist for TauRx Therapeutics

Research

Research Overview

Free Radical Chemistry, Organic Methodology, Medicinal Chemistry

Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.

An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.

Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.

Current Research

Selected Current Projects

  • Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
  • A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
  • Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
  • New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
  • The use of organic molecules as asymmetric catalysts.

 

Teaching

Teaching Responsibilities

Professor Storey teaches in the following courses: 

  • CM1010
  • CM1011
  • CM4017/CM3024 Honours/Advanced Chemistry
  • CM5003 MChem Chemistry Applications

 

Publications

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  • Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling

    Sinclair, J. P., Nicoll, S. L., Storey, J. M. D.
    Patents: Patents

  • Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

    Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A., Harrington, C. R.
    Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720
    Contributions to Journals: Articles

  • A Twist-Bend Nematic Phase Driven by Hydrogen Bonding

    Jansze, S. M., Martinez-Felipe, A., Storey, J. M. D., Marcelis, A. T. M., Imrie, C. T.
    Angewandte Chemie International Edition, vol. 54, no. 2, pp. 643-646
    Contributions to Journals: Articles

  • Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease

    Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., Wischik, C. M.
    Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118
    Contributions to Journals: Articles

  • New insights into the liquid crystal behaviour of hydrogen-bonded mixtures provided by temperature-dependent FTIR spectroscopy

    Paterson, D. A., Martinez-Felipe, A., Jansze, S. M., Marcelis, A. T. M., Storey, J. M. D., Imrie, C. T.
    Liquid Crystals, vol. 42, no. 5-6, pp. 928-939
    Contributions to Journals: Articles

  • Tau-aggregation inhibitor therapy for Alzheimer's disease

    Wischik, C. M., Harrington, C. R., Storey, J. M. D.
    Biochemical Pharmacology, vol. 88, no. 4, pp. 529-539
    Contributions to Journals: Articles

  • TauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX

    Wischik, C. M., Harrington, C. R., Storey, J. M. D.
    13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy, pp. S26
    Contributions to Journals: Abstracts

  • New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes

    Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.
    Patents: Patents

  • The crystalline state of methylene blue: a zoo of hydrates

    Rager, T., Geoffroy, A., Hilfiker, R., Storey, J. M. D.
    Physical Chemistry Chemical Physics, vol. 22, no. 14, pp. 8074-8082
    Contributions to Journals: Articles

  • EPR studies of electron and hole trapping in titania photocatalysts

    MacDonald, I. R., Dixon, S., Holt, E., Grant, N., Storey, J. M. D., Howe, R. F.
    Catalysis Today, vol. 182, no. 1, pp. 39-45
    Contributions to Journals: Articles

  • Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants

    Larch, C. P., Storey, J. M. D., Williamson, C., Marshall, C., Kemp, S. J.
    Patents: Patents

  • 3,7-diamino-10H-phenothiazine salts and their use: WO2007110627

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents

  • 3,6-Disubstituted xanthylium salts

    Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R., Wischik, C. M.
    Patents: Patents

  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds

    Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.
    Patents: Patents

  • Ligands for aggregated tau molecules: WO2010034982

    Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S., Heinrich, T.
    Patents: Patents

  • Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

    Wischik, C. M., Wischik, D. J., Storey, J. M. D., Harrington, C. R.
    Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.), pp. 210-232, 23 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Therapeutic Use of Diaminophenothiazines: WO2009044127

    Wischik, C. M., Damon J., W., Storey, J. M. D., Harrington, C. R.
    Patents: Patents

  • Methods of synthesis and/or purification of diaminophenothiazinium compounds

    Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.
    Patents: Patents

  • Investigation of Reactions Involving Radical Intermediates

    Aldabbagh, F., Bowman, W. R., Storey, J. M.
    The Investigation of Organic Reactions and Their Mechanisms. Maskill, H. (ed.). John Wiley and Sons, pp. 261-292, 32 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Synthesis using aromatic homolytic substitution: recent advances

    Bowman, W. R., Storey, J. M. D.
    Chemical Society Reviews, vol. 36, no. 11, pp. 1803-1822
    Contributions to Journals: Literature Reviews

  • 1-[(S)-1-phenylethyl]-1H-benzimidazole

    Williamson, C., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 8, o3482
    Contributions to Journals: Articles

  • N-(5-bromo-2-iodophenyl)-N-methylcyclopentanecarboxamide

    Slawin, A. M. Z., Nicoll, S. L., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 8, o3407
    Contributions to Journals: Articles

  • Semiconductor Oxide Photocatalysis for Organic Synthesis

    Grant, N., Storey, J. M. D., Howe, R. F.
    Studies in Surface Science and Catalysis, vol. 172, pp. 445-448
    Contributions to Journals: Articles

  • 5-bromo-6-chloro-N-4-methylpyrimidine-2,4-diamine

    Walji, D. V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 6, pp. o2810-o2811
    Contributions to Journals: Articles

  • N,N '-Di-1-naphthylurea revisited

    Slawin, A. M. Z., Lawson, J., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 6, pp. o2925-o2927
    Contributions to Journals: Articles

  • N-(2-bromo-3-pyridyl)-3-methylbut-2-enamide

    Walji, D. V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 6, pp. o2815-o2816
    Contributions to Journals: Articles

  • Benzyl N-(2-formylphenyl)carbamate

    Walji, D. V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 5, pp. o2120-2121
    Contributions to Journals: Articles

  • N-(5-Bromo-2-iodophenyl)-N-methylcyclo-hexanecarboxamide

    Slawin, A. M. Z., Nicoll, S. L., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 5, pp. o2117-o2119
    Contributions to Journals: Articles

  • 4,6-Dibromobenzene-1,3-diol monohydrate

    Kirsop, P. J., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 4, pp. o1577-o1578
    Contributions to Journals: Articles

  • Benzyl N-benzyl-N-(2-formylphenyl)carbamate-benzyl N-benzyl-N-(2-carboxyphenyl)carbamate [0.332(4)/0.668 (4)]

    Walji, D. V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 4, pp. o1575-o1576
    Contributions to Journals: Articles

  • N-(2-Bromophenyl)-N-methylnicotinamide

    Percival, D. A., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 4, pp. o1853-o1854
    Contributions to Journals: Articles

  • N-(2-bromophenyl)pyridine-3-carboxamide

    Percival, D. A., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 4, pp. o1851-o1852
    Contributions to Journals: Articles

  • N-(5-bromopyrimidin-4-yl)cyclopropanecarboxamide

    Walji, D. V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 4, pp. o1761-o1762
    Contributions to Journals: Articles

  • 1-(4-iodobutyl)pyrimidin-1-ium iodide

    Walji, D. V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 3, pp. o1222-o1223
    Contributions to Journals: Articles

  • 4-Bromo-3,5-dihydroxybenzoic acid monohydrate

    Kirsop, P. J., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 3, pp. o1441-o1443
    Contributions to Journals: Articles

  • Ethyl (E)-4-(2-acetylphenoxy)but-2-enoate

    Williamson, C., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 3, pp. o1428-o1429
    Contributions to Journals: Articles

  • Ethyl 2-(2-formylphenoxy)ethanoate-ethyl 2-(2-carboxyphenoxy)ethanoate [0.682(7)/0.318(7)]

    Williamson, C., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 3, pp. o1426-o1427
    Contributions to Journals: Articles

  • Ethyl 3,5-bis(allyloxy)-4-bromobenzoate

    Kirsop, P. J., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 63, no. 2, pp. o833-o835
    Contributions to Journals: Articles

  • Homolytic aromatic substitution: a radical approach towards the synthesis of 5-azaoxindoles

    Storey, J. M. D., Ladwa, M. M.
    Tetrahedron Letters, vol. 47, pp. 381-383
    Contributions to Journals: Articles

  • 2-Bromo-1,3-bis(bromomethyl)-benzene, with Z ' = 1.5: whole-molecule disorder of one of the two independent molecules

    Kirsop, P., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section C, Crystal Structure Communications, vol. C62, no. 7, pp. o376-o378
    Contributions to Journals: Articles

  • Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)

    Storey, J. M. D., Sinclair, J. P., Marshall, C., Tan, H. W., Wischik, C. M.
    Patents: Patents

  • Imidazole based solid-supported catalysts for the benzoin condensation

    Storey, J. M. D., Williamson, C.
    Tetrahedron Letters, vol. 46, pp. 7337-7339
    Contributions to Journals: Articles

  • Ethyl (E)-4-(2-formylphenoxy)but-2-enoate

    Williamson, C., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 61
    Contributions to Journals: Articles

  • N-(2-Bromophenyl)propionamide

    Ronaldson, V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 61
    Contributions to Journals: Articles

  • N-(2-bromophenyl)acetamide

    Ronaldson, V., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 61
    Contributions to Journals: Articles

  • {N-[(S)-1-phenylethyl]carbamoyl}methylaminium chloride

    Williamson, C., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 61
    Contributions to Journals: Articles

  • The mechanism of Bu3SnH-mediated homolytic aromatic substitution

    Beckwith, A. L. J., Bowry, V. W., Bowman, W. R., Mann, E., Parry, J., Storey, J. M. D.
    Angewandte Chemie International Edition, vol. 43, pp. 95-98
    Contributions to Journals: Articles

  • 1,3,5-Tribromo-2,6-dihydroxybenzene

    Kirsop, P., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. E60, pp. o222-o224
    Contributions to Journals: Articles

  • 1-Allyloxy-2-bromo-3-(3-phenylallyloxy)benzene

    Kirsop, P., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section E: Structure Reports Online, vol. 60
    Contributions to Journals: Articles

  • 1-Bromo-2,6-dihydroxybenzene containing R44(8) rings and C(2) helices

    Kirsop, P., Storey, J. M. D., Harrison, W. T. A.
    Acta Crystallographica Section C, Crystal Structure Communications, vol. C60, no. 5, pp. o353-o355
    Contributions to Journals: Articles
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