Professor M Carmen Romano
Personal Chair
- About
-
- Email Address
- m.romano@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272507
- Office Address
- Office 337, Institute for Complex Systems and Mathematical Biology, Department of Physics, Meston Building, Old Aberdeen Office 3:47, Institute of Medical Sciences, Foresterhill
- School/Department
- School of Natural and Computing Sciences
- Research
-
Research Overview
I am interested in the understanding of fundamental biological processes using theoretical approaches based on nonlinear dynamics and statistical physics and combining them with experimental data. In particular, I am interested in the process of translation or synthesis of proteins, the coupling between transcription and translation, how ribosomes, the molecular machines that manufacture proteins, are synthesised, and its relationship to the cell cycle. I am furthermore interested in the effect of combinatorial stresses in yeast, as well as the effects of different types of stress on the cell cycle.
Funding and Grants
SULSA studentship (modeling of translation)/ SABR grant (Combinatorial Responses In Stress Pathways)/BBSRC grant (Ribosome Traffic Flow on the mRNA as a Regulator of Cellular Protein Production)
- Teaching
-
Teaching Responsibilities
Electromagnetism (PX3008, 3rd year Physics) and Introduction to Mathematics and Modelling of Biological Systems (SB5005, MSc in Cell and Molecular Systems Biology)
- Publications
-
Page 1 of 3 Results 1 to 25 of 73
What determines sub-diffusive behavior in crowded protein solutions?
Biophysical Journal, vol. 123, no. 2, pp. 134-146Contributions to Journals: ArticlesExpressInHost: A codon tuning tool for the expression of recombinant proteins in host microorganisms
Journal of Open Research Software, vol. 11, no. 2Contributions to Journals: ArticlesTwo-species totally asymmetric simple exclusion process model: From a simple description to intermittency and traveling traffic jams
Physical Review E, vol. 105, no. 3, 034117Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.105.034117
The molecular aetiology of tRNA synthetase depletion: induction of a GCN4 amino acid starvation response despite homeostatic maintenance of charged tRNA levels
Nucleic Acids Research, vol. 48, no. 6, pp. 3071-3088Contributions to Journals: ArticlesTranslational control of gene expression via interacting feedback loops
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 100, no. 5, 050402(R)Contributions to Journals: ArticlesDefinition Of The Minimal Contents For The Molecular Simulation Of The Yeast Cytoplasm
Frontiers in Molecular Biosciences, vol. 6, 97Contributions to Journals: Articles- [ONLINE] https://www.frontiersin.org/articles/10.3389/fmolb.2019.00097/full#supplementary-material
- [ONLINE] DOI: https://doi.org/10.3389/fmolb.2019.00097
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13056/1/fmolb_Kompella_et_al_Definition_of_minimal_contents_VoR.pdf
- [ONLINE] View publication in Scopus
Power series solution of the inhomogeneous exclusion process
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 97, no. 5, 052139Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.97.052139
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11267/1/PhysRevE.97.052139.pdf
Deciphering mRNA Sequence Determinants of Protein Production Rate
Physical Review Letters, vol. 120, no. 12, 128101Contributions to Journals: ArticlesNovel mRNA-specific effects of ribosome drop-off on translation rate and polysome profile
PLoS Computational Biology , vol. 13, no. 5, e1005555Contributions to Journals: ArticlesSynthetic biology routes to bio-artificial intelligence
Essays in Biochemistry, vol. 60, no. 4, pp. 381-391Contributions to Journals: ArticlesIdentification of the mRNA targets of tRNA-specific regulation using genome-wide simulation of translation
Nucleic Acids Research, vol. 44, no. 19, pp. 9231-9244Contributions to Journals: ArticlesIntegrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans
PloS ONE, vol. 10, no. 9, 0137750Contributions to Journals: ArticlesMinimal model of transcriptional elongation processes with pauses
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 90, no. 5, pp. 1-4Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.90.050701
Ribosome recycling induces optimal translation rate at low ribosomal availability
Journal of the Royal Society Interface, vol. 11, no. 98, 20140589Contributions to Journals: ArticlesStepping and Crowding of Molecular Motors: Statistical Kinetics from an Exclusion Process Perspective
Biophysical Journal, vol. 107, no. 5, pp. 1176-1184Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bpj.2014.07.012
Identifying coupling directions by recurrences
Recurrence Quantification Analysis: Theory and Best Practices - Part I. Webber Jr, C. L., Marwan, N. (eds.). Springer Verlag, pp. 65-99, 35 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-319-07155-8_3
- [ONLINE] View publication in Scopus
Controlling translation elongation efficiency: tRNA regulation of ribosome flux on the mRNA
Biochemical Society Transactions, vol. 42, no. 1, pp. 160-165Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/BST20130132
Dominant-negative release factors and their effect on termination and translational recoding events
RNA UK 2014Contributions to Conferences: PostersThe wiper model: avalanche dynamics in an exclusion process
Journal of statistical mechanics-Theory and experiment, vol. 2013, 10015Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1088/1742-5468/2013/10/P10015
From START to FINISH: the influence of osmotic stress on the cell cycle
PloS ONE, vol. 8, no. 7, e68067Contributions to Journals: ArticlesDominant-negative release factors and their effect on termination and translational recoding events
Translation UK 2013Contributions to Conferences: PostersRibosome traffic on mRNAs maps to gene ontology: genome-wide quantification of translation initiation rates and polysome size regulation
PLoS Computational Biology , vol. 9, no. 1, e1002866Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pcbi.1002866
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3677/1/Ribosome_traffic.pdf
A yeast tRNA mutant that causes pseudohyphal growth exhibits reduced rates of CAG codon translation
Molecular Microbiology, vol. 87, no. 2, pp. 284–300Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/mmi.12096
Transport on a lattice with dynamical defects
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 87, no. 1, 012705Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.87.012705
Combinatorial stresses kill pathogenic Candida species
Medical Mycology, vol. 50, no. 7, pp. 699-709Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3109/13693786.2012.672770