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The Institute of Applied Health Sciences

Dr Carl Counsell

Dr Carl Counsell
Dr Carl Counsell
Dr Carl Counsell

MRCP, MSc, MD

Reader (Clinical)

About
Email Address
carl.counsell@abdn.ac.uk
Office Address

Room 1:009, Polwarth Building Division of Applied Health Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Carl is a clinical reader and honorary consultant in neurology.  He graduated in medicine from Cambridge University in 1988, did his early postgraduate medical training in London, Newcastle and Falkirk and then trained in neurology, stroke and epidemiology in Edinburgh.  He spent a year in Melbourne where he specialised in movement disorders before taking up his present post in 2001.  A committed Christian, he would like to have more time to serve in his church and develop his interests in Fairtrade and conservation. 

Latest Publications

View My Publications

Research

Research Overview

Carl is a consultant neurologist with subspecialty interest in movement disorders.  His main research interests are in evidence-based medicine and broader aspects of clinical epidemiology such as incidence and prognostic studies, particularly in relation to Parkinson's disease, other movement disorders and stroke.  His team have established several cohorts of parkinsonian patients for long-term follow-up and supported a number of non-industry sponsored clinical trials and Cochrane reviews, whilst also trying to promote multidisciplinary neurology research in Aberdeen. 

Research Specialisms

  • Clinical Medicine

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

The PINE study: a population-based incidence cohort of people with Parkinson's disease and other parkinsonian disorders, along with their carers and controls who are being followed up lifelong to establish long-term prognosis.

The Parkinson's Incidence Cohorts Collaboration:  an individual patient data meta-analysis of all population- based incidence cohorts of Parkinson's disease to assess prognosis and allow prognostic modelling.     

The Scottish PSP/CBD prevalence cohort:  a cohort of people with two related Parkinson's plus disorders,  Progressive Supranuclear Palsy and Corticobasal Degeneration as well as Parkinson's disease controls, to assess diagnostic and care pathways and prognosis.  

 

Past Research

Cochrane systematic reviews of randomised trials in stroke care and Parkinson's disease

Prognostic modelling in acute stroke

Incidence of Parkinson's disease and other parkinsonian disorders in North-East Scotland 

Prevalence of multiple sclerosis in North-East Scotland and northern isles

Randomised trial of physiotherapy for cervical dystonia

 

Knowledge Exchange

Member of Parkinson's Excellence Network

Collaborations

Cochrane Collaboration Stroke Review Group, Professors Charles Warlow and Peter Sandercock, University of Edinburgh, UK, 1993-98.

Scottish Audit of Intracranial Vascular Malformations, Professor Rustam Al-Shahi Salman, University of Edinburgh, UK, 2002-2014. 

PDMED trial, Professor Carl Clarke, University of Birmingham, UK, 2004-2020.

Clinical trial methods in neurodegenerative diseases, Professor John Zajicek, University of Plymouth, UK, 2009-2014. 

PDCOMM trial, Professor Sackley, University of Nottingham, UK, 2016-2023.

NICE technology appraisals for multiple sclerosis, Universities of Warwick and Exeter, UK, 2016-2022 

Parkinson's Incidence Cohorts Collaboration, Professor Tysnes, Dr Guido Alves, Professor Lars Forsgren, Dr Caroline Williams-Gray, Dr Alison Yarnall, Universities of Stavanger (Norway), Umea (Sweden), Cambridge (UK) and Newcastle (UK), 2018 ongoing 

PD Connect exercise trial, Julie Jones, Robert Gordon University, Aberdeen, UK, 2019-2022 

 

Supervision

Dr Kate Taylor (MD), 2002-06, Incidence and prognosis of parkinsonism in north-east Scotland: a pilot study.

Clare Harris (MSc), 2006-08, PINE participants attitudes to brain donation. 

Dr Robert Caslake (PhD), 2006-11, Incidence and short-term prognosis of Parkinson's disease and other parkinsonian disorders in north-east Scotland.

Dr Elizabeth Visser (MD), 2009-13, Prevalence of multiple sclerosis in northern Scotland.

Dr David McGhee (PhD), 2009-13, Improving clinical trial design in neurodegenerative diseases.

Dr Angus Macleod (PhD), 2012-15, Predicting mortality and dependency in Parkinson's disease.

Dr Diane Swallow (PhD), 2016-21, Assessing diagnostic pathways in progressive supranuclear palsy and corticobasal degeneration.

Funding and Grants

Research funding has been obtained from:

Parkinson’s UK, Scottish Chief Scientist Office, BMA Doris Hillier award, RS Macdonald Trust, BUPA Foundation, NHS Grampian endowments, Dystonia Society, National Institute for Health Research.  

Teaching

Teaching Responsibilities

Lectures and clinical teaching of neurology for medical and dental students.

Supervising medical student elective and MSc projects 

Non-course Teaching Responsibilities

Regent to medical students

Publications

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  • Statistical analysis, trial design and duration in Alzheimer's disease clinical trials: a review

    Thompson, P., Wright, D., Counsell, C. E., Zajicek, J. P.
    International Psychogeriatrics, vol. 24, no. 5, pp. 689-697
    Contributions to Journals: Articles

  • Fibrinogen depleting agents for acute ischaemic stroke

    Hao, Z., Liu, M., Counsell, C., Wardlaw, J. M., Lin, S., Zhao, X.
    Cochrane Database of Systematic Reviews, no. 3, CD000091
    Contributions to Journals: Articles

  • Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study

    Salman, R. A., Hall, J. M., Horne, M. A., Moultrie, F., Josephson, C. B., Bhattacharya, J. J., Counsell, C. E., Murray, G. D., Papanastassiou, V., Ritchie, V., Roberts, R. C., Sellar, R. J., Warlow, C. P., Scottish Audit of Intracranial Vascular Malformations (SAIVMs) collaborators
    The Lancet neurology, vol. 11, no. 3, pp. 217-224
    Contributions to Journals: Articles

  • Genome-wide homozygosity and multiple sclerosis in Orkney and Shetland Islanders

    McWhirter, R. E., McQuillan, R., Visser, E., Counsell, C., Wilson, J. F.
    EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. , vol. 20, no. 2, pp. 198-202
    Contributions to Journals: Articles

  • Early Mortality in an Incident Cohort of People with Parkinson's Disease and Parkinsonism

    Caslake, R., Scott, N., Harris, C., Gordon, J., Counsell, C.
    Age and Ageing, vol. 41, pp. 67
    Contributions to Journals: Abstracts

  • Parkinsonism Incidence in Northeast Scotland (The Pine Study): The Incidence of Parkinson's Disease and Parkinsonism

    Caslake, R., Harris, C., Gordon, J., Primrose, W., Counsell, C.
    Age and Ageing, vol. 41, pp. 68
    Contributions to Journals: Abstracts

  • The Incidence of Progressive Supranuclear Palsy, Multiple System Atrophy and Vascular Parkinsonism in Northeast Scotland (The Pine Study)

    Caslake, R., Gordon, J., Harris, C., Primrose, W., Counsell, C.
    Age and Ageing, vol. 41, pp. 69
    Contributions to Journals: Abstracts

  • Systematic review of biomarkers for disease progression in Parkinson's disease

    McGhee, D. J. M., Counsell, C. E.
    Annual Meeting of the Association of British Neurologists, pp. e1
    Contributions to Journals: Abstracts

  • The impact of motor and non motor symptoms on health state values in newly diagnosed idiopathic Parkinson's disease

    Shearer, J., Green, C., Counsell, C. E., Zajicek, J. P.
    Journal of Neurology, vol. 259, no. 3, pp. 462-468
    Contributions to Journals: Articles

  • The documentation of lumbar puncture for acute headache presentations: a re-audit

    Baker, J., Counsell, C.
    International Journal of Clinical Practice, vol. 65, no. 11, pp. 1201-1202
    Contributions to Journals: Letters

  • Disease severity and progression in progressive supranuclear palsy and multiple system atrophy: validation of the NNIPPS - PARKINSON PLUS SCALE

    Payan, C. A. M., Viallet, F., Landwehrmeyer, B. G., Bonnet, A., Borg, M., Durif, F., Lacomblez, L., Bloch, F., Verny, M., Fermanian, J., Agid, Y., Ludolph, A. C., Leigh, P. N., Bensimon, G., on behalf of the NNIPPS Study Group, Counsell, C.
    PloS ONE, vol. 6, no. 8, e22293
    Contributions to Journals: Articles

  • The use of decision-analytic models in Parkinson's disease: a systematic review and critical appraisal

    Shearer, J., Green, C., Counsell, C. E., Zajicek, J. P.
    Applied Health Economics and Health Policy, vol. 9, no. 4, pp. 243-258
    Contributions to Journals: Articles

  • Seizure risk from cavernous or arteriovenous malformations: prospective population-based study

    Josephson, C. B., Leach, J., Duncan, R., Roberts, R. C., Counsell, C. E., Al-Shahi Salman, R., Scottish Audit of Intracranial Vascular Malformations (SAIVMs) steering committee and collaborators
    Neurology, vol. 76, no. 18, pp. 1548-1554
    Contributions to Journals: Articles

  • Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

    Nalls, M. A., Plagnol, V., Hernandez, D. G., Sharma, M., Sheerin, U., Saad, M., Simón-Sánchez, J., Schulte, C., Lesage, S., Sveinbjörnsdóttir, S., Stefánsson, K., Martinez, M., Hardy, J., Heutink, P., Brice, A., Gasser, T., Singleton, A. B., Wood, N. W., International Parkinson Disease Genomics Consortium, Counsell, C. E.
    The Lancet, vol. 377, no. 9766, pp. 641-649
    Contributions to Journals: Articles

  • Orphan drugs: Regulation is flawed

    Counsell, C. E.
    BMJ (Clinical research ed.), vol. 341, c7016
    Contributions to Journals: Letters

  • Parkinsonism incidence in north-east Scotland: the PINE study

    Counsell, C., Gordon, J., Primrose, W., Harris, C., Caslake, R.
    Journal of Neurology, Neurosurgery & Psychiatry, vol. 81, no. 11, pp. E21
    Contributions to Journals: Articles

  • The Incidence of Progressive Supranuclear Palsy, Multiple System Atrophy, and Vascular Parkinsonism in North-East Scotland (the PINE Study)

    Caslake, R., Gordon, J., Harris, C., Primrose, W., Counsell, C.
    Movement Disorders, vol. 25, pp. S613-S614
    Contributions to Journals: Articles

  • Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy

    Brown, R. G., Lacomblez, L., Landwehrmeyer, B. G., Bak, T., Uttner, I., Dubois, B., Agid, Y., Ludolph, A., Bensimon, G., Payan, C., Leigh, N. P., NNIPPS Study Group, Counsell, C.
    Brain, vol. 133, no. 8, pp. 2382-2393
    Contributions to Journals: Articles

  • Timed tests of motor function in Parkinson's disease

    MacLeod, A. D., Counsell, C. E.
    Parkinsonism & Related Disorders, vol. 16, no. 7, pp. 442-446
    Contributions to Journals: Articles

  • Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial

    Williams, A., Gill, S., Varma, T., Jenkinson, C., Quinn, N., Mitchell, R., Scott, R., Ives, N., Rick, C., Daniels, J., Patel, S., Wheatley, K., Counsell, C., PD SURG Collaborative Group
    The Lancet neurology, vol. 9, no. 6, pp. 581-591
    Contributions to Journals: Articles

  • Derivation of stem cells from human embryos: the principled arguments of potential donors and recipients

    Porter, M. A., Peddie, V., Counsell, C., Pearson, D., Bhattacharya, S.
    New Genetics and Society, vol. 29, no. 2, pp. 209-220
    Contributions to Journals: Articles

  • Documentation of cerebrospinal fluid opening pressure and other important aspects of lumbar puncture in acute headache

    Hewett, R., Counsell, C.
    International Journal of Clinical Practice, vol. 64, no. 7, pp. 930-935
    Contributions to Journals: Articles

  • Medication management in people with Parkinson's disease during surgical admissions

    Derry, C. P., Shah, K. J., Caie, L., Counsell, C. E.
    Postgraduate Medical Journal, vol. 86, no. 1016, pp. 334-337
    Contributions to Journals: Articles

  • Predicting functional outcome after stroke by modelling baseline clinical and CT variables

    Reid, J., Gubitz, G. J., Dai, D., Kydd, D., Eskes, G., Reidy, Y., Christian, C., Counsell, C. E., Dennis, M., Phillips, S. J.
    Age and Ageing, vol. 39, no. 3, pp. 360-366
    Contributions to Journals: Articles

  • Diagnosis and pharmacological management of Parkinson's disease: summary of SIGN guidelines

    Grosset, D., Macphee, G., Nairn, M., Counsell, C., SIGN development group
    British Medical Journal, vol. 340, pp. b5614
    Contributions to Journals: Articles
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