Senior Research Fellow
- About
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- Email Address
- steven.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438123
- Office Address
Academic Urology Unit Health Sciences Building (2nd Floor) University of Aberdeen Foresterhill Aberdeen AB25 2ZD Tel: +44 (0)1224 559086 Fax: +44 (0)1224 554580 Email: steven.maclennan@abdn.ac.uk
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Steven is a Research Fellow in the Academic Urology Unit at the University of Aberdeen. His research themes cover the broad spectrum of evidence-based medicine in urology. This encompasses assessing the effectiveness of treatments in clinical trials, developing core outcome sets, providing critical reviews of the evidence base, creating evidence-based (or where necessary consensus-based) clinical practice guidelines, and implementing guideline recommendations in clinical practice. Steven is a member of the European Association of Urology (EAU) methodology committee which oversees the quality of the EAU’s systematic review and clinical practice guideline programme and delivers training on core evidence-based medicine skills in systematic reviews and guideline production. He is also a founding member of the IMpact Assessment of Guidelines Implementation and Education (IMAGINE) group which aims to assess current variations in practice, investigate barriers and facilitators to guideline adherent practice, and improve adherence to strong, high level of evidence, guideline recommendations. Prostate Cancer DIagnOsis and TreatmeNt Enhancement through the Power of Big Data in EuRope (PIONEER) is one of Steven’s recent projects, where his heaviest involvement is in the work to help standardise outcome definitions across all stages of disease to support the Big Data analysis work and improve the consistency of outcome reporting, outcome definition and measurement in future clinical trials and clinical audit.
Qualifications
- PhD Sociology2010 - University of Edinburgh
- MRes Social Research Methods2006 - University of Aberdeen
- BA (Hons.) Applied Social Science2005 - The Robert Gordon University
Memberships and Affiliations
- Internal Memberships
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IAHS Athena Swan Self Assessment Team
- External Memberships
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European Association of Urology
- Research
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Research Overview
An overview of current projects:
Core Outcome Set Development Projects
Renal Cancer Core Outcome Sets (R-COS)
In this project, part funded by the Arcobaleno Cancer Trust and NHS Grampian Endowments, we are developing three seperate Core Outcome Sets (COS) for localised, locally advanced, and metastatic stages of kidney cancer. This includes two systematic reviews, an interview study and three Delphi studies. The COMET registration, giving full study details is accessible here: https://www.comet-initiative.org/studies/details/1406
Bladder Cancer Core Outcome Sets (B-COS)
In this project, we are developing Core Outcome Sets for the various stages of bladder cancer. Forming the initial statge of the project, we published an article reviewing outcome reporting heterogeneity in non-muscle invasive bladder cancer - accessible here: https://content.iospress.com/articles/bladder-cancer/blc201510
The COMET registration, giving full study details is availabe here: https://www.comet-initiative.org/studies/details/1135
Prostate Cancer Core Outcome Sets
We devleoped a COS for localised prostate cancer. The results can be accessed here: https://bjui-journals.onlinelibrary.wiley.com/doi/abs/10.1111/bju.13854
Our prostate cancer COS work was subsequently updated and incorporated in the PIONEER project. More detail about PIONEER can be viewed here: https://prostate-pioneer.eu/
Implementation Science Projects
IMAGINE (IMpact Assessment of Guidelines Implementation and Education)
IMAGINE is a European Association of Urology (EAU) working group focussing on mapping adherence to EAU guidelines and, where variation or suboptimal practice is identified, investigating the barriers and facilitators to guideline adherence, and developing implementation interventions to adress the barriers and leverage the facilitators. You can read more about the IMAGINE group in this editorial
RESECT (Transurethral REsection and Single instillation intra-vesical chemotherapy Evaluation in bladder Cancer Treatment (RESECT) Improving quality in TURBT surgery.)
RESECT is a collaborative project with the British Urology Researchers in Surgical Training (BURST) group, including researchers from the Academic Urology Unit and HSRU. A main aim of RESECT is to test intereventions aimed at improving adherence to guidelines around single instilation of chemotherapy adn documentation of the procudure - which have been shown to be associated with improved patient outcomes. You can read more about RESECT here: https://www.bursturology.com/Studies/Resect/Overview/
OPTIMA (OPtimal Treatment for patients wiht solid tumours in Europe through Artificial Intelligence)
OPTIMA is a 34 partners-based IMI project. The programme aim is to design, develop and deliver the first interoperable and GDPR-compliant European real-world oncology data and evidence generation platform based on the needs of the clinicians and patients, in an inclusive and sustainable way. It will be built on a combination of federated and centralised access to a vast network of European data providers to help answer the highest priority research questions in prostate, breast and lung cancer, especially where current existing evidence underpinning clinical practice guidelines is weak. In parallel, comprehensive decision support toolsets based on national and international guidelines with approved regular updates of guideline recommendations underpinned by evidence from advanced statistical analysis and AI will be made available to fill the guidelines gaps and better support shared decision making by clinicians and patients.
Deimplementing ADT
There is evidence to suggest that Androgen Deprivation Therapy (ADT) is overused in men with localised prostate cancer. it is unclear why, and it is unclear what the best strategies for deimplementing ADT are. This reserach problem is the focus of Jennifer Dunsmore's PhD project, which Steven is supervising. You can read more about Jennifer and her reserach here: https://www.abdn.ac.uk/iahs/research/urology/metis/profiles/j.dunsmore.19
Guideline Development Projects
Steven sits on the European Association of Urology (EAU) Guidelines Office Methodology Committee. This committee oversees the training of Guidelines Associates through Systematic Review workshops.
EVOLVE (giving patients a meaningful voice in the design and delivery of care)
EVOLVE is a unique collaboration of a profession society (European Association of Urology), guideline panels, researchers, clinicians and patient representatives to improve guideline development and implementation for genitourinary cancers in Europe. The aim of the project is to develop a model of patient involvement that will give patients a meaningful voice in the design and delivery of care and will investigate how wider stakeholders can help to integrate the patient voice into guidelines. You can read more about EVOLVE here: https://www.abdn.ac.uk/iahs/research/urology/metis/evolve-1618.php
- Teaching
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Teaching Responsibilities
Steven contributes to the design, delivery and assessment of the MSc. level courses in the Institute of Applied Health Sciences linked above. He also supervises MSc. dissertations and often supervises medical student summer placements in the Aberdeen Summer Research Scholarship (ASRS) programme.
Steven currently supervises two PhD. projects and is intersted in supervising any project aligning with his broad interests in the desing and delivery of urology health services.
Non-course Teaching Responsibilities
Alongside formal teaching at the University of Aberdeen, Steven and his colleagues also developed a 2.5 day course for the European Association of Urology (EAU) on systematic reviews for clinical practice guidelines.
Steven also teaches the systematic review element for the European Organisaiton for Research and Treatment of Cancer (EORTC) 'clinical trial statistics for non-statisticians' course. https://event.eortc.org/stats2021/
- Publications
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Should we involve patients while selecting outcomes for systematic reviews?
21rst Annual Scientific Meeting of the UK Continence SocietyContributions to Conferences: AbstractsWhat is the role of patients while selecting outcomes which are important for clinical decision making?: Patients' involvement in a Cochrane Systematic Review
21rst Annual Scientific Meeting of the UK Continence SocietyContributions to Conferences: AbstractsSystematic Review and Meta-analysis of the Clinical Effectiveness of Shock Wave Lithotripsy, Retrograde Intrarenal Surgery, and Percutaneous Nephrolithotomy for Lower-pole Renal Stones
European Urology, vol. 67, no. 4, pp. 612-616Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2014.09.054
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5795/1/Donaldson_2015.pdf
Surgical management for localised penile cancer
Cochrane Database of Systematic Reviews, vol. 2015, no. 3, CD011533Contributions to Journals: Articles- [ONLINE] https://doi.org//10.1002/14651858.CD011533
- [ONLINE] DOI: https://doi.org/10.1002/14651858.CD011533
A core outcome set for localised prostate cancer effectiveness trials: protocol for a systematic review of the literature and stakeholder involvement through interviews and a Delphi survey
Trials, vol. 16, 76Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1186/s13063-015-0598-0
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4460/1/s13063_015_0598_0.pdf
Systematic review and meta-analysis of the clinical effectiveness of bipolar compared with monopolar transurethral resection of the prostate (TURP)
BJU International, vol. 113, no. 1, pp. 24-35Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bju.12281
Systematic Review of Adrenalectomy and Lymph Node Dissection in Locally Advanced Renal Cell Carcinoma
European Urology, vol. 64, no. 5, pp. 799-810Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2013.04.033
Re: Comparative Effectiveness for Survival and Renal Function of Partial and Radical Nephrectomy for Localized Renal Tumors: A Systematic Review and Meta-Analysis: S. P. Kim, R. H. Thompson, S. A. Boorjian, C. J. Weight, L. C. Han, M. H. Murad, N. D. Shippee, P. J. Erwin, B. A. Costello, G. K. Chow and B. C. Leibovich J Urol 2012; 188: 51–57
Journal of Urology, vol. 189, no. 3, pp. 1166-1167Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/j.juro.2012.10.025
- [ONLINE] View publication in Scopus
Systematic review and meta-analysis of the clinical effectiveness of bipolar compared to monopolar transurethral resection of the prostate
European Urology Supplements, pp. e523-e524Contributions to Journals: AbstractsSystematic review of perioperative and quality-of-life outcomes following surgical management of localised renal cancer
European Urology, vol. 62, no. 6, pp. 1097-1117Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2012.07.028
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2588/1/MacLennan_2013.pdf
Corrigendum to "systematic review of oncological outcomes following surgical management of localised renal cancer" [Eur Urol 2012;61:972-93]
European Urology, vol. 62, no. 1Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2012.04.003
- [ONLINE] View publication in Scopus
Systematic review of oncological outcomes following surgical management of localised renal cancer
European Urology, vol. 61, no. 5, pp. 972-993Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2012.02.039
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2550/1/MacLennan_2012.pdf
Assessing risk of bias in non-randomised studies and incorporating GRADE: Initial experience with a new Cochrane ‘risk of bias’ tool under development
Contributions to Conferences: PapersInitial experience with a pilot Cochrane tool for assessing risk of bias for non-randomized studies applying a web-based survey of content experts to derive criteria for imbalance
Contributions to Conferences: PapersThe hazards of extracting hazard ratios from survival curves for meta-analyses in observational studies
Contributions to Conferences: PapersEvidence for partial nephrectomy
Contributions to Conferences: PapersSystematic review of the clinical effectiveness of surgical management for localised renal cell carcinoma
Commissioned by European Association of Urology. University of Aberdeen: Academic Urology UnitBooks and Reports: Commissioned ReportsCommunity
Sociology for Social Work: An Introduction. Yuill, C., Gibson, A. (eds.). Sage PublicationsChapters in Books, Reports and Conference Proceedings: ChaptersCalculating Practices
Working Papers: Working Papers'It wasn't me, Guv. It was the System': MPs Expenses and Rhetorical Accounting Techniques
Contributions to Conferences: Papers