Professor Claude Wischik
Chair in Mental Health (Clin)
- Email Address
- c.m.wischik@abdn.ac.uk
- Office Address
TauRx Therapeutics Ltd
1st Floor, Sir Moir Lockhead Building
395 King Street
Aberdeen
AB24 5RP
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Research Overview
Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology
Page 1 of 3 Results 1 to 50 of 104
FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning
Tripathi, S., McNeil, C., Staff, R., Murray, A., Wischik, C., Schelter, B., Waiter, G.Nuclear Medicine and Molecular ImagingContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s13139-025-00908-2
Hydromethylthionine sustains truncated-tau-dependent inflammation-lowering effects in mouse brain
Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.FEBS JournalContributions to Journals: ArticlesObtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease
Shen, D., Agarwal, A., Misra, V., Schelter, B., Shah, D., Shiells, H., Wischik, C.Scientific Reports, vol. 15, 1671Contributions to Journals: ArticlesRivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia
Schwab, K., Strachan, L., Anschuetz, A., Dreesen, E. S., Magbagbeolu, M., Melis, V., Theuring, F., Harrington, C., Wischik, C., Riedel, G.Brain Research Bulletin, vol. 220, 111172Contributions to Journals: ArticlesHigh-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
Arastoo, M., Penny, L. K., Lofthouse, R. A., Abdallah, A., Abrahamsson, A., Marini, P., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.Alzheimer's Research & Therapy, vol. 16, 209Contributions to Journals: ArticlesRescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine
Cranston, A., Kraev, I., Stewart, M. G., Horsley, D., Robinson, L., Dreesen, E. S., Armstrong, P., Palliyil, S., Harrington, C., Wischik, C., Riedel, G.Cellular Signalling, vol. 121, 111269Contributions to Journals: ArticlesHydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Schwab, K., Lauer, D., Magbagbeolu, M., Institute, M., Institute, M., Institute, M., Harrington, C. R., Wischik, C. M., Niewiadomska, G., Riedel, G.Brain Research Bulletin, vol. 212, 110955Contributions to Journals: ArticlesConsiderations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease
Penny, L. K., Lofthouse, R., Arastoo, M., Porter, A., Palliyil, S., Harrington, C. R., Wischik, C. M.Translational neurodegeneration, vol. 13, 25Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1186/s40035-024-00417-w
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23668/1/s40035-024-00417-w.pdf
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
Schwab, K., Frahm, S., Magbagbeolu, M., Horsley, D., Goatman, E., Melis, V., Theuring, F., Ishaq, A., Storey, J. M. D., Harrington, C., Wischik, C., Riedel, G.European Journal of Pharmacology, vol. 970, 176505Contributions to Journals: ArticlesNeuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model
Zadrozny, M., Drapich, P., Gasiorowska-Bien, A., Niewiadomski, W., Harrington, C. R., Wischik, C. M., Riedel, G., Niewiadomska, G.Cells, vol. 13, no. 7, 642Contributions to Journals: ArticlesAssays for the Screening and Characterization of Tau Aggregation Inhibitors
Horsley, D., Rickard, J. E., Vorley, T., Leeper, M. F., Wischik, C. M., Harrington, C. R.Tau Protein: Methods and Protocols. 2 edition, pp. 93-104, 12 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-3629-9_5
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy
Schwab, K., Magbagbeolu, M., Theuring, F., Harrington, C., Wischik, C., Riedel, G.Scientific Reports, vol. 14, 6239Contributions to Journals: ArticlesApathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia
Robinson, L., Dreesen, E., Mondesir, M., Harrington, C., Wischik, C., Riedel, G.Behavioural Brain Research, vol. 456, 114707Contributions to Journals: ArticlesA Meta-Analysis on Presynaptic Changes in Alzheimer's Disease
Anschuetz, A., Schwab, K., Harrington, C. R., Wischik, C. M., Riedel, G.Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162Contributions to Journals: ArticlesSignificant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate
Wischik, C. M., Schelter, B., Penny, L. K., Miller, S., Stefanacci, R., Heslegrave, A., Zetterberg, H.Alzheimer's Dementia, vol. 19, no. S24, e083153Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/alz.083153
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants
Arastoo, M., Mazanetz, M. P., Miller, S., Shiells, H., Hull, C., Robinson, K., Storey, J. M., Harrington, C. R., Wischik, C. M.International Journal of Molecular Sciences, vol. 24, no. 18, 13747Contributions to Journals: ArticlesMitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.International Journal of Molecular Sciences, vol. 24, no. 13, 10810Contributions to Journals: ArticlesUtility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis
Zabala-Findlay, A., Penny, L. K., Lofthouse, R. A., Porter, A. J., Palliyil, S., Harrington, C. R., Wischik, C. M., Arastoo, M.Cells, vol. 12, no. 8, 1184Contributions to Journals: Review articlesAn Additive-Free Model for Tau Self-Assembly
Al-Hilaly, Y. K., Marshall, K. E., Lutter, L., Biasetti, L., Mengham, K., Harrington, C. R., Xue, W. F., Wischik, C. M., Serpell, L. C.Methods in molecular biology (Clifton, N.J.), vol. 2551, pp. 163-188Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-2597-2_12
- [ONLINE] View publication in Scopus
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Al-Hilaly, Y. K., Hurt, C., Rickard, J. E., Harrington, C. R., Storey, J. M., Wischik, C. M., Serpell, L. C., Siemer, A. B.Frontiers in Neuroscience, vol. 16, 988074Contributions to Journals: ArticlesDityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro
Maina, M. B., Al-Hilaly, Y. K., Oakley, S., Burra, G., Khanom, T., Biasetti, L., Mengham, K., Marshall, K., Harrington, C. R., Wischik, C. M., Serpell, L. C.Journal of Molecular Biology, vol. 434, no. 19, 167785Contributions to Journals: ArticlesOral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate
Wischik, C. M., Bentham, P., Gauthier, S., Miller, S., Kook, K., Schelter, B. O.Journal of Prevention of Alzheimer's Disease, vol. 9, pp. 780-790Contributions to Journals: ArticlesGlutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine
Schwab, K., Chasapopoulou, Z., Frahm, S., Magbagbeolu, M., Cranston, A., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.Cellular Signalling, vol. 97, 110386Contributions to Journals: ArticlesStructural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis
Lutter, L., Al-Hilaly, Y. K., Serpell, C. J., Tuite, M. F., Wischik, C. M., Serpell, L. C., Xue, W. F.Journal of Molecular Biology, vol. 434, no. 7, 167466Contributions to Journals: ArticlesHMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesCrossed cerebellar diaschisis in Alzheimer's disease
Tripathi, S. M., Murray, A. D., Wischik, C. M., Schelter, B.Nuclear Medicine Communications, vol. 43, no. 4, pp. 423-427Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/MNM.0000000000001531
- [ONLINE] View publication in Scopus
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
Kondak, C., Riedel, G., Harrington, C. R., Wischik, C. M., Klein, J.Journal of Neurochemistry, vol. 160, pp. 172-184Contributions to Journals: ArticlesDegeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia
Vuksanovic, V., Staff, R., Morson, S., Ahearn, T., Bracoud, L., Murray, A. D., Bentham, P., Kipps, C. M., Harrington, C., Wischik, C.Brain Communications, vol. 3, no. 4, fcab241Contributions to Journals: ArticlesLong-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier
Bentham, P., Staff, R. T., Schelter, B. O., Shiells, H., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023Contributions to Journals: ArticlesProteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks
Schwab, K., Melis, V., Harrington, C. R., Wischik, C. M., Magbagbeolu, M., Theuring, F., Riedel, G.Cells, vol. 10, no. 8, 2162Contributions to Journals: ArticlesOxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.Cells, vol. 10, no. 3, 703Contributions to Journals: ArticlesDifferential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia
Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523Contributions to Journals: ArticlesAdaptive neurological testing method
Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.Patents: PatentsCurrent Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
Arastoo, M., Lofthouse, R., Penny, L., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19Contributions to Journals: ArticlesTau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.Frontiers in Neurology, vol. 11, 590754Contributions to Journals: ArticlesPaired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells
Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2020.05.027
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14862/1/Pollack_etal_Paired_helical_VOR.pdf
- [ONLINE] View publication in Scopus
Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease
Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. ?., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-200146
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519Contributions to Journals: ArticlesMechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.Current Alzheimer Research, vol. 17, no. 3, pp. 285-296Contributions to Journals: ArticlesCholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration
Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G., Niewiadomska, G.Brain Communications, vol. 2, no. 1, fcaa033Contributions to Journals: ArticlesTau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W., Wischik, C. M., Serpell, L. C.FEBS LETTERS, vol. 594, no. 5, pp. 944-950Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/1873-3468.13675
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13414/2/AlHilaly_etal_FEBS_VOR.pdf
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946Contributions to Journals: ArticlesPhospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study
Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J., Luna-Muñoz, J.Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 631-645Contributions to Journals: ArticlesCortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia
Vuksanovic, V., Staff, R. T., Ahearn, T., Murray, A. D., Wischik, C. M.International Journal of Neural Systems, vol. 29, no. 6, 1850055Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1142/S0129065718500557
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11981/3/Cortical_Thickness_and_Surface_Area_Networks_in_Healthy_Aging_Alzheimer_s_Disease_and_Behavioral_Variant_Fronto_Temporal_Dementia.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G., Klein, J.ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acschemneuro.8b00274
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12993/1/ACSChemNsci_Konig.pdf
- [ONLINE] View publication in Mendeley
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131Contributions to Journals: ArticlesModeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development
Wischik, C. M., Schelter, B. O., Wischik, D. J., Storey, J. M. D., Harrington, C. R.Journal of Alzheimer's Disease, vol. 62, no. 3, pp. 1287-1303Contributions to Journals: ArticlesAlpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease
Frahm, S., Melis, V., Horsley, D., Rickard, J., Riedel, G., Fadda, P., Scherma, M., Harrington, C., Wischik, C., Theuring, F., Schwab, K.Behavioural Brain Research, vol. 339, pp. 153-168Contributions to Journals: ArticlesA Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.Frontiers in Molecular Neuroscience, vol. 10, 447Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457Contributions to Journals: Articles- [ONLINE] https://www.j-alz.com/vol61-1
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170560
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9693/1/Potential_of_Low_Dose.pdf