
Professor Claude Wischik
Chair in Mental Health (Clin)
- Email Address
- c.m.wischik@abdn.ac.uk
- Office Address
TauRx Therapeutics Ltd
1st Floor, Sir Moir Lockhead Building
395 King Street
Aberdeen
AB24 5RP
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Research Overview
Molecular Neuropathology of Alzheimer's Disease, and in particular the therapeutic intervention of tau pathology
Page 1 of 2 Results 1 to 100 of 104
FDG-PET Image Classification in Alzheimer’s Disease: from Traditional Visual Analysis to Advanced Transfer Learning
Tripathi, S., McNeil, C., Staff, R., Murray, A., Wischik, C., Schelter, B., Waiter, G.Nuclear Medicine and Molecular ImagingContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s13139-025-00908-2
Hydromethylthionine sustains truncated-tau-dependent inflammation-lowering effects in mouse brain
Coelho Dos Santos, R., Lee, S. H., Lofthouse, R. A., Melis, V., Strachan, L., Leith, M., Dreesen, E., Armstrong, P., Vorley, T., Goatman, E., Hull, C., Riedel, G., Wischik, C., Harrington, C.FEBS JournalContributions to Journals: ArticlesObtaining personalized predictions from a randomized controlled trial on Alzheimer’s disease
Shen, D., Agarwal, A., Misra, V., Schelter, B., Shah, D., Shiells, H., Wischik, C.Scientific Reports, vol. 15, 1671Contributions to Journals: ArticlesRivastigmine interferes with the pharmacological activity of hydromethylthionine on presynaptic proteins in the line 66 model of frontotemporal dementia
Schwab, K., Strachan, L., Anschuetz, A., Dreesen, E. S., Magbagbeolu, M., Melis, V., Theuring, F., Harrington, C., Wischik, C., Riedel, G.Brain Research Bulletin, vol. 220, 111172Contributions to Journals: ArticlesHigh-affinity antibodies specific to the core region of the tau protein exhibit diagnostic and therapeutic potential for Alzheimer’s disease
Arastoo, M., Penny, L. K., Lofthouse, R. A., Abdallah, A., Abrahamsson, A., Marini, P., Melis, V., Riedel, G., Harrington, C., Wischik, C., Porter, A., Palliyil, S.Alzheimer's Research & Therapy, vol. 16, 209Contributions to Journals: ArticlesRescue of synaptosomal glutamate release defects in tau transgenic mice by the tau aggregation inhibitor hydromethylthionine
Cranston, A., Kraev, I., Stewart, M. G., Horsley, D., Robinson, L., Dreesen, E. S., Armstrong, P., Palliyil, S., Harrington, C., Wischik, C., Riedel, G.Cellular Signalling, vol. 121, 111269Contributions to Journals: ArticlesHydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: interference by cholinesterase inhibitors
Schwab, K., Lauer, D., Magbagbeolu, M., Institute, M., Institute, M., Institute, M., Harrington, C. R., Wischik, C. M., Niewiadomska, G., Riedel, G.Brain Research Bulletin, vol. 212, 110955Contributions to Journals: ArticlesConsiderations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease
Penny, L. K., Lofthouse, R., Arastoo, M., Porter, A., Palliyil, S., Harrington, C. R., Wischik, C. M.Translational neurodegeneration, vol. 13, 25Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1186/s40035-024-00417-w
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23668/1/s40035-024-00417-w.pdf
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy
Schwab, K., Frahm, S., Magbagbeolu, M., Horsley, D., Goatman, E., Melis, V., Theuring, F., Ishaq, A., Storey, J. M. D., Harrington, C., Wischik, C., Riedel, G.European Journal of Pharmacology, vol. 970, 176505Contributions to Journals: ArticlesNeuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model
Zadrozny, M., Drapich, P., Gasiorowska-Bien, A., Niewiadomski, W., Harrington, C. R., Wischik, C. M., Riedel, G., Niewiadomska, G.Cells, vol. 13, no. 7, 642Contributions to Journals: ArticlesAssays for the Screening and Characterization of Tau Aggregation Inhibitors
Horsley, D., Rickard, J. E., Vorley, T., Leeper, M. F., Wischik, C. M., Harrington, C. R.Tau Protein: Methods and Protocols. 2 edition, pp. 93-104, 12 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-3629-9_5
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy
Schwab, K., Magbagbeolu, M., Theuring, F., Harrington, C., Wischik, C., Riedel, G.Scientific Reports, vol. 14, 6239Contributions to Journals: ArticlesApathy-like behaviour in tau mouse models of Alzheimer’s disease and frontotemporal dementia
Robinson, L., Dreesen, E., Mondesir, M., Harrington, C., Wischik, C., Riedel, G.Behavioural Brain Research, vol. 456, 114707Contributions to Journals: ArticlesA Meta-Analysis on Presynaptic Changes in Alzheimer's Disease
Anschuetz, A., Schwab, K., Harrington, C. R., Wischik, C. M., Riedel, G.Journal of Alzheimer's Disease, vol. 97, no. 1, pp. 145-162Contributions to Journals: ArticlesSignificant dose-dependent reduction in neurofilament light chain concentration in plasma with oral tau aggregation inhibitor hydromethylthionine mesylate
Wischik, C. M., Schelter, B., Penny, L. K., Miller, S., Stefanacci, R., Heslegrave, A., Zetterberg, H.Alzheimer's Dementia, vol. 19, no. S24, e083153Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/alz.083153
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants
Arastoo, M., Mazanetz, M. P., Miller, S., Shiells, H., Hull, C., Robinson, K., Storey, J. M., Harrington, C. R., Wischik, C. M.International Journal of Molecular Sciences, vol. 24, no. 18, 13747Contributions to Journals: ArticlesMitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice
Kondak, C., Leith, M., Baddeley, T. C., Santos, R. X., Harrington, C. R., Wischik, C. M., Riedel, G., Klein, J.International Journal of Molecular Sciences, vol. 24, no. 13, 10810Contributions to Journals: ArticlesUtility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer’s Disease: Systematic Review and Meta-Analysis
Zabala-Findlay, A., Penny, L. K., Lofthouse, R. A., Porter, A. J., Palliyil, S., Harrington, C. R., Wischik, C. M., Arastoo, M.Cells, vol. 12, no. 8, 1184Contributions to Journals: Review articlesAn Additive-Free Model for Tau Self-Assembly
Al-Hilaly, Y. K., Marshall, K. E., Lutter, L., Biasetti, L., Mengham, K., Harrington, C. R., Xue, W. F., Wischik, C. M., Serpell, L. C.Methods in molecular biology (Clifton, N.J.), vol. 2551, pp. 163-188Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/978-1-0716-2597-2_12
- [ONLINE] View publication in Scopus
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Al-Hilaly, Y. K., Hurt, C., Rickard, J. E., Harrington, C. R., Storey, J. M., Wischik, C. M., Serpell, L. C., Siemer, A. B.Frontiers in Neuroscience, vol. 16, 988074Contributions to Journals: ArticlesDityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro
Maina, M. B., Al-Hilaly, Y. K., Oakley, S., Burra, G., Khanom, T., Biasetti, L., Mengham, K., Marshall, K., Harrington, C. R., Wischik, C. M., Serpell, L. C.Journal of Molecular Biology, vol. 434, no. 19, 167785Contributions to Journals: ArticlesOral Tau Aggregation Inhibitor for Alzheimer’s Disease: Design, Progress and Basis for Selection of the 16 mg/day Dose in a Phase 3, Randomized, Placebo-Controlled Trial of Hydromethylthionine Mesylate
Wischik, C. M., Bentham, P., Gauthier, S., Miller, S., Kook, K., Schelter, B. O.Journal of Prevention of Alzheimer's Disease, vol. 9, pp. 780-790Contributions to Journals: ArticlesGlutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine
Schwab, K., Chasapopoulou, Z., Frahm, S., Magbagbeolu, M., Cranston, A., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.Cellular Signalling, vol. 97, 110386Contributions to Journals: ArticlesStructural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis
Lutter, L., Al-Hilaly, Y. K., Serpell, C. J., Tuite, M. F., Wischik, C. M., Serpell, L. C., Xue, W. F.Journal of Molecular Biology, vol. 434, no. 7, 167466Contributions to Journals: ArticlesHMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine
Santos, R. X., Melis, V., Goatman, E. A., Leith, M., Baddeley, T. C., Storey, J. M., Riedel, G., Wischik, C. M., Harrington, C. R.Biomedicines, vol. 10, no. 4, 867Contributions to Journals: ArticlesCrossed cerebellar diaschisis in Alzheimer's disease
Tripathi, S. M., Murray, A. D., Wischik, C. M., Schelter, B.Nuclear Medicine Communications, vol. 43, no. 4, pp. 423-427Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/MNM.0000000000001531
- [ONLINE] View publication in Scopus
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine
Kondak, C., Riedel, G., Harrington, C. R., Wischik, C. M., Klein, J.Journal of Neurochemistry, vol. 160, pp. 172-184Contributions to Journals: ArticlesDegeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia
Vuksanovic, V., Staff, R., Morson, S., Ahearn, T., Bracoud, L., Murray, A. D., Bentham, P., Kipps, C. M., Harrington, C., Wischik, C.Brain Communications, vol. 3, no. 4, fcab241Contributions to Journals: ArticlesLong-term hydromethylthionine treatment is associated with delayed clinical onset and slowing of cerebral atrophy in a pre-symptomatic P301S MAPT mutation carrier
Bentham, P., Staff, R. T., Schelter, B. O., Shiells, H., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 83, no. 3, pp. 1017-1023Contributions to Journals: ArticlesProteomic analysis of hydromethylthionine in the line 66 model of frontotemporal dementia demonstrates actions on tau-dependent and tau-independent networks
Schwab, K., Melis, V., Harrington, C. R., Wischik, C. M., Magbagbeolu, M., Theuring, F., Riedel, G.Cells, vol. 10, no. 8, 2162Contributions to Journals: ArticlesOxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates
Maina, M. B., Al-Hilaly, Y. K., Burra, G., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.Cells, vol. 10, no. 3, 703Contributions to Journals: ArticlesDifferential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the Line 66 model of frontotemporal dementia
Lemke, N., Melis, V., Lauer, D., Magbagbeolu, M., Neumann, B., Harrington, C. R., Riedel, G., Wischik, C. M., Theuring, F., Schwab, K.Journal of Biological Chemistry, vol. 295, no. 52, pp. 18508-18523Contributions to Journals: ArticlesAdaptive neurological testing method
Shiells, H. C., Morson, S., Schelter, B., Wischik, D. J., Wischik, C.Patents: PatentsCurrent Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
Arastoo, M., Lofthouse, R., Penny, L., Harrington, C. R., Porter, A., Wischik, C. M., Palliyil, S.International Journal of Molecular Sciences, vol. 21, no. 22, pp. 1-19Contributions to Journals: ArticlesTau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
Oakley, S., Maina, M. B., Marshall, K. E., Al-Hilaly, Y. K., Harrington, C. R., Wischik, C. M., Serpell, L. C.Frontiers in Neurology, vol. 11, 590754Contributions to Journals: ArticlesPaired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells
Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M., Serpell, L. C.Journal of Molecular Biology, vol. 432, no. 17, pp. 4891-4907Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jmb.2020.05.027
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14862/1/Pollack_etal_Paired_helical_VOR.pdf
- [ONLINE] View publication in Scopus
Analysis of the Relationship Between Metalloprotease-9 and Tau Protein in Alzheimer's Disease
Hernandes-Alejandro, M., Montaño, S., Harrington, C. R., Wischik, C. M., Salas-Casas, A., Cortes-Reynosa, P., Pérez Salazar, E., Cazares-Apatiga, J., Apatiga-Perez, R., Ontiveros Torres, M. ?., Perry, G., Pacheco-Herrero, M., Luna-Muñoz, J.Journal of Alzheimer's Disease, vol. 76, no. 2, pp. 553-569Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-200146
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia
Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 75, no. 2, pp. 501-519Contributions to Journals: ArticlesMechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model
Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R., Wischik, C. M.Current Alzheimer Research, vol. 17, no. 3, pp. 285-296Contributions to Journals: ArticlesCholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration
Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G., Niewiadomska, G.Brain Communications, vol. 2, no. 1, fcaa033Contributions to Journals: ArticlesTau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain
Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W., Wischik, C. M., Serpell, L. C.FEBS LETTERS, vol. 594, no. 5, pp. 944-950Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/1873-3468.13675
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13414/2/AlHilaly_etal_FEBS_VOR.pdf
- [ONLINE] View publication in Scopus
Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease
Schelter, B. O., Shiells, H., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 72, no. 3, pp. 931-946Contributions to Journals: ArticlesPhospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study
Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J., Luna-Muñoz, J.Journal of Alzheimer's Disease, vol. 71, no. 2, pp. 631-645Contributions to Journals: ArticlesCortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia
Vuksanovic, V., Staff, R. T., Ahearn, T., Murray, A. D., Wischik, C. M.International Journal of Neural Systems, vol. 29, no. 6, 1850055Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1142/S0129065718500557
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11981/3/Cortical_Thickness_and_Surface_Area_Networks_in_Healthy_Aging_Alzheimer_s_Disease_and_Behavioral_Variant_Fronto_Temporal_Dementia.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)
König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G., Klein, J.ACS Chemical Neuroscience, vol. 10, no. 4, pp. 1915-1922Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acschemneuro.8b00274
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12993/1/ACSChemNsci_Konig.pdf
- [ONLINE] View publication in Mendeley
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)
Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.Journal of Molecular Biology, vol. 430, no. 21, pp. 4119-4131Contributions to Journals: ArticlesModeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development
Wischik, C. M., Schelter, B. O., Wischik, D. J., Storey, J. M. D., Harrington, C. R.Journal of Alzheimer's Disease, vol. 62, no. 3, pp. 1287-1303Contributions to Journals: ArticlesAlpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease
Frahm, S., Melis, V., Horsley, D., Rickard, J., Riedel, G., Fadda, P., Scherma, M., Harrington, C., Wischik, C., Theuring, F., Schwab, K.Behavioural Brain Research, vol. 339, pp. 153-168Contributions to Journals: ArticlesA Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
Schwab, K., Frahm, S., Horsley, D., Rickard, J. E., Melis, V., Goatman, E. A., Magbagbeolu, M., Douglas, M., Leith, M. G., Baddeley, T. C., Storey, J. M. D., Riedel, G., Wischik, C. M., Harrington, C. R., Theuring, F.Frontiers in Molecular Neuroscience, vol. 10, 447Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnmol.2017.00447
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9976/1/fnmol_10_00447.pdf
Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial
Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D., Harrington, C. R., Wischik, C. M.Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 435-457Contributions to Journals: Articles- [ONLINE] https://www.j-alz.com/vol61-1
- [ONLINE] DOI: https://doi.org/10.3233/JAD-170560
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9693/1/Potential_of_Low_Dose.pdf
Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking
Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Serpell, L. C.Journal of Molecular Biology, vol. 429, no. 23, pp. 3650-3665Contributions to Journals: ArticlesThe effect of latent confounding processes on the estimation of the strength of causal influences in chain-type networks
Shiells, H. C., Thiel, M., Wischik, C., Schelter, B.Medical Research Archives , vol. 5, no. 9, 1298Contributions to Journals: ArticlesOrganisation of cortical thickness networks in Alzheimer’s disease and behavioural variant frontotemporal dementia across brain lobes
Vuksanovic, V., Staff, R., Ahearn, T., Bentham, P., Murray, A. D., Wischik, C. M.6th Cambridge Neuroscience SymposiumContributions to Conferences: AbstractsMethod and system for determining network connections
Sommerlade, L., Schelter, B., Wischik, C.Patents: PatentsLMTM DECREASES α-SYNUCLEIN PATHOLOGY AND REDUCES BEHAVIOURAL DEFECTS IN α-SYNUCLEIN TRANSGENIC MICE
Schwab, K., Frahm, S., Magbagbeolu, M., A. Goatman, E., R. Harrington, C., M. Wischik, C., Theuring, F.Alzheimer's and Dementia, vol. 13, no. 7 Suppl., pp. P945-P945Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.jalz.2017.06.1854
Monoaminergic Neuropathology in Alzheimer's disease
Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., Silva, R. d., Giovanni, G. D., Wischik, C. M., Hof, P. R.Progress in Neurobiology, vol. 151, pp. 101-138Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pneurobio.2016.04.001
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8480/1/ProgN_Simic.pdf
Distinct anatomical subtypes of behavioural variant frontotemporal dementia and involvement of intrinsic brain networks: a clustering study
Vuksanovic, V., Staff, R., Ahearn, T. S., Morson, S. M., Bentham, P., Murray, A. D., Wischik, C. M.Alzheimer Research UK (2017)Contributions to Conferences: AbstractsAssays for the Screening and Characterization of Tau Aggregation Inhibitors
Rickard, J. E., Horsley, D., Wischik, C. M., Harrington, C. R.Tau Protein: Methods and Protocols. Smet-Nocca, C. (ed.). Springer, pp. 129-140, 12 pagesChapters in Books, Reports and Conference Proceedings: Chapters (Peer-Reviewed)- [ONLINE] DOI: https://doi.org/10.1007/978-1-4939-6598-4_8
Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial
Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M.The Lancet, vol. 388, no. 10062, pp. 2873-2884Contributions to Journals: ArticlesInhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease
Wischik, C. M., Storey, J. M. D., Wischik, D. J., Harrington, C. R.Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Wolfe, M. S. (ed.). Elsevier Inc., pp. 385-436, 52 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-802173-6.00015-0
- [ONLINE] View publication in Scopus
Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease
Lai, R. Y. K., Harrington, C. R., Wischik, C. M.Biomolecules, vol. 6, no. 2, pp. 1-19Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/biom6020019
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5864/1/biomolecules_06_00019_v2.pdf
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., Wischik, C., Hof, P. R.Biomolecules, vol. 6, no. 1, 6Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.3390/biom6010006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8985/1/biomolecules_06_00006_v2.pdf
- [ONLINE] View publication in Scopus
Neural correlates of cognitive and behavioural impairments in behavioural variant of frontotemporal dementia: A voxel based morphometry analysis
Vuksanovic, V., Staff, R., Ahearn, T., Morson, S. M., Bentham, P., Murray, A. D., Wischik, C. M.SINAPSE Annual Scientific Meeting (2016)Contributions to Conferences: AbstractsPhenothiazine compounds for treating mild cognitive impairment
Wischik, C. M., Harbaran, D. V., Riedel, G., Deiana, S., Goatman, E. A., Wischik, D. J., Murray, A. D., Staff, R. T.Patents: PatentsDifferent pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration
Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G., Theuring, F.Cellular and Molecular Life Sciences, vol. 72, no. 11, pp. 2199-2222Contributions to Journals: ArticlesEffects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models
Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F., Riedel, G.Behavioural Pharmacology, vol. 26, no. 4, pp. 353-368Contributions to Journals: ArticlesCellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease
Harrington, C. R., Storey, J. M. D., Clunas, S., Harrington, K. A., Horsley, D., Ishaq, A., Kemp, S. J., Larch, C. P., Marshall, C., Nicoll, S. L., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, L. J., Wischik, C. M.The Journal of Biological Chemistry, vol. 290, no. 17, pp. 10862-10875Contributions to Journals: ArticlesThe relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease
Flores-Rodríguez, P., Ontiveros-Torres, M. A., Cárdenas-Aguayo, M. C., Luna-Arias, J. P., Meraz-Ríos, M. A., Viramontes-Pintos, A., Harrington, C. R., Wischik, C. M., Mena, R., Florán-Garduño, B., Luna-Muñoz, J.Frontiers in Neuroscience, vol. 9, 33Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3389/fnins.2015.00033
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4290/1/fnins_09_00033.pdf
Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease
Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A., Harrington, C. R.Journal of Alzheimer's Disease, vol. 44, no. 2, pp. 705-720Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3233/JAD-142874
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4205/1/fulltext.pdf
Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer's Disease
Baddeley, T. C., McCaffrey, J., Storey, J. M. D., Cheung, J. K. S., Melis, V., Horsley, D., Harrington, C. R., Wischik, C. M.Journal of Pharmacology and Experimental Therapeutics, vol. 352, no. 1, pp. 110-118Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1124/jpet.114.219352
Tau-aggregation inhibitor therapy for Alzheimer's disease
Wischik, C. M., Harrington, C. R., Storey, J. M. D.Biochemical Pharmacology, vol. 88, no. 4, pp. 529-539Contributions to Journals: ArticlesTauRx global phase 3 trial in Alzheimer's disease with tau aggregation inhibitor LMTX
Wischik, C. M., Harrington, C. R., Storey, J. M. D.13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy, pp. S26Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/j.neurobiolaging.2014.01.128
New phenothiazine diaminium compounds are tau protein aggregation inhibitors, useful to treat e.g. Alzheimer's disease, Pick's disease, progressive supranuclear palsy, frontotemporal dementia and frontotemporal lobar degeneration syndromes
Baddeley, T., Clunas, S., Harrington, C. R., Horsley, D., Ishaq, A., Khan, K., Loh, Y. S., Marshall, C., Rickard, J. E., Simpson, M., Sinclair, J. P., Storey, J. M. D., Williamson, C., Wischik, C. M., Wood, B. A.Patents: PatentsRegional cerebral blood flow and aberrant motor behaviour in Alzheimer's disease
Reilly, T. J., Staff, R. T., Ahearn, T. S., Bentham, P., Wischik, C. M., Murray, A. D.Behavioural Brain Research, vol. 222, no. 2, pp. 375-379Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbr.2011.04.003
The cerebral blood flow correlates of emotional facial processing in mild Alzheimer's disease
Staff, R., Ahearn, T. S., Phillips, L. H., Cooper, C. L., Mowat, D., Wischik, C. M., Whalley, L. J., Murray, A. D.Neuroscience & Medicine, vol. 2, no. 1, pp. 6-13Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.4236/nm.2011.21002
3,7-diamino-10H-phenothiazine salts and their use: WO2007110627
Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.Patents: PatentsStripline resonator and preamplifier for preclinical magnetic resonance imaging at 4.7 T
Lavdas, I., Seton, H., Harrington, C. R., Wischik, C. M.Magnetic Resonance Materials in Physics, Biology and Medicine, vol. 24, no. 6, pp. 331-337Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10334-011-0273-8
3,6-Disubstituted xanthylium salts
Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R., Wischik, C. M.Patents: PatentsMethods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC): methods of treatment of a tauopathy condition comprising the use of thioninium compounds
Wischik, C. M., Rickard, J. E., Harrington, C. R., Horsley, D., Storey, J. M. D., Marshall, C., Sinclair, J. P.Patents: PatentsLigands for aggregated tau molecules: WO2010034982
Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S., Heinrich, T.Patents: PatentsRationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies
Wischik, C. M., Wischik, D. J., Storey, J. M. D., Harrington, C. R.Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.), pp. 210-232, 23 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1039/9781849731065
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4066/1/Wischik_2010_RSC_Chapter.pdf
Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe
Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M., CC75C Collaboration GroupThe Scientific World Journal, vol. 9, pp. 1463-1475Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1100/tsw.2009.151
Therapeutic Use of Diaminophenothiazines: WO2009044127
Wischik, C. M., Damon J., W., Storey, J. M. D., Harrington, C. R.Patents: PatentsMethylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine
Deiana, S., Harrington, C. R., Wischik, C. M., Riedel, G.Psychopharmacology, vol. 202, no. 1-3, pp. 53-65Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00213-008-1394-2
Methods of synthesis and/or purification of diaminophenothiazinium compounds
Wischik, C. M., Storey, J. M. D., Marshall, C., Sinclair, J. P., Baddeley, T.Patents: PatentsThiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints
Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M., Mena, R.Acta Neuropathologica, vol. 116, no. 5, pp. 507-515Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00401-008-0431-x
Inhibitors of protein aggregation: WO2007110629
Wischik, C. M., Rickard, J. E., Horsley, D., Harrington, C. R.Patents: PatentsA55 A rCBF study of hallucinations in dementia.
Staff, R. T., Benjamin, K. D., Murray, A. D., Gemmell, H. G., Wischik, C. M.Nuclear Medicine Communications, vol. 27, no. 3, 295Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1097/00006231-200603000-00066
Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
Storey, J. M. D., Sinclair, J. P., Marshall, C., Tan, H. W., Wischik, C. M.Patents: PatentsInhibition of tau-tau-association
Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M., Klug, A.Patents: PatentsAlzheimer's disease
Wischik, C. M., Harrington, C. R., Roth, M.The Oxford Companion to The Mind. Gregory, R. (ed.). 2 edition. Oxford University Press, pp. 24-27, 4 pagesChapters in Books, Reports and Conference Proceedings: ChaptersNaphthoquinone-type inhibitors of protein aggregation
Wischik, C. M., Horsley, D., Rickard, J. E., Harrington, C. R.Patents: PatentsMaterials and methods relating to protein aggregation in neurodegenerative disease: WO2002059150
Wischik, C. M., Rickard, J. E., Horsley, D., Harrington, C. R.Patents: PatentsLoss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics
Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R., Wischik, C. M.Neuroscience Letters, vol. 317, no. 3, pp. 161-165Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0304-3940(01)02458-2
Inhibition of tau-tau-association
Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M., Klug, A.Patents: PatentsMaterials and methods relating to protein aggregation in neurodegenerative disease: WO2002055720
Wischik, C. M., Horsley, D., Rickard, J. E., Harrington, C. R.Patents: PatentsNeurofibrillary labels
Wischik, C. M., Harrington, C. R., Rickard, J. E., Horsley, D.Patents: PatentsAccumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer’s disease
Garcia-Sierra, F., Wischik, C. M., Harrington, C. R., Luna-Munoz, J., Mena, R.Journal of Chemical Neuroanatomy, vol. 22, no. 1-2, pp. 65-77Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0891-0618(01)00096-5
Loss of synaptic, but not cytoskeletal proteins in the cerebellum of people with chronic schizophrenia
Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R., Wischik, C. M.Schizophrenia Research, vol. 49, no. Suppl. 1, pp. 55Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0920-9964(01)00159-1
The molecular basis of tau protein pathology in Alzheimer's Disease and related neurodegenerative dementias
Wischik, C. M., Theuring, F., Harrington, C. R.Neurobiology of Alzheimer’s Disease. Dawbarn, D., Allen, S. (eds.). 2 edition. Oxford University PressChapters in Books, Reports and Conference Proceedings: Chapters