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The Rowett Institute

Dr Fiona Campbell

Dr Fiona Campbell
Dr Fiona Campbell
Dr Fiona Campbell

Advanced Research Fellow

About
Email Address
fiona.campbell@abdn.ac.uk
Telephone Number
+44 (0)1224 438617
School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I am a principal investigator based at the Rowett Institute and coordinator of the PGT Human Nutrition MSc programme. My research focuses on advanced glycation end-products (AGEs) in the diet. During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body during digestion. To investigate how dietary AGEs, contribute to diet induced conditions such as type 2 diabetes and dementia we are using human intervention studies to test the effects of highly processed foods high in AGEs on sensitive measures of metabolic health and cognition. I am also researching the role of processing methods in improving food quality and the potential for phytochemicals incorporated into processed foods to ameliorate negative health outcomes.

 

External Memberships

Registered Nutritionist with the AfN (RNutr) 

Member of the Nutrition Society,

Member of Biochemical Society,

Member of British Society for Proteome Resarch (BSPR).

Latest Publications

View My Publications

Research

Research Overview

A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.

Current Research

Current research in my laboratory is focused on  investigating damaged proteins/advanced glycation end-products (AGEs) in the diet.

During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body in the course of digestion. AGEs are associated with the metabolic syndrome and dementia.  We aim to identify foods high in AGEs and test the effects of these foods on sensitive measures of metabolic health and cognition in human intervention studies.

In addition we are investigating the role of processing methods in improving food quality e.g. avoiding prolonged heat treatment of dairy products known to increase AGE formation. We are also determining the potential of phytochemicals incorporated into processed foods to ameliorate these negative metabolic outcomes.

This research could lead to the development of new functional foods and improvements to existing food products. It will also provide health professionals and the public with better information on how changes in diet can be beneficial.

This research is part of Scottish Government Strategic Research Programme funded through the Rural and Environment Science and Analytical Services (RESAS) division to advance the evidence base in the development of rural affairs, food and environment policies. 

Teaching

Courses

Teaching Responsibilities

Programme coordinator for MSc Human Nutrition

Course Coordinator for RN5001 Fundamentals of human nutrition and metabolism and RN5003 Foundations of Nutrition.

Publications

Page 1 of 2 Results 1 to 50 of 64

  • Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes

    Biswas, K., McLay, J., Campbell, F. M.
    Journal of Nutrition and Metabolism, vol. 2022, 4715965
    Contributions to Journals: Articles

  • The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction

    Sergi, D., Boulestin, H., Campbell, F. M., Williams, L. M.
    Molecular Nutrition & Food Research, vol. 65, no. 1, 1900934
    Contributions to Journals: Review articles

  • Anthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin

    Alnajjar, M., Barik, S. K., Bestwick, C., Campbell, F., Cruickshank, M., Farquharson, F., Holtrop, G., Horgan, G., Louis, P., Moar, K., Russell, W. R., Scobbie, L., Hoggard, N.
    Journal of Functional Foods, vol. 64, 103597
    Contributions to Journals: Articles

  • Cinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion

    Hayward, N. J., McDougall, G. J., Farag, S., Allwood, J. W., Austin, C., Campbell, F., Horgan, G., Ranawana, V.
    Plant Foods for Human Nutrition, vol. 74, no. 4, pp. 544-552
    Contributions to Journals: Articles

  • Early and reversible changes to the hippocampal proteome in mice on a high-fat diet

    McLean, F. H., Campbell, F. M., Sergi, D., Grant, C., Morris, A. C., Hay, E. A., MacKenzie, A., Mayer, C., Langston, R. F., Williams, L. M.
    Nutrition and Metabolism, vol. 16, no. 1, 57
    Contributions to Journals: Articles

  • A high-fat diet induces rapid changes in the mouse hypothalamic proteome

    McLean, F. H., Campbell, F. M., Langston, R. F., Sergi, D., Resch, C., Grant, C., Morris, A., Mayer, C., Williams, L. M.
    Nutrition and Metabolism, vol. 16, 26
    Contributions to Journals: Articles

  • Do advanced glycation end products contribute to saturated fat induced inflammation?

    Mazepina, L., Morris, A., Campbell, F. M., Williams, L.
    Proceedings of the Nutrition Society, vol. 78, no. OCE1, E42
    Contributions to Journals: Abstracts

  • SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

    Sergi, D., Campbell, F. M., Grant, C., Morris, A. C., Bachmair, E., Koch, C., McLean, F. H., Muller, A., Hoggard, N., de Roos, B., Porteiro, B., Boekschoten, M. V., McGillicuddy, F. C., Kahn, D., Nicol, P., Benzler, J., Mayer, C., Drew, J. E., Roche, H. M., Muller, M., Nogueiras, R., Diéguez, C., Tups, A., Williams, L. M.
    Genes & Nutrition, vol. 13, 28
    Contributions to Journals: Articles

  • Hippocampal proteomics and primary cell cultures demonstrate proteins key in neuronal plasticity are rapidly changed in rodents on a high-fat diet

    McLean, F. H., Campbell, F. M., Langston, R., Williams, L.
    onference: Society for Neuroscience 2018
    Contributions to Conferences: Abstracts

  • Rapid and reversible impairment of episodic memory by a high-fat diet in mice

    McLean, F. H., Grant, C., Morris, A. C., Horgan, G. W., Polanski, A., Allan, K., Campbell, F. M., Langston, R., Williams, L.
    Scientific Reports, vol. 8, 11976
    Contributions to Journals: Articles

  • Beetroot improves oxidative stability and functional properties of processed foods: singular and combined effects with chocolate

    Ranawana, V., Moynihan, E., Campbell, F., Duthie, G., Raikos, V.
    Journal of Food Science and Technology, vol. 55, no. 7, pp. 2401-2409
    Contributions to Journals: Articles

  • Breads Fortified with Freeze-Dried Vegetables: Quality and Nutritional Attributes. Part II: Breads Not Containing Oil as an Ingredient

    Ranawana, V., Campbell, F., Bestwick, C., Nicol, P., Milne, L., Duthie, G., Raikos, V.
    Foods, vol. 5, no. 3, pp. 1-14
    Contributions to Journals: Articles

  • Breads fortified with freeze-dried vegetables: Quality and nutritional attributes. part ii: Breads not containing oil as an ingredient

    Ranawana, V., Campbell, F., Bestwick, C., Nicol, P., Milne, L., Duthie, G., Raikos, V.
    Foods, vol. 5, no. 3, pp. 1-14
    Contributions to Journals: Articles

  • Breads Fortified with Freeze-Dried Vegetables: Quality and Nutritional Attributes. Part 1: Breads Containing Oil as an Ingredient

    Ranawana, V., Raikos, V., Campbell, F., Bestwick, C., Nicol, P., Milne, L., Duthie, G.
    Foods, vol. 5, no. 1, pp. 1-13
    Contributions to Journals: Articles

  • Having your cake and eating it? The impact of Beetroot addition on the Nutrition, oxidative stability and Quality of cake

    Ranawana, D. V., Moynihan, E., Raikos, V., Campbell, F. M., Duthie, G. G.
    Proceedings of the Nutrition Society, vol. 75, no. OCE3, E108
    Contributions to Journals: Abstracts

  • A novel hypothalamic protein regulated by high fat diet and leptin

    Sergi, D., Morris, A. C., Drew, J. E., Campbell, F. M., Nicol, P., Williams, L. M.
    Proceedings of the Nutrition Society, vol. 74, no. OCE3, pp. E190
    Contributions to Journals: Abstracts

  • The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases

    Williams, L. M., Campbell, F. M., Drew, J. E., Koch, C., Hoggard, N., Rees, W. D., Kamolrat, T., Thi Ngo, H., Steffensen, I., Gray, S. R., Tups, A.
    PloS ONE, vol. 9, no. 8, e106159
    Contributions to Journals: Articles

  • Antioxidant effectiveness of vegetable powders on the lipid and protein oxidative stability of cooked Turkey meat patties: implications for health

    Duthie, G., Campbell, F., Bestwick, C., Stephen, S., Russell, W.
    Nutrients, vol. 5, no. 4, pp. 1241-1252
    Contributions to Journals: Articles

  • Decrease in plasma protein markers of oxidative stress and inflammation in overweight/obese type 2 diabetics after supplementation with bilberry extract

    Campbell, F., Nicol, P., Nicol, F., Reid, M., Cantlay, L., Moar, K. M., Cruickshank, M., Hoggard, N.
    Obesity Facts, vol. 5, no. S1, pp. 198-199
    Contributions to Journals: Abstracts

  • Lower levels of damaged protein biomarkers in the plasma of overweight type 2 diabetic men following supplementation with a standardised bilberry extract

    Campbell, F. M., Nicol, P. F., Moar, K., Cruickshank, M., Hoggard, N.
    Proceedings of the Nutrition Society, vol. 71, no. OCE2, pp. E130
    Contributions to Journals: Abstracts

  • Proteomics reveals that a high-fat diet induces rapid changes in hypothalamic proteins related to neuronal damage and inflammation

    Williams, L. M., Nicol, F., Grant, C., Morris, A. C., Reid, M., Nicol, P., Koch, C., Hoggard, N., Tups, A., Campbell, F. M.
    Proceedings of the Nutrition Society, vol. 70, no. OCE6, pp. E370
    Contributions to Journals: Abstracts

  • High-Fat Diet in C57Bl/6 Mice Induces a Rapid Decrease in Insulin Sensitivity and an Acute Phase Response

    Campbell, F. M., Drew, J. E., Tups, A., Hoggard, N., Nicol, P. F., Farquharson, A. J., Koch, C., Grant, C., Morris, A. C., Williams, L. M.
    Endocrine Reviews, vol. 32, no. 03_MeetingAbstracts, pp. 1-483
    Contributions to Journals: Articles

  • Identification of Plasma Protein Markers of Oxidation in Obese Men

    Campbell, F. M., Robins, S., Hoggard, N.
    biochemical society focussed meeting
    Contributions to Conferences: Posters

  • Optimal combinations of acute phase proteins for detecting infectious disease in pigs

    Heegaard, P. M. H., Stockmarr, A., Piñeiro, M., Carpintero, R., Lampreave, F., Campbell, F. M., Eckersall, P. D., Toussaint, M. J., Gruys, E., Skall Sorensen, N.
    Veterinary Research, vol. 42, pp. 50
    Contributions to Journals: Articles

  • Identification of damaged proteins in human serum using modified Ehrlich's reagent to target protein-bound pyrroles

    Campbell, F. M., Rucklidge, G. J., Reid, M. D., Cantlay, L. L., Robins, S. P.
    Analytical Biochemistry, vol. 398, no. 1, pp. 76-82
    Contributions to Journals: Articles

  • Rapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs

    Skovgaard, K., Mortensen, S., Boye, M., Poulsen, K. T., Campbell, F. M., Eckersall, P. D., Heegaard, P. M. H.
    Veterinary Research, vol. 40, no. 3, 23
    Contributions to Journals: Articles

  • SERRS immunoassay for quantitative human CRP analysis

    Campbell, F. M., Ingram, A., Monaghan, P., Cooper, J., Sattar, N., Eckersall, P. D., Graham, D.
    Analyst, vol. 133, no. 10, pp. 1355-1357
    Contributions to Journals: Articles

  • The association between plasma levels of acute phase proteins, haptoglobin, alpha-1 acid glycoprotein (AGP), Pig-MAP, transthyretin and serum amyloid A (SAA) in Large White and Meishan pigs

    Clapperton, M., Bishop, S. C., Piñeiro, M., Campbell, F. M., Glass, E. J.
    Veterinary Immunology and Immunopathology, vol. 119, no. 3-4, pp. 303-309
    Contributions to Journals: Articles

  • Effects of sub-clinical post-weaning colibacillosis and dietary protein on acute phase proteins in weaner pigs

    Houdijk, J. G. M., Campbell, F. M., Fortomaris, P. D., Eckersall, P. D., Kyriazakis, I.
    Livestock Science , vol. 108, no. 1-3, pp. 182-185
    Contributions to Journals: Articles

  • A time-resolved immunofluorometric assay for porcine C-reactive protein quantification in whole blood

    Martinez-Subiela, S., Eckersall, P. D., Campbell, F. M., Parra, M. D., Fuentes, P., Ceron, J. J.
    Luminescence, vol. 22, no. 3, pp. 171-176
    Contributions to Journals: Articles

  • Characterisation of the pig acute phase protein response to road transport

    Piñeiro, M., Piñeiro, C., Carpintero, R., Morales, J., Campbell, F. M., Eckersall, P. D., Toussaint, M. J. M., Lampreave, F.
    Veterinary Journal, vol. 173, no. 3, pp. 669-674
    Contributions to Journals: Articles

  • Pig acute-phase protein levels after stress induced by changes in the pattern of food administration

    Piñeiro, C., Piñeiro, M., Morales, J., Carpintero, R., Campbell, F. M., Eckersall, P. D., Toussaint, M. J. M., Alava, M. A., Lampreave, F.
    Animal , vol. 1, no. 1, pp. 133-139
    Contributions to Journals: Articles

  • The porcine acute phase protein response to acute clinical and subclinical experimental infection with Streptococcus suis

    Sorensen, N. S., Tegtmeier, C., Andresen, L. O., Pineiro, M., Toussaint, M. J. M., Campbell, F. M., Lampreave, F., Heegaard, P. M. H.
    Veterinary Immunology and Immunopathology, vol. 113, no. 1-2, pp. 157-168
    Contributions to Journals: Articles

  • The welfare of finishing pigs in two contrasting housing systems: Fully-slatted versus straw-bedded accommodation

    Scott, K., Chennells, D. J., Campbell, F. M., Hunt, B., Armstrong, D., Taylor, L., Gill, B. P., Edwards, S. A.
    Livestock Production Science, vol. 103, no. 1-2, pp. 104-115
    Contributions to Journals: Articles

  • The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig

    Campbell, F. M., Waterston, M., Andresen, L. O., Sorensen, N. S., Heegaard, P. M. H., Eckersall, P. D.
    Veterinary Research, vol. 36, no. 4, pp. 657-664
    Contributions to Journals: Articles

  • Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart

    Besikci, A. O., Campbell, F. M., Hopkins, T. A., Dyck, J. R. B., Lopaschuk, G. D.
    American Journal of Physiology, Heart and Circulatory Physiology, vol. 284, no. 1, pp. H283-H289
    Contributions to Journals: Articles

  • 45. Acute phase proteins: Biomarkers for use in animal health & welfare and in food quality & safety

    Ekersall, P., Campbell, F. M.
    Research in Veterinary Science, vol. 74, no. Supplement 1
    Contributions to Journals: Abstracts

  • Monitoring the innate immune response with acute phase protein

    Campbell, F. M., Eckersall, P. D.
    SPVS Bulletin, pp. 39-41
    Contributions to Journals: Literature Reviews

  • Arachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells

    Dutta-Roy, A. K., Taylor, J., Gordon, M. J., Hoggard, N., Campbell, F. M.
    Biochemical and Biophysical Research Communications, vol. 299, no. 3, pp. 432-437
    Contributions to Journals: Articles

  • A role for peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac malonyl-CoA levels: REDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARa ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASEREDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARa ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASE

    Campbell, F. M., Kozak, R., Wagner, A., Altarejos, J. Y., Dyck, J. R. B., Belke, D. D., Severson, D. L., Kelly, D. P., Lopaschuk, G. D.
    The Journal of Biological Chemistry, vol. 277, no. 6, pp. 4098-4103
    Contributions to Journals: Articles

  • Low fatty acid oxidation rates in isolated working hearts from PPAR alpha null mice does not impair functional recovery following ischemia

    Campbell, F. M., Kozak, R., Weinheimer, C. J., Courjois, M. R., Kelly, D. P., Lopaschuk, G. D.
    Diabetes, vol. 50, no. Suppl. 2, pp. A308-A309
    Contributions to Journals: Articles

  • PPAR alpha regulates cardiac energy metabolism by controlling malonyl CoA concentrations in the heart

    Campbell, F. M., Kozak, R., Wagner, A., Altarejos, J. Y., Dyck, J. R. B., Belke, D. D., Severson, D. L., Weinheimer, C. J., Courtois, M. R., Kelly, D. P., Lopaschuk, G. D.
    Journal of Molecular and Cellular Cardiology, vol. 33, no. 6, pp. A164
    Contributions to Journals: Articles

  • Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of Guinea pig alveolar apical membranes

    Mukhopadhyay, S., Muimo, R., Campbell, F. M., Gordon, M. J., Monaghan, A. S., Dutta-Roy, A. K.
    Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 62, no. 6, pp. 341-348
    Contributions to Journals: Articles

  • Immunological manipulation of lactation

    Wilde, C. J., Addey, C. V. P., Campbell, F. M., Peaker, M.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

  • Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells

    Crabtree, J. T., Gordon, M. J., Campbell, F. M., Dutta-Roy, A. K.
    Molecular & Cellular Biochemistry, vol. 185, no. 1-2, pp. 191-198
    Contributions to Journals: Articles

  • Detection and cellular localization of plasma membrane-associated and cytoplasmic fatty acid-binding proteins in human placenta

    Campbell, F. M., Bush, P. G., Veerkamp, J. H., Dutta-Roy, A. K.
    Placenta, vol. 19, no. 5-6, pp. 409-415
    Contributions to Journals: Articles

  • Interaction of free fatty acids with human leptin

    Campbell, F. M., Gordon, M. J., Hoggard, N., Dutta-Roy, A. K.
    Biochemical and Biophysical Research Communications, vol. 247, no. 3, pp. 654-658
    Contributions to Journals: Articles

  • Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids

    Campbell, F. M., Gordon, M. J., Dutta-Roy, A. K.
    Life Sciences, vol. 63, no. 4, pp. 235-240
    Contributions to Journals: Articles

  • Preferential uptake of long-chain polyunsaturated fatty acids by human placental cells

    Campbell, F. M., Clohessy, A. M., Gordon, M. J., Dutta-Roy, A. K.
    Chapters in Books, Reports and Conference Proceedings: Conference Proceedings

  • Uptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells

    Campbell, F. M., Clohessy, A. M., Gordon, M. J., Page, K. R., Dutta-Roy, A. K.
    Journal of Lipid Research, vol. 38, no. 12, pp. 2558-2568
    Contributions to Journals: Articles
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