Advanced Research Fellow
- About
-
- Email Address
- fiona.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438617
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am a principal investigator based at the Rowett Institute and coordinator of the PGT Human Nutrition MSc programme. My research focuses on advanced glycation end-products (AGEs) in the diet. During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body during digestion. To investigate how dietary AGEs, contribute to diet induced conditions such as type 2 diabetes and dementia we are using human intervention studies to test the effects of highly processed foods high in AGEs on sensitive measures of metabolic health and cognition. I am also researching the role of processing methods in improving food quality and the potential for phytochemicals incorporated into processed foods to ameliorate negative health outcomes.
External Memberships
Registered Nutritionist with the AfN (RNutr)
Member of the Nutrition Society,
Member of Biochemical Society,
Member of British Society for Proteome Resarch (BSPR).
Latest Publications
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
Journal of Nutrition and Metabolism, vol. 2022, 4715965Contributions to Journals: ArticlesThe Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Molecular Nutrition & Food Research, vol. 65, no. 1, 1900934Contributions to Journals: Review articlesAnthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin
Journal of Functional Foods, vol. 64, 103597Contributions to Journals: ArticlesCinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion
Plant Foods for Human Nutrition, vol. 74, no. 4, pp. 544-552Contributions to Journals: ArticlesEarly and reversible changes to the hippocampal proteome in mice on a high-fat diet
Nutrition and Metabolism, vol. 16, no. 1, 57Contributions to Journals: Articles- [ONLINE] https://rdcu.be/bPqy4
- [ONLINE] DOI: https://doi.org/10.1186/s12986-019-0387-y
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12782/1/McLean2019_Article_EarlyAndReversibleChangesToThe_VoR.pdf
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31462902 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6708244
- [ONLINE] View publication in Mendeley
- Research
-
Research Overview
A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.
Current Research
Current research in my laboratory is focused on investigating damaged proteins/advanced glycation end-products (AGEs) in the diet.
During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body in the course of digestion. AGEs are associated with the metabolic syndrome and dementia. We aim to identify foods high in AGEs and test the effects of these foods on sensitive measures of metabolic health and cognition in human intervention studies.
In addition we are investigating the role of processing methods in improving food quality e.g. avoiding prolonged heat treatment of dairy products known to increase AGE formation. We are also determining the potential of phytochemicals incorporated into processed foods to ameliorate these negative metabolic outcomes.
This research could lead to the development of new functional foods and improvements to existing food products. It will also provide health professionals and the public with better information on how changes in diet can be beneficial.
This research is part of Scottish Government Strategic Research Programme funded through the Rural and Environment Science and Analytical Services (RESAS) division to advance the evidence base in the development of rural affairs, food and environment policies.
- Teaching
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Teaching Responsibilities
Programme coordinator for MSc Human Nutrition
Course Coordinator for RN5001 Fundamentals of human nutrition and metabolism and RN5003 Foundations of Nutrition.
- Publications
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Page 1 of 1 Results 1 to 64 of 64
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
Journal of Nutrition and Metabolism, vol. 2022, 4715965Contributions to Journals: ArticlesThe Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Molecular Nutrition & Food Research, vol. 65, no. 1, 1900934Contributions to Journals: Review articlesAnthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin
Journal of Functional Foods, vol. 64, 103597Contributions to Journals: ArticlesCinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion
Plant Foods for Human Nutrition, vol. 74, no. 4, pp. 544-552Contributions to Journals: ArticlesEarly and reversible changes to the hippocampal proteome in mice on a high-fat diet
Nutrition and Metabolism, vol. 16, no. 1, 57Contributions to Journals: Articles- [ONLINE] https://rdcu.be/bPqy4
- [ONLINE] DOI: https://doi.org/10.1186/s12986-019-0387-y
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12782/1/McLean2019_Article_EarlyAndReversibleChangesToThe_VoR.pdf
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31462902 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6708244
- [ONLINE] View publication in Mendeley
A high-fat diet induces rapid changes in the mouse hypothalamic proteome
Nutrition and Metabolism, vol. 16, 26Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12986-019-0352-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12229/1/A_high_fat_diet_induces_rapid_changes_in.pdf
- [ONLINE] Link to version for sharing
- [ONLINE] https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-019-0352-9
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
Do advanced glycation end products contribute to saturated fat induced inflammation?
Proceedings of the Nutrition Society, vol. 78, no. OCE1, E42Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665119000466
- [ONLINE] View publication in Mendeley
SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice
Genes & Nutrition, vol. 13, 28Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s12263-018-0619-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11568/1/s12263_018_0619_1.pdf
Hippocampal proteomics and primary cell cultures demonstrate proteins key in neuronal plasticity are rapidly changed in rodents on a high-fat diet
onference: Society for Neuroscience 2018Contributions to Conferences: AbstractsRapid and reversible impairment of episodic memory by a high-fat diet in mice
Scientific Reports, vol. 8, 11976Contributions to Journals: ArticlesBeetroot improves oxidative stability and functional properties of processed foods: singular and combined effects with chocolate
Journal of Food Science and Technology, vol. 55, no. 7, pp. 2401-2409Contributions to Journals: ArticlesBreads Fortified with Freeze-Dried Vegetables: Quality and Nutritional Attributes. Part II: Breads Not Containing Oil as an Ingredient
Foods, vol. 5, no. 3, pp. 1-14Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/foods5030062
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7454/1/foods_05_00062.pdf
Breads fortified with freeze-dried vegetables: Quality and nutritional attributes. part ii: Breads not containing oil as an ingredient
Foods, vol. 5, no. 3, pp. 1-14Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/foods5030062
- [ONLINE] View publication in Scopus
Breads Fortified with Freeze-Dried Vegetables: Quality and Nutritional Attributes. Part 1: Breads Containing Oil as an Ingredient
Foods, vol. 5, no. 1, pp. 1-13Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/foods5010019
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5721/1/foods_05_00019.pdf
Having your cake and eating it? The impact of Beetroot addition on the Nutrition, oxidative stability and Quality of cake
Proceedings of the Nutrition Society, vol. 75, no. OCE3, E108Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665116001233
A novel hypothalamic protein regulated by high fat diet and leptin
Proceedings of the Nutrition Society, vol. 74, no. OCE3, pp. E190Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665115002165
The development of diet-induced obesity and glucose intolerance in C57BL/6 mice on a high-fat diet consists of distinct phases
PloS ONE, vol. 9, no. 8, e106159Contributions to Journals: ArticlesAntioxidant effectiveness of vegetable powders on the lipid and protein oxidative stability of cooked Turkey meat patties: implications for health
Nutrients, vol. 5, no. 4, pp. 1241-1252Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3390/nu5041241
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5847/1/nutrients_05_01241_v2.pdf
Decrease in plasma protein markers of oxidative stress and inflammation in overweight/obese type 2 diabetics after supplementation with bilberry extract
Obesity Facts, vol. 5, no. S1, pp. 198-199Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1159/000258190
Lower levels of damaged protein biomarkers in the plasma of overweight type 2 diabetic men following supplementation with a standardised bilberry extract
Proceedings of the Nutrition Society, vol. 71, no. OCE2, pp. E130Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665112001875
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2761/1/NutSocBelfast_2022.pdf
Proteomics reveals that a high-fat diet induces rapid changes in hypothalamic proteins related to neuronal damage and inflammation
Proceedings of the Nutrition Society, vol. 70, no. OCE6, pp. E370Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665111004551
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2762/1/NutSoc_MouseProteomics.pdf
High-Fat Diet in C57Bl/6 Mice Induces a Rapid Decrease in Insulin Sensitivity and an Acute Phase Response
Endocrine Reviews, vol. 32, no. 03_MeetingAbstracts, pp. 1-483Contributions to Journals: ArticlesIdentification of Plasma Protein Markers of Oxidation in Obese Men
biochemical society focussed meetingContributions to Conferences: PostersOptimal combinations of acute phase proteins for detecting infectious disease in pigs
Veterinary Research, vol. 42, pp. 50Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1297-9716-42-50
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2268/1/1297_9716_42_50.pdf
Identification of damaged proteins in human serum using modified Ehrlich's reagent to target protein-bound pyrroles
Analytical Biochemistry, vol. 398, no. 1, pp. 76-82Contributions to Journals: ArticlesRapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs
Veterinary Research, vol. 40, no. 3, 23Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1051/vetres/2009006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/745/1/v09006%255B1%255D.pdf
SERRS immunoassay for quantitative human CRP analysis
Analyst, vol. 133, no. 10, pp. 1355-1357Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/b808087a
The association between plasma levels of acute phase proteins, haptoglobin, alpha-1 acid glycoprotein (AGP), Pig-MAP, transthyretin and serum amyloid A (SAA) in Large White and Meishan pigs
Veterinary Immunology and Immunopathology, vol. 119, no. 3-4, pp. 303-309Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.vetimm.2007.05.008
Effects of sub-clinical post-weaning colibacillosis and dietary protein on acute phase proteins in weaner pigs
Livestock Science , vol. 108, no. 1-3, pp. 182-185Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.livsci.2007.01.048
A time-resolved immunofluorometric assay for porcine C-reactive protein quantification in whole blood
Luminescence, vol. 22, no. 3, pp. 171-176Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bio.945
Characterisation of the pig acute phase protein response to road transport
Veterinary Journal, vol. 173, no. 3, pp. 669-674Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.tvjl.2006.02.006
Pig acute-phase protein levels after stress induced by changes in the pattern of food administration
Animal , vol. 1, no. 1, pp. 133-139Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S1751731107283909
The porcine acute phase protein response to acute clinical and subclinical experimental infection with Streptococcus suis
Veterinary Immunology and Immunopathology, vol. 113, no. 1-2, pp. 157-168Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.vetimm.2006.04.008
The welfare of finishing pigs in two contrasting housing systems: Fully-slatted versus straw-bedded accommodation
Livestock Production Science, vol. 103, no. 1-2, pp. 104-115Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.livsci.2006.01.008
The negative acute phase response of serum transthyretin following Streptococcus suis infection in the pig
Veterinary Research, vol. 36, no. 4, pp. 657-664Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1051/vetres:2005017
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/746/1/v4069.pdf
Relative importance of malonyl CoA and carnitine in maturation of fatty acid oxidation in newborn rabbit heart
American Journal of Physiology, Heart and Circulatory Physiology, vol. 284, no. 1, pp. H283-H289Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1152/ajpheart.00461.2002
45. Acute phase proteins: Biomarkers for use in animal health & welfare and in food quality & safety
Research in Veterinary Science, vol. 74, no. Supplement 1Contributions to Journals: AbstractsMonitoring the innate immune response with acute phase protein
SPVS Bulletin, pp. 39-41Contributions to Journals: Literature ReviewsArachidonic acid stimulates internalisation of leptin by human placental choriocarcinoma (BeWo) cells
Biochemical and Biophysical Research Communications, vol. 299, no. 3, pp. 432-437Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0006-291X(02)02647-5
A role for peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac malonyl-CoA levels: REDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARa ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASEREDUCED FATTY ACID OXIDATION RATES AND INCREASED GLUCOSE OXIDATION RATES IN THE HEARTS OF MICE LACKING PPARa ARE ASSOCIATED WITH HIGHER CONCENTRATIONS OF MALONYL-CoA AND REDUCED EXPRESSION OF MALONYL-CoA DECARBOXYLASE
The Journal of Biological Chemistry, vol. 277, no. 6, pp. 4098-4103Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M106054200
Low fatty acid oxidation rates in isolated working hearts from PPAR alpha null mice does not impair functional recovery following ischemia
Diabetes, vol. 50, no. Suppl. 2, pp. A308-A309Contributions to Journals: ArticlesPPAR alpha regulates cardiac energy metabolism by controlling malonyl CoA concentrations in the heart
Journal of Molecular and Cellular Cardiology, vol. 33, no. 6, pp. A164Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0022-2828(01)90627-3
Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of Guinea pig alveolar apical membranes
Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 62, no. 6, pp. 341-348Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1054/plef.2000.0164
Immunological manipulation of lactation
Chapters in Books, Reports and Conference Proceedings: Conference ProceedingsDifferential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells
Molecular & Cellular Biochemistry, vol. 185, no. 1-2, pp. 191-198Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1023/A:1006852230337
Detection and cellular localization of plasma membrane-associated and cytoplasmic fatty acid-binding proteins in human placenta
Placenta, vol. 19, no. 5-6, pp. 409-415Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0143-4004(98)90081-9
Interaction of free fatty acids with human leptin
Biochemical and Biophysical Research Communications, vol. 247, no. 3, pp. 654-658Contributions to Journals: ArticlesPlacental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids
Life Sciences, vol. 63, no. 4, pp. 235-240Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0024-3205(98)00267-7
Preferential uptake of long-chain polyunsaturated fatty acids by human placental cells
Chapters in Books, Reports and Conference Proceedings: Conference ProceedingsUptake of long chain fatty acids by human placental choriocarcinoma (BeWo) cells
Journal of Lipid Research, vol. 38, no. 12, pp. 2558-2568Contributions to Journals: ArticlesAsymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta
Biochemical Society Transactions, vol. 24, no. 2, pp. 249SContributions to Journals: ArticlesPlatelet membrane glycoprotein IV (CD36) is involved in arachidonic acid induced-platelet aggregation
Biochemical Society Transactions, vol. 24, no. 2, pp. 167SContributions to Journals: Articlesalpha-Tocopherol-binding protein in the cytosol of the human placenta
Biochemical Society Transactions, vol. 24, no. 2, pp. 202SContributions to Journals: ArticlesPreferential uptake of long chain polyunsaturated fatty acids by isolated human placental membranes
Molecular & Cellular Biochemistry, vol. 155, no. 1, pp. 77-83Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/BF00714336
Arachidonic acid uptake by human platelets is mediated by CD36
Platelets, vol. 7, no. 5-6, pp. 291-295Contributions to Journals: ArticlesPlasma-membrane fatty-acid-binding protein (FABP(PM)) is exclusively located in the maternal facing membranes of the human placenta
FEBS Letters, vol. 375, no. 3, pp. 227-230Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/0014-5793(95)01216-2
Plasma-membrane fatty-acid-binding protein in human placenta-identification and characterization
Biochemical and Biophysical Research Communications, vol. 209, no. 3, pp. 1011-1017Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1006/bbrc.1995.1598
Characterization of a novel alpha-tocopherol-binding-protein from bovine heart cytosol
Archives of Biochemistry and Biophysics, vol. 318, no. 1, pp. 140-146Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1006/abbi.1995.1214
Vitamin-E requirements, transport, and metabolism: role of alpha-tocopherol-binding proteins
The Journal of Nutritional Biochemistry, vol. 5, no. 12, pp. 562-570Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1016/0955-2863(94)90010-8
Plasma-membrane fatty-acid-binding protein (FABP(PM)) of the sheep placenta
Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, vol. 1214, no. 2, pp. 187-192Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/0005-2760(94)90043-4
Identification and partial characterization of Fatty-Acid-Binding Sites in Sheep Placental Membranes
Biochemical Society Transactions, vol. 22, no. 2, pp. S117Contributions to Journals: ArticlesIdentification of a low molecular mass (14.2 kDa) a-tocopherol-binding protein in the cytosol of rat liver and heart
Biochemical and Biophysical Research Communications, vol. 196, no. 3, pp. 1108-1112Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1006/bbrc.1993.2365
A low molecular weight (12-15kDa) protein fraction in rat liver binds alpha-tocopherol
Biochemical Society Transactions, vol. 21, no. 4, pp. 408SContributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1042/bst021408s
Alpha-Tocopherol-Binding Protein in Bovine Heart Cytosol
The FASEB Journal, vol. 7, no. 3Contributions to Journals: Abstracts