![Dr Steven MacLennan Dr Steven MacLennan](/img/200x200/staffpages/uploads/sur235/SM_pic_2019.jpg)
Senior Research Fellow
- About
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- Email Address
- steven.maclennan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438123
- Office Address
Academic Urology Unit Health Sciences Building (2nd Floor) University of Aberdeen Foresterhill Aberdeen AB25 2ZD Tel: +44 (0)1224 559086 Fax: +44 (0)1224 554580 Email: steven.maclennan@abdn.ac.uk
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Steven is a Research Fellow in the Academic Urology Unit at the University of Aberdeen. His research themes cover the broad spectrum of evidence-based medicine in urology. This encompasses assessing the effectiveness of treatments in clinical trials, developing core outcome sets, providing critical reviews of the evidence base, creating evidence-based (or where necessary consensus-based) clinical practice guidelines, and implementing guideline recommendations in clinical practice. Steven is a member of the European Association of Urology (EAU) methodology committee which oversees the quality of the EAU’s systematic review and clinical practice guideline programme and delivers training on core evidence-based medicine skills in systematic reviews and guideline production. He is also a founding member of the IMpact Assessment of Guidelines Implementation and Education (IMAGINE) group which aims to assess current variations in practice, investigate barriers and facilitators to guideline adherent practice, and improve adherence to strong, high level of evidence, guideline recommendations. Prostate Cancer DIagnOsis and TreatmeNt Enhancement through the Power of Big Data in EuRope (PIONEER) is one of Steven’s recent projects, where his heaviest involvement is in the work to help standardise outcome definitions across all stages of disease to support the Big Data analysis work and improve the consistency of outcome reporting, outcome definition and measurement in future clinical trials and clinical audit.
Qualifications
- PhD Sociology2010 - University of Edinburgh
- MRes Social Research Methods2006 - University of Aberdeen
- BA (Hons.) Applied Social Science2005 - The Robert Gordon University
Memberships and Affiliations
- Internal Memberships
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IAHS Athena Swan Self Assessment Team
- External Memberships
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European Association of Urology
- Research
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Research Overview
An overview of current projects:
Core Outcome Set Development Projects
Renal Cancer Core Outcome Sets (R-COS)
In this project, part funded by the Arcobaleno Cancer Trust and NHS Grampian Endowments, we are developing three seperate Core Outcome Sets (COS) for localised, locally advanced, and metastatic stages of kidney cancer. This includes two systematic reviews, an interview study and three Delphi studies. The COMET registration, giving full study details is accessible here: https://www.comet-initiative.org/studies/details/1406
Bladder Cancer Core Outcome Sets (B-COS)
In this project, we are developing Core Outcome Sets for the various stages of bladder cancer. Forming the initial statge of the project, we published an article reviewing outcome reporting heterogeneity in non-muscle invasive bladder cancer - accessible here: https://content.iospress.com/articles/bladder-cancer/blc201510
The COMET registration, giving full study details is availabe here: https://www.comet-initiative.org/studies/details/1135
Prostate Cancer Core Outcome Sets
We devleoped a COS for localised prostate cancer. The results can be accessed here: https://bjui-journals.onlinelibrary.wiley.com/doi/abs/10.1111/bju.13854
Our prostate cancer COS work was subsequently updated and incorporated in the PIONEER project. More detail about PIONEER can be viewed here: https://prostate-pioneer.eu/
Implementation Science Projects
IMAGINE (IMpact Assessment of Guidelines Implementation and Education)
IMAGINE is a European Association of Urology (EAU) working group focussing on mapping adherence to EAU guidelines and, where variation or suboptimal practice is identified, investigating the barriers and facilitators to guideline adherence, and developing implementation interventions to adress the barriers and leverage the facilitators. You can read more about the IMAGINE group in this editorial
RESECT (Transurethral REsection and Single instillation intra-vesical chemotherapy Evaluation in bladder Cancer Treatment (RESECT) Improving quality in TURBT surgery.)
RESECT is a collaborative project with the British Urology Researchers in Surgical Training (BURST) group, including researchers from the Academic Urology Unit and HSRU. A main aim of RESECT is to test intereventions aimed at improving adherence to guidelines around single instilation of chemotherapy adn documentation of the procudure - which have been shown to be associated with improved patient outcomes. You can read more about RESECT here: https://www.bursturology.com/Studies/Resect/Overview/
OPTIMA (OPtimal Treatment for patients wiht solid tumours in Europe through Artificial Intelligence)
OPTIMA is a 34 partners-based IMI project. The programme aim is to design, develop and deliver the first interoperable and GDPR-compliant European real-world oncology data and evidence generation platform based on the needs of the clinicians and patients, in an inclusive and sustainable way. It will be built on a combination of federated and centralised access to a vast network of European data providers to help answer the highest priority research questions in prostate, breast and lung cancer, especially where current existing evidence underpinning clinical practice guidelines is weak. In parallel, comprehensive decision support toolsets based on national and international guidelines with approved regular updates of guideline recommendations underpinned by evidence from advanced statistical analysis and AI will be made available to fill the guidelines gaps and better support shared decision making by clinicians and patients.
Deimplementing ADT
There is evidence to suggest that Androgen Deprivation Therapy (ADT) is overused in men with localised prostate cancer. it is unclear why, and it is unclear what the best strategies for deimplementing ADT are. This reserach problem is the focus of Jennifer Dunsmore's PhD project, which Steven is supervising. You can read more about Jennifer and her reserach here: https://www.abdn.ac.uk/iahs/research/urology/metis/profiles/j.dunsmore.19
Guideline Development Projects
Steven sits on the European Association of Urology (EAU) Guidelines Office Methodology Committee. This committee oversees the training of Guidelines Associates through Systematic Review workshops.
EVOLVE (giving patients a meaningful voice in the design and delivery of care)
EVOLVE is a unique collaboration of a profession society (European Association of Urology), guideline panels, researchers, clinicians and patient representatives to improve guideline development and implementation for genitourinary cancers in Europe. The aim of the project is to develop a model of patient involvement that will give patients a meaningful voice in the design and delivery of care and will investigate how wider stakeholders can help to integrate the patient voice into guidelines. You can read more about EVOLVE here: https://www.abdn.ac.uk/iahs/research/urology/metis/evolve-1618.php
- Teaching
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Teaching Responsibilities
Steven contributes to the design, delivery and assessment of the MSc. level courses in the Institute of Applied Health Sciences linked above. He also supervises MSc. dissertations and often supervises medical student summer placements in the Aberdeen Summer Research Scholarship (ASRS) programme.
Steven currently supervises two PhD. projects and is intersted in supervising any project aligning with his broad interests in the desing and delivery of urology health services.
Non-course Teaching Responsibilities
Alongside formal teaching at the University of Aberdeen, Steven and his colleagues also developed a 2.5 day course for the European Association of Urology (EAU) on systematic reviews for clinical practice guidelines.
Steven also teaches the systematic review element for the European Organisaiton for Research and Treatment of Cancer (EORTC) 'clinical trial statistics for non-statisticians' course. https://event.eortc.org/stats2021/
- Publications
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How can we improve patient-clinician communication in men diagnosed with prostate cancer?: PA04
23rd International Meeting of the European Association of Urology NursesContributions to Conferences: AbstractsHow can we improve patient-clinician communication in men diagnosed with prostate cancer?
38th Annual EAU CongressContributions to Conferences: AbstractsA systematic review of heterogeneity in outcome definition and reporting in localised renal cancer
European Urology Open Science, vol. 48, pp. 1-11Contributions to Journals: ArticlesA BURST-BAUS consensus document for best practice in the conduct of scrotal exploration for suspected testicular torsion: the Finding consensus for orchIdopeXy In Torsion (FIX-IT) study
BJU International, vol. 130, no. 5, pp. 662-670Contributions to Journals: ArticlesEAU-EANM Consensus Statements on the Role of Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Patients with Prostate Cancer and with Respect to [177Lu]Lu-PSMA Radioligand Therapy
European Urology Oncology, vol. 5, no. 5, pp. 530-536Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.euo.2022.05.003
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20070/2/Fanti_etal_ERO_EAU_EANM_Consensus_AAM.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20070/1/Fanti_etal_EUO_EAU_EANM_Consensus_Statements_VoR.pdf
- [ONLINE] View publication in Scopus
A Systematic Review to Evaluate Patient-Reported Outcomes Measures (PROMs) for Metastatic Prostate Cancer According to the COnsensus-based Standard for the selection of Health Measurement INstruments (COSMIN) Methodology
Cancers, vol. 14, no. 20, 5120Contributions to Journals: ArticlesImproving guideline adherence in urology
European Urology Focus, vol. 8, no. 5, pp. 1545-1552Contributions to Journals: Review articlesReply to Ruobing Lei, Yuehuan Li, and Yaolong Chen's Letter to the Editor re Katharina Beyer, Lisa Moris, Michael Lardas, et al. Updating and Integrating Core Outcome Sets for Localised, Locally Advanced, Metastatic, and Nonmetastatic Castration-resistant Prostate Cancer: An Update from the PIONEER Consortium. Eur Urol 2022;81:503-14. Improving the Methodological Quality of Prostate Cancer Core Outcome Sets in Future Updates
European Urology, vol. 82, no. 3, pp. e68-e69Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2022.05.014
Secondary Treatment for Men with Localized Prostate Cancer: a pooled analysis of PRIAS and ERSPC-Rotterdam data within the PIONEER data platform
Journal of Personalized Medicine, vol. 12, no. 5, 751Contributions to Journals: ArticlesUpdating and integrating core outcome sets for localised, locally advanced, metastatic and non-metastatic castration resistant prostate cancer: an update from the PIONEER Consortium
European Urology, vol. 81, no. 5, pp. 503-514Contributions to Journals: ArticlesDiagnostic and prognostic factors in patients with prostate cancer: a systematic review
BMJ Open, no. 12, e058267Contributions to Journals: ArticlesSystematic review of active surveillance for clinically localized prostate cancer to develop recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and surveillance repeat biopsy strategy
European Urology, vol. 81, no. 4, pp. 337-346Contributions to Journals: ArticlesStandardising the Assessment of Patient-reported Outcome Measures in Localised Prostate Cancer. A Systematic Review
European Urology Oncology, vol. 5, no. 2, pp. 153-163Contributions to Journals: ArticlesOutcomes of importance to men with advanced prostate cancer:: PIONEER interview study
37th Annual Congress of the European Association of Urology, S1550Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0302-2838(22)01129-0
Orchidopexy for Testicular Torsion: A Systematic Review of Surgical Technique
European Urology Focus, vol. 7, no. 6, pp. 1493-1503Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.euf.2020.07.006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17006/1/Moore_etal_EUF_Torsion_AAM.pdf
- [ONLINE] View publication in Scopus
EVALUATING PATIENT-REPORTED OUTCOMES MEASURES (PROMS) FOR LOCALISED PROSTATE CANCER: A SYSTEMATIC REVIEW USING THE CONSENSUS-BASED STANDARD FOR THE SELECTION OF HEALTH MEASUREMENT INSTRUMENTS (COSMIN) METHODOLOGY
Journal of Urology, vol. 206, no. S3, pp. E212-E212Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1097/JU.0000000000001989.07
What influences adherence to guidance for post-operative instillation of intravesical chemotherapy to bladder cancer patients?
BJU International, vol. 128, no. 2, pp. 225-235Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bju.15336
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16878/2/Dunsmore_et_al_BJUI_WhatInfluencesAdherence_AAM.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16878/1/Dunsmore_etal_BJUI_What_influences_adherence_VOR.pdf
- [ONLINE] View publication in Scopus
Is There Outcome Reporting Heterogeneity in Trials That Aim to Assess the Effectiveness of Surgical Treatments for Stress Urinary Incontinence in Women?
European Urology Focus, vol. 7, no. 4, pp. 857-868Contributions to Journals: Review articlesThe need for core outcome sets in urological cancer research
Translational andrology and urology, vol. 10, no. 6, pp. 2832-2835Contributions to Journals: EditorialsDiagnostic and prognostic factors in patients with prostate cancer
EAU21 Virtual Congress, pp. S428-S429Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0302-2838(21)00685-0
Evaluating Patient-Reported Outcomes Measures (PROMs) for localised prostate cancer: A systematic review using the Consensus-based Standard for the selection of health Measurement Instruments (COSMIN) methodology
EAU21 Virtual Congress, pp. S430-S431Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0302-2838(21)00686-2
Secondary treatment for men with localized prostate cancer: A pooled analysis of PRIAS and ERSPC-Rotterdam datasets within the PIONEER data platform
EAU21 Virtual Congress, pp. S1480-S1481Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1016/S0302-2838(21)01420-2
A Systematic Review of Outcome Reporting, Definition and Measurement Heterogeneity in Non-Muscle Invasive Bladder Cancer Effectiveness Trials of Adjuvant, Prophylactic Treatment after Transurethral Resection
Bladder Cancer, vol. 7, no. 2, pp. 221-241Contributions to Journals: Review articlesNon-antibiotic strategies for the prevention of infectious complications following prostate biopsy: A Systematic Review and Meta-analysis
Journal of Urology, vol. 205, no. 3, pp. 653-663Contributions to Journals: ArticlesIMAGINE-IMpact Assessment of Guidelines Implementation and Education: The Next Frontier for Harmonising Urological Practice Across Europe by Improving Adherence to Guidelines
European Urology, vol. 79, no. 2, pp. 173-176Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.eururo.2020.10.011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17404/1/IMAGINE_ImpactAssessment_AAM.pdf
- [ONLINE] View publication in Scopus