BSc MSc MRes PhD (Cantab.)
Advanced Research Fellow
- About
-
- Email Address
- fergal.waldron@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
My research focuses on the roles of immunity, inflammation, and the gut-brain axis in ALS. I also work on biomarker developement in neurodegenerative disease but for ALS in particular. I am interested in heterogeneity, and early detection of disease, and my work involves a combination of experimental, molecular, histological, bioinformatics and meta-analytical approaches to answer fundamental questions in ALS research.
I obtained my PhD in Evolutionary Genetics from the University of Cambridge before undertaking postdoctoral work at the Institute of Evolutionary Biology at the University of Edinburgh.
Qualifications
- BSc Zoology2003 - National University of Ireland, Galway
- MRes Zoology2006 - National University of Ireland, Galway
- MSc Evolutionary Genetics and Genome Analysis2008 - University of Edinburgh
- PhD Evolutionary Genetics2013 - University of Cambridge
Internal Memberships
The Genetics Society
The Pathological Society of Great Britain and Ireland
Latest Publications
Integrating Transfer Learning and Attention Mechanisms for Accurate ALS Diagnosis and Cognitive Impairment Detection
Working Papers: Discussion Papers- [ONLINE] DOI: https://doi.org/10.1101/2024.09.22.24313406
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis
Brain Pathology, e13287Contributions to Journals: ArticlesUnderstanding the influence of altered lipid metabolism on TDP-43 pathology:: a protocol for a systematic review and meta-analysis v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.8epv5xk75g1b/v1
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, 50Contributions to Journals: ArticlesSOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1
- Research
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Funding and Grants
A Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £201,732 | 2018-06 to 2021-10 | Grant | The Leverhulme Trust (London, GB)
Establishment of a Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £44,364 | 2017-04 to 2017-12 | Grant | Wellcome Trust ISSF (London, GB)
Antiviral immune expression in the mollusc Lymnaea stagnalis (co-writer); £1,791 | 2017-02 to 2017-06 | Grant | University of Edinburgh Moray Endowement Fund (Edinburgh, GB)
Next Generation Sequencing workshop hosted by the Vienna Graduate School of Population Genetics Registration and Travel Award; €1,000 | 2011-05 to 2011-06 | AwardEuropean Science Foundation (Strasbourg, FR)
St. John’s College, Cambridge Learning and Research Fund; £1,000 | 2010-06 to 2010-07 | Award | St. John's College, University of Cambridge (Cambridge, GB)
Summer Institute in Statistics and Modelling in Infectious Diseases workshop hosted by The University of Washington Registration and Travel Award; $4,000 | 2010-06 to 2010-07 | Award | National Institutes of Health (Bethesda, Maryland, US)
Marie Curie Early Stage Research Fellowship; £24,055 | 2007-09 to 2008-08 | Salary award | Marie Curie (London, GB)
Embark Initiative Thermadapt Programme Research Fellowship; €38,012 | 2003-09 to 2005-08 | Salary award | Irish Research Council (Dublin, IE)
- Publications
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Page 1 of 2 Results 1 to 25 of 30
Integrating Transfer Learning and Attention Mechanisms for Accurate ALS Diagnosis and Cognitive Impairment Detection
Working Papers: Discussion Papers- [ONLINE] DOI: https://doi.org/10.1101/2024.09.22.24313406
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis
Brain Pathology, e13287Contributions to Journals: ArticlesUnderstanding the influence of altered lipid metabolism on TDP-43 pathology:: a protocol for a systematic review and meta-analysis v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.8epv5xk75g1b/v1
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
Acta Neuropathologica, vol. 147, 50Contributions to Journals: ArticlesSOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1
TDP-43 RNA aptamer staining to detect pathological TDP-43 in FFPE human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica):: A SOP and tick-sheet. v2
protocols.io (article).Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v2
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts
Brain, vol. 146, no. 12, pp. 5124-5138Contributions to Journals: ArticlesRNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2023.10.24.563701
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: Using systematic reviews to inform expert consensus
BMJ Open, vol. 13, no. 2, e064169Contributions to Journals: ArticlesALS and the Gut-Brain Axis: A protocol for a systematic review and meta-analysis assessing the relationship between amyotrophic lateral sclerosis, the gut and its microbiome.
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.5qpvorqpzv4o/v1
Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts
Working Papers: Preprint PaperspTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data
Journal of Pathology: Clinical Research, vol. 9, no. 1, pp. 44-55Contributions to Journals: ArticlesA Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease
Working Papers: Preprint PapersInterferon signalling as a potentional therapeutic target in amyotrophic lateral sclerosis and frontotemporal dementia – protocol for a systematic review and meta-analysis
protocols.io.Other Contributions: Other ContributionspTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis
Working Papers: Preprint PapersBuilding a Systematic Online Living Evidence Summary of COVID-19 Research
Journal of EAHIL, vol. 17, no. 2, pp. 21-26Contributions to Journals: ArticlesTesting evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies (Drosophila melanogaster)
Evolution, vol. 75, no. 2, pp. 450-463Contributions to Journals: Articles- [ONLINE] https://doi.org/10.5061/dryad.80gb5mkq2
- [ONLINE] DOI: https://doi.org/10.1111/evo.14146
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20298/1/Charter_etal_RRH_The_Word_That_VOR.pdf
- [ONLINE] View publication in Scopus
Unlocking Spatial Molecular & Cellular Relationships of SARS-CoV-2 in Archived Human Tissue
protocols.io.Other Contributions: Other ContributionsTesting evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2020.06.18.159731
- [ONLINE] http://europepmc.org/abstract/PPR/PPR178319
Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-Analysis of Preclinical Research
Frontiers in Neuroscience, vol. 14, no. 2020, 511Contributions to Journals: ArticlesCorrection: Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
PLoS Genetics, vol. 16, no. 3, e1008679Contributions to Journals: ArticlesTargeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis
Brain Communications, vol. 1, no. 1, fcz009Contributions to Journals: ArticlesCreation and maintenance of Ashworth outcrossed DGRP population V.1
protocols.io.Other Contributions: Other Contributions- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.zbuf2nw
Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes.
PLoS Genetics, vol. 14, no. 7, e1008679Contributions to Journals: ArticlesThe virome of Drosophila suzukii, an invasive pest of soft fruit
Virus Evolution, vol. 4, no. 1, vey009Contributions to Journals: Articles
