Dr Fergal Waldron | People | The University of Aberdeen

Dr Fergal Waldron

BSc MSc MRes PhD (Cantab.)

Advanced Research Fellow

About

Email Address: fergal.waldron@abdn.ac.uk
Office Address: 5.15.5 Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD
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School/Department: School of Medicine, Medical Sciences and Nutrition

ORCiD

Biography

My research focuses on the roles of immunity, inflammation, and the gut-brain axis in ALS. I also work on biomarker developement in neurodegenerative disease but for ALS in particular. I am interested in heterogeneity, and early detection of disease, and my work involves a combination of experimental, molecular, histological, bioinformatics and meta-analytical approaches to answer fundamental questions in ALS research.

I obtained my PhD in Evolutionary Genetics from the University of Cambridge before undertaking postdoctoral work at the Institute of Evolutionary Biology at the University of Edinburgh.

Qualifications

BSc Zoology
2003 - National University of Ireland, Galway
MRes Zoology
2006 - National University of Ireland, Galway
MSc Evolutionary Genetics and Genome Analysis
2008 - University of Edinburgh
PhD Evolutionary Genetics
2013 - University of Cambridge

Internal Memberships

The Genetics Society

The Pathological Society of Great Britain and Ireland

Latest Publications

Integrating Transfer Learning and Attention Mechanisms for Accurate ALS Diagnosis and Cognitive Impairment Detection
2024 - Published
Xia, Y., Gregory, J. M., Waldron, F. M., Spence, H., Vallejo, M.
Working Papers: Discussion Papers
- [ONLINE] DOI: https://doi.org/10.1101/2024.09.22.24313406
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis
2024 - Accepted/In press
Rifai, O. M., Waldron, F., Sleibi, D., O'shaughnessy, J., Leighton, D. J., Gregory, J.
Brain Pathology, e13287
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/bpa.13287
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/24057/1/Rifai_etal_BP_Clinicopathological_analysis_NEK1_VOR.pdf
- [ONLINE] View publication in Scopus
Understanding the influence of altered lipid metabolism on TDP-43 pathology:: a protocol for a systematic review and meta-analysis v1
2024 - Published
Langerova, T., Spence, H., Waldron, F. M., Gregory, J.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.8epv5xk75g1b/v1
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
2024 - Published
Spence, H., Waldron, F., Saleeb, R. S., Brown, A., Rifai, O. M., Gilodi, M., Read, F., Nellany, K., Milne, G., Wilkinson, D., O'shaughnessy, J., Pastore, A., Fratta, P., Shneider, N., Tartaglia, G. G., Zacco, E., Horrocks, M. H., Gregory, J.
Acta Neuropathologica, vol. 147, 50
Contributions to Journals: Articles
- [ONLINE] https://doi.org/10.1101/2023.10.24.563701
- [ONLINE] DOI: https://doi.org/10.1007/s00401-024-02705-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23029/1/Spence_etal_AN_RNA_Aptamer_Reveals_Nuclear_VOR.pdf
- [ONLINE] View publication in Scopus
SOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
2024 - Published
Waldron, F. M., Gregory, J., Spence, H.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1

View My Publications

Research

Funding and Grants

A Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £201,732 | 2018-06 to 2021-10 | Grant | The Leverhulme Trust (London, GB)

Establishment of a Laboratory Model for Antiviral Immunity in Molluscs (co-writer); £44,364 | 2017-04 to 2017-12 | Grant | Wellcome Trust ISSF (London, GB)

Antiviral immune expression in the mollusc Lymnaea stagnalis (co-writer); £1,791 | 2017-02 to 2017-06 | Grant | University of Edinburgh Moray Endowement Fund (Edinburgh, GB)

Next Generation Sequencing workshop hosted by the Vienna Graduate School of Population Genetics Registration and Travel Award; €1,000 | 2011-05 to 2011-06 | AwardEuropean Science Foundation (Strasbourg, FR)

St. John’s College, Cambridge Learning and Research Fund; £1,000 | 2010-06 to 2010-07 | Award | St. John's College, University of Cambridge (Cambridge, GB)

Summer Institute in Statistics and Modelling in Infectious Diseases workshop hosted by The University of Washington Registration and Travel Award; $4,000 | 2010-06 to 2010-07 | Award | National Institutes of Health (Bethesda, Maryland, US)

Marie Curie Early Stage Research Fellowship; £24,055 | 2007-09 to 2008-08 | Salary award | Marie Curie (London, GB)

Embark Initiative Thermadapt Programme Research Fellowship; €38,012 | 2003-09 to 2005-08 | Salary award | Irish Research Council (Dublin, IE)

Publications

Page 1 of 1 Results 1 to 30 of 30

Integrating Transfer Learning and Attention Mechanisms for Accurate ALS Diagnosis and Cognitive Impairment Detection
2024 - Published
Xia, Y., Gregory, J. M., Waldron, F. M., Spence, H., Vallejo, M.
Working Papers: Discussion Papers
- [ONLINE] DOI: https://doi.org/10.1101/2024.09.22.24313406
Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis
2024 - Accepted/In press
Rifai, O. M., Waldron, F., Sleibi, D., O'shaughnessy, J., Leighton, D. J., Gregory, J.
Brain Pathology, e13287
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/bpa.13287
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/24057/1/Rifai_etal_BP_Clinicopathological_analysis_NEK1_VOR.pdf
- [ONLINE] View publication in Scopus
Understanding the influence of altered lipid metabolism on TDP-43 pathology:: a protocol for a systematic review and meta-analysis v1
2024 - Published
Langerova, T., Spence, H., Waldron, F. M., Gregory, J.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.8epv5xk75g1b/v1
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS
2024 - Published
Spence, H., Waldron, F., Saleeb, R. S., Brown, A., Rifai, O. M., Gilodi, M., Read, F., Nellany, K., Milne, G., Wilkinson, D., O'shaughnessy, J., Pastore, A., Fratta, P., Shneider, N., Tartaglia, G. G., Zacco, E., Horrocks, M. H., Gregory, J.
Acta Neuropathologica, vol. 147, 50
Contributions to Journals: Articles
- [ONLINE] https://doi.org/10.1101/2023.10.24.563701
- [ONLINE] DOI: https://doi.org/10.1007/s00401-024-02705-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23029/1/Spence_etal_AN_RNA_Aptamer_Reveals_Nuclear_VOR.pdf
- [ONLINE] View publication in Scopus
SOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1
2024 - Published
Waldron, F. M., Gregory, J., Spence, H.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v1
TDP-43 RNA aptamer staining to detect pathological TDP-43 in FFPE human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica):: A SOP and tick-sheet. v2
2024 - Published
Waldron, F. M., Spence, H., Gregory, J.
protocols.io (article).
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.eq2lyjo4mlx9/v2
Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts
2023 - Published
Rifai, O. M., O'shaughnessy, J., Dando, O. R., Munro, A. F., Sewell, M. D., Abrahams, S., Waldron, F. M., Sibley, C. R., Gregory, J. M.
Brain, vol. 146, no. 12, pp. 5124-5138
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/brain/awad243
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22662/1/Rifai_etal_B_Distinct_Neuroinflammatory_Signatures_VoR.pdf
- [ONLINE] View publication in Scopus
RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS
2023 - Published
Spence, H., Waldron, F. M., Saleeb, R. S., Brown, A., Rifai, O. M., Gilodi, M., Read, F., Roberts, K., Milne, G., Wilkinson, D., O’Shaughnessy, J., Pastore, A., Fratta, P., Shneider, N., Tartaglia, G. G., Zacco, E., Horrocks, M. H., Gregory, J. M.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/2023.10.24.563701
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: Using systematic reviews to inform expert consensus
2023 - Published
Wong, C., Gregory, J. M., Liao, J., Egan, K., Vesterinen, H. M., Ahmad Khan, A., Anwar, M., Beagan, C., Brown, F. S., Cafferkey, J., Cardinali, A., Chiam, J. Y., Chiang, C., Collins, V., Dormido, J., Elliott, E., Foley, P., Foo, Y. C., Fulton-Humble, L., Gane, A. B., Glasmacher, S. A., Heffernan, ?., Jayaprakash, K., Jayasuriya, N., Kaddouri, A., Kiernan, J., Langlands, G., Leighton, D., Liu, J., Lyon, J., Mehta, A. R., Meng, A., Nguyen, V., Park, N. H., Quigley, S., Rashid, Y., Salzinger, A., Shiell, B., Singh, A., Soane, T., Thompson, A., Tomala, O., Waldron, F. M., Selvaraj, B. T., Chataway, J., Swingler, R., Connick, P., Pal, S., Chandran, S., Macleod, M.
BMJ Open, vol. 13, no. 2, e064169
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1136/bmjopen-2022-064169
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20235/1/Wong_etal_BMJO_Systematic_comprehensive_evidencebased_VOR.pdf
- [ONLINE] View publication in Scopus
ALS and the Gut-Brain Axis: A protocol for a systematic review and meta-analysis assessing the relationship between amyotrophic lateral sclerosis, the gut and its microbiome.
2023 - Published
Jackson, A. T., Press, R. G., Waldron, F., Gregory, J.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.5qpvorqpzv4o/v1
Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts
2023 - Published
Rifai, O. M., O'shaughnessy, J., Dando, O., Munro, A. F., Sewell, M. D., Abrahams, S., Waldron, F., Sibley, C. R., Gregory, J.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/2023.01.19.524561
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20968/1/Rifai_etal_Distinct_Neuuroinflammatory_Signatures_PP.pdf
pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data
2023 - Published
Pattle, S. B., O'shaughnessy, J., Kantelberg, O., Rifai, O. M., Pate, J., Nellany, K., Hays, N., Arends, M. J., Horrocks, M., Waldron, F. M., Gregory, J.
Journal of Pathology: Clinical Research, vol. 9, no. 1, pp. 44-55
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/cjp2.297
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/19245/2/Pattle_etal_TJPCR_pTDP_43_aggregates_accumulate_VOR.pdf
- [ONLINE] View publication in Scopus
A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease
2022 - Published
Wong, C., Gregory, J., Liao, J., Egan, K., Vesterinen, H. M., Khan, A. A., Anwar, M., Beagan, C., Brown, F., Cafferkey, J., Cardinali, A., Chiam, J. Y., Chiang, C., Collins, V., Dormido, J., Elliott, E., Foley, P., Foo, Y. C., Fulton-Humble, L., Gane, A. B., Glasmacher, S., Heffernan, ?., Jayaprakash, K., Jayasuriya, N., Kaddouri, A., Kiernan, J., Langlands, G., Leighton, D., Liu, J., Lyon, J., Mehta, A. R., Meng, A., Nguyen, V., Park, K. H., Quigley, S., Rashid, Y., Salzinger, A., Shiell, B., Singh, A., Soane, T., Thompson, A., Tomala, O., Waldron, F. M., Selvaraj, B. T., Chataway, J., Swingler, R., Connick, P., Pal, S., Chandran, S., Macleod, M. R.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/2022.04.13.22273823
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/18866/1/Wong_A_Systematic_Approach_Preprint.pdf
Interferon signalling as a potentional therapeutic target in amyotrophic lateral sclerosis and frontotemporal dementia – protocol for a systematic review and meta-analysis
2022 - Published
Waldron, F., Rifai, O. M., Gregory, J.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.bp2l61d5zvqe/v1
- [ONLINE] http://dx.doi.org/10.17504/protocols.io.bp2l61d5zvqe/v1
pTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis
2022 - Published
Pattle, S. B., O'shaughnessy, J., Rifai, O. M., Pate, J., Arends, M. J., Waldron, F., Gregory, J.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/2022.03.17.484805
- [ONLINE] https://www.biorxiv.org/content/early/2022/03/19/2022.03.17.484805
Building a Systematic Online Living Evidence Summary of COVID-19 Research
2021 - Published
Gabriel, B., CAMARADES COVID-SOLES group, Waldron, F.
Journal of EAHIL, vol. 17, no. 2, pp. 21-26
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.32384/jeahil17465
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/17458/1/CamaradesGroup_Building_a_systematic_VOR.pdf
Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies (Drosophila melanogaster)
2021 - Published
Savola, E., Montgomery, C., Waldron, F., Monteith, K., Vale, P., Walling, C. A.
Evolution, vol. 75, no. 2, pp. 450-463
Contributions to Journals: Articles
- [ONLINE] https://doi.org/10.5061/dryad.80gb5mkq2
- [ONLINE] DOI: https://doi.org/10.1111/evo.14146
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/20298/1/Charter_etal_RRH_The_Word_That_VOR.pdf
- [ONLINE] View publication in Scopus
Unlocking Spatial Molecular & Cellular Relationships of SARS-CoV-2 in Archived Human Tissue
2020 - Published
Pattle, S. B., Gregory, J., Waldron, F.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.bmjxk4pn
- [ONLINE] http://dx.doi.org/10.17504/protocols.io.bmjxk4pn
Testing evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster
2020 - Published
Savola, E., Montgomery, C., Waldron, F., Monteith, K., Vale, P., Walling, C. A.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/2020.06.18.159731
- [ONLINE] http://europepmc.org/abstract/PPR/PPR178319
Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-Analysis of Preclinical Research
2020 - Published
Elliott, E., Bailey, O., Waldron, F. M., Hardingham, G. E., Chandran, S., Gregory, J. M.
Frontiers in Neuroscience, vol. 14, no. 2020, 511
Contributions to Journals: Articles
- [ONLINE] https://www.frontiersin.org/articles/10.3389/fnins.2020.00511
- [ONLINE] DOI: https://doi.org/10.3389/fnins.2020.00511
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/21118/1/Bailey_etal_FN_Therapeutic_Targeting_of_VOR.pdf
Correction: Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
2020 - Published
Waldron, F. M., Stone, G. N., Obbard, D. J.
PLoS Genetics, vol. 16, no. 3, e1008679
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1371/journal.pgen.1008679
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/19686/1/Waldron_et_al_PLOSGenetics_Correction_MetagenomicSequencing_VOR.pdf
- [ONLINE] View publication in Scopus
Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis
2019 - Published
Mehta, A. R., Walters, R., Waldron, F. M., Pal, S., Selvaraj, B. T., Macleod, M. R., Hardingham, G. E., Chandran, S., Gregory, J.
Brain Communications, vol. 1, no. 1, fcz009
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/braincomms/fcz009
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/18989/1/Mehta_etal_BC_Targeting_mitochondrial_Dysfunction_VOR.pdf
- [ONLINE] http://dx.doi.org/10.1093/braincomms/fcz009
Creation and maintenance of Ashworth outcrossed DGRP population V.1
2019 - Published
Waldron, F., Monteith, K. M., Vale, P.
protocols.io.
Other Contributions: Other Contributions
- [ONLINE] DOI: https://doi.org/10.17504/protocols.io.zbuf2nw
Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes.
2018 - Published
Waldron, F., Stone, G., Obbard, D.
PLoS Genetics, vol. 14, no. 7, e1008679
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1371/journal.pgen.1007533
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23105/1/Waldron_etal_PLOSG_Metagenomic_sequencing_suggests_VOR.pdf
- [ONLINE] http://europepmc.org/abstract/med/30059538
The virome of Drosophila suzukii, an invasive pest of soft fruit
2018 - Published
Medd, N. C., Fellous, S., Waldron, F., Xuéreb, A., Nakai, M., Cross, J. V., Obbard, D. J.
Virus Evolution, vol. 4, no. 1, vey009
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/ve/vey009
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23131/1/Medd_etal_VE_The_virome_of_Drosophila_VoR.pdf
- [ONLINE] https://academic.oup.com/ve/article/doi/10.1093/ve/vey009/4956221
The virome of Drosophila suzukii, an invasive pest of soft fruit
2018 - Published
Medd, N. C., Fellous, S., Waldron, F., Xuéreb, A., Nakai, M., Cross, J. V., Obbard, D. J.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/190322
Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
2017 - Published
Waldron, F., Stone, G. N., Obbard, D. J.
Working Papers: Preprint Papers
- [ONLINE] DOI: https://doi.org/10.1101/166488
- [ONLINE] http://dx.doi.org/10.1101/166488
Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis
2016 - Published
Gregory, J., Waldron, F. M., Soane, T., Fulton, L., Leighton, D., Chataway, J., Pal, S., Chandran, S., Macleod, M. R.
Evidence-based Preclinical Medicine, vol. 3, no. 2, pp. 17-19
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1002/ebm2.23
- [ONLINE] https://onlinelibrary.wiley.com/doi/10.1002/ebm2.23
The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster
2015 - Published
Webster, C. L., Waldron, F. M., Robertson, S., Crowson, D., Ferrari, G., Quintana, J. F., Brouqui, J., Bayne, E. H., Longdon, B., Buck, A. H., Lazzaro, B. P., Akorli, J., Haddrill, P. R., Obbard, D. J.
PLoS Biology, vol. 13, no. 7, e1002210
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1371/journal.pbio.1002210
- [ONLINE] http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000360617100022&KeyUID=WOS:000360617100022
Elevated levels of expression associated with regions of the Drosophila genome that lack crossing over
2008 - Published
Haddrill, P. R., Waldron, F. M., Charlesworth, B.
Biology Letters, vol. 4, no. 6, pp. 758-761
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1098/rsbl.2008.0376
- [ONLINE] http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000260719800042&KeyUID=WOS:000260719800042

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Latest Publications

Integrating Transfer Learning and Attention Mechanisms for Accurate ALS Diagnosis and Cognitive Impairment Detection

Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis

Understanding the influence of altered lipid metabolism on TDP-43 pathology:: a protocol for a systematic review and meta-analysis v1

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

SOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1

Funding and Grants

Integrating Transfer Learning and Attention Mechanisms for Accurate ALS Diagnosis and Cognitive Impairment Detection

Clinicopathological analysis of NEK1 variants in amyotrophic lateral sclerosis

Understanding the influence of altered lipid metabolism on TDP-43 pathology:: a protocol for a systematic review and meta-analysis v1

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

SOP and tick-sheet for using TDP-43 RNA aptamer (TDP-43APT) to detect pathological TDP-43 in FFPE-preserved human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica) v1

TDP-43 RNA aptamer staining to detect pathological TDP-43 in FFPE human tissue, as described in Spence and Waldron et al., 2024 (Acta Neuropathologica):: A SOP and tick-sheet. v2

Distinct neuroinflammatory signatures exist across genetic and sporadic amyotrophic lateral sclerosis cohorts

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides withSTMN-2cryptic splicing and precedes clinical manifestation in ALS

Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: Using systematic reviews to inform expert consensus

ALS and the Gut-Brain Axis: A protocol for a systematic review and meta-analysis assessing the relationship between amyotrophic lateral sclerosis, the gut and its microbiome.

Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts

pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data

A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease

Interferon signalling as a potentional therapeutic target in amyotrophic lateral sclerosis and frontotemporal dementia – protocol for a systematic review and meta-analysis

pTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis

Building a Systematic Online Living Evidence Summary of COVID-19 Research

Testing evolutionary explanations for the lifespan benefit of dietary restriction in fruit flies (Drosophila melanogaster)

Unlocking Spatial Molecular & Cellular Relationships of SARS-CoV-2 in Archived Human Tissue

Testing evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster

Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis: a Systematic Review and Meta-Analysis of Preclinical Research

Correction: Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes

Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis

Creation and maintenance of Ashworth outcrossed DGRP population V.1

Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes.

The virome of Drosophila suzukii, an invasive pest of soft fruit

The virome of Drosophila suzukii, an invasive pest of soft fruit

Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes

Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis

The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster

Elevated levels of expression associated with regions of the Drosophila genome that lack crossing over

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