MSc, DPhil, FHEA
Senior Lecturer
- About
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- Email Address
- a.roelofs@abdn.ac.uk
- Office Address
Arthritis and Regenerative Medicine Group
Room 3:16
Institute of Medical Sciences
Foresterhill
Aberdeen AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I completed my MSc in Biology, with specialisation in Medical Biology, at the University of Groningen in the Netherlands in 2003 cum laude (first class). I then moved to the University of Oxford, where I obtained my DPhil in Medical Science in 2007. I continued my post-doctoral research career at the University of Aberdeen, where I am currently Senior Lecturer in Skeletal Regenerative Medicine. I am a member of the Arthritis and Regenerative Medicine team within the Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH).
Qualifications
- MSc Biology2003 - University of Groningen
- DPhil Medical Sciences2007 - University of Oxford
- FHEA Fellow of the Higher Education Academy2023 - Advance HE
- Research
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Current Research
My current research interests are centered around synovial joint biology, with a particular focus on the roles of adult stem cells in joint maintenance, repair, and disease. We seek to enhance our understanding of the identity, ontogeny, regulation and functions of stem cells in the joint using approaches such as genetic cell lineage tracing and scRNA-seq. Our ultimate aim is to develop novel treatments that target endogenous stem cells to promote skeletal joint health and regeneration.
Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.
- Teaching
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Programmes
- Postgraduate, 3 stage, September start
Programme coordinator
Courses
Course coordinator
- Student Selected Component 1 (ME2511)
- Publications
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Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells
Bone, vol. 42, no. 5, pp. 848-860Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/J.BONE.2007.12.225
Apomine enhances the antitumor effects of lovastatin on myeloma cells by down-regulating 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Journal of Pharmacology and Experimental Therapeutics, vol. 322, no. 1, pp. 228-235Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1124/jpet.106.116467
Differential Effects of Stress on Adult Hippocampal Cell Proliferation in Low and High Aggressive Mice
Journal of Neuroendocrinology, vol. 19, no. 7, pp. 489-498Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2826.2007.01555.x
Apomine (TM), an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo
International Journal of Cancer, vol. 120, no. 8, pp. 1657-1663Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ijc.22478
Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells
International Journal of Cancer, vol. 119, no. 6, pp. 1254-1261Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ijc.21977
Molecular mechanisms of action of bisphosphonates: current status
Clinical Cancer Research, vol. 12, no. 20 PT 2, pp. 6222S-6230SContributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-06-0843