MSc, DPhil, FHEA
Senior Lecturer
- About
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- Email Address
- a.roelofs@abdn.ac.uk
- Office Address
Arthritis and Regenerative Medicine Group
Room 3:16
Institute of Medical Sciences
Foresterhill
Aberdeen AB25 2ZD- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I completed my MSc in Biology, with specialisation in Medical Biology, at the University of Groningen in the Netherlands in 2003 cum laude (first class). I then moved to the University of Oxford, where I obtained my DPhil in Medical Science in 2007. I continued my post-doctoral research career at the University of Aberdeen, where I am currently Senior Lecturer in Skeletal Regenerative Medicine. I am a member of the Arthritis and Regenerative Medicine team within the Aberdeen Centre for Arthritis and Musculoskeletal Health (ACAMH).
Qualifications
- MSc Biology2003 - University of Groningen
- DPhil Medical Sciences2007 - University of Oxford
- FHEA Fellow of the Higher Education Academy2023 - Advance HE
- Research
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Current Research
My current research interests are centered around synovial joint biology, with a particular focus on the roles of adult stem cells in joint maintenance, repair, and disease. We seek to enhance our understanding of the identity, ontogeny, regulation and functions of stem cells in the joint using approaches such as genetic cell lineage tracing and scRNA-seq. Our ultimate aim is to develop novel treatments that target endogenous stem cells to promote skeletal joint health and regeneration.
Please visit our Arthritis and Regenerative Medicine page to find out more about our team and the research that we do.
- Teaching
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Programmes
- Postgraduate, 3 stage, September start
Programme coordinator
Courses
Course coordinator
- Student Selected Component 1 (ME2511)
- Publications
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Bone Marrow Contribution to Synovial Hyperplasia Following Joint Surface Injury
Arthritis Research & Therapy, vol. 18, 166Contributions to Journals: ArticlesFluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine
Bioconjugate Chemistry, vol. 27, no. 2, pp. 329-340Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acs.bioconjchem.5b00369
Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
Arthritis Research & Therapy, vol. 17, 147Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0639-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7388/1/s13075_015_0639_9.pdf
In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum
European Cells & Materials, vol. 27, pp. 185-195Contributions to Journals: ArticlesCell-based Approaches to Joint Surface Repair: A Research Perspective
Osteoarthritis and Cartilage, vol. 21, no. 7, pp. 892-900Contributions to Journals: Review articlesBisphosphonates: Mechanisms of action
Handbook of cancer-related bone disease. Coleman, R., Abrahamsson, P., Hadji, P. (eds.). 2 edition. BioScientifica, pp. 75-99, 25 pagesChapters in Books, Reports and Conference Proceedings: ChaptersInfluence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo
Journal of Bone and Mineral Research, vol. 27, no. 4, pp. 835-847Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/jbmr.1543
Synergistic inhibitory effect of apomine and lovastatin on osteosarcoma cell growth
Cancer, vol. 118, no. 3, pp. 750-760Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cncr.26336
Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field
European Cells & Materials, vol. 22, no. -, pp. 344-358Contributions to Journals: ArticlesSynthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs
Phosphorus, Sulfur and SIlicon and the Related Elements, vol. 186, no. 4, pp. 970-971Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1080/10426507.2010.526674
- [ONLINE] View publication in Scopus