This is a past event
Chemistry Departmental Seminar
For more information please see: http://www.isas.de/Home.67.0.html?&L=0
Abstract
The Mitochondrial Proteome: from inventory to function
Mitochondria are cellular powerhouses, synthesizing the bulk of the ATP used by eukaryotic cells. The cellular function of mitochondria, however, is not limited to bioenergetics. They play crucial roles in the metabolism of amino acids and lipids, the biosynthesis of heme and iron-sulfur clusters, cell signaling, and apoptosis. Mitochondrial proteins are encoded by two genomes. In humans, the mitochondrial genome codes for only 13 proteins; the remaining 99% of mitochondrial proteins are encoded by nuclear genes and are synthesized as precursors on cytosolic ribosomes and then are imported into mitochondria. To understand the role of mitochondria in health and disease, it is important to know the protein composition of this organelle.
References:
Schmidt, O., A.B. Harbauer, S. Rao, B. Eyrich, R.P. Zahedi, D. Stojanovski, B. Schonfisch, B. Guiard, A. Sickmann, N. Pfanner, and C. Meisinger, Regulation of Mitochondrial Protein Import by Cytosolic Kinases. Cell, 2011
Vogtle, F.N., S. Wortelkamp, R.P. Zahedi, D. Becker, C. Leidhold, K. Gevaert, J. Kellermann, W. Voos, A. Sickmann, N. Pfanner, and C. Meisinger, Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell, 2009. 139(2): p. 428-39.
Meisinger, C., A. Sickmann, and N. Pfanner, The mitochondrial proteome: from inventory to function. Cell, 2008.
Sickmann, A., J. Reinders, Y. Wagner, C. Joppich, R. Zahedi, H.E. Meyer, B. Schonfisch, I. Perschil, A. Chacinska, B. Guiard, P. Rehling, N. Pfanner, and C. Meisinger, The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A, 2003. 100(23): p. 13207-12.
- Speaker
- Prof Albert Sickmann (ISAS, Leibniz Institut for Analytische Wissenschaften, Dortmund)
- Hosted by
- Prof Joerg Feldmann
- Venue
- FN3, Fraser Noble