This is a past event
The utility of applying approaches rooted in physical organic chemistry to the development of manufacturing processes for active pharmaceutical ingredients (APIs) will be demonstrated through three AstraZeneca case studies. These will illustrate applications to a reaction, work-up and to control a reaction occurring during the formation and crystallisation of a salt. The work-up phase of a reaction will be illustrated by an investigation of a pH controlled extraction. Unexpectedly we found that we were able to separate unreacted starting material from the product of a Buchwald-Hartwig coupling reaction despite the two compounds having nearly identical pKas. These observations led us to propose a general equation for the partition of ionisable molecules as a function of pH and the molecules partition coefficient.
- Speaker
- Ian Ashworth, Principle Scientist - Astra Zeneca
- Hosted by
- Dr Eve Wildman
- Venue
- Meston Lecture Theatre 6