![Professor Mark Vickers Professor Mark Vickers](/img/200x200/staffpages/assets/images/default-profile-picture.jpg)
MBChB MRCP DM FRCPath
Chair in Applied Medicine (Clin)
- About
-
- Email Address
- m.a.vickers@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272401
- Office Address
1. Room 3:25, Institute of Medical Sciences
2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.
External Memberships
Member of Royal College of Physicians
Fellow of Royal College of Pathologists
British Society for Haematology
- Research
-
Research Overview
My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.
Knowledge Exchange
I have given talks about the use of convalescent plasma and T cells to treat COVID-19.
Collaborations
Prof. Alex Rowe, Edinburgh University.
Prof. Stuart Haslam, Imperial College London.
Prof. David Rees, King's College London.
Supervision
Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.
- Teaching
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Teaching Responsibilities
I organise, and deliver much of, the haematology training in the medical school. I remain an enthusiastic bedside teacher. I co-ordinated the third year medical degree 1997-2010.
- Publications
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Page 1 of 2 Results 1 to 50 of 90
Measurement of erythrocyte membrane mannoses to assess splenic function
British Journal of Haematology, vol. 198, no. 1, pp. 155-164Contributions to Journals: ArticlesHyposplenism and gastrointestinal diseases: significance and mechanisms
Digestive Diseases, vol. 40, pp. 290–298Contributions to Journals: Review articlesOxidative stress, malaria, sickle cell disease, and innate immunity
Trends in Immunology, vol. 42, no. 10, pp. 849-851Contributions to Journals: ArticlesCytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy
Clinical and Experimental Immunology, vol. 206, no. 1, 68-81Contributions to Journals: ArticlesThe Red Blood Cell as a Novel Regulator of Human B-cell Activation
Immunology, vol. 163, no. 4Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/imm.13327
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16803/1/Lennon_etal_The_red_blood_VOR.pdf
- [ONLINE] View publication in Scopus
Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-γ: results from the D-SIRe2 randomised controlled trial
Frontiers in Immunology, vol. 12, 623087Contributions to Journals: ArticlesSialic acid‐binding immunoglobulin‐like lectin (Siglec)‐15 is a rapidly internalised cell‐surface antigen expressed by acute myeloid leukaemia cells
British Journal of Haematology, vol. 193, no. 5, pp. 946-950Contributions to Journals: ArticlesRed blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
Nature Communications, vol. 12, no. 1, 1792Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41467-021-21814-z
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16159/1/Cao_etal_NC_Red_blood_Cell_VoR.pdf
- [ONLINE] View publication in Scopus
Human erythrocyte surface fucose expression increases with age and hyperglycemia: [version 1; peer review: awaiting peer review]
Wellcome open research, vol. 6, 28Contributions to Journals: Articles- [ONLINE] https://doi.org/10.17605/OSF.IO/XF8AM
- [ONLINE] DOI: https://doi.org/10.12688/wellcomeopenres.16409.1
High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria
bioRxivContributions to Journals: ArticlesParaprotein associated syndrome treated successfully with chemotherapy
BMJ Case Reports, vol. 13, no. 9, e232866Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bcr-2019-232866
- [ONLINE] View publication in Scopus
Long-Term Follow Up After Third Party Viral-Specific Cytotoxic Lymphocytes For Immunosuppression- And Epstein-Barr Virus-Associated Lymphoproliferative Disease
Haematologica, vol. 104, no. 8, pp. e356-e359Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3324/haematol.2018.207548
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
Investigating thrombocytosis
BMJ (Online), vol. 366, l4183Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.l4183
- [ONLINE] View publication in Scopus
- [ONLINE] http://www.bmj.com/lookup/doi/10.1136/bmj.l4183
- [ONLINE] View publication in Mendeley
Combination peptide immunotherapy suppresses antibody and helper T cell responses to the major human platelet autoantigen GPIIb/IIIa in HLA-transgenic mice
Haematologica, vol. 104, no. 5, pp. 1074-1082Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3324/haematol.2017.179424
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12261/1/Combination_Peptide_Immunotherapy_Suppresses_Antibody_And_Helper_T_Cell_Responses_To_The_Major_Human_Platelet_Autoantigen_Glycoprotein_IIbIIIa_In_HLA_Transgenic_Mice.pdf
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
Adoptive T Cell Therapy Strategies for Viral Infections in Patients Receiving Haematopoietic Stem Cell Transplantation
Cells, vol. 8, no. 1, 47Contributions to Journals: Review articlesSimilarities and differences in surface receptor expression by THP-1 monocytes and differentiated macrophages polarized using seven different conditioning regimens
Cellular Immunology, vol. 332, pp. 58-76Contributions to Journals: ArticlesCombined linkage and association analysis of classical Hodgkin lymphoma
Oncotarget, vol. 9, no. 29, pp. 20377-20385Contributions to Journals: ArticlesCytotoxic T-lymphocyte therapy for post-transplant lymphoproliferative disorder after solid organ transplantation in children
Pediatric Transplantation, vol. 22, no. 2, 13133Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/petr.13133
Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia
Cancer Research, vol. 78, no. 1, pp. 75-87Contributions to Journals: ArticlesExteriorisation of Mannoses on Human Erythrocyte Membrane Skeleton Provides 'Eat Me' Signals for Oxidatively Damaged Cells to be Cleared By Macrophages: A Pathway Mediating Hemolysis in Sickle Cell Disease
Blood, vol. 130, no. 1, pp. 919Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.V130.Suppl_1.919.919
- [ONLINE] View publication in Scopus
Season of infectious mononucleosis as a risk factor for multiple sclerosis: a UK primary care case-control study
Multiple Sclerosis and Related Disorders, vol. 17, pp. 103-106Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.msard.2017.07.009
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/2/Revised_Paper_clean.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/1/im_in_ms_flow_chart.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/3/Supplemental_Tables.docx
Effective antigen presentation to helper T cells by human eosinophils
Immunology, vol. 149, no. 4, pp. 413-422Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/imm.12658
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9327/1/Farhan_et_al_2016_Immunology.pdf
Leukocyte Ig-Like receptor B1 restrains dendritic cell function through increased expression of the NF-κB regulator ABIN1/TNIP1
Journal of Leukocyte Biology, vol. 100, no. 4, pp. 737-746Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1189/jlb.1A0915-420RRR
Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes
Journal of Allergy and Clinical Immunology, vol. 137, no. 5, pp. 1498-1505Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jaci.2015.12.1311
Intraoperative salvage does not affect expression of markers for erythrophagocytosis
Transfusion Medicine, vol. 26, no. 2, pp. 147-149Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1111/tme.12288
Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis
Arthritis Research & Therapy, vol. 17, pp. 274Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0755-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4995/1/s13075_015_0755_6.pdf
Intraoperative cell salvage may damage erythrocytes as indicated by macrophage uptake
Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, pp. 31-31Contributions to Journals: AbstractsHow do immune responses differ against senescent and damaged erythrocytes: profiling sugar and protein changes on the cell surface
Immunology, vol. 143, no. s2, pp. 118-119Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/imm.12406
Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease
British Journal of Haematology, vol. 167, no. 3, pp. 402-410Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bjh.13051
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4107/1/bjh13051.pdf
Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A
Clinical and Experimental Immunology, vol. 178, no. 2, pp. 373-383Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/cei.12408
Combination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice
54th Annual Scientific Meeting of the British-Society-for-Haematology, pp. 12-12Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/bjh.12802
Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge
European Journal of Immunology, vol. 44, no. 4, pp. 1069-1083Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/eji.201343604
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3241/1/EJI_whibley.pdf
The epidemiology of infectious mononucleosis in Northern Scotland: a decreasing incidence and winter peak
BMC Infectious Diseases, vol. 14, 151Contributions to Journals: ArticlesCombination peptide immunotherapy suppresses antibody and helper T cell responses to the RhD protein in HLA-transgenic mice
Haematologica, vol. 99, no. 3, pp. 588-596Contributions to Journals: ArticlesSystematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus
Arthritis Research & Therapy, vol. 16, no. 1, R3Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/ar4429
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5476/1/ar4429.pdf
Quantitative variation in plasma angiotensin-i converting enzyme activity shows allelic heterogeneity in the ABO blood group locus
Annals of Human Genetics, vol. 77, no. 6, pp. 465-471Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/ahg.12034
- [ONLINE] View publication in Scopus
The soluble isoform of CTLA-4 as a regulator of T-cell responses
European Journal of Immunology, vol. 43, no. 5, pp. 1274-1285Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/eji.201242529
Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and multiple sclerosis
PloS ONE, vol. 8, no. 4, e61110Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pone.0061110
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3605/1/Systematic_review.pdf
Acute myeloid leukemia presenting in a mother and daughter pair with the identical acquired karyotypic abnormality consisting of inversion 3q21q26 and monosomy 7: a review of possible mechanisms
Cancer Genetics and Cytogenetics, vol. 205, no. 11, pp. 599-602Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.cancergen.2012.09.001
Production of the effector cytokine interleukin-17, rather than interferon-γ, is more strongly associated with autoimmune hemolytic anemia
Haematologica, vol. 97, no. 10, pp. 1494-1500Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3324/haematol.2011.060822
Candida albicans evades protective immunity by promoting the expansion of induced CD4(+) CD25(+) FoxP3(+) Helioslo regulatory T cells that enhance Th17 responses
European Congress of Immunology, pp. 206-206Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/imm.12002
Identification, immunomodulatory activity, and immunogenicity of the major helper T-cell epitope on the K blood group antigen
Blood, vol. 119, no. 23, pp. 5563-5574Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2012-02-410324
Effects of ultraviolet light on human serum 25-hydroxyvitamin D and systemic immune function
Journal of Allergy and Clinical Immunology, vol. 129, no. 6, pp. 1554-1561Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jaci.2012.03.001
Candida albicans promotes the differentiation of induced CD4(+) CD25(+) Foxp3(+) regulatory T cells
Immunology, vol. 135, no. Suppl. 1, pp. 161Contributions to Journals: AbstractsEvidence-based focused review of the treatment of idiopathic warm immune hemolytic anemia in adults
Blood, vol. 118, no. 15, pp. 4036-4040Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2011-05-347708
Foundation Years Journal
Other Contributions: Other ContributionsThe doctor's dilemma: stimulating T cells
Blood, vol. 114, no. 16, pp. 3361-3362Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1182/blood-2009-08-236778
Helper T cells point the way to specific immunotherapy for autoimmune disease
Cardiovascular & Hematological Disorders - Drug Targets, vol. 9, no. 3, pp. 159-166Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2174/187152909789007043
A case of apples and pears?
Blood, vol. 113, no. 24, pp. 6259-6260Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1182/blood-2009-03-211169
Genetic variants linked to coronary artery disease are not associated with carotid artery intima-media thickness or intermediate risk phenotypes
Atherosclerosis, vol. 203, no. 1, pp. 41-44Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.atherosclerosis.2008.06.025