MBChB MRCP DM FRCPath
Chair in Applied Medicine (Clin)
- About
-
- Email Address
- m.a.vickers@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272401
- Office Address
1. Room 3:25, Institute of Medical Sciences
2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.
External Memberships
Member of Royal College of Physicians
Fellow of Royal College of Pathologists
British Society for Haematology
- Research
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Research Overview
My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.
Knowledge Exchange
I have given talks about the use of convalescent plasma and T cells to treat COVID-19.
Collaborations
Prof. Alex Rowe, Edinburgh University.
Prof. Stuart Haslam, Imperial College London.
Prof. David Rees, King's College London.
Supervision
Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.
- Teaching
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Teaching Responsibilities
I organise, and deliver much of, the haematology training in the medical school. I remain an enthusiastic bedside teacher. I co-ordinated the third year medical degree 1997-2010.
- Publications
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Pro-coagulant effects of environmental particles (PM10)
Occupational and Environmental Medicine, vol. 62, pp. 164-171Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/oem.2004.014951
Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.
Clinical and Laboratory Haematology, vol. 27, pp. 402-404Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2257.2005.00730.x
The cryptic path from epitope to clot: a story of two domains?
Blood, vol. 105, pp. 1371-1372Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1182/blood-2004-11-4556
Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma
Blood, vol. 103, no. 5, pp. 1755-1762Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2003-07-2594
Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles.
Toxicology and Applied Pharmacology, vol. 195, pp. 35-44Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.taap.2003.10.003
Markers of endothelial activation and atherothrombosis in women with history of preeclampsia or gestational hypertension
Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1192-1197Contributions to Journals: Articles- [ONLINE] View publication in Scopus
Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 1
Journal of Immunology, vol. 170, no. 12, pp. 6183-6189Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.4049/jimmunol.170.12.6183
- [ONLINE] View publication in Scopus
Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 11
The Journal of Immunology, vol. 170, no. 12, pp. 6183-6189Contributions to Journals: ArticlesFatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones [1]
Leukemia, vol. 17, no. 3, pp. 634-635Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1038/sj.leu.2402842
- [ONLINE] View publication in Scopus
Imatinib mesylate-induced molecular remission of Philadelphia chromosome-positive myelodysplastic syndrome [3]
Leukemia, vol. 17, no. 2, pp. 463-465Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1038/sj.leu.2402814
- [ONLINE] View publication in Scopus