Professor Mark Vickers

Professor Mark Vickers
Professor Mark Vickers
Professor Mark Vickers

MBChB MRCP DM FRCPath

Chair in Applied Medicine (Clin)

About
Email Address
m.a.vickers@abdn.ac.uk
Telephone Number
+44 (0)1224 272401
Office Address

1. Room 3:25, Institute of Medical Sciences

2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.

External Memberships

Member of Royal College of Physicians

Fellow of Royal College of Pathologists

British Society for Haematology

 

Research

Research Overview

My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria.  The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection.  I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19.  I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers.  I am also involved in collection and use of convalescent plasma for COVID-19.

 

Knowledge Exchange

I have given talks about the use of convalescent plasma and T cells to treat COVID-19.

Collaborations

Prof. Alex Rowe, Edinburgh University.

Prof. Stuart Haslam, Imperial College London.

Prof. David Rees, King's College London.

Supervision

Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.

Teaching

Teaching Responsibilities

I organise, and deliver much of, the haematology training in the medical school.  I remain an enthusiastic bedside teacher.  I co-ordinated the third year medical degree 1997-2010.

Publications

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  • Pro-coagulant effects of environmental particles (PM10)

    Gilmour, P. S., Morrison, E. R., Henriksen, P., Vickers, M. A., Ford, I., Greaves, M., Donaldson, K., MacNee, W.
    Occupational and Environmental Medicine, vol. 62, pp. 164-171
    Contributions to Journals: Articles
  • Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.

    Mittal, S., Milner, B. J., Vickers, M. A.
    Clinical and Laboratory Haematology, vol. 27, pp. 402-404
    Contributions to Journals: Articles
  • The cryptic path from epitope to clot: a story of two domains?

    Vickers, M. A., Greaves, M.
    Blood, vol. 105, pp. 1371-1372
    Contributions to Journals: Editorials
  • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

    Marshall, N. A., Christie, L. E., Munro, L. R., Culligan, D. J., Johnston, P. W., Barker, R. N., Vickers, M. A.
    Blood, vol. 103, no. 5, pp. 1755-1762
    Contributions to Journals: Articles
  • Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles.

    Gilmour, P. S., Ziesenis, A., Morrison, E. R., Vickers, M. A., Drost, E. M., Ford, I., Karg, E., Mossa, C., Schroeppel, A., Ferron, G. A., Heyder, J., Greaves, M., MacNee, W., Donaldson, K.
    Toxicology and Applied Pharmacology, vol. 195, pp. 35-44
    Contributions to Journals: Articles
  • Markers of endothelial activation and atherothrombosis in women with history of preeclampsia or gestational hypertension

    Vickers, M., Ford, I., Morrison, R., Prescott, G., Watson, S., Hannaford, P., Smith, C., Campbell, D., Greaves, M.
    Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1192-1197
    Contributions to Journals: Articles
  • Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 1

    Marshall, N. A., Vickers, M. A., Barker, R. N.
    Journal of Immunology, vol. 170, no. 12, pp. 6183-6189
    Contributions to Journals: Articles
  • Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 11

    Marshall, N. A., Vickers, M. A., Barker, R. N.
    The Journal of Immunology, vol. 170, no. 12, pp. 6183-6189
    Contributions to Journals: Articles
  • Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones [1]

    Chee, Y. L., Vickers, M. A., Stevenson, D., Holyoake, T. L., Culligan, D. J.
    Leukemia, vol. 17, no. 3, pp. 634-635
    Contributions to Journals: Letters
  • Imatinib mesylate-induced molecular remission of Philadelphia chromosome-positive myelodysplastic syndrome [3]

    Drummond, M. W., Lush, C. J., Vickers, M. A., Reid, F. M., Kaeda, J., Holyoake, T. L.
    Leukemia, vol. 17, no. 2, pp. 463-465
    Contributions to Journals: Letters
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