MBChB MRCP DM FRCPath
Chair in Applied Medicine (Clin)
- About
-
- Email Address
- m.a.vickers@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272401
- Office Address
1. Room 3:25, Institute of Medical Sciences
2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.
External Memberships
Member of Royal College of Physicians
Fellow of Royal College of Pathologists
British Society for Haematology
- Research
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Research Overview
My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.
Knowledge Exchange
I have given talks about the use of convalescent plasma and T cells to treat COVID-19.
Collaborations
Prof. Alex Rowe, Edinburgh University.
Prof. Stuart Haslam, Imperial College London.
Prof. David Rees, King's College London.
Supervision
Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.
- Teaching
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Teaching Responsibilities
I organise, and deliver much of, the haematology training in the medical school. I remain an enthusiastic bedside teacher. I co-ordinated the third year medical degree 1997-2010.
- Publications
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Page 1 of 9 Results 1 to 10 of 90
Measurement of erythrocyte membrane mannoses to assess splenic function
British Journal of Haematology, vol. 198, no. 1, pp. 155-164Contributions to Journals: ArticlesHyposplenism and gastrointestinal diseases: significance and mechanisms
Digestive Diseases, vol. 40, pp. 290–298Contributions to Journals: Review articlesOxidative stress, malaria, sickle cell disease, and innate immunity
Trends in Immunology, vol. 42, no. 10, pp. 849-851Contributions to Journals: ArticlesCytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy
Clinical and Experimental Immunology, vol. 206, no. 1, 68-81Contributions to Journals: ArticlesThe Red Blood Cell as a Novel Regulator of Human B-cell Activation
Immunology, vol. 163, no. 4Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/imm.13327
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16803/1/Lennon_etal_The_red_blood_VOR.pdf
- [ONLINE] View publication in Scopus
Low-Dose Vitamin D3 Supplementation Does Not Affect Natural Regulatory T Cell Population but Attenuates Seasonal Changes in T Cell-Produced IFN-γ: results from the D-SIRe2 randomised controlled trial
Frontiers in Immunology, vol. 12, 623087Contributions to Journals: ArticlesSialic acid‐binding immunoglobulin‐like lectin (Siglec)‐15 is a rapidly internalised cell‐surface antigen expressed by acute myeloid leukaemia cells
British Journal of Haematology, vol. 193, no. 5, pp. 946-950Contributions to Journals: ArticlesRed blood cell mannoses as phagocytic ligands mediating both sickle cell anaemia and malaria resistance
Nature Communications, vol. 12, no. 1, 1792Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41467-021-21814-z
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16159/1/Cao_etal_NC_Red_blood_Cell_VoR.pdf
- [ONLINE] View publication in Scopus
Human erythrocyte surface fucose expression increases with age and hyperglycemia: [version 1; peer review: awaiting peer review]
Wellcome open research, vol. 6, 28Contributions to Journals: Articles- [ONLINE] https://doi.org/10.17605/OSF.IO/XF8AM
- [ONLINE] DOI: https://doi.org/10.12688/wellcomeopenres.16409.1
High mannose N-glycans on red blood cells as phagocytic ligands, mediating both sickle cell anaemia and resistance to malaria
bioRxivContributions to Journals: Articles