MD PhD FRCP, Hon Consultant Rheumatologist
Clinical Chair in Experimental Medicine and Rheumatology
- About
-
- Email Address
- c.debari@abdn.ac.uk
- Office Address
School of Medicine, Medical Sciences and Nutrition
University of Aberdeen
Aberdeen Centre for Arthritis and Musculoskeletal Health
Arthritis and Regenerative Medicine Laboratory
Institute of Medical Sciences
Foresterhill, Aberdeen AB25 2ZD
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.
Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.
Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.
External Memberships
Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.
Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.
- Research
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Research Overview
The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.
The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.
The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.
- Publications
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A homeostatic function of CXCR2 signalling in articular cartilage
Annals of the Rheumatic Diseases, vol. 74, no. 12, pp. 2207-2215Contributions to Journals: ArticlesYes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells
Arthritis Research & Therapy, vol. 17, 147Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0639-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7388/1/s13075_015_0639_9.pdf
Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys?
Arthritis Research & Therapy, vol. 17, 113Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0634-1
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4800/1/s13075_015_0634_1.pdf
Homing of mesenchymal stem cells: mechanistic or stochastic? Implications for targeted delivery in arthritis
Rheumatology, vol. 54, no. 2, pp. 210-218Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/keu377
Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice
Cartilage, vol. 5, no. 4, pp. 231-240Contributions to Journals: Articles- [ONLINE] http://car.sagepub.com/content/5/4/231.full
- [ONLINE] DOI: https://doi.org/10.1177/1947603514541274
The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation
Cancer Cell, vol. 26, no. 2, pp. 273-287Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ccr.2014.05.029
In vivo phenotypic characterisation of nucleoside label-retaining cells in mouse periosteum
European Cells & Materials, vol. 27, pp. 185-195Contributions to Journals: ArticlesProspective purification of a subpopulation of human synovial mesenchymal stem cells with enhanced chondro-osteogenic potency.
Rheumatology, vol. 52, no. 10, pp. 1758-1768Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/ket205
- [ONLINE] View publication in Scopus
Cell-based Approaches to Joint Surface Repair: A Research Perspective
Osteoarthritis and Cartilage, vol. 21, no. 7, pp. 892-900Contributions to Journals: Review articlesMesenchymal stem cell niches in joint health and disease
European Cells & Materials, vol. 26, no. suppl. 3, pp. 5Contributions to Journals: Articles- [ONLINE] View publication in Scopus