![Professor Cosimo De Bari Professor Cosimo De Bari](/img/200x200/staffpages/uploads/mmd803/avatar/TNenltCJemp3BX2SvYa6FWJOs9F44gEpTqkEw0KE.jpeg)
MD PhD FRCP, Hon Consultant Rheumatologist
Clinical Chair in Experimental Medicine and Rheumatology
- About
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- Email Address
- c.debari@abdn.ac.uk
- Office Address
School of Medicine, Medical Sciences and Nutrition
University of Aberdeen
Aberdeen Centre for Arthritis and Musculoskeletal Health
Arthritis and Regenerative Medicine Laboratory
Institute of Medical Sciences
Foresterhill, Aberdeen AB25 2ZD
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.
Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.
Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.
External Memberships
Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.
Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.
- Research
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Research Overview
The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.
The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.
The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.
- Publications
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The Hippo pathway member Yap plays a key role in influencing fate decisions in muscle satellite cells
Journal of Cell Science, vol. 125, no. 24, pp. 6009-6019Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1242/jcs.109546
Immunostaining of skeletal tissues
Methods in Molecular Biology, vol. 816, no. 4, pp. 321-334Contributions to Journals: ArticlesDirected migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field
European Cells & Materials, vol. 22, no. -, pp. 344-358Contributions to Journals: ArticlesRole of mesenchymal stem cells in reestablishing immunologic tolerance in autoimmune rheumatic diseases
Arthritis & Rheumatism, vol. 63, no. 9, pp. 2547-2557Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.30474
Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo
Arthritis & Rheumatism, vol. 63, no. 5, pp. 1289-1300Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.30234
Future dentistry: cell therapy meets tooth and periodontal repair and regeneration
Journal of Cellular and Molecular Medicine, vol. 15, no. 5, pp. 1054-1065Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1582-4934.2010.01251.x
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
Journal of Cell Biology, vol. 193, no. 3, pp. 551-564Contributions to Journals: ArticlesDual origin of mesenchymal stem cells contributing to organ growth and repair
PNAS, vol. 108, no. 16, pp. 6503-6508Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1015449108
Mesenchymal differentiation propensity of a human embryonic stem cell line
Cell Proliferation, vol. 44, no. 2, pp. 120-127Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2184.2011.00744.x
Prospects of stem cell therapy in osteoarthritis
Regenerative Medicine, vol. 6, no. 3, pp. 351-366Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2217/rme.11.21