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The Institute of Applied Health Sciences

Dr Carl Counsell

Dr Carl Counsell
Dr Carl Counsell
Dr Carl Counsell

MRCP, MSc, MD

Reader (Clinical)

About
Email Address
carl.counsell@abdn.ac.uk
Office Address

Room 1:009, Polwarth Building Division of Applied Health Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

Carl is a clinical reader and honorary consultant in neurology.  He graduated in medicine from Cambridge University in 1988, did his early postgraduate medical training in London, Newcastle and Falkirk and then trained in neurology, stroke and epidemiology in Edinburgh.  He spent a year in Melbourne where he specialised in movement disorders before taking up his present post in 2001.  A committed Christian, he would like to have more time to serve in his church and develop his interests in Fairtrade and conservation. 

Latest Publications

View My Publications

Research

Research Overview

Carl is a consultant neurologist with subspecialty interest in movement disorders.  His main research interests are in evidence-based medicine and broader aspects of clinical epidemiology such as incidence and prognostic studies, particularly in relation to Parkinson's disease, other movement disorders and stroke.  His team have established several cohorts of parkinsonian patients for long-term follow-up and supported a number of non-industry sponsored clinical trials and Cochrane reviews, whilst also trying to promote multidisciplinary neurology research in Aberdeen. 

Research Specialisms

  • Clinical Medicine

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

The PINE study: a population-based incidence cohort of people with Parkinson's disease and other parkinsonian disorders, along with their carers and controls who are being followed up lifelong to establish long-term prognosis.

The Parkinson's Incidence Cohorts Collaboration:  an individual patient data meta-analysis of all population- based incidence cohorts of Parkinson's disease to assess prognosis and allow prognostic modelling.     

The Scottish PSP/CBD prevalence cohort:  a cohort of people with two related Parkinson's plus disorders,  Progressive Supranuclear Palsy and Corticobasal Degeneration as well as Parkinson's disease controls, to assess diagnostic and care pathways and prognosis.  

 

Past Research

Cochrane systematic reviews of randomised trials in stroke care and Parkinson's disease

Prognostic modelling in acute stroke

Incidence of Parkinson's disease and other parkinsonian disorders in North-East Scotland 

Prevalence of multiple sclerosis in North-East Scotland and northern isles

Randomised trial of physiotherapy for cervical dystonia

 

Knowledge Exchange

Member of Parkinson's Excellence Network

Collaborations

Cochrane Collaboration Stroke Review Group, Professors Charles Warlow and Peter Sandercock, University of Edinburgh, UK, 1993-98.

Scottish Audit of Intracranial Vascular Malformations, Professor Rustam Al-Shahi Salman, University of Edinburgh, UK, 2002-2014. 

PDMED trial, Professor Carl Clarke, University of Birmingham, UK, 2004-2020.

Clinical trial methods in neurodegenerative diseases, Professor John Zajicek, University of Plymouth, UK, 2009-2014. 

PDCOMM trial, Professor Sackley, University of Nottingham, UK, 2016-2023.

NICE technology appraisals for multiple sclerosis, Universities of Warwick and Exeter, UK, 2016-2022 

Parkinson's Incidence Cohorts Collaboration, Professor Tysnes, Dr Guido Alves, Professor Lars Forsgren, Dr Caroline Williams-Gray, Dr Alison Yarnall, Universities of Stavanger (Norway), Umea (Sweden), Cambridge (UK) and Newcastle (UK), 2018 ongoing 

PD Connect exercise trial, Julie Jones, Robert Gordon University, Aberdeen, UK, 2019-2022 

 

Supervision

Dr Kate Taylor (MD), 2002-06, Incidence and prognosis of parkinsonism in north-east Scotland: a pilot study.

Clare Harris (MSc), 2006-08, PINE participants attitudes to brain donation. 

Dr Robert Caslake (PhD), 2006-11, Incidence and short-term prognosis of Parkinson's disease and other parkinsonian disorders in north-east Scotland.

Dr Elizabeth Visser (MD), 2009-13, Prevalence of multiple sclerosis in northern Scotland.

Dr David McGhee (PhD), 2009-13, Improving clinical trial design in neurodegenerative diseases.

Dr Angus Macleod (PhD), 2012-15, Predicting mortality and dependency in Parkinson's disease.

Dr Diane Swallow (PhD), 2016-21, Assessing diagnostic pathways in progressive supranuclear palsy and corticobasal degeneration.

Funding and Grants

Research funding has been obtained from:

Parkinson’s UK, Scottish Chief Scientist Office, BMA Doris Hillier award, RS Macdonald Trust, BUPA Foundation, NHS Grampian endowments, Dystonia Society, National Institute for Health Research.  

Teaching

Teaching Responsibilities

Lectures and clinical teaching of neurology for medical and dental students.

Supervising medical student elective and MSc projects 

Non-course Teaching Responsibilities

Regent to medical students

Publications

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  • A systematic review of biomarkers for disease progression in Alzheimer's disease

    McGhee, D. J. M., Ritchie, C. W., Thompson, P. A., Wright, D. E., Zajicek, J. P., Counsell, C. E.
    PloS ONE, vol. 9, no. 2, e88854
    Contributions to Journals: Articles

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    Nalls, M. A., Pankratz, N., Lill, C. M., Do, C. B., Hernandez, D. G., Saad, M., Destefano, A. L., Kara, E., Bras, J., Sharma, M., Schulte, C., Keller, M. F., Arepalli, S., Letson, C., Edsall, C., Stefansson, H., Liu, X., Pliner, H., Lee, J. H., Cheng, R., Ikram, M. A., Ioannidis, J. P., Hadjigeorgiou, G. M., Bis, J. C., Martinez, M., Perlmutter, J. S., Goate, A., Marder, K., Fiske, B., Sutherland, M., Xiromerisiou, G., Myers, R. H., Clark, L. N., Stefansson, K., Hardy, J. A., Heutink, P., Chen, H., Wood, N. W., Houlden, H., Payami, H., Brice, A., Scott, W. K., Gasser, T., Bertram, L., Eriksson, N., Foroud, T., Singleton, A. B., Plagnol, V., Sheerin, U. M., Counsell, C., International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson’s Study Group (PSG) Parkinson’s Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), The Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson’s Disease Consortium, Alzheimer Genetic Analysis Group
    Nature Genetics, vol. 46, no. 9, pp. 989-993
    Contributions to Journals: Articles

  • Outcome after conservative management or intervention for unruptured brain arteriovenous malformations

    Al-Shahi Salman, R., White, P. M., Counsell, C. E., du Plessis, J., van Beijnum, J., Josephson, C. B., Wilkinson, T., Wedderburn, C. J., Chandy, Z., St George, E. J., Sellar, R. J., Warlow, C. P., Scottish Audit of Intracranial Vascular Malformations Collaborators
    JAMA, vol. 311, no. 16, pp. 1661-1669
    Contributions to Journals: Articles

  • The Mini-Mental Parkinson's (MMP) as a cognitive screening tool in people with Parkinson's disease

    Caslake, R., Summers, F., McConachie, D., Ferris, C., Gordon, J., Harris, C., Caie, L., Counsell, C.
    Current Aging Science, vol. 6, no. 3, pp. 273-279
    Contributions to Journals: Articles

  • The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson's disease with a sexual dimorphism

    Klebe, S., Golmard, J. L., Nalls, M. A., Saad, M., Singleton, A. B., Bras, J. M., Hardy, J., Simon-Sanchez, J., Heutink, P., Kuhlenbäumer, G., Charfi, R., Klein, C., Hagenah, J., Gasser, T., Wurster, I., Lesage, S., Lorenz, D., Deuschl, G., Durif, F., Pollak, P., Damier, P., Tison, F., Durr, A., Amouyel, P., Lambert, J. C., Tzourio, C., Maubaret, C., Charbonnier-Beaupel, F., Tahiri, K., Vidailhet, M., Martinez, M., Brice, A., Corvol, J. C., The French Parkinson's Disease Genetics Study Group, Agid, Y., Anheim, M., Bonnet, A. M., Borg, M., Brice, A., Broussolle, E., Corvol, J. C., Damier, P., Destée, A., Durif, F., Klebe, S., Lohmann, E., Martinez, M., Penet, C., Pollak, P., Krack, P., Counsell, C.
    Journal of Neurology, Neurosurgery and Psychiatry, vol. 84, no. 6, pp. 666-673
    Contributions to Journals: Articles

  • Age-, gender-, and socioeconomic status-specific incidence of Parkinson's disease and parkinsonism in North East Scotland: The PINE study

    Caslake, R., Taylor, K., Scott, N., Gordon, J., Harris, C., Wilde, K., Murray, A., Counsell, C.
    Parkinsonism & Related Disorders, vol. 19, no. 5, pp. 515-521
    Contributions to Journals: Articles

  • Attitudes to brain donation for Parkinson's research and how to ask: A qualitative study with suggested guidelines for practice

    Harris, C. E., Kiger, A. M., Counsell, C. E.
    Journal of Advanced Nursing, vol. 69, no. 5, pp. 1096-1108
    Contributions to Journals: Articles

  • A systematic review of biomarkers for disease progression in Parkinson's disease

    McGhee, D. J. M., Royle, P. L., Thompson, P. A., Wright, D. E., Zajicek, J. P., Counsell, C. E.
    BMC Neurology, vol. 13, 35
    Contributions to Journals: Articles

  • Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial

    Al-Chalabi, A., Allen, C., Counsell, C. E., Farrin, A., Dickie, B., Kelly, J., Leigh, P., Murphy, C., Payan, C., Reynolds, G., Shaw, P., Steen, I., Thornhill, M., Waters, J., Zajicek, J., Young, C. A., Morrison, K. E., Dhariwal, S., Hornabrook, R., Savage, L., Burn, D. J., Khoo, T. K., Kelly, J., Dougherty, A., Wijesekera, L., Thornhill, M., Ellis, C. M., O'Hanlon, K., Panicker, J., Pate, L., Ray, P., Wyatt, L., Copeland, L., Ealing, J., Hamdalla, H., Leroi, I., Murphy, C., O'Keeffe, F., Oughton, E., Partington, L., Paterson, P., Rog, D., Sathish, A., Sexton, D., Smith, J., Vanek, H., Dodds, S., Williams, T. L., Clarke, J., Eziefula, C., Howard, R., Orrell, R., Sidle, K., Sylvester, R., Barrett, W., Merritt, C., Talbot, K., Turner, M. R., Whatley, C., Williams, C., Williams, J., Cosby, C., Hanemann, C. O., Imam, I., Phillips, C., Timings, L., Crawford, S. E., Hewamadduma, C., Hibberd, R., Hollinger, H., McDermott, C., Mills, G., Rafiq, M., Taylor, A., Waines, E., Walsh, T., Addison-Jones, R., Birt, J., Hare, M., Majid, T.
    The Lancet neurology, vol. 12, no. 4, pp. 339-345
    Contributions to Journals: Articles

  • Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease

    Keller, M. F., Saad, M., Bras, J., Bettella, F., Nicolaou, N., Simón-Sánchez, J., Mittag, F., Büchel, F., Sharma, M., Gibbs, J. R., Schulte, C., Moskvina, V., Durr, A., Holmans, P., Kilarski, L. L., Guerreiro, R., Hernandez, D. G., Brice, A., Ylikotila, P., Stefánsson, H., Majamaa, K., Morris, H. R., Williams, N., Gasser, T., Heutink, P., Wood, N. W., Hardy, J., Martinez, M., Singleton, A. B., Nalls, M. A., Plagnol, V., Sheerin, U. M., Lesage, S., Sveinbjörnsdóttir, S., Arepalli, S., Barker, R., Ben-Shlomo, Y., Berendse, H. W., Berg, D., Bhatia, K., de Bie, R. M., Biffi, A., Bloem, B., Bochdanovits, Z., Bonin, M., Brockmann, K., Brooks, J., Burn, D. J., Charlesworth, G., Counsell, C., The International Parkinson's Disease Genomics Consortium (IPDGC), The Wellcome Trust Case Control Consortium 2 (WTCCC2)
    Human Molecular Genetics, vol. 21, no. 22, pp. 4996-5009
    Contributions to Journals: Articles
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