![Professor Marion Campbell Professor Marion Campbell](/img/200x200/staffpages/uploads/sme098/avatar/ZLjE8vL4N76auwU15zJUYuOVjpMZZqvIXx1cI3SL.jpeg)
BSc (Hons), MSc, PhD, CStat, FSS, FFPH, FSCT, FRSE, FMedSci
Chair in HSRU
- About
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- Email Address
- m.k.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 273161
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Marion Campbell is Professor of Health Services Research at the University of Aberdeen. She is also co-Director of the RCSEng Aberdeen Surgical Trials Centre. Marion is a medical statistician by training, a clinical trialist and methodologist. Her main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has published widely on clinical trials methodology including on cluster randomised trials, design of trials of surgical interventions, pragmatic trials and trials reporting. She has served on many national and international funding agencies and committees and is an elected Fellow of the Academy of Medical Sciences, the Royal Society of Edinburgh, the Faculty of Public Health, and the International Society for Clinical Trials and is a previous NIHR senior investigator.
Previously Marion was Vice-Principal (Research) for the University of Aberdeen. In this role, she had primary responsibility for promoting the University's research ambitions, ensuring effective delivery of the University's strategic objectives for research. and for enabling a research context for academic colleagues to deliver world-leading, impactful research. She also led on the establishment of interdisciplinary research across the institution. Prior to this, Marion was Dean of Research for Life Sciences and Medicine following ten years as Director of the Scottish government core-funded Health Services Research Unit.
Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health. Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the University of Aberdeen in 1993.
External Memberships
Chair. MRC Better Methods Better Research Panel
Member of REF2021 UoA2 sub-panel
- Research
-
Research Overview
Marion’s main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has also published widely on clinical trials methodology including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting.
Some examples of current and recent research include:
REINFORCE: The NIHR-funded REINFORCE study aims to evaluation the introduction and scale up of robot-assisted surgery across the NHS. Further information is available at: https://www.abdn.ac.uk/hsru/what-we-do/research/projects/reinforce-291
UK-REBOA: The NIHR-funded UK-REBOA trial aims to establish the clinical and cost-effectiveness of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), in addition to standard major trauma centre treatment, for the treatment of patients with life-threatening torso haemorrhage. The trial is currently live across major trauma centres in England. Further information is available on the trial website: https://w3.abdn.ac.uk/hsru/REBOA/Public/Public/index.cshtml
TOPKAT: The NIHR-funded TOPKAT trial is investigating the clinical and cost effectiveness of partial (PKR) vs total (THR) knee replacements. The trial recruited 528 patients from across the UK. Five year results have been published in the Lancet (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31281-4/fulltext) and showed that PKR has similar, if not a slightly better clinical outcome than TKR. More importantly, the economic benefit of using PKR is substantial. Patients are now being followed up to 10 years.
CLASS: The NIHR-funded CLASS trial is assessing the clinical and cost-effectiveness of three treatment modalities for the treatment of varicose veins: a) foam; b) EVLA with subsequent foam to varicosities when required; and c) surgery. A total of 798 adult patients were recruited into the trial and randomised to one of the treatment options. Six weeks results have been published in the NEJM (http://www.nejm.org/doi/full/10.1056/NEJMoa1400781). Five year follow-up is now complete.
KAT: The NIHR-funded KAT trial, explores different knee replacement surgery options (the effects of patellar resurfacing, mobile bearings and metal backing were investigated). A total of 116 surgeons in 34 UK centres participated and 2352 participants were randomised. Ten year outcomes were previously published (https://www.journalslibrary.nihr.ac.uk/hta/hta18190/#/abstract); long term follow up to 20 years is underway.
Research Areas
Applied Health Sciences
Research Specialisms
- Healthcare Science
- Medical Statistics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women
The American Journal of Clinical Nutrition, vol. 81, no. 4, pp. 922-933Contributions to Journals: ArticlesIssues in data monitoring and interim analysis of trials
Health Technology Assessment, vol. 9, no. 7, pp. 1-238Contributions to Journals: ArticlesA proposed charter for clinical trial data monitoring committees: helping them to do their job well.
The Lancet, vol. 365, no. 9460, pp. 711-722Contributions to Journals: ArticlesAn integrated approach to consumer representation and involvement in a multicentre randomised controlled trial
Clinical Trials, vol. 2, no. 1, pp. 1-8Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1191/1740774505cn065oa
An integrated approach to consumer representation and involvement in a multicentre randomized controlled trial
Clinical Trials, vol. 2, pp. 80-87Contributions to Journals: ArticlesAn investigation into People's perceptions of 'Quality of Life' when completing health-related quality of life questionnaires
1 page.Other Contributions: Other ContributionsCluster randomised trials of professional and organisational behaviour change interventions in health care settings.
Annals of the American Academy of Political and Social Science, vol. 599, pp. 71-93Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1177/0002716205274576
Data monitoring in randomised controlled trials: surveys of recent practice and policies
Clinical Trials, vol. 2, pp. 22-33Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1191/1740774505cn064oa
Experimental evaluations of change and improvements strategies
Improving patient care: the implementation of change in clinical practice., pp. 235-247, 12 pagesChapters in Books, Reports and Conference Proceedings: ChaptersImproving the referral process for familial breast cancer genetic counselling: findings of three randomised controlled trials of two interventions - Introduction
Health Technology Assessment, vol. 9, pp. 1Contributions to Journals: Literature ReviewsThe CONSORT statement for cluster randomised trials
Medicina Clínica, vol. 125, no. Suppl. 1, pp. 28-31Contributions to Journals: ArticlesLow Back Pain: Influence of Early MR Imaging or CT on Treatment and Outcome—Multicenter Randomized Trial
Radiology, vol. 231, no. 2, pp. 343-351Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1148/radiol.2312030886
- [ONLINE] View publication in Scopus
Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement
Health Technology Assessment, vol. 8, no. 21, pp. 1-182Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta8210
Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported
BMC Medical Research Methodology, vol. 4, 9Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1471-2288-4-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3902/1/Intracluster_correlation.pdf
Cervical screening in women over the age of fifty: results of a population based multicentre study
British Journal of Obstetrics and Gynaecology, vol. 111, no. 4, pp. 362-368Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1471-0528.2004.00085.x
Lower estimates of net endogenous noncarbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women
The American Journal of Clinical Nutrition, vol. 79, no. 1, pp. 131-138Contributions to Journals: ArticlesNutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids
The American Journal of Clinical Nutrition, vol. 79, no. 1, pp. 155-165Contributions to Journals: ArticlesAminobisphosphonate versus other active treatment for Paget's disease of the bone in adults
Other Contributions: Other ContributionsCONSORT statement: extension to cluster randomised trials
British Medical Journal, vol. 328, no. 7441, pp. 702-708Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.328.7441.702
Continuous ambulatory peritoneal dialysis (CAPD) versus hospital or home haemodialysis for end-stage renal disease in adults
Cochrane Database of Systematic Reviews, no. 4, pp. CD003963Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/14651858.CD003963.pub2
Delivering clinical trial supplies by post to elderly trial participants: a feasibility study
Applied Clinical Trials, no. Feb, pp. 58-59Contributions to Journals: ArticlesDoes early magnetic resonance imaging influence management or improve outcome in patients referred to secondary care with low back pain? A pragmatic randomised controlled trial
Health Technology Assessment, vol. 8, pp. 1Contributions to Journals: Literature ReviewsInfluence of weight and weight change on bone loss in perimenopausal and early postmenopausal Scottish women
Osteoporosis International, vol. 16, no. 2, pp. 163-171Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00198-004-1657-7
Quality of life data: What to do when it is missing?
Quality of Life Research, vol. 13, no. 9, pp. 1520-1520Contributions to Journals: ArticlesRecruitment to multicentre trials
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 111, no. 1, pp. 3-5Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1471-0528.2004.00011.x
Reported use of data monitoring committees in the main published reports of randomized controlled trials: a cross-sectional study
Clinical Trials, vol. 1, no. 1, pp. 48-59Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1191/1740774504cn003oa
Sample size calculator for cluster randomized trials
Computers in Biology and Medicine, vol. 34, no. 2, pp. 113-125Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0010-4825(03)00039-8
Small group processes relevant to data monitoring committees in controlled clinical trials: an overview of reviews
Clinical Trials, vol. 1, no. 3, pp. 282-296Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1191/1740774504cn023oa
Systematic qualitative review of the literature on data monitoring committees for randomized controlled trials
Clinical Trials, vol. 1, no. 1, pp. 60-79Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1191/1740774504cn004rr
The effects of an open design on trial participant recruitment, compliance and retention - a randomised controlled trial comparison with a blinded, placebo-controlled design
Clinical Trials, vol. 1, no. 6, pp. 490-498Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1191/1740774504cn053oa
What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials
Journal of Human Nutrition and Dietetics, vol. 17, no. 4, pp. 317-335Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-277X.2004.00531.x
What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions
Journal of Human Nutrition and Dietetics, vol. 17, no. 4, pp. 293-316Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-277X.2004.00530.x
Determinants of the intracluster correlation coefficient in cluster randomised trials
Controlled Clinical Trials, vol. 24, no. 3, Suppl.1, pp. 174S-174SContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0197-2456(03)00050-3
Continuous ambulatory peritoneal dialysis (CAPD) versus hospital or home haemodialysis for end-stage renal disease in adults
Cochrane Database of Systematic Reviews, no. 1, CD003963Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/14651858.CD003963
Experiences of consumer organisation involvement in a UK multicentre randomised controlled trial
Controlled Clinical Trials, vol. 24, no. 3s, pp. 155s-156sContributions to Journals: ArticlesLongitudinal changes in weight in perimenopausal and early postmenopausal women: effects of dietary energy intake, energy expenditure, dietary calcium intake and hormone replacement therapy
International Journal of Obesity, vol. 27, no. 6, pp. 669-676Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.ijo.0802283
Research designs for studies evaluating the effectiveness of change and improvement strategies
Quality & safety in health care, vol. 12, no. 1, pp. 47-52Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/qhc.12.1.47
Research designs for studies evaluating the effectiveness of change and improvement strategies
In: Quality improvement research: understanding the science of change in health care (eds. Grol,R.;Baker,R.;Moss,F.), BMJ Books, London, pp. 97-114, 17 pagesChapters in Books, Reports and Conference Proceedings: ChaptersThe PRISM Trial: A DNA repository sub-study
Calcified Tissue International, vol. 76, no. 6Contributions to Journals: ArticlesThe PRISM Trial: A randomised trial of intensive vs. symptomatic management for Paget’s disease of the bone
Calcified Tissue International, vol. 76, no. 6Contributions to Journals: ArticlesChanges in public awareness of, attitudes to, and use of complementary therapy in North East Scotland: Surveys in 1993 and 1999
Complementary Therapies in Medicine, vol. 10, no. 3, pp. 148-153Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0965229902000663
Frequency of administration of recombinant human erythropoietin for anaemia of end-stage renal disease in dialysis patients
Cochrane Database of Systematic Reviews, no. 2Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/14651858.CD003895
Age-restricted cervical screening: HPV testing at age 50 identifies a high risk group for cervical disease
International Journal of Gynecological Cancer, vol. 12, no. 6, pp. 735-740Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/j.1525-1438.2002.01116.x
The method of minimization for allocation to clinical trials: a review
Controlled Clinical Trials, vol. 23, no. 6, pp. 662-674Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0197-2456(02)00242-8
Epidemiological methods
Studying the organization and delivery of the health services: Research methods. Fulop, N., Allen, P. (eds.). Taylor & Francis, pp. 56-72, 16 pagesChapters in Books, Reports and Conference Proceedings: ChaptersDouble bag or Y-set versus standard transfer systems for continuous ambulatory peritoneal dialysis in end-stage renal disease
Cochrane Database of Systematic Reviews, no. 2, CD003078Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/14651858.CD003078
A systematic review of discharge coding accuracy
Journal of Public Health Medicine, vol. 23, no. 3, pp. 205-211Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/pubmed/23.3.205
Attributes of clinical recommendations that influence changes in practice following audit and feedback
Journal of Clinical Epidemiology, vol. 55, no. 7, pp. 717-722Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0895-4356(02)00403-1
COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss
Journal of Bone and Mineral Research, vol. 16, no. 9, pp. 1634-1641Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1359/jbmr.2001.16.9.1634
Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size
Statistics in Medicine, vol. 20, no. 3, pp. 391-399Contributions to Journals: Articles