![Professor Marion Campbell Professor Marion Campbell](/img/200x200/staffpages/uploads/sme098/avatar/ZLjE8vL4N76auwU15zJUYuOVjpMZZqvIXx1cI3SL.jpeg)
BSc (Hons), MSc, PhD, CStat, FSS, FFPH, FSCT, FRSE, FMedSci
Chair in HSRU
- About
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- Email Address
- m.k.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 273161
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Marion Campbell is Professor of Health Services Research at the University of Aberdeen. She is also co-Director of the RCSEng Aberdeen Surgical Trials Centre. Marion is a medical statistician by training, a clinical trialist and methodologist. Her main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has published widely on clinical trials methodology including on cluster randomised trials, design of trials of surgical interventions, pragmatic trials and trials reporting. She has served on many national and international funding agencies and committees and is an elected Fellow of the Academy of Medical Sciences, the Royal Society of Edinburgh, the Faculty of Public Health, and the International Society for Clinical Trials and is a previous NIHR senior investigator.
Previously Marion was Vice-Principal (Research) for the University of Aberdeen. In this role, she had primary responsibility for promoting the University's research ambitions, ensuring effective delivery of the University's strategic objectives for research. and for enabling a research context for academic colleagues to deliver world-leading, impactful research. She also led on the establishment of interdisciplinary research across the institution. Prior to this, Marion was Dean of Research for Life Sciences and Medicine following ten years as Director of the Scottish government core-funded Health Services Research Unit.
Marion graduated with an honours degree in Statistics from the University of Aberdeen and subsequently gained an MSc in Statistics and PhD in Public Health. Following early career appointments within the National Health Service in the fields of Operational Research and Statistics of Medical Audit, she joined the University of Aberdeen in 1993.
External Memberships
Chair. MRC Better Methods Better Research Panel
Member of REF2021 UoA2 sub-panel
- Research
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Research Overview
Marion’s main research interests are in the design, conduct and analysis of clinical trials especially complex trial design and the design and conduct of surgical and device trials. She has also published widely on clinical trials methodology including on cluster randomised trials, design of trials of non-pharmacological interventions, pragmatic trials and trials reporting.
Some examples of current and recent research include:
REINFORCE: The NIHR-funded REINFORCE study aims to evaluation the introduction and scale up of robot-assisted surgery across the NHS. Further information is available at: https://www.abdn.ac.uk/hsru/what-we-do/research/projects/reinforce-291
UK-REBOA: The NIHR-funded UK-REBOA trial aims to establish the clinical and cost-effectiveness of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA), in addition to standard major trauma centre treatment, for the treatment of patients with life-threatening torso haemorrhage. The trial is currently live across major trauma centres in England. Further information is available on the trial website: https://w3.abdn.ac.uk/hsru/REBOA/Public/Public/index.cshtml
TOPKAT: The NIHR-funded TOPKAT trial is investigating the clinical and cost effectiveness of partial (PKR) vs total (THR) knee replacements. The trial recruited 528 patients from across the UK. Five year results have been published in the Lancet (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31281-4/fulltext) and showed that PKR has similar, if not a slightly better clinical outcome than TKR. More importantly, the economic benefit of using PKR is substantial. Patients are now being followed up to 10 years.
CLASS: The NIHR-funded CLASS trial is assessing the clinical and cost-effectiveness of three treatment modalities for the treatment of varicose veins: a) foam; b) EVLA with subsequent foam to varicosities when required; and c) surgery. A total of 798 adult patients were recruited into the trial and randomised to one of the treatment options. Six weeks results have been published in the NEJM (http://www.nejm.org/doi/full/10.1056/NEJMoa1400781). Five year follow-up is now complete.
KAT: The NIHR-funded KAT trial, explores different knee replacement surgery options (the effects of patellar resurfacing, mobile bearings and metal backing were investigated). A total of 116 surgeons in 34 UK centres participated and 2352 participants were randomised. Ten year outcomes were previously published (https://www.journalslibrary.nihr.ac.uk/hta/hta18190/#/abstract); long term follow up to 20 years is underway.
Research Areas
Applied Health Sciences
Research Specialisms
- Healthcare Science
- Medical Statistics
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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Use of randomisation in clinical trials: a survey of UK practice
Trials, vol. 13, 198Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-13-198
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2738/1/McPherson_2012.pdf
Consort 2010 statement: extension to cluster randomised trials
BMJ, vol. 345, pp. e5661Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.e5661
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2742/1/Campbell_2012.e5661
Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D3 and/or calcium (RECORD trial)
Journal of Clinical Endocrinology and Metabolism, vol. 97, no. 2, pp. 614-622Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1210/jc.2011-1309
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2671/1/Avenell_2011.pdf
A pragmatic multi-centre randomised controlled trial of fluid loading in high-risk surgical patients undergoing major elective surgery: the FOCCUS study
Critical Care, vol. 15, no. 6, R296Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/cc10592
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2650/1/Cuthbertson_2011.pdf
Patellar resurfacing in total knee replacement: five-year clinical and economic results of a large randomized controlled trial
The Journal of Bone & Joint Surgery. American Volume, vol. 93, no. 16, pp. 1473-1481Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2106/JBJS.J.00725
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2477/1/Breeman_2011.pdf
Developing the clinical components of a complex intervention for a glaucoma screening trial: a mixed methods study
BMC Medical Research Methodology, vol. 11, no. -, 54Contributions to Journals: ArticlesRandomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients
British Medical Journal, vol. 342, no. -, d1542Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.d1542
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2321/1/Andrews_2011.pdf
Using a business model approach and marketing techniques for recruitment to clinical trials
Trials, vol. 12, pp. 74Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-12-74
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2657/1/McDonald%25202011.pdf
Developing a placebo-controlled trial in surgery: issues of design, acceptability and feasibility
Trials, vol. 12, 50Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-12-50
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3971/1/Campbell%25202011.pdf
A Cost-Utility Analysis of Microwave Endometrial Ablation versus Thermal Balloon Endometrial Ablation
Value in Health, vol. 13, no. 5, pp. 528-534Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1524-4733.2010.00704.x
A pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol
Trials, vol. 11, no. 41Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-11-41
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2236/1/CuthbertsonTrials2010.pdf
Reasons for participating in randomised controlled trials: conditional altruism and considerations for self
Trials, vol. 11, pp. 31Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-11-31
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2652/1/McCann2010.pdf
Promoting public awareness of randomised clinical trials using the media
British Journal of Clinical Pharmacology, vol. 69, no. 2, pp. 128-135Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1365-2125.2009.03561.x
Effectiveness and cost-effectiveness of arthroscopic lavage in the treatment of osteoarthritis of the knee: a mixed methods study of the feasibility of conducting a surgical placebo-controlled trial (the KORAL study)
Health Technology Assessment, vol. 14, no. 5, pp. 1-180Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta14040
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2655/1/Campbell2010.pdf
Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone
Journal of Bone and Mineral Research, vol. 25, no. 1, pp. 20-31Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1359/jbmr.090709
A study of the perceived risks, benefits and barriers to the use of SDD in adult critical care units (the SuDDICU study)
Trials, vol. 11, pp. 117Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1745-6215-11-117
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/1134/1/Cuthbertson%25202010.pdf
Pragmatic multi-centre randomised trial of (1) routine postoperative ICU care and/or (2) pre-operative fluid loading in high-risk surgical patients undergoing major elective and urgent surgery
Edinburgh, United Kingdom: Chief Scientist Office. 7 pagesBooks and Reports: Commissioned ReportsThe PRaCTICaL study of nurse led, intensive care follow-up programmes for improving long term outcomes from critical illness: a pragmatic randomised controlled trial
British Medical Journal, vol. 339, b3723Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.b3723
When should a placebo be used in surgical trials?
Clinical Trials, vol. 6, no. 5, pp. 509Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1177/1740774509345176
Evaluation and stages of surgical innovations
The Lancet, vol. 374, no. 9695, pp. 1089-1096Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(09)61083-7
No surgical innovation without evaluation: the IDEAL recommendations
The Lancet, vol. 374, no. 9695, pp. 1105-1112Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/S0140-6736(09)61116-8
Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease: cost effectiveness study
British Medical Journal, vol. 339, b2576Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bmj.b2576
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/790/1/Epstein%25202009.pdf
Clinical outcomes from a randomised comparison of Microwave Endometrial Ablation with Thermal Balloon endometrial ablation for the treatment of heavy menstrual bleeding
BJOG-An International Journal of Obstetrics and Gynaecology, vol. 116, no. 8, pp. 1038-1045Contributions to Journals: ArticlesMeaning behind measurement: self-comparisons affect responses to health-related quality of life questionnaires
Quality of Life Research, vol. 18, no. 2, pp. 221-230Contributions to Journals: Articles- [ONLINE] http://aura.abdn.ac.uk/handle/2164/306
- [ONLINE] DOI: https://doi.org/10.1007/s11136-008-9435-1
The Knee Arthroplasty Trial (KAT): design features, baseline characteristics, and two-year functional outcomes after alternative approaches to knee replacement
The Journal of Bone & Joint Surgery. American Volume, vol. 91, no. 1, pp. 134-141Contributions to Journals: Articles- [ONLINE] http://aura.abdn.ac.uk/handle/2164/272
- [ONLINE] DOI: https://doi.org/10.2106/JBJS.G.01074