Dr Sharon Mitchell | The School of Biological Sciences

Dr Sharon Mitchell

PhD (Aberdeen University 2002)

Advanced Research Fellow

About

Email Address: s.e.mitchell@abdn.ac.uk
Office Address: 319, Zoology Building, Tillydrone Avenue, Aberdeen, AB24 2TZ
School/Department: School of Biological Sciences

Biography

2015-date Research Fellow, Lab Manager Energetics Research Group

Research

Research Overview

PhD Students

2016-date Megan Simpson

2016-2020 Jazmin Mendoza “Impacts of the thermic effect of food on feeding behaviour in mice: a test of the heat dissipation limits theory”

2015-2020 Emem Udoh PhD “Impacts of Calorie Restriction on Behaviour and Post-restriction Hyperphagia”

2015-2017 Heba Althubaiti “Fruit and Vegetable Intake and its Relationship with Health Parameters in Primary School Children”

Masters

2021-2022 Master of Science by Research Daniel Phillips “Bioinformatic Characterisation of Alternative Splicing in Three Different Tissues of Male C57BL/6 Mice Following Short-Term Graded Calorie Restriction"

2019-2020 MSci Daniel Phillips “Remodelling of three different tissues in the male C57BL/6 mouse during short-term graded caloric restriction is caused by tissue-specific variations in cell size and number”

2018-2019 MRes Stephanie Summers "The Impact of Short-Term Graded Calorie Restriction on Melanocortin-3 receptor (MC3R) Knockout Mice"

2013-2015 MSci Megan Simpson “The effect of maternal age on offspring susceptibility to high fat diet induced obesity and offspring expression of hypothalamic obesity related genes”.

2011-2013 MRes Dawn Graham, “The Role of Neuropeptides and their Receptors in Response to Increased Hunger, Reduced Food Intake and Reduced Body Fat Content”.

2011-2013 MRes Nicole Culbert, “Does Hunger Neuropeptide and Energy Balance Manipulation Affect Metabolic Rate and Antioxidant Activity in C57BL/6 Mice under Caloric Restriction?”

Supervisor of a number of Erasmus Funded Internships from AgroSup, Djon, France.

Teaching

Teaching Responsibilities

Lab Skills in Biosciences (BI3812), co-coordinator with Cath Jones

Parasitology Field trip (BI25F3), co-coordinator with Jerry Sternberg

Supervisor for laboratory-based research projects for Honours students

Lecturer on following courses:

Environmental Physiology (ZO3513)

Principles of Animal Physiology (BI2510)

Diversity of Life 2 (BI1512)

Publications

Page 1 of 3 Results 1 to 25 of 64

Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory
2024 - Published
Mitchell, S. E., Simpson, M., Coulet, L., Gouedard, S., Hambly, C., Morimoto, J., Allison, D. B., Speakman, J. R.
Proceedings of the National Academy of Sciences of the United States of America, vol. 121, no. 42, e2408682121
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1073/pnas.2408682121
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/24570/1/Mitchell_etal_PNAS_Reproduction_has_Immediate_VOR.pdf
- [ONLINE] View publication in Scopus
Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake
2024 - Published
Smith, D. L., Mitchell, S. E., Johnson, M. S., Gibbs, V. K., Dickinson, S., Henschel, B., Li, R., Kaiser, K. A., Chusyd, D. E., Brown, A. W., Allison, D. B., Speakman, J. R., Nagy, T. R.
GeroScience, vol. 46, pp. 4809–4826
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s11357-024-01166-4
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/24383/1/Smith_etal_GS_Benefits_Of_Calorie_VoR.pdf
Carbon, nitrogen, and sulfur elemental and isotopic variations in mouse hair and bone collagen during short-term graded calorie restriction
2024 - Published
Gutierrez, E., Mitchell, S., Hambly, C., Sayle, K. l., Von kriegsheim, A., Speakman, J. r., Britton, K.
iScience, vol. 27, no. 6, 110059
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.isci.2024.110059
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23793/1/Guitierrez_etal_i_Carbon_nitrogen_sulfur_VOR.pdf
Not feeling the heat?: Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature.
2024 - E-pub ahead of print
Osorio Mendoza, J., Mitchell, S., Hambly, C., Allison, D. B., Speakman, J.
Appetite
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.appet.2024.107421
Turmeric shortens lifespan in houseflies
2024 - Published
Laurie, S., Ainslie, L., Mitchell, S., Morimoto, J.
Frontiers in Insect Science, vol. 4, 1376011
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.3389/finsc.2024.1376011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23888/1/Laurie_etal_FiIS_Turmeric_Shortens_Lifespan_VOR.pdf
- [ONLINE] View publication in Scopus
The effects of graded levels of calorie restriction: XX. impact of long term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice
2023 - Published
Mitchell, S. E., Togo, J., Green, C. L., Derous, D., Hambly, C., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 78, no. 11, pp. 1953-1963
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glad152
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22231/1/Mitchell_etal_TJOG_The_Effects_Of_VoR.pdf
A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation
2023 - Published
Semerciöz-Oduncuoğlu, A. S., Mitchell, S. E., Özilgen, M., Yilmaz, B., Speakman, J. R.
Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 37, e2300624120
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1073/pnas.2300624120
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22003/1/Selcen_etal_PNAS_A_Step_Toward_VoR.pdf
- [ONLINE] View publication in Scopus
Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice
2023 - Published
Krol, E., Turner, F., Derous, D., Mitchell, S. E., Martin, S., Douglas, A., Speakman, J.
Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, pp. 171-192
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1007/s00360-023-01474-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/19855/1/Krol_etal_JCPB_Fur_Removal_Promotes_VoR.pdf
The effects of graded levels of calorie restriction XVIII: tissue specific changes in cell size and number in response to calorie restriction
2022 - Published
Phillips, D., Mathers, H., Mitchell, S. E., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 77, no. 10, pp. 1994-2001
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glac110
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/21227/1/Phillips_etal_JGSA_The_Effects_of_VOR.pdf
Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes
2021 - Published
Nychyk, O., Barton, W., Rudolf, A. M., Boscaini, S., Walsh, A., Bastiaanssen, T. F., Giblin, L., Cormican, P., Chen, L., Piotrowicz, Y., Derous, D., Fanning, ?., Yin, X., Grant, J., Melgar, S., Brennan, L., Mitchell, S. E., Cryan, J. F., Wang, J., Cotter, P. D., Speakman, J. R., Nilaweera, K. N.
Cell Reports, vol. 35, no. 6, 109093
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.celrep.2021.109093
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/16444/1/Nychyk_etal_CR_Protein_Quality_And_VoR.pdf
Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice
2021 - Published
Wu, Y., Li, B., Li, L., Mitchell, S. E., Green, C. L., D'Agostino, G., Wang, G., Wang, L., Li, M., Li, J., Niu, C., Jin, Z., Wang, A., Zheng, Y., Douglas, A., Speakman, J. R.
Cell Metabolism, vol. 33, no. 5, pp. P888-904.E6
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.cmet.2021.01.017
The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes
2020 - Published
Sun, D., Liu, F., Mitchell, S. E., Ma, H., Derous, D., Wang, Y., Han, J. J., Daniel E.L., P., Lusseau, D., Douglas, A., Speakman, J. R., Chen, L.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 5, pp. 858-866
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glaa055
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15966/1/Sun_etal_Effects_AAM.pdf
- [ONLINE] View publication in Scopus
The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice
2020 - Published
Green, C. L., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 2, pp. 218-229
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glz023
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13574/1/Green_etal_JGer_Effects_graded_XIV_VOR.pdf
- [ONLINE] https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glz023/5435643
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues
2019 - Published
Lipina, C., Walsh, S. K., Mitchell, S. E., Speakman, J. R., Wainwright, C. L., Hundal, H. S.
The FASEB Journal, vol. 33, no. 1, pp. 1299-1312
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1096/fj.201800171R
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11743/1/FASEB_Article.pdf
- [ONLINE] View publication in Scopus
The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice
2019 - Published
Green, C. L., Soltow, Q. A., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Jones, D. P., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 74, no. 1, pp. 16-26
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/gly058
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11691/1/The_Effects_of_Graded_Levels_of_Calorie_Restriction.pdf
- [ONLINE] View publication in Scopus
Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet
2018 - Published
McIlroy, G., Mitchell, S. E., Han, W., Delibegovic, M., Rochford, J. J.
Scientific Reports, vol. 8, 17863
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1038/s41598-018-36078-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11669/1/Female_adipose_tissue_specific_Bscl2_knockout_mice_develop_only_moderate_metabolic_dysfunction_when_housed_at_thermoneutrality_and_fed_a_high_fat_diet.pdf
The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon
2018 - Published
Fontana, L., Mitchell, S. E., Wang, B., Tosti, V., van Vliet, T., Veronese, N., Bertozzi, B., Early, D. S., Maissan, P., Speakman, J. R., Demaria, M.
Aging Cell, vol. 17, no. 3, e12746
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/acel.12746
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10451/1/Fontana_et_al_2018_Aging_Cell.pdf
Limits to sustained energy intake XXVII: trade-offs between first and second litters in lactating mice support the ecological context hypothesis
2018 - Published
Vaanholt, L. M., Osei, D. A., Balduci, S., Mitchell, S. E., Hambly, C., Speakman, J. R.
Journal of Experimental Biology, vol. 221, no. 5, jeb170902
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/jeb.170902
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12041/1/jeb170902.full.pdf
The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue
2018 - Published
Derous, D., Mitchell, S. E., Green, C. L., Wang, Y., Han, J. D. J., Chen, L., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 73, no. 3, pp. 279-288
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1093/gerona/glx101
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10142/1/The_Effects_of_Graded_Levels_of_Calorie_Restriction.pdf
Limits to sustained energy intake XXVIII: Beneficial effects of high dietary fat on lactation performance in mice
2018 - Published
Kagya-Agyemang, J. K., Vaanholt, L. M., Hambly, C., Król, E., Mitchell, S. E., Speakman, J. R.
Journal of Experimental Biology, vol. 221, jeb180828
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1242/jeb.180828
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12758/1/Limits_to_sustained_energy_intake._XXVIII._Beneficial_effects_of_high.pdf
Energy balance and the sphingosine-1-phosphate/ceramide axis
2017 - Published
Green, C., Mitchell, S., Speakman, J.
Aging, vol. 9, no. 12, pp. 2463-2464
Contributions to Journals: Editorials
- [ONLINE] DOI: https://doi.org/10.18632/aging.101347
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9890/1/zzEbzToKopC5bGMkZ.pdf
- [ONLINE] View publication in Scopus
The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome
2017 - Published
Derous, D., Mitchell, S. E., Wang, L., Green, C. L., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
Aging, vol. 9, no. 7, pp. 1770-1824
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/aging.101269
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9096/1/The_effects_of_graded_levels_of_calorie_restriction_XI._Evaluation_of_the_main_hypotheses_underpinning_the_life_extension_effects_of_CR_using_the_hepatic_transcriptome.pdf
The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice
2017 - Published
Green, C. L., Mitchell, S. E., Derous, D., Wang, Y., Chen, L., Han, J. J., Promislow, D. E. L., Lusseau, D., Douglas, A., Speakman, J. R.
Aging Cell, vol. 16, no. 3, pp. 529-540
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1111/acel.12570
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8135/3/Green_et_al_2017_Aging_Cell_1_.pdf
The effects of graded levels of calorie restriction: VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse
2017 - Published
Mitchell, S. E., Tang, Z. H., Kerbois, C., Delville, C., Derous, D., Green, C. L., Wang, Y., Han, J. J. D., Chen, L., Douglas, A., Lusseau, D., Promislow, D. E. L., Speakman, J. R.
Oncotarget, vol. 8, no. 11, pp. 17453-17474
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.15294
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8366/1/The_effects_of_graded_levels_of_calorie_restriction.pdf
Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone
2016 - Published
Speakman, J. R., Mitchell, S. E., Mazidi, M.
Experimental Gerontology, vol. 86, pp. 28-38
Contributions to Journals: Articles
- [ONLINE] DOI: https://doi.org/10.1016/j.exger.2016.03.011
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8354/1/Protein_restriction_after_review.docx
- [ONLINE] View publication in Scopus

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Reproduction has immediate effects on female mortality, but no discernible lasting physiological impacts: A test of the disposable soma theory

Benefits of calorie restriction in mice are mediated via energy imbalance, not absolute energy or protein intake

Carbon, nitrogen, and sulfur elemental and isotopic variations in mouse hair and bone collagen during short-term graded calorie restriction

Not feeling the heat?: Effects of dietary protein on satiation and satiety in mice are not due to its impact on body temperature.

Turmeric shortens lifespan in houseflies

The effects of graded levels of calorie restriction: XX. impact of long term graded calorie restriction on survival and body mass dynamics in male C57BL/6J mice

A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation

Fur removal promotes an earlier expression of involution-related genes in mammary gland of lactating mice

The effects of graded levels of calorie restriction XVIII: tissue specific changes in cell size and number in response to calorie restriction

Protein quality and quantity influence the effect of dietary fat on weight gain and tissue partitioning via host-microbiota changes

Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice

The effects of graded levels of calorie restriction XV: phase space attractors reveal distinct behavioral phenotypes

The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

The Effects of Graded Levels of Calorie Restriction: XIII. Global Metabolomics Screen Reveals Graded Changes in Circulating Amino Acids, Vitamins, and Bile Acids in the Plasma of C57BL/6 Mice

Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon

Limits to sustained energy intake XXVII: trade-offs between first and second litters in lactating mice support the ecological context hypothesis

The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue

Limits to sustained energy intake XXVIII: Beneficial effects of high dietary fat on lactation performance in mice

Energy balance and the sphingosine-1-phosphate/ceramide axis

The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome

The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice

The effects of graded levels of calorie restriction: VIII. impact of short term calorie and protein restriction on basal metabolic rate in the C57BL/6 mouse

Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone

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