![Dr Fiona Campbell Dr Fiona Campbell](/img/200x200/staffpages/uploads/rwt085/UFC_pic.jpg)
Advanced Research Fellow
- About
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- Email Address
- fiona.campbell@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438617
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I am a principal investigator based at the Rowett Institute and coordinator of the PGT Human Nutrition MSc programme. My research focuses on advanced glycation end-products (AGEs) in the diet. During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body during digestion. To investigate how dietary AGEs, contribute to diet induced conditions such as type 2 diabetes and dementia we are using human intervention studies to test the effects of highly processed foods high in AGEs on sensitive measures of metabolic health and cognition. I am also researching the role of processing methods in improving food quality and the potential for phytochemicals incorporated into processed foods to ameliorate negative health outcomes.
External Memberships
Member of the Nutrition Society,
Member of Biochemical Society,
Member of British Society for Proteome Resarch (BSPR).
Latest Publications
Selenium Supplementation in Pregnancy-Maternal and Newborn Outcomes
Journal of Nutrition and Metabolism, vol. 2022, 4715965Contributions to Journals: ArticlesThe Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Molecular Nutrition & Food Research, vol. 65, no. 1, 1900934Contributions to Journals: Review articlesAnthocyanin-enriched bilberry extract attenuates glycaemic response in overweight volunteers without changes in insulin
Journal of Functional Foods, vol. 64, 103597Contributions to Journals: ArticlesCinnamon Shows Antidiabetic Properties that Are Species-Specific: Effects on Enzyme Activity Inhibition and Starch Digestion
Plant Foods for Human Nutrition, vol. 74, no. 4, pp. 544-552Contributions to Journals: ArticlesEarly and reversible changes to the hippocampal proteome in mice on a high-fat diet
Nutrition and Metabolism, vol. 16, no. 1, 57Contributions to Journals: Articles- [ONLINE] https://rdcu.be/bPqy4
- [ONLINE] DOI: https://doi.org/10.1186/s12986-019-0387-y
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12782/1/McLean2019_Article_EarlyAndReversibleChangesToThe_VoR.pdf
- [ONLINE] http://www.ncbi.nlm.nih.gov/pubmed/31462902 http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC6708244
- [ONLINE] View publication in Mendeley
- Research
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Research Overview
A high-fat/sugar diet leads to the formation of Advanced Glycation End products (AGEs) in body tissues. AGEs cause damage and inflammation and are also absorbed from the diet particularly from processed foods. We are interested in how dietary AGEs contribute to diet induced conditions such as type 2 diabetes and cognitive decline.
Current Research
Current research in my laboratory is focused on investigating damaged proteins/advanced glycation end-products (AGEs) in the diet.
During food processing AGEs are formed as the result of the Maillard reaction and are absorbed by the body in the course of digestion. AGEs are associated with the metabolic syndrome and dementia. We aim to identify foods high in AGEs and test the effects of these foods on sensitive measures of metabolic health and cognition in human intervention studies.
In addition we are investigating the role of processing methods in improving food quality e.g. avoiding prolonged heat treatment of dairy products known to increase AGE formation. We are also determining the potential of phytochemicals incorporated into processed foods to ameliorate these negative metabolic outcomes.
This research could lead to the development of new functional foods and improvements to existing food products. It will also provide health professionals and the public with better information on how changes in diet can be beneficial.
This research is part of Scottish Government Strategic Research Programme funded through the Rural and Environment Science and Analytical Services (RESAS) division to advance the evidence base in the development of rural affairs, food and environment policies.
- Teaching
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Teaching Responsibilities
Programme coordinator for MSc Human Nutrition
Course Coordinator for RN5001 Fundamentals of human nutrition and metabolism and RN5003 Foundations of Nutrition.
- Publications
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Page 3 of 7 Results 21 to 30 of 64
Proteomics reveals that a high-fat diet induces rapid changes in hypothalamic proteins related to neuronal damage and inflammation
Proceedings of the Nutrition Society, vol. 70, no. OCE6, pp. E370Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665111004551
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2762/1/NutSoc_MouseProteomics.pdf
High-Fat Diet in C57Bl/6 Mice Induces a Rapid Decrease in Insulin Sensitivity and an Acute Phase Response
Endocrine Reviews, vol. 32, no. 03_MeetingAbstracts, pp. 1-483Contributions to Journals: ArticlesIdentification of Plasma Protein Markers of Oxidation in Obese Men
biochemical society focussed meetingContributions to Conferences: PostersOptimal combinations of acute phase proteins for detecting infectious disease in pigs
Veterinary Research, vol. 42, pp. 50Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1297-9716-42-50
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2268/1/1297_9716_42_50.pdf
Identification of damaged proteins in human serum using modified Ehrlich's reagent to target protein-bound pyrroles
Analytical Biochemistry, vol. 398, no. 1, pp. 76-82Contributions to Journals: ArticlesRapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs
Veterinary Research, vol. 40, no. 3, 23Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1051/vetres/2009006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/745/1/v09006%255B1%255D.pdf
SERRS immunoassay for quantitative human CRP analysis
Analyst, vol. 133, no. 10, pp. 1355-1357Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/b808087a
The association between plasma levels of acute phase proteins, haptoglobin, alpha-1 acid glycoprotein (AGP), Pig-MAP, transthyretin and serum amyloid A (SAA) in Large White and Meishan pigs
Veterinary Immunology and Immunopathology, vol. 119, no. 3-4, pp. 303-309Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.vetimm.2007.05.008
Effects of sub-clinical post-weaning colibacillosis and dietary protein on acute phase proteins in weaner pigs
Livestock Science , vol. 108, no. 1-3, pp. 182-185Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.livsci.2007.01.048
A time-resolved immunofluorometric assay for porcine C-reactive protein quantification in whole blood
Luminescence, vol. 22, no. 3, pp. 171-176Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/bio.945