MSc PhD
Personal Chair
- About
-
- Email Address
- b.deroos@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438636
- Office Address
Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Baukje de Roos is an internationally recognised nutrition scientist having >25 years of experience in the design and delivery of dietary intervention studies to assess how nutrients, foods and diets affect cardiovascular health outcomes and resilience to disease development. Earlier leading work in the field of proteomics and biomarker discovery led to funding for several European research projects, a BBSRC Case studentship and an invitation to join an International Life Sciences Institute (ILSI) task force to establish the usefulness of proteomics for efficacy demonstration of dietary bioactives. Current work focusses on developing and implementing novel and state-of-the-art interdisciplinary precision and personalised nutrition approaches to improve population and individual health, as well as identifying responders and non-responders to interventions, supported by RCUK and industry funding as well as several international research collaborations. Her Scottish Government RESAS-funded work focusses on exploratory modelling of relationships between ‘healthiness’, ‘carbon footprint’, ‘level of processing’ and ‘cost’ of UK diets to identify the most important potential food switches in real-time UK diets, work which is now being developed into a ‘foodswap’ app. Her expertise in the area of diet and health has formed the basis of contracts and consultancies with large food companies (Unilever, By-Health, Stephan Nutrition, Cognis, MacPhie of Glenbervie, Provexis, Kelloggs), food levy boards (Seafish), the food and drink support sector (Food and Drink Innovation Service, Scotland Food & Drink), and national UK television (Channel 4’s Food Hospital and Superfoods series).
Qualifications
- MSc Human Nutrition1995 - Wageningen University, the Netherlands
- PhD Human Nutrition2000 - Wageningen University, the Netherlands
Memberships and Affiliations
- Internal Memberships
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Deputy Director, the Rowett Institute, School of Medicine, Medical Sciences and Nutrition
Member of the Senior Management Team of the School of Medicine, Medical Sciences and Nutrition, University of Aberdeen.
Chair of the Human Studies Management Committee at the Rowett Institute.
- External Memberships
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Jan 2021 - : Editorial Board Member for the American Journal of Clinical Nutrition
Sep 2014 – Jan 2020: Director NuGO (European Nutrigenomics Organisation)
- Research
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Research Overview
- Clinical and dietary intervention trials assessing how diets, foods and nutrients affect disease risk and resilience to disease development
- Personalised and precision nutrition and biomarker discovery
- Modelling healthy, sustainable and affordable diets
- Food systems and human health outcomes, especially in relation to sea food consumption.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Nutrition and Health.
Please get in touch if you would like to discuss your research ideas further.
Current Research
Seafood and human health
- Investigating the effects of traditional versus sustainable feeding regimes of farmed salmon on heart health, micronutrient status, inflammation, oxidative stress and gut health in the Scottish population (Scottish Government Rural and Environment Science and Analytical Services)
- Development of a metric for assessing the impacts on nutrition and health of agroecosystems producing farmed seafood (Immana)
- Strategies to balance enhanced fish consumption with sustainable fish production (BBSRC)
Modelling healthy, sustainable and affordable diets
- Modelling foods/drinks that drive healthiness, carbon footprint and costs within UK diets to identify ‘food switches’ in real-time UK diets (Scottish Government Rural and Environment Science and Analytical Services)
Precision nutrition
- Modelling individual responses to healthier diets and new ways to quantify the importance of physiology and behaviour for successful dietary changes (Unilever, BBSRC)
- Individual efficacy of anthocyanins in blueberries to affect metabolic health (ByHealth)
- Inter-individual variation in response to consumption of plant food bioactives and determinants involved (EU COST Action POSTIVe)
Clinical and dietary intervention trials
- Development of nutritional and exercise strategies to increase resilience and improve health outcomes (BBSRC)
Collaborations
- Anne Wanders, Liesbeth Zandstra, Peter Zock (Unilever, the Netherlands)
- Paul Fernandes (School of Biological Sciences, University of Aberdeen)
- Lorraine Brennan (UCD, Ireland)
- Alan Sneddon (Rowett, University of Aberdeen)
- Dave Little, Frances Murray, Alexandra Pounds (University of Stirling)
- Nanna Roos (University of Copenhagen)
- Eleanor Grieve (University of Glasgow)
- Gulshan Ara, Santhia Ireen, Tahmeed Ahmed (icddr,b, Bangladesh)
- Abdullah-Al Mamun (Noakhali Science and Technology University, Bangladesh)
- Christine Morand, Claudine Manach (Université Clermont Auvergne, INRA, France)
- Felix Zhang, Jiehua Chen (ByHealth, China)
- Niamh O'Kennedy (SIS, UK)
- Dr Jetty Lee, Hong Kong University, China
- Dr Vasanthi Siruguri / Dr Radhika Madhari, National Institute of Nutrition, India
- Prof Marianne Geleijnse, Wageningen University, the Netherlands
- Prof Anne-Marie Minihane, University of East Anglia, UK
- Prof Zoltan Takats, Imperial College London
Supervision
My current supervision areas are: Nutrition and Health.
2018-2022: supervision of Tilly Potter (BBSRC DTP / Unilever PhD studentship)
2016-2021: co-supervision of Anneli Lofstedt (EASTBIO PhD studentship)
2016-2020: supervision of Teresa Grohmann (By Health-funded PhD studentship)
2015-2018: supervision of Khairun Nafisa (Malaysian Government PhD studentship)
2013-2017: supervision of Dom Partridge (BBSRC Case/SiS PhD studentship)
2011-2014: supervision of Felix Zhang (Industrial PhD studentship)
2009-2012: supervision of Eva-Maria Bachmair (Industrial PhD studentship)
2008-2011: co-supervision of Lisa Michel (BHF PhD studentship)
2007-2011: supervision of Luisa Ostertag (Rowett/IFR PhD studentship)
2007-2009: co-supervision of Vanessa Rungapamestry (Post-doctoral student from UCD)
2007-2009: supervision of Guillermo Rodriguez Guttierez (Post-doctoral fellow)
2007-2008: supervision of Katie Crosley (Post-doctoral fellow on NuGO project)
2005-2008: supervision of Yiannis Mavrommatis (Rowett PhD-studentship)
2005-2006: supervision of Jose Miguel Arbones-Mainar (Post-doctoral fellow)
Funding and Grants
2019-2023. By-Health, Dupont, AkerBiomarine and Indena. An open label parallel randomised trial to assess the effects of a MOnitored PErsonalised Diet and Supplement intervention on the remission of metabolic syndrome (MOPEDS). £174,122
2020-2021. UKIERI. UKIERI Mobility Programme: Study in India. £33,680
2020-2021. GCRF – SFC. Sustainable Intensification : Integrating Aquaculture into Food Systems. £9,800
2019-2020. MRC Development Award. Mycotoxin exposure, intestinal inflammation and childhood stunting in India. £23,915
2019-2023. MRC UK Consortium for MetAbolic Phenotyping (MAP UK). £2,138,277
2018-2022. BBSRC DTP / Unilever. Modelling individual responses to healthier diets and new ways to quantify the importance of physiology and behaviour for successful dietary changes. £144K
2017. BBSRC GCRF IAA. Introduction of health technologies to monitor dietary intake in relation to metabolic health in India. £11K
2016-2020. EASTBIO. Strategies to balance enhanced fish consumption with sustainable fish production. £70K
2016-2018. Immana-DFID Aquatic Food for Health and Nutrition (AQN): A metric for assessing the impacts on nutrition and health of agroecosystems producing farmed seafood. £250K
2016-2021. Scottish Government (part of Rowett rolling grant). ‘(Shell)fish and human health’. ~£1M
2016-2020. By Health, China. Efficacy of anthocyanins in blueberries to affect metabolic health in a Chinese/Asian population living in China and in the UK. £90K
- Teaching
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Teaching Responsibilities
In the past years I have led and facilitated the successful Rowett expansion in Nutrition postgraduate teaching (PGT), from the delivery of a 1-year MSc Human Nutrition programme (since 1984) to that of a portfolio of face-to-face and new on-line MSc programmes, courses, a Massive Open Online course (MOOC) and Continuing Professional Development (CPD) (‘on demand’) offerings.
I have developed a Rowett teaching strategy that ensures that we capitalise on recent successes to ensure that we can sustain and further develop the growth of our nutrition PGT and CPD nutrition programmes and courses. I pro-actively participate in the development and delivery of on-campus lectures (Foundation of Nutrition, Nutrition & Health, Molecular Nutrition and Clinical Nutrition courses) and on-line content and discussion forums (Fundamentals of Human Nutrition and Metabolism, Clinical Nutrition for Disease Prevention, Nutrition and Health through the Life Stages courses, Food Choice and Behaviour CPD, Nutrition and Wellbeing MOOC).
- Publications
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Supplementation with a 9c,11t-rich conjugated linoleic acid blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial
Molecular Nutrition & Food Research, vol. 59, no. 4, pp. 741-750Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mnfr.201400495
Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle
PloS ONE, vol. 10, no. 12, e0145244Contributions to Journals: ArticlesDietary manipulation of platelet function
Pharmacology & Therapeutics, vol. 144, no. 2, pp. 97-113Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pharmthera.2014.05.008
- [ONLINE] View publication in Scopus
Transcriptome analysis of peripheral blood mononuclear cells in human subjects following a 36 h fast provides evidence of effects on genes regulating inflammation, apoptosis and energy metabolism
Genes & Nutrition, vol. 9, no. 6, pp. 1-11Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s12263-014-0432-4
- [ONLINE] View publication in Scopus
Oat-enriched diet reduces inflammatory status assessed by circulating cell-derived microparticle concentrations in type 2 diabetes
Molecular Nutrition & Food Research, vol. 58, no. 6, pp. 1322-1332Contributions to Journals: ArticlesPlatelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status
Journal of Thrombosis and Thrombolysis, vol. 37, no. 4, pp. 455-463Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s11239-013-1000-2
Bound phytophenols from ready-to-eat cereals: comparison with other plant-based foods
Food Chemistry, vol. 141, no. 3, pp. 2880-2886Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.foodchem.2013.05.023
Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way: A randomized-controlled human intervention trial
Molecular Nutrition & Food Research, vol. 57, no. 2, pp. 191-202Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mnfr.201200283
Personalised nutrition: ready for practice?
Proceedings of the Nutrition Society, vol. 72, no. 1, pp. 48-52Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S0029665112002844
Mechanisms of Fish Oil-Modulated Inflammation and Health
Bioactive Food as Interventions for Arthritis and Related Inflammatory Diseases. Watson, R. R., Preedy, V. R. (eds.). Elsevier Inc, pp. 545-553, 9 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-397156-2.00213-1
- [ONLINE] View publication in Scopus
Proteomic approaches to predict bioavailability of fatty acids and their influence on cancer and chronic disease prevention
The Journal of Nutrition, vol. 142, no. 7, pp. 1370S-1376SContributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3945/jn.111.157206
A key role for dietary bioactives in the prevention of atherosclerosis
Molecular Nutrition & Food Research, vol. 56, no. 7, pp. 1001-1002Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1002/mnfr.201270054
Alperujo extract, hydroxytyrosol, and 3,4-dihydroxyphenylglycol are bioavailable and have antioxidant properties in vitamin E-deficient rats: a proteomics and network analysis approach
Molecular Nutrition & Food Research, vol. 56, no. 7, pp. 1131-1147Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mnfr.201100808
Effect of supplementation with an 80:20 cis9, trans11 conjugated linoleic acid blend on the human platelet proteome
Molecular Nutrition & Food Research, vol. 56, no. 7, pp. 1148-1159Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mnfr.201100763
Fish as a dietary source of healthy long chain n-3 polyunsaturated fatty acids (LCn-3 PUFA) and vitamin D: A Review of the current literature
Food and Health Innovation ServiceBooks and Reports: Commissioned ReportsHuman O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: Implications for studies concerned with quantifying epicatechin bioavailability
Pharmacological Research, vol. 65, no. 6, pp. 592-602Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.phrs.2012.02.005
Inter-organ proteomic analysis reveals insights into the molecular mechanisms underlying the anti-diabetic effects of cis-9, trans-11-conjugated linoleic acid in ob/ob mice
Proteomics, vol. 12, no. 3, pp. 461-476Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/pmic.201100312
A diet rich in unsaturated fatty acids prevents progression toward heart failure in a rabbit model of pressure and volume overload
Circulation. Heart Failure, vol. 5, no. 3, pp. 376-384Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.111.963116
Potential benefits of ready meal reformulation for the elderly
Aberdeen: Rowett Institute of Nutrition and Health. 4 pagesBooks and Reports: Commissioned ReportsIn vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations
Molecular Nutrition & Food Research, vol. 55, no. 11, pp. 1624-1636Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mnfr.201100135
A high intake of industrial or ruminant trans fatty acids does not affect the plasma proteome in healthy men
Proteomics, vol. 11, no. 19, pp. 3928-3934Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/pmic.201100163
Anti-platelet effects of olive oil extract: in vitro functional and proteomic studies
European Journal of Nutrition, vol. 50, no. 7, pp. 553-562Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00394-010-0162-3
Metabolomics of prolonged fasting in humans reveals new catabolic markers
Metabolomics, vol. 7, no. 3, pp. 375-387Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s11306-010-0255-2
Determination of 3,4-dihydroxyphenylglycol, hydroxytyrosol and tyrosol purified from olive oil by-products with HPLC in animal plasma and tissues
Food Chemistry, vol. 126, no. 4, pp. 1948-1952Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.foodchem.2010.12.044
Alterations in hepatic one-carbon metabolism and related pathways following a high fat dietary intervention
Physiological Genomics, vol. 43, no. 8, pp. 408-416Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1152/physiolgenomics.00179.2010
2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fasting
BMC Medical Genomics, vol. 4, 24Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1755-8794-4-24
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3758/1/2D.pdf
Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation
Journal of Proteome Research, vol. 9, no. 4, pp. 1941-1950Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/pr901103n
Intervention with fish oil, but not with docosahexaenoic acid, results in lower levels of hepatic soluble epoxide hydrolase with time in apoE knockout mice
British Journal of Nutrition, vol. 103, no. 1, pp. 16-24Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S0007114509991450
Dietary supplementation with cis-9, trans-11 conjugated linoleic acid and aortic stiffness in overweight and obese adults
The American Journal of Clinical Nutrition, vol. 91, no. 1, pp. 175-183Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3945/ajcn.2009.28192
Impact of dietary polyphenols on human platelet function: a critical review of controlled dietary intervention studies
Molecular Nutrition & Food Research, vol. 54, no. 1, pp. 60-81Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1002/mnfr.200900172
Proteomic analysis of plasma, platelets and peripheral blood mononuclear cells in nutritional intervention studies
Design of Human Nutrigenomics Studies. Astley, S., Penn, L. (eds.). Wageningen Academic Publishers, pp. 55-64, 10 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.3920/978-90-8686-672-4
- [ONLINE] View publication in Scopus
Nutritional systems biology modeling: from molecular mechanisms to physiology
PLoS Computational Biology , vol. 5, no. 11, e1000554Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.1371/journal.pcbi.1000554
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/3676/1/Nutritional_systems.pdf
Long-chain n-3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammation and coronary heart disease
British Journal of Pharmacology, vol. 158, no. 2, pp. 413-428Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1476-5381.2009.00189.x
Nutrition proteomics and biomarker discovery
Expert Review of Proteomics, vol. 6, no. 4, pp. 349-351Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1586/EPR.09.52
Proteomic analysis of plasma, platelets and PBMC in nutritional intervention studies
Design of human nutrigenomic studies. Astley, S., Penn, L. (eds.). Wageningen Academic Publishers, pp. 55-64, 10 pagesChapters in Books, Reports and Conference Proceedings: ChaptersAttenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet
Proteomics, vol. 9, no. 12, pp. 3244-3256Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/pmic.200800761
Variation in protein levels obtained from human blood cells and biofluids for platelet, peripheral blood mononuclear cell, plasma, urine and saliva proteomics
Genes & Nutrition, vol. 4, no. 2, pp. 95-102Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s12263-009-0121-x
The relationship between hypothalamic and hepatic response to a high-fat diet in relation to insulin sensitivity and leptin action
Journal of Diabetes, vol. 1, no. S1, pp. A70Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/j.1753-0407.2009.00019.x
Dietary fatty acids affecting hepatic metabolism and atherosclerosis: mechanisms unravelled using a proteomics approach
Grasas y Aceites, vol. 60, no. 1, pp. 28-32Contributions to Journals: Literature Reviews- [ONLINE] DOI: https://doi.org/10.3989/gya.086308
Proteomic analysis of human plasma and blood cells in nutritional studies: development of biomarkers to aid disease prevention
Expert Review of Proteomics, vol. 5, no. 6, pp. 819-826Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1586/14789450.5.6.819
The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation
Genes & Nutrition, vol. 3, no. 3-4, pp. 147-151Contributions to Journals: EditorialsHepatic Proteomics of Fat-1 Mice
Journal of Nutrigenetics and Nutrigenomics, vol. 1, no. 6, pp. 270-270Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1159/000154473
Proteomic methodological recommendations for studies involving human plasma, platelets, and peripheral blood mononuclear cells
Journal of Proteome Research, vol. 7, no. 6, pp. 2280-2290Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/pr700714x
Proteomics as a tool for the modelling of biological processes and biomarker development in nutrition research
British Journal of Nutrition, vol. 99 , no. Suppl. 3, pp. S66-S71Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1017/S0007114508006909
Identification of potential serum biomarkers of inflammation and lipid modulation that are altered by fish oil supplementation in healthy volunteers
Proteomics, vol. 8, no. 10, pp. 1965-1974Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/pmic.200700457
Hepatic proteomics in II-1-R1-/- mice that are resistant to obesity-induced insulin resistance following a high fat diet
Proceedings of the Nutrition Society, vol. 66, no. Suppl. OCA-B, 58AContributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665107005952
The effects of fish oil and DHA on soluble epoxide hydrolase in apoE-/- mice
Proceedings of the Nutrition Society, vol. 66, no. Supplement OCA-B , 103AContributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1017/S0029665107005952
Identification of Platelet Proteins Involved in Platelet Structure and Inflammation That Are Regulated by Fish Oil Supplementation in Healthy Volunteers
Arteriosclerosis Thrombosis and Vascular Biology, vol. 27, no. 6, pp. e54-e54Contributions to Journals: ArticlesExtra virgin oil decreases atherosclerosis despite increased hepatic fat accumulation in apolipoprotein E knockout mice: A proteomics approach
Diabetes and Vascular Disease Research, vol. 4, no. 1 Suppl. , S189Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.3132/dvdr.2007.012
Hepatic proteomics in IL-1R1-/- mice that are resistant to obesity-induced insulin resistance following a high fat diet
Diabetes and Vascular Disease Research, vol. 4, no. 1 Suppl. , S189Contributions to Journals: Abstracts