![Professor Valerie Speirs Professor Valerie Speirs](/img/200x200/staffpages/uploads/s04vs8/VSpeirs_web.jpg)
BSc (Hons), PhD, FRCPath, FHEA
Chair in Molecular Oncology
- About
-
- Email Address
- valerie.speirs@abdn.ac.uk
- Office Address
Foresterhill
Institute of Medical Sciences
4.32 (office) / 4.42 (lab)
Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Prof Valerie Speirs is Chair in Molecular Oncology. Following postdoctoral spells at the Hospital for Sick Children in Toronto, Canada, and the universities of Liverpool and Hull, she started her independent research career at the University of Hull, before moving to Leeds. She obtained a Personal Chair in Experimental Pathology & Oncology at the University of Leeds in 2012, relocating to her alma mater in July 2018 and is visiting Professor at Leeds.
As a cancer biologist, she focuses mainly on breast cancer but has growing interest in glioblastoma and uses digital pathology in her work. Past/current funding includes: Cancer Research UK, MRC, NC3Rs, Yorkshire Cancer Research, Breast Cancer Now, Breast Cancer UK, Animal Free Research UK, Pathological Society and Friends of Anchor.
As part of a consortium which recognised that scientists required access to human breast tissue to help accelerate research, she helped establish the Breast Cancer Now Tissue Bank (www.breastcancertissuebank.org/). She leads the Aberdeen centre and is co-PI nationally. She established SEARCHBreast, a virtual resource aimed at sharing materials which are often surplus following animal studies on breast cancer, thus reducing the numbers of animals used in research (www.searchbreast.org).
Ongoing work includes establishing the Aberdeen Cancer Centre, bringing together a team of scientists and clinicians working collaboratively to deliver patient-centred research. This bench to bedside approach aims to translate new laboratory findings into the clinic with the goal of directly improving patient outcomes.
Outside of work she enjoys spending time hiking in the beautiful Aberdeenshire countryside.
Qualifications
- BSc Zoology1986 - University of Aberdeen
- PhD Cancer Biology1990 - University of Glasgow
Memberships and Affiliations
- Internal Memberships
-
Research Committee, School of Medicine, Medical Sciences and Nutrition
Education Steering Committee, School of Medicine, Medical Sciences and Nutrition
- External Memberships
-
Honorary Secretary, British Association for Cancer Research
Chair, Meetings & Training Committee, British Association for Cancer Research
Member, British Breast Group
Member, Breast Cancer Now Tissue Bank Advisory Council
Member, National Cancer Research Institute’s Cellular Molecular Pathology (CM-Path)
Chair, CM-Path consenting subgroup
Member, Pathological Society of Great Britain & Ireland
Member British & European Associations for Cancer Research
Latest Publications
A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
Oncogene, vol. 43, pp. 2578–2594Contributions to Journals: ArticlesAdvances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders
Expert Reviews in Molecular MedicineContributions to Journals: ArticlesAffimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles
iScience, vol. 27, no. 8, 110461Contributions to Journals: ArticlesPlatelet-derived microvesicles isolated from type-2 diabetes mellitus patients harbour an altered miRNA signature and drive MDA-MB-231 triple-negative breast cancer cell invasion
PloS ONE, vol. 19, no. 6, e0304870Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pone.0304870
- [ONLINE] View publication in Scopus
Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling
Communications Biology, vol. 7, 602Contributions to Journals: Articles
Prizes and Awards
Personal
- Breast Cancer Now award for Outstanding Contribution to Breast Cancer Research (2011)
As project supervisor
- BACR – Hamilton-Fairley Young Investigator Award at the 10th NCRI Cancer Conference, Liverpool, 2-5 2014 for presentation entitled: ‘Insulin like Growth Factor Binding Proteins and Tamoxifen Resistance in Breast Cancer’, Y Hawsawi, C Twelves, V Speirs, J Beattie
- Journal of Pathology Prize at the Pathological Society of GB & Ireland annual conference, Edinburgh, June 18-21, 2013 for presentation entitled: ‘Developing and Characterising a Novel 3D in vitro Model of Normal Breast for Cancer Initiation Studies’, C Nash, D Holliday, G Mavria, D Tomlinson, A Hanby, F Berditchevski, V Speirs
- British Journal of Surgery Prize at the Association of Breast Surgery annual conference, Manchester, 21 May 2013, for presentation entitled: ‘The Prognostic Significance of Tumour-Stromal Ratio in Oestrogen Receptor-Positive Breast Cancer’, CL Downey, SA Simpkins, J White, DL Holliday, JL Jones, LB Jordan, SS Rajan, HH Thygesen, S Pollock, AM Hanby, V Speirs
- Research
-
Research Overview
Research in my group focuses mainly on investigating the biology of breast cancer, using tissue-based approaches to understand the disease and its progression. We study biomarkers and how these might influence clinical outcome, oestrogen receptor biology (in particular the regulation and expression of oestrogen receptor β) and are exploring the breast cancer microenvironment, notably tumour-stroma interactions, and how this might be influenced by endocrine disrupting agents, including oestrogenic substances found in the environment. We use a range of tools to address this, including bepsoke 3D cell culture models, digital pathology, Raman spectrocopy and fast-field cycling MRI.
Breast cancer affects both genders and we have a long-standing interest in male breast cancer, having accrued one of the largest collections in the world, available as tissue microarrays.
We have developed several 3D in vitro models of breast cancer and continue to improve these to use as tools in our research.
Our lab is on the same campus as the Aberdeen Royal Infirmary, which allows us direct access to clinical samples to use in our work. As a results we work closely with clinicians, including pathologists, surgeons, radiologist, oncologists and often host medical students for intercalated or summer projects.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Current Research
Functional modelling of male breast cancer (UoA Development Trust & Elphinstone scholarship)
Examining how components of the breast cancer microenvironment influence cancer cells (Elphinstone scholarship)
Breast Cancer Now Tissue Bank and Cell Culture Programme (coPI with JL Jones, QMUL/Barts; Breast Cancer Now)
Fully humanised 3D vascular perfused model for breast cancer modelling and therapeutic screening (NC3Rs)
Investigating a new approach to treeing metastatic bone disease: radiotherapy first? (with A Rieman et al; NHS Grampian)
Public Engagement in Pathology (Pathological Society of GB & Ireland)
Examining how endocrine disrupting agents may modulate activity of fibroblasts generated from breast tissue of high and low mammographic density (Animal Free Research UK & Breast Cancer UK)
Elucidating the role of ROCKII in angiogenesis and the microenvironment of breast cancer brain metastases using genetic deletion approaches. (with G Mavria, Leeds; Breast Cancer Now).
Developing an organ on a chip model to test the therapeutic efficiency of Adhirons in breast cancer (NC3Rs)
Past Research
Projects completed in the last 10 years include:
Developing Adhirons as new research tools to help understand the role of estrogen receptor β in breast cancer (funded by Breast Cancer Now)
SEARCHbreast - a virtual resource to facilitate sharing breast cancer materials and knowledge to benefit the 3Rs (funded by NC3Rs)
Exploiting male breast carcinoma transcriptomics to identify new prognostic, predictive or therapeutic targets (funded by Yorkshire Cancer Research)
Characterising the breast cancer proteome using multicellular 3D breast cancer models: a feasibility study. (funded by Breast Cancer Now)
Identification of protein biomarkers for basal-like breast cancer (funded by Yorkshire Cancer Research)
Elucidating the role of DOCK4 in tumour angiogenesis and brain metastasis using genetic deletion approaches and mouse models of human cancer (funded by Breast Cancer Now)
Exploring the function of ERβ2 in breast cancer at different sub-cellular locations (funded by Pathological Society of GB & Ireland)
Stratified Medicine Programme (funded by Cancer Research UK)
The role of miR-92 in regulating breast cancer behaviour (funded by Breast Cancer Now)
Application of the 3Rs to breast cancer: Validating novel 3-dimensional in vitro models of breast cancer as a replacement for animal experiments. (funded by Lord Dowding Fund)
Molecular profiling of breast cancers of different ethnicity. (funded by Yorkshire Cancer Research)
Investigating fibroblasts as mediators of breast tumour progression using 3D models (funded by Breast Cancer Now)
Validation and computer reconstruction of a 3D model of breast cancer (funded by Dr Hadwen Trust)
Collaborations
Prof Louise Jones, Barts Cancer Institute, London
Dr Georgia Mavria, University of Leeds
Dr Laura Matthews, University ofLeeds
Dr Darren Tomlinson, University of Leeds
Prof Cathy Merry, University of Nottingham
Supervision
My current supervision areas are: Biomedical Sciences.
Current PhD students
Kerri Palmer: Examining how endocrine disrupting agents may modulate activity of fibroblasts generated from breast tissue of high and low mammographic density
Katie Hanna: Exploring the breast tumour microenviroment using digital pathology, Raman imagingand fast field cycling MRI
Subarnerekha Chatterji: Understanding the biology of male breast cancer: a data driven approach
Previous PhD/MD students
Leeds
Sophie Roberts: Generating a 3D cell culture model to test the efficacy of Affimers in the inhibition of HER2+ breast cancer cell growth (writing up PhD)
Aishah Alhodhodi: Oestrogen receptor (ER) expression and activity during osteogenic differentiation of dental pulp stem cells. PhD awarded 2018 (returned to dental practice, Saudi Arabia)
Mohammed Elmoursi: Structural and functional characterisation of placental syncytial nuclear aggregates in healthy and high-risk pregnancy. PhD awarded 2017 (returned to higher medical training, Scotland)
E Smart: The functional role of ERβ2 at different cellular locations. PhD awarded 2016 (now Postdoc, USA)
S Rajan: Investigating male breast cancer using transcriptomics and immunohistochemistry. MD awarded 2016 (returned to higher surgical training, North West Deanery)
Y Hawsawi: Role of insulin-like growth factor (IGF) axis in the acquisition of tamoxifen resistance in breast cancer epithelial cells. PhD awarded 2015 (associate scientist, Saudi Arabia)
W Hamilton-Burke: The role of ERβ and associated proteins in breast cancer. MD awarded 2015 (now Consultant Breast Surgeon, Huddersfield)
C Nash: Development of an organotypic model of the normal breast: A tool to investigate breast cancer initiation and progression. PhD awarded 2014 (now Senior Scientist, Charles River Laboratories)
M Charalambous: Investigating the metabolism of breast cancer cells using 1H-NMR based metabonomics. MD awarded 2013 (now Consultant Breast Surgeon, London)
W Yabsley: NMR–based metabolomic studies: towards a biomarker for breast cancer. PhD awarded 2013
H Al-Nakhale: Mechanisms of estrogen receptor β regulation in breast cancer. PhD awarded 2010 (Lecturer, Saudi Arabia)
L Maraqa: Characterisation of novel genes associated with endocrine resistance. MD awarded 2010 (now Consultant Breast Surgeon, Sheffield)
MB Peter: The prognostic significance of estrogen receptor β and its isoforms and correlation with other biological markers in breast cancer. MD awarded 2010 (now Consultant GI Surgeon, Huddersfield)
M Saleh: Characterisation of the role of CSMD1 in cancer. PhD awarded 2010 (now Postdoc, USA)
CA Green: Further defining the role of ERβ in the mammary gland. PhD awarded 2009 (now Biomedical Scientist, Leeds)
AM Waterworth: Investigating the role of fibroblasts, β-catenin and Wnt signalling in neoplastic transformation. MD awarded 2006 (now Consultant Breast Surgeon, Huddersfield)
K Munot: Gene silencing in breast cancer: is there evidence for an epigenetic phenotype? MD awarded 2005 (now Consultant Breast Surgeon, York)
AT Parkes: The role of estrogen receptor and their associated coregulators in the development of antiestrogen resistance in breast cancer. PhD awarded 2004 (now Clincal Trials Coordinator, Australia)
Hull
AR Green: Regulatory factors in human breast cancer: Cytokines and 17β-hydroxysteroid dehydrogenase.
PhD awarded 1997 (now Associate Professor, University of Nottingham)
Funding and Grants
Grants awarded (from 2015)
2019-24 Breast Cancer Now Tissue Bank and cell culture Programme. Breast Cancer Now £7M (coPI with JL Jones, QMUL/Barts; Aberdeen component ~£300 000)
2019-21 Fully humanised 3D vascular perfused model for breast cancer modelling and therapeutic screening. NC3Rs, £74 999
2019-20 Investigating a new approach to treating metastatic bone disease: radiotherapy first? NHS Grampian, £12 000 (with A Rieman et al)
2019 Animal Free Research UK vacation scholarship, £2000
2019 Friends of Anchor vacation scholarship, £2000
2019 Sponsorship of BACR Special Conference on Breast Cancer. Pathological Society of GB & Ireland, £3000
2018-21 Examining how endocrine disrupting agents may modulate activity of fibroblasts generated from breast tissue of high and low mammographic density (PhD studentship). Animal Free Research UK/Breast Cancer UK (jointly funded), £90 000
2017-20 The MUC-ST/Singlec-9 innate check point axis in cancer: prevalence, prognostic significance and potential therapeutics. MRC, £275 000 (with J Burchell, KCL)
2017-20 Elucidating the role of ROCKII in angiogenesis and the microenvironment of breast cancer brain metastases using genetic deletion approaches. Breast Cancer Now, £238 080 (with G Mavria Leeds et al).
2016-19 Developing an organ on a chip model to test the therapeutic efficiency of Adhirons in breast cancer. NC3Rs, £90 000
2016 Dr Hadwen Trust vacation scholarship, £2000
2015-17 Breast Cancer Now Tissue Bank (Leeds). Breast Cancer Campaign, £1.1M
2015-18 Identification of biomarkers that predict recurrence of DCIS after breast conserving surgery from the Sloane Project. Breast Cancer Now, £238 080 (with E Sawyer KCL et al)
- Teaching
-
Teaching Responsibilities
Undergraduate
PA3802: Mechanisms of Disease & Principles of Chemotherapy
BC4314: Biochemistry Option 2
Postgraduate
MB5525: MRes Extended Research Project
MB5903: MSc Research Project
Non-course Teaching Responsibilities
Postgraduate Research Development Coordinator
- Publications
-
Page 1 of 2 Results 1 to 100 of 188
A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
Oncogene, vol. 43, pp. 2578–2594Contributions to Journals: ArticlesAdvances in Raman spectroscopy for characterising oral cancer and oral potentially malignant disorders
Expert Reviews in Molecular MedicineContributions to Journals: ArticlesAffimer reagents enable targeted delivery of therapeutic agents and RNA via virus-like particles
iScience, vol. 27, no. 8, 110461Contributions to Journals: ArticlesPlatelet-derived microvesicles isolated from type-2 diabetes mellitus patients harbour an altered miRNA signature and drive MDA-MB-231 triple-negative breast cancer cell invasion
PloS ONE, vol. 19, no. 6, e0304870Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1371/journal.pone.0304870
- [ONLINE] View publication in Scopus
Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling
Communications Biology, vol. 7, 602Contributions to Journals: ArticlesExploring the One Health Paradigm in Male Breast Cancer
Journal of Mammary Gland Biology and Neoplasia, vol. 29, 8Contributions to Journals: ArticlesA single-cell atlas enables mapping of homeostatic cellular shifts in the adult human breast
Nature Genetics, vol. 56, no. 4, pp. 652-662Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41588-024-01688-9
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/23344/1/Reed_etal_NG_A_Single_Cell_VOR.pdf
- [ONLINE] View publication in Scopus
Prediction models for hormone receptor status in female breast cancer do not extend to males: further evidence of sex-based disparity in breast cancer
Breast Cancer, vol. 9, no. 1, 91Contributions to Journals: ArticlesEngaging undergraduate medical and dental students with academic medicine: the Aberdeen INSPIRE summer school
PloS ONE, vol. 18, no. 11, e0293633Contributions to Journals: ArticlesTrailblazers in Cancer Research: The Next Generation – The British Association of Cancer Research Early Career Conference
Open Biology, vol. 12, no. 10, bio060121Contributions to Journals: ArticlesBiglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain
Frontiers in Oncology, vol. 13, 1191980Contributions to Journals: ArticlesMorphological features and immunohistochemical profiling of male breast gynaecomastia; a large tissue microarray study
Frontiers in Oncology, vol. 12, 875839Contributions to Journals: ArticlesTspan6 stimulates the chemoattractive potential of breast cancer cells for B cells in an EV- and LXR-dependent manner
Cell Reports, vol. 42, no. 3, 112207Contributions to Journals: ArticlesValidation of a 3D perfused cell culture platform as a tool for humanised preclinical drug testing in breast cancer using established cell lines and patient-derived tissues
PloS ONE, vol. 18, no. 3, 0283044Contributions to Journals: ArticlesOPTIMA: New research project aims to improve treatment for patients with prostate, breast and lung cancer through artificial intelligence
Annual EAU Conference 2024, pp. A0992Contributions to Conferences: AbstractsDefining genomic, transcriptomic, proteomic, epigenetic, and phenotypic biomarkers with prognostic capability in male breast cancer: a systematic review
The Lancet Oncology, vol. 24, no. 2, pp. e74-e85Contributions to Journals: Review articlesLabeling of a Mutant Estrogen Receptor with an Affimer in a Breast Cancer Cell Line
Biophysical Journal, vol. 121, no. 19, pp. 3651-3662Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bpj.2022.06.028
Integrative, In Silico and Comparative Analysis of Breast Cancer Secretome Highlights Invasive-Ductal-Carcinoma-Grade Progression Biomarkers
Cancers, vol. 14, no. 16, 3854Contributions to Journals: ArticlesDeveloping research skills with weekly online seminars over the summer
Europhysiology 2022Contributions to Journals: AbstractsAnalysis of the Clinical Advancements for BRCA-Related Malignancies Highlights the Lack of Treatment Evidence for BRCA-Positive Male Breast Cancer
Cancers, vol. 14, no. 13, 3175Contributions to Journals: ArticlesObituary – Margaret Wilcox
British Journal of Cancer, vol. 126, 1508Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1038/s41416-022-01760-3
Raman spectroscopy: current applications in breast cancer diagnosis, challenges and future prospects
British Journal of Cancer, vol. 126, no. 8, pp. 1125-1139Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41416-021-01659-5
- [ONLINE] https://europepmc.org/article/med/34893761
A biobank perspective on use of tissue samples donated by trial participants
The Lancet Oncology, vol. 23, no. 5, pp. e205Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/S1470-2045(22)00186-3
- [ONLINE] View publication in Scopus
Code of practice needed to ensure good use is made of tissue samples donated by clinical trial participants: a biobank perspective
The Lancet Oncology, vol. 23, no. 5, E205Contributions to Journals: LettersRadiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations
The Journal of Pathology. Clinical Research, vol. 8, no. 1, pp. 3-13Contributions to Journals: ArticlesMale breast cancer: an update
Virchows Archiv, vol. 480, pp. 85-93Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1007/s00428-021-03190-7
Preclinical models of glioblastoma: limitations of current models and the promise of new developments
Expert Reviews in Molecular Medicine, vol. 23, e20Contributions to Journals: ArticlesMicroRNA-495/TGF-β/FOXC1 axis regulates multidrug resistance in metaplastic breast cancer cells
Biochemical Pharmacology, vol. 192, 114692Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bcp.2021.114692
Exploring the influence of rural residence on uptake of organized cancer screening: a systematic review of international literature
Cancer Epidemiology, vol. 74, 101995Contributions to Journals: ArticlesBiobanking in radiotherapy trials — a challenge to the clinical research community
Nature Reviews Clinical Oncology, vol. 18, pp. 191–192Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41571-021-00486-0
- [ONLINE] View publication in Scopus
The Cellular and Molecular Pathology Biobanking Sample Quality Improvement Tool: A Guide for Improving the Quality of Tissue Collections for Biomedical Research and Clinical Trials in Cancer
Biopreservation and Biobanking, vol. 19, no. 1, pp. 86-90Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1089/bio.2020.0009
- [ONLINE] View publication in Scopus
Quality considerations when using tissue samples for biomarker studies in cancer research
Biomarker Insights, vol. 16Contributions to Journals: ArticlesDownregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer
Exploration of Targeted Anti-tumor Therapy, vol. 1, pp. 355-371Contributions to Journals: ArticlesReflections on the Upsurge of Virtual Cancer Conferences During the COVID-19 Pandemic
British Journal of Cancer, vol. 123, pp. 698-699Contributions to Journals: ArticlesIncidence of male breast cancer in Scotland over a twenty-five-year period (1992 - 2017)
European Journal of Surgical Oncology, vol. 46, no. 8, pp. 1546-1550Contributions to Journals: ArticlesPan-cancer image-based detection of clinically actionable genetic alterations
Nature Cancer, vol. 1, no. 8, pp. 789-799Contributions to Journals: ArticlesThe CM-Path Biobanking Sample Quality Improvement Tool: A Guide for Improving the Quality of Tissue Collections for Biomedical Research and Clinical Trials in Cancer
Biopreservation and BiobankingContributions to Journals: ArticlesBPA and risk assessment
The Lancet Diabetes and Endocrinology, vol. 8, no. 4, pp. 269Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1016/S2213-8587(20)30068-1
- [ONLINE] View publication in Scopus
A Review of International Biobanks and Networks: Success Factors and Key Benchmarks—A 10-Year Retrospective Review
Biopreservation and Biobanking, vol. 17, no. 6, pp. 512-519Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1089/bio.2019.29060.djc.SI
Metastatic-niche labelling reveals parenchymal cells with stem features
Nature, vol. 572, no. 7771, pp. 603-608Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/s41586-019-1697-y
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13754/1/Ombrato_et_al_Nature_AAM.pdf
- [ONLINE] View publication in Nature
- [ONLINE] View publication in Mendeley
Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer
The Journal of pathology, vol. 247, no. 3, pp. 381-391Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/path.5197
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13265/1/PDF_of_SUBMITTED_REVISION.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13265/2/Westbrook_et_al_JofPat_IdentificationAndValidationOfDOCK4_VOR.pdf
- [ONLINE] View publication in Scopus
- [ONLINE] View publication in Mendeley
Barriers to the release of human tissue for clinical trials research in the UK: a national survey of cellular pathology laboratories on behalf of the National Cancer Research Institute's Cellular Molecular Pathology (CM-Path) initiative
Journal of Clinical Pathology, vol. 72, no. 1, pp. 52-57Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jclinpath-2018-205476
- [ONLINE] View publication in Mendeley
Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer
The Journal of Pathology. Clinical Research, vol. 4, no. 4, pp. 241-249Contributions to Journals: ArticlesDifferential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities
Pathobiology, vol. 85, no. 4, pp. 220-226Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1159/000488456
- [ONLINE] Deposit in University of Leeds repository
Characterising the adipose-inflammatory microenvironment in male breast cancer
ENDOCRINE-RELATED CANCER, vol. 25, no. 7, pp. 773-781Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1530/ERC-17-0407
- [ONLINE] deposit in Leeds Uni repository
Risk factors for the development of invasive cancer in unresected ductal carcinoma in situ
European Journal of Surgical Oncology, vol. 44, no. 4, pp. 429-435Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ejso.2017.12.007
Evaluation of applying IHC4 as a prognostic model in the translational study of Intergroup Exemestane Study (IES): PathIES
Breast Cancer Research and Treatment, vol. 168, no. 1, pp. 169-178Contributions to Journals: ArticlesAttitudes of female staff and students from two United Kingdom Medical Schools towards donating normal healthy breast tissue and blood samples for biomedical research
Breast Cancer Research and Treatment, vol. 166, no. 2, pp. 651-652Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10549-017-4459-2
- [ONLINE] Item in Leeds Uni repository
Oestrogen receptor β (ERβ) regulates osteogenic differentiation of human dental pulp cells
The Journal of Steroid Biochemistry and Molecular Biology, vol. 174, pp. 296-302Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jsbmb.2017.10.012
- [ONLINE] deposit in Leeds Uni repository
CIP2A expression predicts recurrences of tamoxifen-treated breast cancer
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, vol. 39, no. 10, pp. 1010428317722064Contributions to Journals: ArticlesAnalysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
Scientific Reports, vol. 7, no. 1, 8078Contributions to Journals: ArticlesAdvances in the development of improved animal-free models for use in breast cancer biomedical research
Biophysical Journal, vol. 9, no. 4, pp. 321-327Contributions to Journals: Review articlesAssociation between AXL, Hippo Transducers, and Survival Outcomes in Male Breast Cancer
Journal of Cellular Physiology, vol. 232, no. 8, pp. 2246-2252Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/jcp.25745
- [ONLINE] Deposit in Leeds Uni repository
Loss of CSMD1 expression disrupts mammary duct formation while enhancing proliferation, migration and invasion
Oncology Reports, vol. 38, no. 1, pp. 283-292Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3892/or.2017.5656
- [ONLINE] Deposit in Leeds Uni repository
A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer
Clinical Cancer Research, vol. 23, no. 10, pp. 2575-2583Contributions to Journals: Articles- [ONLINE] http://clincancerres.aacrjournals.org/
- [ONLINE] DOI: https://doi.org/10.1158/1078-0432.CCR-16-1952
- [ONLINE] Deposit in Leeds Uni repository
In vivo models in breast cancer research: progress, challenges and future directions
Disease Models & Mechanisms, vol. 10, no. 4, pp. 359-371Contributions to Journals: Review articlesCharacterisation of male breast cancer: a descriptive biomarker study from a large patient series
Scientific Reports, vol. 7, 45293Contributions to Journals: ArticlesThe Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research
PLoS Biology, vol. 15, no. 1, e2000719Contributions to Journals: ArticlesHMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes
Scientific Reports, vol. 6, 35121Contributions to Journals: ArticlesSEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals
The Journal of pathology, vol. 240, no. 1, pp. 120Contributions to Journals: ArticlesThe Hippo transducers TAZ/YAP and their target CTGF in male breast cancer
Oncotarget, vol. 7, no. 28, pp. 43188-43198Contributions to Journals: ArticlesIntroducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research
Breast Cancer, vol. 2, 16020Contributions to Journals: ArticlesAn Evaluation of Matrix-Containing and Humanised Matrix-Free 3-Dimensional Cell Culture Systems for Studying Breast Cancer
PloS ONE, vol. 11, no. 6, e0157004Contributions to Journals: ArticlesSEARCHBreast: a new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers
Breast Cancer Research, vol. 18, 59Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13058-016-0716-2
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/22548/1/SEARCHBreast_BMC.pdf
Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro
Oncotarget, vol. 7, no. 22, pp. 32129-32143Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.8534
CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment
Journal of the National Cancer Institute, vol. 108, no. 4Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/jnci/djv360
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10776/1/CAPG_and_GIPC1.pdf
SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs
Breast Cancer Research and Treatment, vol. 156, no. 3, pp. 447-452Contributions to Journals: ArticlesManagement of breast cancer in an Asian man with post-traumatic stress disorder: a case report
Journal of Medical Case Reports, vol. 10, no. 1, 77Contributions to Journals: ArticlesTumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness
Nature Communications, vol. 7, 10305Contributions to Journals: Articles3-D Tissue Modelling and Virtual Pathology as New Approaches to Study Ductal Carcinoma In Situ
ATLA Alternatives to Laboratory Animals, vol. 43, no. 6, pp. 377-383Contributions to Journals: Articles- [ONLINE] http://www.atla.org.uk/booth43-6/
- [ONLINE] View publication in Scopus
SEARCHBreast workshop proceedings: 3D modelling of breast cancer
ATLA Alternatives to Laboratory Animals, vol. 43, no. 6, pp. 367-375Contributions to Journals: Articles- [ONLINE] http://www.atla.org.uk/morrissey43-6/
- [ONLINE] View publication in Scopus
Lack of CD151/integrin α3β1 complex is predictive of poor outcome in node-negative lobular breast carcinoma: opposing roles of CD151 in invasive lobular and ductal breast cancers
British Journal of Cancer, vol. 113, no. 9, pp. 1350-1357Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2015.344
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10816/1/Lack_of_CD151_integrin.pdf
Androgen receptor and antiandrogen therapy in male breast cancer
Cancer Letters, vol. 368, no. 1, pp. 20-25Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.canlet.2015.07.040
Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis
PloS ONE, vol. 10, no. 10, e0139698Contributions to Journals: ArticlesPrognostic and predictive value of ERβ1 and ERβ2 in the Intergroup Exemestane Study (IES)-first results from PathIES
Annals of Oncology, vol. 26, no. 9, pp. 1890-1897Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/annonc/mdv242
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis
Nature Communications, vol. 6, 7286Contributions to Journals: ArticlesAnimal research: share surplus animal tissue
Nature, vol. 522, no. 7555, 156Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/522156c
Obesity and male breast cancer: provocative parallels?
BMC medicine , vol. 13, 134Contributions to Journals: ArticlesThree-dimensional reconstruction of ductal carcinoma in situ with virtual slides
Histopathology, vol. 66, no. 7, pp. 966-973Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/his.12561
Reponse to: comment on, 'Tumour-stroma ratio (TSR) in oestrogen-positive breast cancer patients'
British Journal of Cancer, vol. 112, no. 11, pp. 1833-1834Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2014.571
Role of gonadotropin-releasing hormone analogues in metastatic male breast cancer: results from a pooled analysis
Hematological Oncology, vol. 8, 53Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13045-015-0147-z
Inflammatory breast cancer: time to standardise diagnosis assessment and management, and for the joining of forces to facilitate effective research
British Journal of Cancer, vol. 112, no. 9, pp. 1613-1615Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2015.115
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10819/1/Inflammatory_breast_cancer.pdf
Adding value to rare tissue samples donated to biobanks: characterisation of breast tissue and primary cell cultures obtained from a female-to-male transgender patient
Cell and tissue banking, vol. 16, no. 1, pp. 27-34Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10561-014-9444-y
A Global View of Breast Tissue Banking
Biobanking in the 21st Century. Karimi-Busheri, F. (ed.). Springer, pp. 69-77, 9 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-319-20579-3_6
Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: A tool for cancer initiation studies
Oncotarget, vol. 6, no. 15, pp. 13731-13741Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.18632/oncotarget.3803
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10821/1/3803_50092_3_PB.pdf
- [ONLINE] View publication in Scopus
Antiandrogen therapy in metastatic male breast cancer: results from an updated analysis in an expanded case series
Breast Cancer Research and Treatment, vol. 148, no. 1, pp. 73-80Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10549-014-3138-9
Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer
Breast Cancer Research and Treatment, vol. 148, no. 1, pp. 221-229Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10549-014-3153-x
Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer
Oncogene, vol. 33, no. 37, pp. 4579-4588Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/onc.2014.45
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10811/1/onc201445.pdf
The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer
British Journal of Cancer, vol. 110, no. 7, pp. 1744-1747Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/bjc.2014.69
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10812/1/bjc201469.pdf
PSMD9 expression predicts radiotherapy response in breast cancer
Molecular Cancer, vol. 13, 73Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/1476-4598-13-73
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10813/1/document.pdf
The value of archival tissue blocks in understanding breast cancer biology
Journal of Clinical Pathology, vol. 67, no. 3, pp. 272-275Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jclinpath-2013-201854
Steroid hormone receptor expression in breast cancer stroma
Breast Cancer Research and Treatment, vol. 143, no. 3, pp. 605-607Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1007/s10549-013-2815-4
External validation of the ImmunoRatio image analysis application for ERα determination in breast cancer
Journal of Clinical Pathology, vol. 67, no. 1, pp. 72-75Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jclinpath-2013-201680
The potential utility of geminin as a predictive biomarker in breast cancer
Breast Cancer Research and Treatment, vol. 143, no. 1, pp. 91-98Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s10549-013-2786-5
Identification of Stage-Specific Breast Markers Using Quantitative Proteomics
Journal of Proteome Research, vol. 12, no. 12, pp. 5696-5708Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/pr400662k
Estrogen receptor β: putting a positive into triple negative breast cancer?
Hormone molecular biology and clinical investigation, vol. 16, no. 3, pp. 117-123Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1515/hmbci-2013-0042
Insulin-like growth factor — Oestradiol crosstalk and mammary gland tumourigenesis
Biochimica et Biophysica Acta, vol. 1836, no. 2, pp. 345-353Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1016/j.bbcan.2013.10.005
- [ONLINE] AM available from WRRO repository.
Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region
International Journal of Oncology, vol. 43, no. 6, pp. 2039-2045Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3892/ijo.2013.2112
MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion
The Journal of pathology, vol. 231, no. 3, pp. 388-399Contributions to Journals: ArticlesCritical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Breast Cancer Research, vol. 15, no. 5, R92Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1186/bcr3493
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10788/1/bcr3493.pdf