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Dr Sergio Dall'Angelo

Dr Sergio Dall'Angelo
Dr Sergio Dall'Angelo
Dr Sergio Dall'Angelo

Ph.D. in Industrial Chemistry (Universita' Statale di Milano)

Advanced Research Fellow

Accepting PhDs

About
Email Address
s.dallangelo@abdn.ac.uk
Telephone Number
+44 (0)1224 437563
Office Address
6.29 Institute of Medical Sciences
Foresterhill Campus
Ashgrove Road West
AB25 2ZD

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School/Department
School of Medicine, Medical Sciences and Nutrition
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Biography

I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.

In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University.  In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen.

Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.

 

Memberships and Affiliations

Internal Memberships

Member of the Concordat Steering Group

Member of the IMS Health, Safety & Wellbeing Committee

Member of Nvision Committee

IMS First Aider

External Memberships

Member of the Royal Society of Chemistry (RSC) https://www.rsc.org/

Member of European Society for Molecular Imaging (ESMI) https://e-smi.eu/

Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence)  http://www.sinapse.ac.uk/

Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics

Latest Publications

View My Publications

Research

Research Overview

Research interest in:

  • PET Chemistry
  • Peptide synthesis
  • Synthetic Organic Chemistry
  • Medicinal Chemistry

My research current research is focused on:

  1. the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
  2. the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
  3. the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)

I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.

Research Areas

Accepting PhDs

I am currently accepting PhDs in Chemistry, Biomedical Sciences.

Please get in touch if you would like to discuss your research ideas further.

Email Me

Chemistry

Supervising
Accepting PhDs
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Biomedical Sciences

Supervising
Accepting PhDs
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Research Specialisms

  • Diagnostic Imaging
  • Medicinal Chemistry
  • Applied Chemistry
  • Organic Chemistry

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Current Research

  • Development of prostate cancer PET tracers
  • [18F]FAZA and [18F]FMISO hypoxia PET imaging
  • Fluorinase mediate Fluorine-18 tracers synthesis
  • Peptide synthesis
Teaching

Courses

Publications

Page 2 of 2 Results 26 to 41 of 41

  • Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

    Testa, A., Dall'Angelo, S., Mingarelli, M., Augello, A., Schweiger, L., Welch, A. E., Elmore, C. S., Sharma, P., Zanda, M.
    Bioorganic & Medicinal Chemistry, vol. 25, no. 3, pp. 963-976
    Contributions to Journals: Articles

  • Synthesis and radio-synthesis of prospective 2-nitroimidazole hypoxia PET tracers via thiazolidine ligation with 5-fluorodeoxyribose (FDR)

    Musolino, M., Dall'angelo, S., Zanda, M.
    SynOpen, vol. 1, no. 1, pp. 173-179
    Contributions to Journals: Articles

  • Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

    Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E., Zanda, M.
    Organic & Biomolecular Chemistry, vol. 15, no. 9, pp. 2086-2096
    Contributions to Journals: Articles

  • Last-step enzymatic [18F]-fluorination of cysteine-tethered RGD peptides using modified Barbas linkers

    Zhang, Q., Dall'Angelo, S., Fleming, I. N., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Chemistry : a European Journal, vol. 22, no. 31, pp. 10998-11004
    Contributions to Journals: Articles

  • NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting

    Graziadio, A., Zanda, M., Frau, S., Fleming, I. N., Musolino, M., Dall'Angelo, S., Baldassarre, M., Piras, M.
    Bioconjugate Chemistry, vol. 27, no. 5, pp. 1332-1340
    Contributions to Journals: Articles

  • Arginine Analogues Incorporating Carboxylate Bioisosteric Functions are Micromolar Inhibitors of Human Recombinant DDAH-1

    Tommasi, S., Zanato, C., Lewis, B. C., Nair, P. C., Dall'Angelo, S., Zanda, M., Mangoni, A. A.
    Organic & Biomolecular Chemistry, vol. 46, no. 13, pp. 11315-11330
    Contributions to Journals: Articles

  • An Efficient Route to N-Monosubstituted Guanidino-Lactams

    Tommasi, S., Zanato, C., Carabeo, R., Mangoni, A., Dall'Angelo, S., Zanda, M.
    Synthesis, vol. 47, no. 19, pp. 3067-3078
    Contributions to Journals: Articles

  • Pyrazole-type Cannabinoid Ligands conjugated with Fluoro-deoxy-carbohydrates as Potential PET-Imaging Agents: Synthesis and CB1/CB2 receptor affinity evaluation

    Frau, S., Dall'Angelo, S., Baillie, G. L., Ross, R. A., Pira, M., Tseng, C., Lazzari, P., Zanda, M.
    Journal of Fluorine Chemistry, vol. 152, pp. 166-172
    Contributions to Journals: Articles

  • Efficient bioconjugation of 5-fluoro-5-deoxy-ribose (FDR) to RGD peptides for positron emission tomography (PET) imaging of αvβ3 integrin receptor

    Dall'angelo, S., Zhang, Q., Fleming, I. N., Piras, M., Schweiger, L. F., O'Hagan, D., Zanda, M.
    Organic & Biomolecular Chemistry, vol. 27, no. 11, pp. 4551-4558
    Contributions to Journals: Articles

  • Molecular insights into bacteroid development during Rhizobium-legume symbiosis

    Haag, A. F., Arnold, M. F. F., Myka, K. K., Kerscher, B., Dall'angelo, S., Zanda, M., Mergaert, P., Ferguson, G. P.
    FEMS Microbiology Reviews, vol. 37, no. 3, pp. 364-383
    Contributions to Journals: Articles

  • Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18F]fluoro-5-deoxyribose as a novel tracer

    Dall'Angelo, S., Bandaranayaka, N., Windhorst, A. D., Vugts, D., van der Born, D., Onega, M., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Nuclear Medicine and Biology, vol. 40, no. 4, pp. 464-470
    Contributions to Journals: Articles

  • [18F]-Barbiturates as PET-tracers for Alzheimer's disease

    Zanda, M., Calamai, E., Dall'Angelo, S., Koss, D., Mingarelli, M., Schweiger, L., Welch, A., Platt, B.
    245th National Spring Meeting of the American-Chemical-Society (ACS)
    Contributions to Journals: Abstracts

  • 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease

    Calamai, E., Dall'Angelo, S., Koss, D., Domarkas, J., McCarthy, T. J., Mingarelli, M., Riedel, G., Schweiger, L. F., Welch, A. E., Platt, B., Zanda, M.
    Chemical Communications, vol. 49, no. 8, pp. 792-794
    Contributions to Journals: Articles

  • [18F]-5-Fluoro-5-deoxyribose, an efficient peptide bioconjugation ligand for positron emission tomography (PET) imaging

    Li, X. G., Dall'Angelo, S., Schweiger, L. F., Zanda, M., O'Hagan, D.
    Chemical Communications, vol. 48, no. 43, pp. 5247-5249
    Contributions to Journals: Articles

  • Role of cysteine residues and disulfide bonds in the activity of a legume root nodule-specific, cysteine-rich peptide

    Haag, A. F., Kerscher, B., Dall'Angelo, S., Sani, M., Longhi, R., Baloban, M., Wilson, H. M., Mergaert, P., Zanda, M., Ferguson, G. P.
    The Journal of Biological Chemistry, vol. 287, no. 14, pp. 10791-10798
    Contributions to Journals: Articles

  • Protection of Sinorhizobium against host cysteine-rich antimicrobial peptides is critical for symbiosis

    Haag, A. F., Baloban, M., Sani, M., Kerscher, B., Pierre, O., Farkas, A., Longhi, R., Boncompagni, E., Hérouart, D., Dall'angelo, S., Kondorosi, E., Zanda, M., Mergaert, P., Ferguson, G. P.
    PLoS Biology, vol. 9, no. 10, e1001169
    Contributions to Journals: Articles
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