Ph.D. in Industrial Chemistry (Universita' Statale di Milano)
Advanced Research Fellow
- About
-
- Email Address
- s.dallangelo@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437563
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I got my PhD at the University of Milan in 2008 and, after a brief experience as a consultant, in 2009 I moved to Aberdeen to contribute in the set-up of an organic/medicinal chemistry lab at the Institute of Medical Sciences. Here I worked on several projects spacing from medicinal chemistry to radiochemistry and more recently peptide chemistry.
In 2012 I was awarded a Postdoctoral and Early Career Researcher Exchange Fund by SINAPSE for 9 months visit to Prof. Tobias Ritter’s Laboratory, at Harvard University. In 2019 I became an independent Research Fellow at the Institute of Medical Sciences, Aberdeen.
Over the years I gained experience in the synthesis of organic small molecules, peptidomimetics and peptides as well in the preparation of clinical grade PET tracers (mainly Fluorine 18 based such as ([18F]FDG, [18F]NaF, [18F]FMISO, [18F]FAZA, [18F]FLT,) and in the development of novel radiotracers.
Memberships and Affiliations
- Internal Memberships
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Member of the Concordat Steering Group
Member of the IMS Health, Safety & Wellbeing Committee
Member of Nvision Committee
IMS First Aider
- External Memberships
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Member of the Royal Society of Chemistry (RSC) https://www.rsc.org/
Member of European Society for Molecular Imaging (ESMI) https://e-smi.eu/
Member of SINAPSE (Scottish Imaging Network: A Platform for Scientific Excellence) http://www.sinapse.ac.uk/
Memebr of the SULSA Strategic Committee - Diagnostics and Therapeutics
Latest Publications
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
Patents: PatentsProtein tyrosine phosphatase 1B in metabolic diseases and drug development
Nature Reviews Endocrinology , vol. 20, no. 6, pp. 366-378Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1038/s41574-024-00965-1
- [ONLINE] View publication in Scopus
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Experimental Physiology, vol. 109, no. 1, pp. 81-99Contributions to Journals: ArticlesChemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides
Angewandte Chemie International Edition, vol. 62, no. 16, e202215979Contributions to Journals: ArticlesMetal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications
Electrochemical Science Advances, vol. 2, no. 6, e2100164Contributions to Journals: Articles
- Research
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Research Overview
Research interest in:
- PET Chemistry
- Peptide synthesis
- Synthetic Organic Chemistry
- Medicinal Chemistry
My research current research is focused on:
- the preparation of new radiotracers for PET imaging and the repurpose of already developed tracers as imaging tools for new diseases,
- the investigation of new fluorine-18 radiochemical methodologies/strategies to prepare PET tracers,
- the design and synthesis of peptides and peptidomimetics useful as drugs for the treatment of different diseases (Diabetes, atherosclerosis and other cardiovascular diseases, cancer, etc)
I am always happy to embark on new field explorations and I am open to multidisciplinary collaborations.
Research Areas
Accepting PhDs
I am currently accepting PhDs in Chemistry, Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Diagnostic Imaging
- Medicinal Chemistry
- Applied Chemistry
- Organic Chemistry
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
- Development of prostate cancer PET tracers
- [18F]FAZA and [18F]FMISO hypoxia PET imaging
- Fluorinase mediate Fluorine-18 tracers synthesis
- Peptide synthesis
- Teaching
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Courses
Course coordinator
Coordinator
Supervisor
- Masters Research Project (LABORATORY) - MB5904
Course Co-Coordinator
Supervisor
Practical on Drug Discovery
Practical on Drug Discovery
Radiochemistry
- Student Selected Component 2 (ME3013)
Coordinator
Supervisor
Practical on Protein purification
Lecturer on Peptide Therapeutics
Supervisor
- Introduction to Chemistry for Biologists - EastBio masterclass
http://www.eastscotbiodtp.ac.uk/foundation-masterclasses
- Masters Research Project (LABORATORY) - MB5904 MB5021
Course co-coordinator
Supervisor
- Publications
-
Page 1 of 2 Results 1 to 25 of 41
Inhibitors of PTP1B/NCK1 interaction and methods of making and using same
Patents: PatentsProtein tyrosine phosphatase 1B in metabolic diseases and drug development
Nature Reviews Endocrinology , vol. 20, no. 6, pp. 366-378Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1038/s41574-024-00965-1
- [ONLINE] View publication in Scopus
The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2
Experimental Physiology, vol. 109, no. 1, pp. 81-99Contributions to Journals: ArticlesChemoenzymatic Late-Stage Modifications Enable Downstream Click-Mediated Fluorescent Tagging of Peptides
Angewandte Chemie International Edition, vol. 62, no. 16, e202215979Contributions to Journals: ArticlesMetal-free phthalimide-labeled peptide nucleic acids for electrochemical biosensing applications
Electrochemical Science Advances, vol. 2, no. 6, e2100164Contributions to Journals: ArticlesBiochemical Characterization of a Cyanobactin Arginine-N-Prenylase from the Autumnalamide Biosynthetic Pathway
Chemical Communications, vol. 58, no. 86, pp. 12054-12057Contributions to Journals: ArticlesGuanidinoneomycin-Maleimide Molecular Transporter: Synthesis, Chemistry and Cellular Uptake
Organic & Biomolecular Chemistry, vol. 19, no. 29, pp. 6513-6520Contributions to Journals: ArticlesClinical value of 3'-deoxy-3'-[18F]fluorothymidine-positron emission tomography for diagnosis, staging and assessing therapy response in lung cancer
Insights into Imaging, vol. 12, no. 1, 90Contributions to Journals: ArticlesSynthesis, Radiosynthesis and in vitro Studies on Novel Hypoxia PET Tracers Incorporating [18F]FDR
European Journal of Organic Chemistry, vol. 2021, no. 9, pp. 1429-1439Contributions to Journals: Articles4,4,16-Trifluoropalmitate: design, synthesis, tritiation, radiofluorination and pre-clinical PET imaging studies on myocardial fatty acid oxidation
ChemMedChem, vol. 15, no. 23, pp. 2317-2331Contributions to Journals: ArticlesDesign, synthesis, conjugation and reactivity of novel trans,trans-1,5-cyclooctadiene-derived bioorthogonal linkers
Bioconjugate Chemistry, vol. 31, no. 9, pp. 2201-2210Contributions to Journals: ArticlesWidespread tissue hypoxia dysregulates cell and metabolic pathways in SMA
Annals of Clinical and Translational Neurology, vol. 7, no. 9, pp. 1580-1593Contributions to Journals: ArticlesDesign, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents
ChemMedChem, vol. 15, no. 16, pp. 1579-1590Contributions to Journals: ArticlesHypoxia PET/CT and Colorectal Cancer: A Case Report
Journal of Case Reports and Images in Oncology, vol. 1(1), no. 2-5Contributions to Journals: ArticlesA Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms
Microorganisms, vol. 8, no. 7, 1066Contributions to Journals: Articles[18F]ZCDD083: a PFKFB3-targeted PET tracer for atherosclerotic plaque imaging
ACS Medicinal Chemistry Letters, vol. 11, no. 5, pp. 933-939Contributions to Journals: ArticlesEnzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)
Organic & Biomolecular Chemistry, vol. 17, no. 6, pp. 1480-1486Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/C8OB03150A
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13531/1/Enzymatic_PSMA_manuscript.pdf
- [ONLINE] View publication in Mendeley
The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators (PAMs)
Journal of Medicinal Chemistry, vol. 62, no. 10, pp. 5049-5062Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acs.jmedchem.9b00252
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/14228/1/The_Trifluoromethyl_Group_Accepted_Manuscript.pdf
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
- [ONLINE] https://abdn.pure.elsevier.com/en/en/researchoutput/the-trifluoromethyl-group-as-a-bioisosteric-replacement-of-the-aliphatic-nitro-group-in-cb1-receptor-positive-allosteric-modulators-pams(be1c59c4-139f-40c4-8183-31a797b12efb).html
Enzymatic Fluorination of Biotin and Tetrazine Conjugates for Pretargeting Approaches to Positron Emission Tomography Imaging
ChemBioChem, vol. 19, no. 18, pp. 1969-1978Contributions to Journals: ArticlesPreclinical Evaluation of [18F]LCATD as a PET Tracer to Study Drug-Drug Interactions Caused by Inhibition of Hepatic Transporters
Contrast Media & Molecular Imaging, vol. 2018, 3064751Contributions to Journals: ArticlesBinding of αvβ3 Integrin-Specific Radiotracers Is Modulated by Both Integrin Expression Level and Activation Status
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, vol. 20, no. 1, pp. 27-36Contributions to Journals: ArticlesA New Class of Fluorinated A2A Adenosine Receptor Agonist with Application to Last-Step Enzymatic 18F Fluorination for PET Imaging
ChemBioChem, vol. 18, no. 21, pp. 2156-2164Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/cbic.201700382
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/11141/1/Manuscript_Edited_002_.docx
High Affinity “Click” RGD Peptidomimetics as Radiolabeled Probes for Imaging αvβ3 Integrin
ChemMedChem, vol. 12, no. 14, pp. 1142-1151Contributions to Journals: ArticlesSynthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy
Bioorganic & Medicinal Chemistry, vol. 25, no. 10, pp. 2730-2742Contributions to Journals: ArticlesSynthesis and Superpotent Anticancer Activity of Tubulysins Carrying Non-hydrolysable N-Substituents on Tubuvaline
Chemistry : a European Journal, vol. 23, no. 24, pp. 5842-5850Contributions to Journals: Articles
