BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis
Personal Chair
- About
-
- Email Address
- n.j.mutch@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437492
- Office Address
Lab 1.33 01224 437417
Office 5.16 01224 437492
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Education
University of Aberdeen, Department of Molecular and Cellular Biology and Department of Medince and Therapeutics. Aberdeen, UK. PhD in Haemostasis & Vascular Biology (1997-2000). Supervisor Dr Nuala A Booth. Funded by ACTR.
University of Aberdeen, Aberdeen, UK. BSc (Hons) (1993-1997) in Molecular and Cellular Biology.
Employment
2016: Senior Lecturer, University of Aberdeen, School of Medicine, Medical Sciences and Nutrition. Insitute of Medical Sciences, (IMS).
2011-2016: British Heart Foundation Fellow, Senior Research Fellow, School of Medicine and Dentistry, IMS.
2010-2011: Research Fellow funded by British Heart Foundation, School of Medicine and Dentistry, IMS.
2007-2010: Tenure-track Independent Research Fellow in Cardiovascular Medicine, Department of BIological Sciences, University of Leeds, Leeds, UK.
2004-2006: Postdoctoral research associate, University of Illinois at Urbana-Champaign, Department of Medicine, Champaign, Illinois, USA.
2001-2003: Postdoctoral research fellow, Department of Molecular and Cellular Biology, University of Aberdeen, UK.
Qualifications
- BSc hons Molecular Biology1997 - University of Aberdeen
- PhD Thrombosis & Vascular Biology2001 - University of Aberdeen
Latest Publications
Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Blood Advances, 2024012979Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/bloodadvances.2024012979
Standardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2059-2070Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.005
- [ONLINE] View publication in Scopus
A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma
Journal of Thrombosis and Haemostasis, vol. 22, no. 6, pp. 1758-1771Contributions to Journals: ArticlesFibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3589-3596Contributions to Journals: ArticlesThe Fibrinolysis Renaissance
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3304-3316Contributions to Journals: Articles
- Research
-
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biological Sciences
- Human Biology
- Cardiology
- Cell Biology
- Immunology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
POST-DOC
Dr Claire Whyte
BHF funded post-doc (Dec 2015-May 2019). Claire has been in the lab since January 2011 and is on her second BHF-funded project grant. Claire is currently working on the role of platelet-derived plasmiongen in driving local fibrinolysis.
CURRENT PhD STUDENTS
Mohammad Jalal: Start date 01/12/2012; Funded by the Saudi Arabian Government. 4 year PhD.
Paraskevi Untiveros: Start date 01/09/2014; Funded by the Chief Scientist Office. Clinical Fellow 3 year PhD.
Gael Morrow: Start date 12/01/2015; Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood. 3 Year PhD.
Maria-Louise Williams: Start date 01/10/16; Funded by the Institute of Medical Sciences, University of Aberdeen. 3 year PhD.
LAB ALLUMNI
Mrs Ausra Lionikiene. Ausra was employed a research technician on my BHF-funded fellowship and studying the biological significance of factor XII. Ausra was an integral member of the team organising the lab, finances and all the personnel.
Funding and Grants
CURRENT GRANTS
1. British Heart Foundation Project Grant PI: NJ Mutch (Dec 2015-Dec 2018) 'Platelet plasminogen as a driver of local fibrinolysis'
2. British Society of Haematology / Lifeblood / British Society of Thrombosis & Haemostasis PhD Studentship PI: NJ Mutch; Co-I CS Whyte (Jan 2015-Jan 2018) 'The impact of thrombus composition on regulation of fibrinolysis under flow'
4. Friends of Anchor PI: Dr Paraskevi Untiveros, Co-I Dr Nicola J Mutch, Dr Henry Watson (Aug 2016-Aug 2017) The role of ABO blood group in thrombosis
5. Chief Scientist Office, Scottish Government Fellow: P Untiveros; Supervisors: NJ Mutch, H Watson ''Influence of Anaemia on Clot Structure'
6. Friends of Anchor PI: NJ Mutch (Apr 2015-Nov 2016) 'A functional role of platelet FXIII-A in clot retraction'
RECENT GRANTS
1. British Heart Foundation Basic Science Fellowship Fellow: NJ Mutch (Mar 2011-Mar 2016 Includes two maternity leaves) 'Characterising the physiological role of factor XII and the contact system'
2. British Heart Foundation Project Grant PI: NJ Mutch; Co-I: RAS Ariëns (Jan 2012-Dec 2015) 'Changes in fibrin clot structure and susceptibility to lysis induced by polyphosphate'
3. Aberdeen Development Trust PhD Studentship PI: NJ Mutch (Oct 2012-Apr 2016) 'The antifibrinolytic function of factor XIII'
4. Chest, Heart and Stroke Scotland PI Isobel Ford Co-I NJ Mutch, MJ McLeod. () Responsiveness to thrombolytic therapy of for Ischaemic stroke
5. British Heart Foundation Project Grant (PG/07/122/23480). PI: NJ Mutch (Jun 2008-Oct 2012) 'Polyphosphate as a physiological surface for contact activation
' - Teaching
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Courses
- MT5524/MT5024 - Molecular Pharmacology
- BDS - Cardiovascular System
- BDS - Endocrinology
Teaching Responsibilities
Course coordinator for BM5003 Cardiovascular Health and Disease
- Publications
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Page 2 of 2 Results 51 to 81 of 81
Evaluation of and recommendation for the nomenclature of the CPB2 gene product (also known as TAFI and proCPU): Communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 13, no. 12, pp. 2277-2278Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jth.13168
- [ONLINE] View publication in Scopus
Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)
Thrombosis Research, vol. 136 , no. Suppl 1, pp. S3-S7Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.thromres.2015.07.034
Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow
Blood, vol. 125, no. 16, pp. 2568 - 2578Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2014-09-599480
Functional factor XIII-A is exposed on the stimulated platelet surface
Blood, vol. 124, no. 26, pp. 3982–3990Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2014-06-583070
Single-chain factor XII exhibits activity when complexed to polyphosphate
Journal of Thrombosis and Haemostasis, vol. 12, no. 9, pp. 1513-1522Contributions to Journals: ArticlesEndothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
Biochemical Society Transactions, vol. 42, no. 4, pp. 928-933Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/BST20140113
Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation
Blood, vol. 122, no. 23, pp. 3847-3849Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1182/blood-2013-09-525840
Thrombin-anti-thrombin levels and patency of arterio-venous fistula in patients undergoing haemodialysis compared to healthy volunteers: a prospective analysis
PloS ONE, vol. 8, no. 7, e67799Contributions to Journals: ArticlesInsights into thrombin activatable fibrinolysis inhibitor function and regulation
Journal of Thrombosis and Haemostasis, vol. 11, no. Suppl 1, pp. 306-315Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jth.12216
Plasmin and the thrombin-thrombomodulin complex both contribute to thrombin-activatable fibrinolysis inhibitor activation in whole blood model thrombi
Journal of Thrombosis and Haemostasis, vol. 11, no. 1, pp. 190-192Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jth.12062
The Role of Platelets in Fibrinolysis
Platelets. Michelson, A. (ed.). 3 edition. Elsevier Inc, pp. 469-485, 17 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-387837-3.00023-7
- [ONLINE] View publication in Scopus
Immobilized transition metal ions stimulate contact activation and drive factor XII-mediated coagulation
Journal of Thrombosis and Haemostasis, vol. 10, no. 10, pp. 2108-2115Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2012.04890.x
"A Growing Body of Evidence Demonstrates Crosstalk Within the Haemostatic System, and It Appears That These Interconnecting Pathways Allow Fine Tuning and Balance of the Different Systems in Our Body"
Circulation, vol. 125, no. 23, pp. F133-F134Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1161/CIR.0b013e318260a878
Impact of fibrin structure on fibrinolysis by different plasminogen activators: studies using fluorescent confocal microscopy
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E24Contributions to Journals: Reviews of Books, Films and Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2012.04749.x
Platelet factor XIII stabilises thrombi against premature fibrin degradation
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E15Contributions to Journals: Reviews of Books, Films and Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2012.04749.x
Polyphosphate scores a hat trick in regulating host defense mechanisms
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. 1142-1144Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2012.04741.x
Polyphosphate stabilises factor XIIa and acts as a cofactor in factor XIIa-mediated plasminogen activation
Journal of Thrombosis and Haemostasis, vol. 10, no. 6, pp. E13Contributions to Journals: Reviews of Books, Films and Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2012.04749.x
The antifibrinolytic function of factor XIII is exclusively expressed through a2-antiplasmin cross-linking. Blood. 2011;117(23):6371-6374.
Blood, vol. 118, no. 26, pp. 6993Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2011-10-384107
Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin
Blood, vol. 118, no. 14, pp. 3942-3951Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2011-03-339572
Emerging roles for factor XII in vivo
Journal of Thrombosis and Haemostasis, vol. 9, no. 7, pp. 1355-1358Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2011.04329.x
The antifibrinolytic function of factor XIII is exclusively expressed through α2-antiplasmin cross-linking
Blood, vol. 117, no. 23, pp. 6371-6374Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2011-02-333203
Platelet polyphosphate is a proinflammatory and procoagulant mediator in vivo
Arteriosclerosis Thrombosis and Vascular Biology, vol. 30, no. 11, pp. E192Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1161/ATV.0b013e3181eac982
Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis
Journal of Thrombosis and Haemostasis, vol. 8, no. 9, pp. 2017-2024Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2010.03963.x
Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets
Journal of Thrombosis and Haemostasis, vol. 8, no. 6, pp. 1313-1322Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2010.03813.x
Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin
Blood, vol. 115, no. 19, pp. 3980-3988Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood-2009-11-254029
Polyphosphate binds with high affinity to exosite II of thrombin
Journal of Thrombosis and Haemostasis, vol. 8, no. 3, pp. 548-555Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1538-7836.2009.03723.x
Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo
Cell, vol. 139, no. 6, pp. 1143-1156Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.cell.2009.11.001
TAFIa, PAI-1 and α2-antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots
Journal of Thrombosis and Haemostasis, vol. 5, no. 4, pp. 812-817Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/J.1538-7836.2007.02430.X
Polyphosphate modulates blood coagulation and fibrinolysis
PNAS, vol. 103, no. 4, pp. 903-908Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.0507195103
Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI
Journal of Thrombosis and Haemostasis, vol. 1, no. 9, pp. 2000-2007Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1046/J.1538-7836.2003.00383.X
Localization and identification of thrombin and plasminogen activator activities in model human thrombi by in situ zymography
Thrombosis and Haemostasis, vol. 88, no. 6, pp. 996-1003Contributions to Journals: Articles