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Professor Mark Vickers

Professor Mark Vickers
Professor Mark Vickers
Professor Mark Vickers

MBChB MRCP DM FRCPath

Chair in Applied Medicine (Clin)

About
Email Address
m.a.vickers@abdn.ac.uk
Telephone Number
+44 (0)1224 272401
Office Address

1. Room 3:25, Institute of Medical Sciences

2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.

External Memberships

Member of Royal College of Physicians

Fellow of Royal College of Pathologists

British Society for Haematology

 

Research

Research Overview

My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria.  The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection.  I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19.  I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers.  I am also involved in collection and use of convalescent plasma for COVID-19.

 

Knowledge Exchange

I have given talks about the use of convalescent plasma and T cells to treat COVID-19.

Collaborations

Prof. Alex Rowe, Edinburgh University.

Prof. Stuart Haslam, Imperial College London.

Prof. David Rees, King's College London.

Supervision

Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.

Teaching

Teaching Responsibilities

I organise, and deliver much of, the haematology training in the medical school.  I remain an enthusiastic bedside teacher.  I co-ordinated the third year medical degree 1997-2010.

Publications

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  • Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma

    Mittal, S., Marshall, N. A., Duncan, L., Culligan, D. J., Barker, R. N., Vickers, M. A.
    Blood, vol. 111, no. 11, pp. 5359-5370
    Contributions to Journals: Articles

  • Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia

    Ward, F. J., Hall, A. M., Cairns, L. S., Leggat, A. S., Urbaniak, S. J., Vickers, M. A., Barker, R. N.
    Blood, vol. 111, no. 2, pp. 680-687
    Contributions to Journals: Articles

  • A high rate of CLL phenotype lymphocytes in autoimmune haemolytic anaemia and immune thrombocytopenic purpura

    Mittal, S., Blaylock, M. G., Culligan, D. J., Barker, R. N., Vickers, M. A.
    Haematologica, vol. 93, no. 1, pp. 151-152
    Contributions to Journals: Articles

  • ABO(H) blood groups and vascular disease: a systematic review and meta-analysis

    Wu, O., Bayoumi, N., Vickers, M. A., Clark, P.
    Journal of Thrombosis and Haemostasis, vol. 6, no. 1, pp. 62-69
    Contributions to Journals: Literature Reviews

  • CD4(+) T-cell responses to Epstein-Barr virus (EBV) latent membrane protein 1 in infectious mononucleosis and EBV-associated non-Hodgkin lymphoma: Th1 in active disease but Tr1 in remission

    Marshall, N. A., Culligan, D. J., Johnston, P. W., Millar, C., Barker, R. N., Vickers, M. A.
    British Journal of Haematology, vol. 139, no. 1, pp. 81-89
    Contributions to Journals: Articles

  • JAK2 V617F-positive polycythemia rubra vera maintained by approximately 18 stochastic stem cell divisions/year, explaining age of onest by a single rate-limiting mutation

    Vickers, M. A.
    Blood, vol. 110, no. 5, pp. 1675-1680
    Contributions to Journals: Articles

  • The relationships between Epstein-Barr virus latent membrane protein 1 and regulatory T cells in Hodgkin's lymphoma

    Marshall, N. A., Culligan, D. J., Tighe, J., Johnston, P. W., Barker, R. N., Vickers, M. A.
    Experimental Hematology, vol. 35, no. 4, pp. 596-604
    Contributions to Journals: Articles

  • Controlling autoimmunity—Lessons from the study of red blood cells as model antigens

    Barker, R. N., Vickers, M. A., Ward, F. J.
    Immunology Letters, vol. 108, no. 1, pp. 20-26
    Contributions to Journals: Articles

  • X inactivation patterns of closely, but not distantly, related cells are highly correlated: little evidence for stem cell plasticity in normal females

    Vickers, M. A., Canning, S. J., Craig, W. L., Masson, N. M., Wilson, I. J.
    Stem Cells, vol. 24, no. 11, pp. 2398-2405
    Contributions to Journals: Articles

  • Rh autoantigen presentation to helper T cells in chronic lymphocytic leukemia by malignant B cells

    Hall, A. M., Vickers, M. A., McLeod, E., Barker, R. N.
    Blood, vol. 105, no. 5, pp. 2007-2015
    Contributions to Journals: Articles

  • Pro-coagulant effects of environmental particles (PM10)

    Gilmour, P. S., Morrison, E. R., Henriksen, P., Vickers, M. A., Ford, I., Greaves, M., Donaldson, K., MacNee, W.
    Occupational and Environmental Medicine, vol. 62, pp. 164-171
    Contributions to Journals: Articles

  • Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.

    Mittal, S., Milner, B. J., Vickers, M. A.
    Clinical and Laboratory Haematology, vol. 27, pp. 402-404
    Contributions to Journals: Articles

  • The cryptic path from epitope to clot: a story of two domains?

    Vickers, M. A., Greaves, M.
    Blood, vol. 105, pp. 1371-1372
    Contributions to Journals: Editorials

  • Immunosuppressive regulatory T cells are abundant in the reactive lymphocytes of Hodgkin lymphoma

    Marshall, N. A., Christie, L. E., Munro, L. R., Culligan, D. J., Johnston, P. W., Barker, R. N., Vickers, M. A.
    Blood, vol. 103, no. 5, pp. 1755-1762
    Contributions to Journals: Articles

  • Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles.

    Gilmour, P. S., Ziesenis, A., Morrison, E. R., Vickers, M. A., Drost, E. M., Ford, I., Karg, E., Mossa, C., Schroeppel, A., Ferron, G. A., Heyder, J., Greaves, M., MacNee, W., Donaldson, K.
    Toxicology and Applied Pharmacology, vol. 195, pp. 35-44
    Contributions to Journals: Articles

  • Markers of endothelial activation and atherothrombosis in women with history of preeclampsia or gestational hypertension

    Vickers, M., Ford, I., Morrison, R., Prescott, G., Watson, S., Hannaford, P., Smith, C., Campbell, D., Greaves, M.
    Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1192-1197
    Contributions to Journals: Articles

  • Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 1

    Marshall, N. A., Vickers, M. A., Barker, R. N.
    Journal of Immunology, vol. 170, no. 12, pp. 6183-6189
    Contributions to Journals: Articles

  • Regulatory T cells secreting IL-10 dominate the immune response to EBV latent membrane protein 11

    Marshall, N. A., Vickers, M. A., Barker, R. N.
    The Journal of Immunology, vol. 170, no. 12, pp. 6183-6189
    Contributions to Journals: Articles

  • Fatal myelodysplastic syndrome developing during therapy with imatinib mesylate and characterised by the emergence of complex Philadelphia negative clones [1]

    Chee, Y. L., Vickers, M. A., Stevenson, D., Holyoake, T. L., Culligan, D. J.
    Leukemia, vol. 17, no. 3, pp. 634-635
    Contributions to Journals: Letters

  • Imatinib mesylate-induced molecular remission of Philadelphia chromosome-positive myelodysplastic syndrome [3]

    Drummond, M. W., Lush, C. J., Vickers, M. A., Reid, F. M., Kaeda, J., Holyoake, T. L.
    Leukemia, vol. 17, no. 2, pp. 463-465
    Contributions to Journals: Letters

  • Cellular turnover of normal gastrointestinal epithelium assessed by changes in telomeric: total DNA signal ratios

    Craig, W. L., McKinlay, A., Vickers, M. A.
    European Journal of Gastroenterology & Hepatology, vol. 15, no. 11, pp. 1195-1201
    Contributions to Journals: Articles

  • Markers of endothelial activation and atherothrombosis in women with history of pre-eclampsia or gestational hypertension

    Vickers, M. A., Ford, I., Morrison, R., Prescott, G. J., Watson, S., Hannaford, P. C., Smith, W. C. S., Campbell, D. M., Greaves, M.
    Thrombosis and Haemostasis, vol. 90, no. 6, pp. 1192-1197
    Contributions to Journals: Articles

  • Polymorphisms in the interleukin-10 and interferon gamma genes in Hodgkin lymphoma

    Munro, L. R., Johnston, P. W., Canning, S. J., Vickers, M. A., Marshall, N. A., Hewitt, S. G., Tveita, K.
    Leukemia & Lymphoma, vol. 44, no. 12, pp. 2083-2088
    Contributions to Journals: Articles

  • Interleukin-10-mediated regulatory T-cell responses to epitopes on a human red blood cell autoantigen

    Hall, A. M., Ward, F. J., Vickers, M. A., Stott, L., Urbaniak, S., Barker, R. N.
    Blood, vol. 100, no. 13, pp. 4529-4536
    Contributions to Journals: Articles

  • Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review

    Morrison, E. R., Miedzybrodzka, Z. H., Campbell, D. M., Haites, N. E., Wilson, B., Watson, M., Greaves, M., Vickers, M. A.
    Thrombosis and Haemostasis, vol. 87, no. 5, pp. 779-785
    Contributions to Journals: Articles

  • Estimation of mutation rate at human glycophorin A locus in hematopoietic stem cell progenitors

    Vickers, M. A., Hoy, T., Kyoizumi, S., Hewitt, M., Lake, H., Boyse, J.
    Environmental and Molecular Mutagenesis, vol. 39, no. 4, pp. 333-341
    Contributions to Journals: Articles

  • Genotype at a promoter polymorphism of the interleukin-6 gene is associated with baseline levels of plasma C-reactive protein

    Vickers, M. A., Green, F. R., Mayosi, B. M., Lathrop, M., Ratcliffe, P., Watkins, H., Keavney, B., Terry, C., Julier, C.
    Cardiovascular Research, vol. 53, no. 4, pp. 1029-1034
    Contributions to Journals: Articles

  • The ninety-fifth annual general meeting of the association of physicians of Great Britain and Ireland 2001

    Finlayson, N. D., Tomlinson, S., Weetman, A. P., Connell, J. M., Hill, A. V., Savage, C. O., Wiles, C. M., Williams, B., Ireland, J., Vallance, P., Whyte, M., Seckl, J. R., Jung, R., McKillop, J. H., Stout, R. W., Atkinson, A. B., Tomkin, G. H., Adgey, A. A., Axon, A. T., Beck, P., Eastwood, J. B., Fitzgerald, M., Godman, M. J., Heath, D. A., Kendall, M. J., MacGregor, G. A., Petrie, J. C., Ell, R. G., Allan, R. N., Barry, R. E., Boulton Jones, J. M., Evans, C. C., George, C. F., Heading, R. C., Jewell, D. P., Lazarus, J. H., Parker, A. C., Rawlins, M. D., Thurston, H., Cappuccio, F. P., Conlon, C. P., John, C. S., Dornhurst, A., Douglas, J. G., Elborn, J. S., El-Omar, E., Friedland, J. S., Gilks, C. F., Groves, R. W., Hall, A. S., Hawkey, C. J., Hillhouse, E., Hughes, J., Isaacs, J., Jardine, A. G., Jodrell, D. I., Jones, D. E., Monson, J. P., Price, P., Pugh, C. W., Ray, D. W., Santis, G., Satsangi, J., Scott, D. G., Scott, D. L., Vickers, M. A., Wardlaw, A.
    QJM - Monthly Journal of the Association of Physicians, vol. 94, no. 11, pp. 643-655
    Contributions to Journals: Articles

  • Assessment of mechanism of acquired skewed X inactivation by analysis of twins

    Vickers, M. A., McLeod, E., Wilson, I. J., Spector, T. D.
    Blood, vol. 97, no. 5, pp. 1274-1281
    Contributions to Journals: Articles

  • Plasma homocysteine concentrations in the acute and convalescent periods of atherothrombotic stroke

    Meiklejohn, D. J., Vickers, M. A., Dijkhuisen, R., Greaves, M.
    Stroke, vol. 32, no. 1, pp. 57-62
    Contributions to Journals: Articles

  • Evidence for a quantitative trait locus for plasma fibrinogen from a family-based association study.

    Mayosi, B. M., Vickers, M. A., Green, F. R., Ratcliffe, P. J., Julier, C., Lathrop, G. M., Watkins, H., Keavney, B.
    Genescreen, vol. 1, pp. 151-155
    Contributions to Journals: Articles

  • In vivo platelet activation in atherothrombotic stroke is not determined by polymorphisms of human platelet glycoprotein IIIa or Ib

    Meiklejohn, D. J., Vickers, M. A., Morrison, E. R., Dijkhuisen, R., Moore, I., Urbaniak, S., Greaves, M.
    British Journal of Haematology, vol. 112, no. 3, pp. 621-631
    Contributions to Journals: Articles

  • Monosomy for the most telomeric, gene-rich region of human chromosome 16p causes minimal phenotypic effects

    Horsley, S. W., Daniels, R. J., Anguita, E., Raynham, H. A., Peden, J. F., Villegas, A., Vickers, M. A.
    EJHG : European journal of human genetics : the official journal of the European Society of Human Genetics. , vol. 9, pp. 217-225
    Contributions to Journals: Articles

  • Beta-tubulin gene mutations and response to vinca alkaloids in acute lymphoblastic leukaemia

    Milner, B. J., Vickers, M. A., Schofield, A. C., Culligan, D. J., Tighe, J. E., Haites, N. E., King, D.
    Journal of Medical Genetics, vol. 37, no. Supplement, pp. S42
    Contributions to Journals: Articles

  • Genetic basis of variation in fibrinogen and CRP

    Mayosi, B. M., Green, F. R., Vickers, M. A., Watkins, H., Keavney, B.
    Heart, vol. 83, no. SUPPL. 1
    Contributions to Journals: Articles

  • Modelling haemopoietic stem cell division by analysis of mutant red cells

    Vickers, M., Brown, G. C., Cologne, J. B., Kyoizumi, S.
    British Journal of Haematology, vol. 110, pp. 54-62
    Contributions to Journals: Articles

  • The incidence of acute promyelocytic leukemia appears constant over most of a human lifespan, implying only one rate limiting mutation

    Vickers, M., Jackson, G., Taylor, P.
    Leukemia, vol. 14, pp. 722-726
    Contributions to Journals: Articles

  • Splenic irradiation before bone marrow transplantation for chronic myeloid leukaemia (multiple letters) [9]

    Vickers, M., Gratwohl, A., Hermans, J.
    British Journal of Haematology, vol. 97, no. 1, pp. 248-249
    Contributions to Journals: Letters

  • More or less hematopoietic stem cells

    Vickers, M.
    Nature Medicine, vol. 2, no. 12, pp. 1281-1282
    Contributions to Journals: Letters

  • Estimation of the number of mutations necessary to cause chronic myeloid leukaemia from epidemiological data

    Vickers, M.
    Contributions to Journals: Short Survey
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