MBChB MRCP DM FRCPath
Chair in Applied Medicine (Clin)
- About
-
- Email Address
- m.a.vickers@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272401
- Office Address
1. Room 3:25, Institute of Medical Sciences
2. Blood Transfusion Centre, Foresterhill Road, Aberdeen AB25 2ZW
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I graduated from Oxford Medical School in 1983, having completed a Biochemistry Part II at Cambridge. After general medical jobs in London, I worked with Doug Higgs on genes surrounding the alpha-globin gene cluster. I then trained in clinical Haematology at the Hammersmith, Reading and John Radcliffe Hospitals (1990–1996). I moved to Aberdeen in 1996 and was promoted to Professor in the section of Applied Medicine in 2008. I took over directorship of the Academic Transfusion Medicine Unit in 2010.
External Memberships
Member of Royal College of Physicians
Fellow of Royal College of Pathologists
British Society for Haematology
- Research
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Research Overview
My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.My main current interest is in how cells are recognised as being damaged by phagocytes, using red blood cells as the main model system. Our work has implicated unusual glycosylation motifs as being key to the process and are of particular relevance to the mechanism of haemolysis in sickle cell disease and malaria. The mechanism gives insight into splenic function, notably susceptibility to pneumococcal infection. I have interests in cellular immunotherapy, including the use of blood donor derived cytotoxic lymphocytes to treat post-transplant lympoproliferative disease and COVID-19. I am supervising PhD students developing innate immunotherapeutic reagents to treat cancers. I am also involved in collection and use of convalescent plasma for COVID-19.
Knowledge Exchange
I have given talks about the use of convalescent plasma and T cells to treat COVID-19.
Collaborations
Prof. Alex Rowe, Edinburgh University.
Prof. Stuart Haslam, Imperial College London.
Prof. David Rees, King's College London.
Supervision
Shiva Nickaria, Raquel Ferro, Ellen Main - all working on immunotherapies.
- Teaching
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Teaching Responsibilities
I organise, and deliver much of, the haematology training in the medical school. I remain an enthusiastic bedside teacher. I co-ordinated the third year medical degree 1997-2010.
- Publications
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Season of infectious mononucleosis as a risk factor for multiple sclerosis: a UK primary care case-control study
Multiple Sclerosis and Related Disorders, vol. 17, pp. 103-106Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.msard.2017.07.009
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/2/Revised_Paper_clean.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/1/im_in_ms_flow_chart.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/3/Supplemental_Tables.docx
Effective antigen presentation to helper T cells by human eosinophils
Immunology, vol. 149, no. 4, pp. 413-422Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/imm.12658
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9327/1/Farhan_et_al_2016_Immunology.pdf
Leukocyte Ig-Like receptor B1 restrains dendritic cell function through increased expression of the NF-κB regulator ABIN1/TNIP1
Journal of Leukocyte Biology, vol. 100, no. 4, pp. 737-746Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1189/jlb.1A0915-420RRR
Adoptive immunotherapy for primary immunodeficiency disorders with virus-specific T lymphocytes
Journal of Allergy and Clinical Immunology, vol. 137, no. 5, pp. 1498-1505Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jaci.2015.12.1311
Intraoperative salvage does not affect expression of markers for erythrophagocytosis
Transfusion Medicine, vol. 26, no. 2, pp. 147-149Contributions to Journals: Letters- [ONLINE] DOI: https://doi.org/10.1111/tme.12288
Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and rheumatoid arthritis
Arthritis Research & Therapy, vol. 17, pp. 274Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13075-015-0755-6
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4995/1/s13075_015_0755_6.pdf
Intraoperative cell salvage may damage erythrocytes as indicated by macrophage uptake
Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, pp. 31-31Contributions to Journals: AbstractsHow do immune responses differ against senescent and damaged erythrocytes: profiling sugar and protein changes on the cell surface
Immunology, vol. 143, no. s2, pp. 118-119Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/imm.12406
Establishment and operation of a Good Manufacturing Practice-compliant allogeneic Epstein-Barr virus (EBV)-specific cytotoxic cell bank for the treatment of EBV-associated lymphoproliferative disease
British Journal of Haematology, vol. 167, no. 3, pp. 402-410Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bjh.13051
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4107/1/bjh13051.pdf
Human interleukin-27: wide individual variation in plasma levels and complex inter-relationships with interleukin-17A
Clinical and Experimental Immunology, vol. 178, no. 2, pp. 373-383Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/cei.12408