![Dr Laurent Trembleau Dr Laurent Trembleau](/img/200x200/staffpages/uploads/che676/lt.jpg)
PhD, Chemical Engineer
Senior Lecturer
- About
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- Email Address
- l.trembleau@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272922
- Office Address
Telephone: +44 (0)1224 272922 Address: School of Natural and Computing Sciences University of Aberdeen Meston Building, Room G95 Aberdeen AB24 3UE
- School/Department
- School of Natural and Computing Sciences
Biography
Laurent Trembleau received his undergraduate education at the "Institut Universitaire de Technologie" of Orléans (France) and obtained a "Diplôme d'Ingénieur" in Fine Chemistry and Engineering, and a "Diplôme d'Etudes Approfondies" (DEA) in Chemistry at the "Institut National des Sciences Appliquées" of Rouen, France (1993). In 1994, he moved to Louvain-la-Neuve (Belgium) to undertake a PhD in the group of Professor Léon Ghosez. His work, financed by Rhône-Poulenc Rorer, involved the development of new Diels-Alder reactions and methods towards the synthesis of ottelione A, a natural product inhibitor of tubulin polymerisation. In 2001, he moved to the Scripps Research Institute (USA) for a 2-year post-doctoral position in the group of Professor Julius Rebek where he designed a water-soluble receptor of acetylcholine, described the helical conformation of alkanes in synthetic receptors, and was involved in the synthesis of oxazole-based macrocycles. In 2004, he did a short post-doctoral position in the group of Dr Simon Webb, where he worked on the synthesis of novel lipids designed to mimic cell adhesion molecules. At the end of 2004, he accepted a Lectureship in Medicinal Chemistry at the University of Aberdeen, where he is currently studying the total synthesis and SAR of bioactive molecules, the development of organic catalysts and novel methods for application in Organic Synthesis and Medicinal Chemistry.
- Research
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Current Research
1) Methodology
Peptide Synthesis
We are interested in the development of efficient solution and solid-phase syntheses of peptides. We have recently optimized a repetitive procedure that contains features from both solid-phase and solution-phase methods, making it an effective method for the synthesis of short peptides. We are currently modifying resins to improve the synthesis of "difficult peptide sequences".
Supramolecular Chemistry
1) We are investigating the properties of novel organocatalysts that mimic the residues of enzymes involved in catalysis.
2) We are developing new foldamers with the aim to bind anions (especially fluoride) in aqueous media.
2) Medicinal Chemistry
Inhibitors of Protein-Protein Interactions (PPI): This project involves the design and synthesis of inhibitors of protein-protein interactions. We are developing macrocyclic molecules possessing large surface areas in the aim to inhibit specific protein-protein interactions (in collaboration with Prof M. Jaspars, Dr W. Houssen, and Prof J. Naismith).
Funding and Grants
- European Commission "New Chemical Biology for Tayloring Novel Therapeutics - PDRA (2014-2019) (with Prof Marcel Jaspars and Prof Jim Naismith)
- Scottish Enterprise "Validation of the Commercial Potential of Diversity-Oriented Biosynthesis to Create Novel Macrocycle Drugs" - (2015-2016) with Prof Marcel Jaspars, Prof Jim Naismith and Dr Wael Houssen.
- Teaching
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Teaching Responsibilities
Dr Trembleau teaches in the following courses
- CM1022 Elements of Chemistry 1 (2 lectures)
- CM2512 Organic and Biological Chemistry (8 lectures)
- CM3521 Organic and Biological Chemistry (12 lectures)
- CM4516 Honours/Advanced Chemistry (12 lectures)
- CM5003 MChem Chemistry Applications (10 lectures)
- Publications
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Page 1 of 3 Results 1 to 25 of 58
Accraspiroketides A-B, Phenylnaphthacenoid-Derived Polyketides with Unprecedented [6+6+6+6]+[5+5] Spiro-Architecture
Journal of Natural Products, vol. 87, no. 4, pp. 831-836Contributions to Journals: ArticlesDesign, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents
Pharmaceuticals, vol. 16, no. 7, 1039Contributions to Journals: ArticlesDesign, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors
Journal of enzyme inhibition and medicinal chemistry, vol. 38, no. 1, 2218602Contributions to Journals: ArticlesDiscovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action
RSC Medicinal Chemistry, vol. 14, no. 4, pp. 734-744Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/d3md00038a
- [ONLINE] View publication in Scopus
Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways
Molecules, vol. 28, no. 3, 1269Contributions to Journals: ArticlesA ribosomally synthesised and post-translationally modified peptide containing a β-enamino acid and a macrocyclic motif
Nature Communications, vol. 13, no. 1, 5044Contributions to Journals: ArticlesSynthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors
Pharmaceuticals, vol. 15, no. 8, 1006Contributions to Journals: ArticlesOptimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities
Bioorganic Chemistry, vol. 120, 105616Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bioorg.2022.105616
- [ONLINE] View publication in Scopus
Characterization of a class II ketol-acid reductoisomerase from Mycobacterium tuberculosis
RSC Advances, vol. 12, no. 17, pp. 10540-10544Contributions to Journals: ArticlesDiscovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease
Bioorganic Chemistry, vol. 116, 105363Contributions to Journals: ArticlesNovel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects
Bioorganic Chemistry, vol. 116, 105302Contributions to Journals: ArticlesDesign, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity
Bioorganic Chemistry, vol. 112, 104960Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bioorg.2021.104960
Discovery and biosynthetic investigation of a new antibacterial dehydrated non‐ribosomal tripeptide
Angewandte Chemie International Edition, vol. 60, no. 6, pp. 3229-3237Contributions to Journals: ArticlesA novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models
Neuropsychopharmacology, vol. 46, no. 2, pp. 413-422Contributions to Journals: ArticlesProductive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels–Alder Pattern Common to Three Classes of Natural Products
Chemistry - A European Journal, vol. 26, no. 67, pp. 15477-15481Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/chem.202002372
- [ONLINE] View publication in Scopus
Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors
Bioorganic Chemistry, vol. 104, 104260Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.bioorg.2020.104260
- [ONLINE] View publication in Scopus
A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms
Microorganisms, vol. 8, no. 7, 1066Contributions to Journals: ArticlesCharacterization of the promiscuous N-acyl CoA transferase, LgoC, in legonoxamine biosynthesis
Organic & Biomolecular Chemistry, vol. 18, no. 12, pp. 2219-2222Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1039/d0ob00320d
- [ONLINE] View publication in Scopus
Structure‐based design, synthesis and bioactivity of a new anti‐TNFα cyclopeptide
Molecules, vol. 25, no. 4, 922Contributions to Journals: ArticlesEnzymatic Reconstitution and Biosynthetic Investigation of the Bacterial Carbazole Neocarazostatin A
Journal of Organic Chemistry, vol. 84, no. 24, pp. 16323-16328Contributions to Journals: ArticlesPhysicochemical Tools: Toward a Detailed Understanding of the Architecture of Targeted Radiotherapy Nanoparticles
ACS Applied Bio Materials, vol. 1, no. 5, pp. 1639-1646Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/acsabm.8b00476
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13128/1/Cabello_et_alFinal.pdf
Cyclic Peptides – A Look to the Future
Cyclic Peptides: From Bioorganic Synthesis to Applications. Koehnke, J., Naismith, J., van der Donk, W. A. (eds.). Royal Society of Chemistry (Great Britain), pp. 340-373, 34 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1039/9781788010153-00340
Cyclic peptide production using a macrocyclase with enhanced substrate promiscuity and relaxed recognition determinants
Chemical Communications, vol. 53, no. 77, pp. 10656-10659Contributions to Journals: ArticlesA Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize
The Journal of Physical Chemistry Letters, vol. 8, no. 10, pp. 2310-2315Contributions to Journals: ArticlesDevelopment of indole sulfonamides as cannabinoid receptor negative allosteric modulators
Bioorganic & Medicinal Chemistry Letters, vol. 26, no. 18, pp. 4403-4407Contributions to Journals: Articles