Dr Lynda Constable

Biography

I joined HSRU as a Trial Manager in 2012 and took up the role of Deputy Senior Trial Manager in 2021.

I am the Lead Trial Manager on the DIAMOND, CATHETER II, VUE,  MASTER and ASICA trials.

DIAMOND is an NIHR-HTA funder multi-centre randomised controlled trial (RCT) to compare medical management versus early planned surgery in women with deep endometriosis.

CATHETER II is an NIHR-HTA funded RCT to determine whether or not a weekly prophylactic catheter washout regime improves catheter related complications.

VUE is two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse, funded by the NIHR HTA.

MASTER is an NIHR-HTA funded RCT investigating the surgical treatment of male stress urinary incontinence after prostate surgery.

ASICA is a Cancer Research UK funded pilot RCT investigating the ASICA (Achieving self-directed integrated cancer aftercare) digital intervention for supporting high quality total skin self-examination in those with cutaneous melanoma.

I also coordinate the Institute of Applied Health Sciences seminars.

I gained a BSc in Biosciences and Chemistry and a PhD in Cancer cell and Molecular biology. Prior to joining the unit, I worked as a Research Fellow at Aberdeen University on a range of projects with an emphasis on cancer biomarkers.

Research Overview

Clinical trials methodology

Clinical trial management

Current Research

VUE Trial: Vault or Uterine prolapse surgery evaluation: Two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse.

MASTER Trial: investigating the surgical treatment of male stress incontinence after prostate surgery.

ASICA: Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: A randomised patient-focused trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma

CATHETER II Trial: evaluating the effect of weekly saline or acidic prophylactic catheter washout policies with standard care on catheter related complications.

Teaching Responsibilities

I have supervised a number of BSc and MSc student research projects, including topics such as understanding patient's decision making to participate in clinical trials; rapid introduction of new cancer therapies; personalised cancer therapies; and investigation of the mode of action novel cancer therapeutics.