Search Menu
People

Dr Lynda Constable

Dr Lynda Constable
Dr Lynda Constable
Dr Lynda Constable

BSc (Hons), PhD

Trial Manager

About
Email Address
l.constable@abdn.ac.uk
Office Address

Centre for Healthcare Randomised Trials (CHaRT)

Health Services Research Unit

University of Aberdeen

3rd Floor Health Sciences Building

Foresterhill

ABERDEEN AB25 2ZD

School/Department
School of Medicine, Medical Sciences and Nutrition

Biography

I joined HSRU as a Trial Manager in 2012 and took up the role of Deputy Senior Trial Manager in 2021.

I am the Lead Trial Manager on the DIAMOND, CATHETER II, VUE,  MASTER and ASICA trials.

DIAMOND is an NIHR-HTA funder multi-centre randomised controlled trial (RCT) to compare medical management versus early planned surgery in women with deep endometriosis.

CATHETER II is an NIHR-HTA funded RCT to determine whether or not a weekly prophylactic catheter washout regime improves catheter related complications.

VUE is two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse, funded by the NIHR HTA.

MASTER is an NIHR-HTA funded RCT investigating the surgical treatment of male stress urinary incontinence after prostate surgery.

ASICA is a Cancer Research UK funded pilot RCT investigating the ASICA (Achieving self-directed integrated cancer aftercare) digital intervention for supporting high quality total skin self-examination in those with cutaneous melanoma.

I also coordinate the Institute of Applied Health Sciences seminars.

I gained a BSc in Biosciences and Chemistry and a PhD in Cancer cell and Molecular biology. Prior to joining the unit, I worked as a Research Fellow at Aberdeen University on a range of projects with an emphasis on cancer biomarkers.

Memberships and Affiliations

Internal Memberships

IAHS Seminars Coordinator

External Memberships

Member of the Education Committee for the Society for Clinical Trials (2013 - 2020)

Chair of the Education Committee for the Society for Clinical Trials (2018-2019)

Co-Chair of the Education Committee for the Society for Clinical Trials (2017-2018)

Chair of the Webinar Committee for the Society for Clinical Trials (2017-2018)

Member of the Board of Directors for the Society for Clinical Trials (2016)

Latest Publications

  • CATHETER II, a randomised controlled trial comparing the clinical and cost effectiveness of various washout policies versus no washout policy in preventing catheter associated complications in adults living with long term catheters

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Dimitropoulos, K., Evans, S., Granitsiotis, P., Hashim, H., Kilonzo, M., Larcombe, J., Little, P., Murchie, P., Myint, P. K., N'Dow, J., Paterson, C., Powell, K., Scotland, G., Thiruchelvam, N., Young, A. J., Cotton, S., Norrie, J., MacLennan, G.
    BMJ Open
    Contributions to Journals: Articles

  • Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Tripathee, S., Johnson, D., Constable, L., Cotton, S., Omar, M. I., Abdel-Fattah, M., MacLennan, S.
    RCOG World Congress 2024
    Contributions to Conferences: Posters

  • Patient and health care professionals’ perception of weekly prophylactic catheter washout in adults living with long-term catheters: Qualitative Study of the CATHETER II Trial

    Tripathee, S., Johnson, D., Constable, L., Cotton, S., Omar, M. I., Abdel-Fattah, M., MacLennan, S.
    The International Continence Society
    Contributions to Conferences: Posters

  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    RCOG World Congress 2024
    Contributions to Conferences: Posters

  • RCT comparing the clinical and cost effectiveness of various catheter washout policies

    Abdel-Fattah, M., Omar, M. I., Johnson, D., Cooper, D., Constable, L., Tripathee, S., MacLennan, S., Cotton, S., Norrie, J., MacLennan, G., Team, C. I.
    The International Continence Society
    Contributions to Conferences: Posters

View My Publications

Research

Research Overview

Clinical trials methodology

Clinical trial management

Research Areas

Applied Health Sciences

View Research Area

Current Research

VUE Trial: Vault or Uterine prolapse surgery evaluation: Two parallel randomised controlled trials of surgical options for upper compartment (vault or uterine) pelvic organ prolapse.

MASTER Trial: investigating the surgical treatment of male stress incontinence after prostate surgery.

ASICA: Achieving Self-Directed Integrated Cancer Aftercare (ASICA) in melanoma: A randomised patient-focused trial of delivering the ASICA intervention as a means to earlier detection of recurrent and second primary melanoma

CATHETER II Trial: evaluating the effect of weekly saline or acidic prophylactic catheter washout policies with standard care on catheter related complications.

Teaching

Teaching Responsibilities

I have supervised a number of BSc and MSc student research projects, including topics such as understanding patient's decision making to participate in clinical trials; rapid introduction of new cancer therapies; personalised cancer therapies; and investigation of the mode of action novel cancer therapeutics.

Publications

Page 3 of 3 Results 21 to 30 of 30

  • Two parallel, pragmatic, UK multicentre, randomised controlled trials comparing surgical options for upper compartment (vault or uterine) pelvic organ prolapse (the VUE Study): study protocol for a randomised controlled trial

    Glazener, C., Constable, L., Hemming, C., Breeman, S., Elders, A., Cooper, K., Freeman, R., Smith, A. R. B., Hagen, S., McDonald, A., McPherson, G., Montgomery, I., Kilonzo, M., Boyers, D., Goulao, B., Norrie, J.
    Trials, vol. 17, pp. 1-18
    Contributions to Journals: Articles

  • How effective is mesh in pelvic organ prolapse surgery? An updated systematic review of randomised controlled trials

    Stewart, F., Constable, L. D., Cruickshank, M., Robertson, C., Glazener, C. M. A.
    Neurourology and Urodynamics, vol. 35, no. Suppl., pp. S299
    Contributions to Journals: Abstracts

  • The influence of bisnaphthalimidopropyl polyamines on DNA instability and repair in Caco-2 colon epithelial cells

    Bestwick, C. S., Ralton, L. D., Milne, L., Lin, P. K. T., Duthie, S. J.
    Cell Biology and Toxicology, vol. 27, no. 6, pp. 455-463
    Contributions to Journals: Articles

  • The proteomics of colorectal cancer: identification of a protein signature associated with prognosis

    O'Dwyer, D., Ralton, L. D., O'Shea, A., Murray, G. I.
    PloS ONE, vol. 6, no. 11, e27718
    Contributions to Journals: Articles

  • The use of formalin fixed wax embedded tissue for proteomic analysis

    Ralton, L. D., Murray, G. I.
    Journal of Clinical Pathology, vol. 64, no. 4, pp. 297-302
    Contributions to Journals: Articles

  • Biomarkers for colorectal cancer: identification through proteomics

    Ralton, L. D., Murray, G. I.
    Current Proteomics, vol. 7, no. 3, pp. 212-221
    Contributions to Journals: Articles

  • Bisnaphthalimidopropyl spermidine induces apoptosis within colon carcinoma cells

    Ralton, L. D., Bestwick, C. S., Milne, L., Duthie, S., Lin, P. K. T.
    Chemico-Biological Interactions, vol. 177, no. 1, pp. 1-6
    Contributions to Journals: Articles

  • Polyamine Analogues and Derivatives as Potential Anticancer Agents

    Ralton, L., Bestwick, C., Kong, P. T. L.
    Current Bioactive Compounds, vol. 3, no. 3, pp. 179-191
    Contributions to Journals: Articles

  • The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum

    Oliveira, J., Ralton, L. D., Tavares, J., Codeiro-da-Silva, A., Bestwick, C., McPherson, A., Lin, P. K. T.
    Bioorganic & Medicinal Chemistry, vol. 15, no. 1, pp. 541-545
    Contributions to Journals: Articles

  • Synthesis and biological activities of bisnaphthalimido polyamines derivatives

    Dance, A. M., Ralton, L. D., Fuller, Z., Milne, L., Duthie, S. J., Bestwick, C., Lin, P. K. T.
    Biochemical Pharmacology, vol. 69, no. 1, pp. 19-27
    Contributions to Journals: Articles
Show 10 | 25 | 50 | 100 results per page

Refine

Contributions to Conferences

Contributions to Journals

Update