BSc, PhD (KC, London)
Chair in Pharmaceutical Industrial Chemistry
- About
-
- Email Address
- j.storey@abdn.ac.uk
- Telephone Number
- +44 (0)1224 272926
- Office Address
- Meston Room G106
- School/Department
- School of Natural and Computing Sciences
External Memberships
Head Chemist for TauRx Therapeutics
- Research
-
Research Overview
Free Radical Chemistry, Organic Methodology, Medicinal Chemistry
Our ability as organic chemists to develop new drugs to combat various diseases depends critically on understanding the behaviour of molecules and using this knowledge to prepare molecules efficiently. It is probably true to say that organic chemistry has reached a point where most molecules can be synthesised given sufficient resources. However, we are far from the position where this can be routinely accomplished in an efficient, atom economical, stereocontrolled and environmentally friendly manner. The major focus of my research effort is, therefore, the development of new synthetic methods and strategies in an attempt to meet some of these shortfalls.
An area that we are particularly interested in is the use of free radical reactions. Radical reactions offer the synthetic organic chemist a number of advantages, which include mild reaction conditions, high levels of regio control and significant functional group tolerance without the need to use protecting groups. We are interested in developing new methods of conducting radical reactions, the use of radical reactions in new bond forming processes and the use of radicals for the synthesis of biologically active compounds of medicinal significance.
Other research areas within the group include mechanistic studies in a variety of reactions, sugar chemistry with a view to the synthesis of biologically active fused carbosugars and tandem bond forming reaction protocols using organochromium compounds. We are also involved in a number of collaborative projects with the medical faculty.
Current Research
Selected Current Projects
- Synthesis of biologically active fused pyridine, pyrimidine and pteridine heterocycles via radical translocation followed by cyclisation.
- A protecting group strategy for the synthesis of C-glycosides, disaccharides and fused carbosugars.
- Iodine atom transfer cyclisation as a route to a range of heterocyclic systems of biological significance.
- New methods of conducting and mediating radical reactions with an emphasis on the development of environmentally friendly systems.
- The use of organic molecules as asymmetric catalysts.
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- Teaching
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Teaching Responsibilities
Professor Storey teaches in the following courses:Â
- CM1010
- CM1011
- CM4017/CM3024 Honours/Advanced Chemistry
- CM5003 MChem Chemistry Applications
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- Publications
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Page 9 of 15 Results 81 to 90 of 149
Electrically tunable laser based on oblique heliconical cholesteric liquid crystal
PNAS, vol. 113, no. 46, pp. 12925-12928Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1612212113
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7849/1/PNAS_2016_Xiang_12925_8.pdf
- [ONLINE] View publication in Scopus
Magnetically tunable selective reflection of light by heliconical cholesterics
Physical Review. E, Statistical, Nonlinear and Soft Matter Physics, vol. 94, no. 4, 042705Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1103/PhysRevE.94.042705
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7841/1/PhysRevE.94.042705.pdf
- [ONLINE] View publication in Scopus
An FT-IR spectroscopic study of the role of hydrogen bonding in the formation of liquid crystallinity for mixtures containing bipyridines and 4-pentoxybenzoic acid
RSC Advances, vol. 6, no. 110, pp. 108164 –108179Contributions to Journals: ArticlesWeak interactions in the crystal structures of two indole derivatives
Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 7, pp. 964-968Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S2056989016008616
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6283/1/sj5499.pdf
Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease
Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Wolfe, M. S. (ed.). Elsevier Inc., pp. 385-436, 52 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-802173-6.00015-0
- [ONLINE] View publication in Scopus
Different N—H···π interactions in two indole derivatives
Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 5, pp. 699-703Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S2056989016006162
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5932/1/pk2578.pdf
Reversible Isothermal Twist-Bend Nematic-Nematic Phase Transition Driven by the Photoisomerization of an Azobenzene-Based Nonsymmetric Liquid Crystal Dimer
Journal of the American Chemical Society, vol. 138, no. 16, pp. 5283-5289Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/jacs.5b13331
Crystal structures of four indole derivatives with a phenyl substituent at the 2-position and a carbonyl group at the 3-position: the C(6) N-H⋯O chain remains the same, but the weak reinforcing inter-actions are different
Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 3, pp. 363-369Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S2056989016002620
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7673/1/xu5883.pdf
Investigations into the construction of the pentasubstituted ring C of Neosurugatoxin – a crystallographic study
Acta Crystallographica Section E: Crystallographic Communications, vol. 72, no. 1, pp. 44-48Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S2056989015023506
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5293/1/gk2648.pdf
Ethyl 2-(5-bromo-2-iodoanilino)cyclopent-1-ene-1-carboxylate
IUCrData, vol. 1, no. 1, pp. 1-7Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1107/S2414314615021781
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5529/1/wm4001.pdf