Senior Lecturer
- About
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- Email Address
- i.n.fleming@abdn.ac.uk
- Telephone Number
- +44 (0)1224 438357
- Office Address
Aberdeen Biomedical Imaging Centre, Office 6.16, Institute of Medical Research, Foresterhill, Aberdeen AB25 2ZD, UK
- School/Department
- School of Medicine, Medical Sciences and Nutrition
- Research
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Research Overview
Development of novel Positron Emission Tomography (PET) radiotracers to study the biological processes that are characteristic of tumour cells.
Development, validation and/or qualification of existing PET radiotracers so that they can be used as predictive, prognostic, pharmacological and/or surrogate response biomarkers in oncology patients.
Current Research
Current projects involve tracers to study cell proliferation, hypoxia and angiogenesis.
Collaborations
Prof Fiona Gilbert, University of Cambridge
Prof Paula Ghaneh, University of Liverpool
Prof David O'Hagan, University of St Andrews
Kemotech, Italy
Funding and Grants
Current Grants:
Validation of FLT-PET as a predictive biomarker in breast cancer (Cancer Research UK)
18F-fluoroazomycin-arabinofuranoside (FAZA) as a PET tracer in the detection of tumour hypoxia in patients with colorectal carcinoma: A pilot study (NHS Grampian Endowment)
Detection of hypoxia in breast cancer with Fluoroazomycin arabinoside (FAZA) analogues (Breast Cancer Campaign)
Studying the effect of different hypoxic subtypes on anti-cancer therapeutics in breast cancer cells (NHS Grampian Endowment)
Developing a novel αvβ3 radiotracer to report on tumour angiogenesis (Knowledge Exchange Transfer Fund)
Development of 18F-labelled PET tracer for preclinical HER2 imaging of gastroesophageal adenocarcinomas (NHS Grampian Endowment)
- Teaching
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Teaching Responsibilities
Programme coordinator & lecturer BT3006: Working Out? Placement & Career skills
Programme coordinator BT5007: Industrial Placement/MSci course
Course coordinator & lecturer PA3802: Principles of Chemotherapy and mechanisms of disease
Course coordinator & lecturer BP5003: Biomedical and other Professional Topics
Lecturer SM2501: Research skills for Medical Sciences
Coordinator of Hotstart programme
- Publications
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Subcellular distribution of N-ethylmaleimide-sensitive and -insensitive phosphatidic acid phosphohydrolase in rat brain
Biochimica et Biophysica Acta, vol. 1254, no. 2, pp. 161-8Contributions to Journals: ArticlesPartial purification of cell-signalling phosphatidic acid phosphohydrolase from rat liver
Biochemical Society Transactions, vol. 21, no. 4, pp. 366SContributions to Journals: ArticlesThe activity of the metabolic form of hepatic phosphatidate phosphohydrolase correlates with the severity of alcoholic fatty liver in human beings
Hepatology, vol. 18, no. 4, pp. 832-8Contributions to Journals: Articles
