BSc, PhD
Lecturer
- About
-
- Email Address
- dthompson@abdn.ac.uk
- Office Address
office 6.15/lab 2.48
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences,
Foresterhill, Aberdeen
ext: office:7513
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
I received my B.Sc Hons in Pharmacology from the University of Aberdeen before obtaining a Ph.D from the University of Strathclyde under the supervision of Prof Susan Pyne, where I studied the enzymes sphingosine kinase and sphingosine-1-phosphate phosphatase. My postdoctoral training began at the Ernest Gallo Clinic and Research Centre (University of California, San Francisco) in the laboratory of Professor Jennifer Whistler, where I investigated the consequences of disrupted GPCR trafficking in health an disease. Specifically, my work focused on the dopamine receptor family and their role in cocaine sensitisation. From here, I moved to the MRC Clinical Sciences Centre at Imperial College London followed by training at the William Harvey Research Centre at Queen Mary London in the laboratory of Profs Mauro Perretti and Roderick Flower where I studied the trafficking properties of the Formylpeptide receptor family (also GPCRs) and their role in innate immunity. I returned to the University of Aberdeen and continued my postdoctoral studies under the supervision of Prof Mirela Delibegovic investigating the role of protein tyrosine phosphatase 1B (PTP1B) in inflammation. In January 2020 I was appointed Lecturer in Medical Sciences.
- Research
-
Research Overview
My research philosophy involves determining processes at the molecular level and translating these into whole animal physiology. My specific focus is G protein-coupled receptor (GPCR) regulation and the molecular mechanisms controlling GPCR endocytosis and post-endocytic fate, how these control cellular function, how disruption of these process alters cell function and ultimately how this leads to disease in the animal.
Research Areas
Biomedical Sciences
Research Specialisms
- Pharmacology
- Neuroscience
- Cell Biology
- Immunology
- Diabetes
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
- Publications
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Page 1 of 2 Results 1 to 25 of 30
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
Cell Metabolism, vol. 36, no. 5, pp. 1076-1087Contributions to Journals: ArticlesA refined method of adult tissue resident stem cell derived primary human hepatic organoid cultures
Contributions to Journals: Conference Articles- [ONLINE] DOI: https://doi.org/10.1136/gutjnl-2023-BSG.101
FGF21 sensitivity in hepatocellular carcinoma could be impaired through reduction in FGFR1 and KLB expression
Contributions to Journals: Conference Articles- [ONLINE] DOI: https://doi.org/10.1136/gutjnl-2023-BSG.24
Hydroxysteroid 17-beta dehydrogenase 13(Hsd17b13)knockdown attenuates liver steatosis in high-fat diet obese mice
Working Papers: Preprint Papers- [ONLINE] DOI: https://doi.org/10.1101/2024.02.27.582262
P125: Development and Evaluation of a Novel Antibody to Human FGF21
Journal of Pathology, vol. 261, no. S1, pp. S63Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1002/path.6226
Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism
Journal of translational medicine, vol. 21, 715Contributions to Journals: ArticlesGenerating a novel 3D primary human hepatic organoid model for study of metabolic diseases
Contributions to Journals: Conference Articles- [ONLINE] DOI: https://doi.org/10.1136/heartjnl-SCF-2023.17
Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR-/- mice
Scientific Reports, vol. 13, 3937Contributions to Journals: ArticlesUsing Game of Thrones to teach physiology during lockdown and beyond.
Europhysiology 2022, pp. 263-264Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/apha.13875
Using Game of Thrones to teach neuroscience and neuropharmacology during lockdown
University of Aberdeen Annual Academic Development Symposium 2021Contributions to Conferences: PostersPhosphoprotein enriched in astrocytes (PEA)-15 is a novel regulator of adipose tissue expansion
Scientific Reports, vol. 11, 6949Contributions to Journals: ArticlesDesign, synthesis, radiosynthesis and biological evaluation of Fenretinide analogues as anticancer and metabolic syndromepreventive agents
ChemMedChem, vol. 15, no. 16, pp. 1579-1590Contributions to Journals: ArticlesEndocytic Sorting and Downregulation of the M2 Acetylcholine Receptor is Regulated by Ubiquitin and the ESCRT Complex
Neuropharmacology, vol. 162, 107828Contributions to Journals: ArticlesResponse to comment by Moxon et al
Clinical Science, vol. 132, no. 1, pp. 39-41Contributions to Journals: LettersPharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis
Clinical Science, vol. 131, no. 20, pp. 2489-2501Contributions to Journals: ArticlesMyeloid protein tyrosine phosphatase 1B (PTP1B) deficiency protects against atherosclerotic plaque formation in the ApoE−/− mouse model of atherosclerosis with alterations in IL10/AMPKα pathway
Molecular Metabolism, vol. 6, no. 8, pp. 845-853Contributions to Journals: ArticlesNovel G protein-coupled receptors in Pancreatic Beta cells
Experimental Biology, 1052.1Contributions to Journals: AbstractsIdentification of a novel recycling sequence in the C-tail of FPR2/ALX: association with cell protection from apoptosis
The Journal of Biological Chemistry, vol. 289, pp. 36166-36178Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M114.612630
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4240/1/36166.full.pdf
Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses
PNAS, vol. 110, no. 45, pp. 18232-18237Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1308253110
Increased axonal bouton dynamics in the aging mouse cortex
PNAS, vol. 110, no. 16, pp. E1514-E1523Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1073/pnas.1218731110
Trafficking properties of the D5 dopamine receptor
Traffic, vol. 12, no. 5, pp. 644-56Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1600-0854.2011.01179.x
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions
Journal of Medicinal Chemistry, vol. 54, no. 7, pp. 2477-91Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1021/jm101639t
Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1
The Journal of Biological Chemistry, vol. 286, no. 2, pp. 1598-608Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1074/jbc.M110.158345
Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1
Neuropsychopharmacology, vol. 35, no. 6, pp. 1363-73Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/npp.2010.6
The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28
Traffic, vol. 11, no. 5, pp. 660-74Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1600-0854.2010.1045.x
