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Dr Dawn Thompson

Dr Dawn Thompson
Dr Dawn Thompson
Dr Dawn Thompson

BSc, PhD

Lecturer

About
Email Address
dthompson@abdn.ac.uk
Office Address

office 6.15/lab 2.48

School of Medicine, Medical Sciences and Nutrition,

Institute of Medical Sciences,

Foresterhill, Aberdeen

ext: office:7513

School/Department
School of Medicine, Medical Sciences and Nutrition
ORCiD

Biography

I received my B.Sc Hons in Pharmacology from the University of Aberdeen before obtaining a Ph.D from the University of Strathclyde under the supervision of Prof Susan Pyne, where I studied the enzymes sphingosine kinase and sphingosine-1-phosphate phosphatase. My postdoctoral training began at the Ernest Gallo Clinic and Research Centre (University of California, San Francisco) in the laboratory of Professor Jennifer Whistler, where I investigated the consequences of disrupted GPCR trafficking in health an disease. Specifically, my work focused on the dopamine receptor family and their role in cocaine sensitisation. From here, I moved to the MRC Clinical Sciences Centre at Imperial College London followed by training at the William Harvey Research Centre at Queen Mary London in the laboratory of Profs Mauro Perretti and Roderick Flower where I studied the trafficking properties of the Formylpeptide receptor family (also GPCRs) and their role in innate immunity.  I returned to the University of Aberdeen and continued my postdoctoral studies under the supervision of Prof Mirela Delibegovic investigating the role of protein tyrosine phosphatase 1B (PTP1B) in inflammation. In January 2020 I was appointed Lecturer in Medical Sciences.     

Research

Research Overview

My research philosophy involves determining processes at the molecular level and translating these into whole animal physiology. My specific focus is G protein-coupled receptor (GPCR) regulation and the molecular mechanisms controlling GPCR endocytosis and post-endocytic fate, how these control cellular function, how disruption of these process alters cell function and ultimately how this leads to disease in the animal.  

Research Areas

Biomedical Sciences

View Research Area

Research Specialisms

  • Pharmacology
  • Neuroscience
  • Cell Biology
  • Immunology
  • Diabetes

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Publications

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  • Trafficking properties of the D5 dopamine receptor

    Thompson, D., Whistler, J. L.
    Traffic, vol. 12, no. 5, pp. 644-56
    Contributions to Journals: Articles

  • Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions

    Tschammer, N., Elsner, J., Goetz, A., Ehrlich, K., Schuster, S., Ruberg, M., Kühhorn, J., Thompson, D., Whistler, J., Hübner, H., Gmeiner, P.
    Journal of Medicinal Chemistry, vol. 54, no. 7, pp. 2477-91
    Contributions to Journals: Articles

  • Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1

    Thompson, D., Whistler, J. L.
    The Journal of Biological Chemistry, vol. 286, no. 2, pp. 1598-608
    Contributions to Journals: Articles

  • Differential regulation of behavioral tolerance to WIN55,212-2 by GASP1

    Martini, L., Thompson, D., Kharazia, V., Whistler, J. L.
    Neuropsychopharmacology, vol. 35, no. 6, pp. 1363-73
    Contributions to Journals: Articles

  • The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28

    Tschische, P., Moser, E., Thompson, D., Vischer, H. F., Parzmair, G. P., Pommer, V., Platzer, W., Schwarzbraun, T., Schaider, H., Smit, M. J., Martini, L., Whistler, J. L., Waldhoer, M.
    Traffic, vol. 11, no. 5, pp. 660-74
    Contributions to Journals: Articles

  • Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine

    Thompson, D., Martini, L., Whistler, J. L.
    PloS ONE, vol. 5, no. 6, pp. e11038
    Contributions to Journals: Articles

  • Changes in G protein-coupled receptor sorting protein affinity regulate postendocytic targeting of G protein-coupled receptors

    Thompson, D., Pusch, M., Whistler, J. L.
    The Journal of Biological Chemistry, vol. 282, no. 40, pp. 29178-85
    Contributions to Journals: Articles

  • Modulation of Kv3 subfamily potassium currents by the sea anemone toxin BDS: significance for CNS and biophysical studies

    Yeung, S. Y. M., Thompson, D., Wang, Z., Fedida, D., Robertson, B.
    Journal of Neuroscience, vol. 25, no. 38, pp. 8735-45
    Contributions to Journals: Articles

  • Sphingosine kinase 1 is an intracellular effector of phosphatidic acid

    Delon, C., Manifava, M., Wood, E., Thompson, D., Krugmann, S., Pyne, S., Ktistakis, N. T.
    The Journal of Biological Chemistry, vol. 279, no. 43, pp. 44763-74
    Contributions to Journals: Articles

  • Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells

    Waters, C., Sambi, B., Kong, K., Thompson, D., Pitson, S. M., Pyne, S., Pyne, N. J.
    The Journal of Biological Chemistry, vol. 278, no. 8, pp. 6282-90
    Contributions to Journals: Articles
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