BSc (Aberdeen, 1991), PhD (London, 1994). Recipient of the College of Life Sciences and Medicine award for Excellence in Teaching, 2009 and of the Aberdeen University Students Association award for Most Accessible Lecturer (Champion for Disabilities), 201
Senior Lecturer
- About
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- Email Address
- d.shewan@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437381
- Office Address
Room 5.28, IMS.
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Derryck Shewan graduated in Physiology from the University of Aberdeen in 1991, having gained a particular interest in the mechanisms of axon guidance. He undertook a studentship with Prof Jim Cohen at Guy’s Hospital Medical School, under the co-supervision of Prof Martin Berry, in the Developmental Neurobiology department, which has since evolved to the MRC Unit for Developmental Neurobiology at Hunt’s House, Kings College London. He gained his PhD in Anatomy and Cell Biology in 1994 having studied mechanisms of axon growth and regeneration, building up an appreciation of the changing nature of neuronal behaviour during development. In 1994 Dr Shewan was appointed a Research Fellow in Dr Cohen’s laboratory, which involved some time working with Dr Geneviève Rougon and her colleagues at the CNRS Faculté des Sciences de Luminy in Marseille. In 1997 he moved to the Department of Anatomy at the University of Cambridge as a Research Associate in Prof Christine Holt’s laboratory. Having spent 3 years studying the development of the visual system, Dr Shewan moved on in 2000 to the Department of Physiology at the University of Cambridge as a Research Associate in Professor James Fawcett’s laboratory. In 2001 he moved with Professor Fawcett’s group to he Cambridge Centre for Brain Repair. Dr Shewan was appointed Lecturer in Biomedical Sciences at the University of Aberdeen in 2003, and promoted to Senior Lecturer in 2006. He now forms part of the Aberdeen University Spinal Injury Research Group. He was afforded the College of Life Sciences and Medicine Award for Excellence in Teaching in 2009, nominated again in 2010, nominated for the Students Association award for Supporting Students in 2011 and afforded the Students Association award for most Accessible Lecturer (Champion for Disabilities) in 2016.
- Research
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Research Overview
Dr Shewan is interested in the changing intracellular signalling mechanisms that accompany neuronal maturation. In particular, he focuses on the growth and regenerative capacities of embryonic and adult neurons in order to find differences that may help to explain why neurons of the central nervous system become incapable of regenerating after injury. A more detailed synopsis of Dr Shewan's work can be found at the Cell and Developmental Biology Research Theme at the University of Aberdeen.
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- Teaching
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Teaching Responsibilities
I am the co-ordinator of Biomedical Sciences Honours year research projects (BM4501, DB 4501, PA4501, PY4501 and SR4501).
Also at Level 4 I deliver lectures on axon guidance and contribute to course assessments on the Honours year core course on Advanced Molecules, Membranes and Cells (BM4004), as well as lecture on Sensory Systems and participate in the assessment of student seminars on Brain Function and Malfunction (AN4002).
At level 2 I present and demonstrate on Foundation Skills for Life Sciences (BI2005) and also tutor and act as Theme leader for 'Nervous System Diseases' on the Research Skills for Life Sciences course (BI2506). I deliver lectures on Sensory Systems on Physiology of Human Cells (BI20B2).
I co-ordinate the DevelopMental Theme for the Phase 1 MBChB Student Selected Module 1.
I participate in University Open, Applicant and Induction days, and host School visits for secondary school pupils.
- Publications
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Page 1 of 2 Results 1 to 25 of 27
Reflections on going paperless in the Science Teaching Hub
14th University of Aberdeen Annual Academic Development Symposium 2023Contributions to Conferences: PostersAn evaluation of Medical Sciences skills to inform Co-curricular Enhancement
13th University of Aberdeen Annual Academic Development Symposium 2022Contributions to Conferences: PostersThe therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3′,5′-monophosphate (Epac) for central nervous system trauma
Neural Regeneration Research, vol. 16, no. 3, pp. 460-469Contributions to Journals: Review articlesEpac2 Elevation Reverses Inhibition by Chondroitin Sulfate Proteoglycans In Vitro and Transforms Postlesion Inhibitory Environment to Promote Axonal Outgrowth in an Ex Vivo Model of Spinal Cord Injury
Journal of Neuroscience, vol. 39, no. 42, pp. 8330-8346Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1523/JNEUROSCI.0374-19.2019
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/13690/1/Guijarro_Belmar_atal_JNeurosci_Epac2_Elevation_VOR.pdf
- [ONLINE] http://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0374-19.2019
- [ONLINE] View publication in Mendeley
- [ONLINE] View publication in Scopus
The cAMP-producing agonist beraprost inhibits human vascular smooth muscle cell migration via exchange protein directly activated by cAMP
Cardiovascular Research, vol. 107, no. 4, pp. 546-555Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/cvr/cvv176
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4659/3/546.full.pdf
Inception of an online skills resource for medical science undergraduates: The School of Medical Science Skills Support Centre
Contributions to Conferences: PostersDevelopment of interactive online resources to support and enhance numerical skills among Medical Science students
Contributions to Conferences: PapersMammalian growth cone turning assays identify distinct cell signalling mechanisms that underlie axon growth, guidance and regeneration
Chapters in Books, Reports and Conference Proceedings: Conference Proceedings- [ONLINE] DOI: https://doi.org/10.1007/978-1-61779-536-7_15
VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm
Neuron, vol. 70, no. 5, pp. 951-965Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.neuron.2011.02.052
New perspectives in cyclic AMP-mediated axon growth and guidance: the emerging epoch of Epac
Brain Research Bulletin, vol. 84, no. 4-5, pp. 280-288Contributions to Journals: Special Issues- [ONLINE] DOI: https://doi.org/10.1016/j.brainresbull.2010.09.002
cAMP-Dependent Axon Guidance is Distinctly Regulated by Epac and Protein Kinase A
Journal of Neuroscience, vol. 29, no. 49, pp. 15434-15444Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1523/JNEUROSCI.3071-09.2009
cGMP promotes neurite outgrowth and growth cone turning and improves axon regeneration on spinal cord tissue in combination with cAMP
Brain Research, vol. 1294, pp. 12-21Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.brainres.2009.07.071
B-raf Regulates cAMP-Dependant Axon Growth and Guidance
Scottish Neuroscience Group Annual Meeting (2009)Contributions to Conferences: PostersB-raf regulates cAMP-dependent axon growth and guidance
Scottish Neuroscience Group Meeting 2009Contributions to Conferences: PostersEpac promotes axon regeneration in vitro
Contributions to Conferences: PapersEpac mediates cyclic AMP-dependent axon growth, guidance and regeneration
Molecular and Cellular Neuroscience, vol. 38, no. 4, pp. 578-588Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.mcn.2008.05.006
Differential mechanisms of cAMP signalling in astrocyte-mediated inhibition of axon regeneration
Society for Neuroscience Annual Meeting (2008)Contributions to Conferences: PostersThe use of FRET sensors to examine age-dependent signalling mechanisms in DRG growth cones
Society for Neuroscience Annual Meeting (2008)Contributions to Conferences: PostersDistinct Mechanisms of cAMP-Dependent Axon Guidance
Society for Neuroscience Annual Meeting (2007)Contributions to Conferences: PostersNeuronal Signalling Pathways Controlling Axon Growth and Regeneration
Scottish Neuroscience Group Annual Meeting (2007)Contributions to Conferences: PostersNeuronal Signalling Pathways Controlling Axon Growth and Regeneration
Contributions to Conferences: PapersRegenerating the central nervous system by making neurons young again
SET for Britain, House of Commons, WestminsterContributions to Conferences: PostersAxon Growth and Regeneration Through Manipulation of Neuronal Cell Signalling
Society for Neuroscience Annual Meeting (2006)Contributions to Conferences: PosterscAMP Mediated Axon Growth and Guidance
British Neuroscience Association MeetingContributions to Conferences: PostersAxon behaviour at Schwann cell-astrocyte boundaries: manipulation of axon signalling pathways and the neural adhesion molecule L1 can enable axons to cross
European Journal of Neuroscience, vol. 20, no. 6, pp. 1425-1435Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/j.1460-9568.2004.03573.x