MRCP, MSc, MD
Reader (Clinical)
- About
-
- Email Address
- carl.counsell@abdn.ac.uk
- Office Address
Room 1:009, Polwarth Building Division of Applied Health Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Carl is a clinical reader and honorary consultant in neurology. He graduated in medicine from Cambridge University in 1988, did his early postgraduate medical training in London, Newcastle and Falkirk and then trained in neurology, stroke and epidemiology in Edinburgh. He spent a year in Melbourne where he specialised in movement disorders before taking up his present post in 2001. A committed Christian, he would like to have more time to serve in his church and develop his interests in Fairtrade and conservation.
Latest Publications
Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study
Journal of Neurology, vol. 271, pp. 2929-2937Contributions to Journals: ArticlesTotal Patient Delay: A comparison of patient and clinician/health system delays in the diagnosis of progressive supranuclear palsy and corticobasal syndrome
Movement Disorders Clinical Practice, vol. 11, no. 5, pp. 478-487Contributions to Journals: ArticlesIncidence and risk factors of institutionalisation in Parkinson's disease and atypical parkinsonism
Parkinsonism & Related Disorders, vol. 118Contributions to Journals: ArticlesProgressive multifocal leukoencephalopathy associated with carbamazepine -: induced immune dysfunction and recovery after carbamazepine cessation
BMJ Case Reports, vol. 16, no. 7, e255119Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bcr-2023-255119
- [ONLINE] View publication in Scopus
The evolution of diagnosis from symptom onset to death in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) compared to Parkinson’s disease (PD)
Journal of Neurology, vol. 270, pp. 3464-3474Contributions to Journals: Articles
- Research
-
Research Overview
Carl is a consultant neurologist with subspecialty interest in movement disorders. His main research interests are in evidence-based medicine and broader aspects of clinical epidemiology such as incidence and prognostic studies, particularly in relation to Parkinson's disease, other movement disorders and stroke. His team have established several cohorts of parkinsonian patients for long-term follow-up and supported a number of non-industry sponsored clinical trials and Cochrane reviews, whilst also trying to promote multidisciplinary neurology research in Aberdeen.
Research Specialisms
- Clinical Medicine
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
The PINE study: a population-based incidence cohort of people with Parkinson's disease and other parkinsonian disorders, along with their carers and controls who are being followed up lifelong to establish long-term prognosis.
The Parkinson's Incidence Cohorts Collaboration: an individual patient data meta-analysis of all population- based incidence cohorts of Parkinson's disease to assess prognosis and allow prognostic modelling.
The Scottish PSP/CBD prevalence cohort: a cohort of people with two related Parkinson's plus disorders, Progressive Supranuclear Palsy and Corticobasal Degeneration as well as Parkinson's disease controls, to assess diagnostic and care pathways and prognosis.
Past Research
Cochrane systematic reviews of randomised trials in stroke care and Parkinson's disease
Prognostic modelling in acute stroke
Incidence of Parkinson's disease and other parkinsonian disorders in North-East Scotland
Prevalence of multiple sclerosis in North-East Scotland and northern isles
Randomised trial of physiotherapy for cervical dystonia
Knowledge Exchange
Member of Parkinson's Excellence Network
Collaborations
Cochrane Collaboration Stroke Review Group, Professors Charles Warlow and Peter Sandercock, University of Edinburgh, UK, 1993-98.
Scottish Audit of Intracranial Vascular Malformations, Professor Rustam Al-Shahi Salman, University of Edinburgh, UK, 2002-2014.
PDMED trial, Professor Carl Clarke, University of Birmingham, UK, 2004-2020.
Clinical trial methods in neurodegenerative diseases, Professor John Zajicek, University of Plymouth, UK, 2009-2014.
PDCOMM trial, Professor Sackley, University of Nottingham, UK, 2016-2023.
NICE technology appraisals for multiple sclerosis, Universities of Warwick and Exeter, UK, 2016-2022
Parkinson's Incidence Cohorts Collaboration, Professor Tysnes, Dr Guido Alves, Professor Lars Forsgren, Dr Caroline Williams-Gray, Dr Alison Yarnall, Universities of Stavanger (Norway), Umea (Sweden), Cambridge (UK) and Newcastle (UK), 2018 ongoing
PD Connect exercise trial, Julie Jones, Robert Gordon University, Aberdeen, UK, 2019-2022
Supervision
Dr Kate Taylor (MD), 2002-06, Incidence and prognosis of parkinsonism in north-east Scotland: a pilot study.
Clare Harris (MSc), 2006-08, PINE participants attitudes to brain donation.
Dr Robert Caslake (PhD), 2006-11, Incidence and short-term prognosis of Parkinson's disease and other parkinsonian disorders in north-east Scotland.
Dr Elizabeth Visser (MD), 2009-13, Prevalence of multiple sclerosis in northern Scotland.
Dr David McGhee (PhD), 2009-13, Improving clinical trial design in neurodegenerative diseases.
Dr Angus Macleod (PhD), 2012-15, Predicting mortality and dependency in Parkinson's disease.
Dr Diane Swallow (PhD), 2016-21, Assessing diagnostic pathways in progressive supranuclear palsy and corticobasal degeneration.
Funding and Grants
Research funding has been obtained from:
Parkinson’s UK, Scottish Chief Scientist Office, BMA Doris Hillier award, RS Macdonald Trust, BUPA Foundation, NHS Grampian endowments, Dystonia Society, National Institute for Health Research.
- Teaching
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Teaching Responsibilities
Lectures and clinical teaching of neurology for medical and dental students.
Supervising medical student elective and MSc projects
Non-course Teaching Responsibilities
Regent to medical students
- Publications
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Page 1 of 4 Results 1 to 50 of 191
Accuracy of routinely collected hospital administrative discharge data and death certificate ICD-10 diagnostic coding in progressive supranuclear palsy and corticobasal syndrome: a systematic review and validation study
Journal of Neurology, vol. 271, pp. 2929-2937Contributions to Journals: ArticlesTotal Patient Delay: A comparison of patient and clinician/health system delays in the diagnosis of progressive supranuclear palsy and corticobasal syndrome
Movement Disorders Clinical Practice, vol. 11, no. 5, pp. 478-487Contributions to Journals: ArticlesIncidence and risk factors of institutionalisation in Parkinson's disease and atypical parkinsonism
Parkinsonism & Related Disorders, vol. 118Contributions to Journals: ArticlesProgressive multifocal leukoencephalopathy associated with carbamazepine -: induced immune dysfunction and recovery after carbamazepine cessation
BMJ Case Reports, vol. 16, no. 7, e255119Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/bcr-2023-255119
- [ONLINE] View publication in Scopus
The evolution of diagnosis from symptom onset to death in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) compared to Parkinson’s disease (PD)
Journal of Neurology, vol. 270, pp. 3464-3474Contributions to Journals: ArticlesCognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia
Movement Disorders Clinical Practice, vol. 10, no. 6, pp. 980-986Contributions to Journals: ArticlesAchieving proportionate governance review in Scotland: Threats and solutions
Journal of the Royal College of Physicians of Edinburgh, vol. 53, no. 1, pp. 74-79Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1177/14782715231153033
- [ONLINE] View publication in Scopus
Is the assumption of waning of treatment effect applied consistently across NICE technology appraisals?: A case-study focusing on disease-modifying therapies for treatment of multiple sclerosis
International Journal of Technology Assessment in Health Care, vol. 38, no. 1, pp. e83Contributions to Journals: Review articlesThe incidence, baseline predictors and outcomes of dementia in an incident cohort of Parkinson’s disease and controls
Journal of Neurology, vol. 269, pp. 4288–4298Contributions to Journals: ArticlesSystematic review of prevalence studies of progressive supranuclear palsy and corticobasal syndrome
Movement Disorders Clinical Practice, vol. 9, no. 5, pp. 604-613Contributions to Journals: ArticlesManagement of the first stage of convulsive status epilepticus in adults: a systematic review of current randomised evidence
Journal of Neurology, vol. 269, no. 7, pp. 3420-3429Contributions to Journals: Review articlesPrevalence of progressive supranuclear palsy and corticobasal syndrome in Scotland
Neuroepidemiology, vol. 56, no. 4, pp. 291–297Contributions to Journals: ArticlesGBA and APOE Impact Cognitive Decline in Parkinson's Disease: A 10-Year Population-Based Study
Movement Disorders, vol. 37, no. 5, pp. 1016-1027Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mds.28932
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/18036/1/Szwedo_etal_MD_GBA_And_APOE_VoR.pdf
- [ONLINE] View publication in Scopus
Pre-hospital and emergency department treatment of convulsive status epilepticus in adults: an evidence synthesis
Health technology assessment (Winchester, England), vol. 26, no. 20, pp. 1-76Contributions to Journals: ArticlesLong-term Effectiveness of Adjuvant Treatment With Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared With Dopamine Agonists Among Patients With Parkinson Disease Uncontrolled by Levodopa Therapy: The PD MED Randomized Clinical Trial
JAMA Neurology, vol. 79, no. 2, pp. 131-140Contributions to Journals: ArticlesLack of Association Between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts
Journal of Parkinson's Disease, vol. 11, no. 4, pp. 1569-1578Contributions to Journals: ArticlesFirst delirium episode in Parkinson’s disease and parkinsonism: incidence, predictors and outcomes
npj Parkinson's Disease, vol. 7, no. 1, 92Contributions to Journals: ArticlesOcrelizumab not recommended in France for patients with primary progressive multiple sclerosis while recommended in England: a review comparing the assessment by HAS and NICE
Expert opinion on biological therapy, vol. 21, no. 6, pp. 741-747Contributions to Journals: Review articlesAssociation of GBA Genotype With Motor and Functional Decline in Patients With Newly Diagnosed Parkinson Disease
Neurology, vol. 96, no. 7, pp. e1036-e1044Contributions to Journals: ArticlesAssociation of SNCA Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients
Frontiers in Neurology, vol. 11, 620585Contributions to Journals: Articles- [ONLINE] https://www.frontiersin.org/articles/10.3389/fneur.2020.620585/full#supplementary-material
- [ONLINE] DOI: https://doi.org/10.3389/fneur.2020.620585
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15812/1/Szwedo_et_al_FiN_AssociationOfSNCAParkinson_VoR.pdf
- [ONLINE] View publication in Scopus
Accuracy of death certificates for recording parkinsonian syndromes and associated dementia
Journal of Neurology, vol. 268, pp. 140–146Contributions to Journals: ArticlesValidation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease
Parkinsonism & Related Disorders, vol. 76, pp. 49-53Contributions to Journals: ArticlesOcrelizumab for Treating Patients with Primary Progressive Multiple Sclerosis: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
Pharmacoeconomics, vol. 38, no. 6, pp. 527-536Contributions to Journals: Review articles- [ONLINE] DOI: https://doi.org/10.1007/s40273-020-00889-4
- [ONLINE] View publication in Scopus
Treatment Responsiveness of Motor Features in Parkinson's Disease: A Matched Case‐Control Analysis
Movement Disorders Clinical Practice, vol. 7, no. 1, pp. 45-51Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/mdc3.12856
- [ONLINE] View publication in Scopus
Comparative effectiveness of beta-interferons and glatiramer acetate for relapsing-remitting multiple sclerosis: systematic review and network meta-analysis of trials including recommended dosages
BMC Neurology, vol. 18, 162Contributions to Journals: ArticlesAge-related selection bias in Parkinson's disease research: are we recruiting the right participants?
Parkinsonism & Related Disorders, vol. 55, pp. 128-133Contributions to Journals: ArticlesAssociation of glucocerebrosidase polymorphisms and mutations with dementia in incident Parkinson's disease
Alzheimer's and Dementia, vol. 14, no. 10, pp. 1293-1301Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jalz.2018.04.006
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/12286/1/ADJ_D_17_00600_R1.pdf
Author response: Early weight loss in parkinsonism predicts poor outcomes: Evidence from an incident cohort study
Neurology, vol. 91, no. 6, pp. 287-287Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1212/WNL.0000000000005937
Short and long-term clinical outcomes of use of beta-interferon or glatiramer acetate for people with clinically isolated syndrome: a systematic review of randomised controlled trials and network meta-analysis
Journal of Neurology, vol. 265, no. 5, pp. 999-1009Contributions to Journals: ArticlesAuthor response: Early weight loss in neurodegenerative disorders could be related to increased protein metabolism in the brain
NeurologyContributions to Journals: Comments and DebatesDevelopment and validation of prognostic survival models in newly diagnosed Parkinson’s disease
Movement Disorders, vol. 33, no. 1, pp. 108-116Contributions to Journals: ArticlesEarly weight loss in parkinsonism predicts poor outcomes: evidence from an incident cohort study
Neurology, vol. 89, no. 22, pp. 2254-2261Contributions to Journals: ArticlesSeason of infectious mononucleosis as a risk factor for multiple sclerosis: a UK primary care case-control study
Multiple Sclerosis and Related Disorders, vol. 17, pp. 103-106Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.msard.2017.07.009
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/2/Revised_Paper_clean.pdf
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/1/im_in_ms_flow_chart.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10717/3/Supplemental_Tables.docx
Clinical effectiveness and cost-effectiveness of beta-interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation
Health Technology Assessment, vol. 21, no. 52, pp. 1-352Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3310/hta21520
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9366/1/3010990.pdf
Genome-wide pleiotropy between Parkinson disease and autoimmune diseases
JAMA Neurology, vol. 74, no. 7, pp. 780-792Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1001/jamaneurol.2017.0469
- [ONLINE] View publication in Scopus
Simple prediction scores predict good and devastating outcomes after stroke more accurately than physicians
Age and Ageing, vol. 46, no. 3, pp. 421-426Contributions to Journals: ArticlesDiscovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing
Genome Biology, vol. 18, no. 1, 22Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1186/s13059-017-1147-9
- [ONLINE] View publication in Scopus
Medium-term prognosis of an incident cohort of parkinsonian patients compared to controls
Parkinsonism & Related Disorders, vol. 32, pp. 36-41Contributions to Journals: ArticlesPredictors of functional dependency in Parkinson’s disease
Movement Disorders, pp. 1482-1488Contributions to Journals: ArticlesStroke: Are care and outcomes better for participants of stroke trials?
Nature Reviews Neurology, vol. 12, no. 9, pp. 498-499Contributions to Journals: Review articlesRisk of fracture amongst patients with Parkinson's disease and other forms of parkinsonism
Parkinsonism & Related Disorders, vol. 29, pp. 60-65Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.parkreldis.2016.05.026
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9129/2/fractures_in_PD_park_and_related_diseases_revised_final.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9129/3/Figure_1_a_and_b_.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/9129/1/supplementary_figure_2.tif
Co-morbidity burden in Parkinson’s disease: Comparison with controls and its influence on prognosis
Parkinsonism & Related Disorders, vol. 28, pp. 124-129Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.parkreldis.2016.05.013
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6015/4/Figure_1_colour_online_only_.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6015/3/Figure_2_colour_online_only_.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/6015/2/1_s2.0_S1353802016301651_main.pdf
A review of clinical trial designs used to detect a disease-modifying effect of drug therapy in Alzheimer's disease and Parkinson's disease
BMC Neurology, vol. 16, pp. 1-13Contributions to Journals: ArticlesA randomized trial of specialized versus standard neck physiotherapy in cervical dystonia
Parkinsonism & Related Disorders, vol. 23, pp. 72-79Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.parkreldis.2015.12.010
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8114/1/CDphysiotrial_second_revision_final.doc
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8114/7/Fig1.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8114/4/Fig2.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8114/3/FigS1.tif
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8114/2/Supplementary_data.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8114/6/Table_1.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8114/5/Table_2.docx
Motor complications in an incident Parkinson’s disease cohort
European Journal of Neurology, vol. 23, no. 2, pp. 304-312Contributions to Journals: ArticlesA systematic review of loss of independence in Parkinson's disease
Journal of Neurology, vol. 263, no. 1, pp. 1-10Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1007/s00415-015-7847-8
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7917/1/Macleod_v2.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7917/2/Macleod_tables.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7917/4/Figure_1.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7917/3/Figure_2.docx
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/7917/5/Figure_3.docx
Fracture risk in incident Parkinsonian cohort versus controls
Annual Meeting of the Association-of-British-Neurologists (ABN) - 2015, pp. e4Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1136/jnnp-2015-312379.174
Pre-hospital notification is associated with improved stroke thrombolysis timing
Journal of the Royal College of Physicians of Edinburgh, vol. 45, no. 3, pp. 190-195Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.4997/JRCPE.2015.303
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/5088/1/jrcpe_45_3_khor.pdf
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
Molecular Psychiatry, vol. 20, no. 5, pp. 647-656Contributions to Journals: Comments and Debates- [ONLINE] DOI: https://doi.org/10.1038/mp.2014.107
- [ONLINE] View publication in Scopus
Using 'dead or dependent' as an outcome measure in clinical trials in Parkinson's disease
Journal of Neurology, Neurosurgery & Psychiatry, vol. 86, no. 2, pp. 180-185Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/jnnp-2014-307703
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/4207/1/180.full.pdf