MD PhD FRCP, Hon Consultant Rheumatologist
Clinical Chair in Experimental Medicine and Rheumatology
- About
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- Email Address
- c.debari@abdn.ac.uk
- Office Address
School of Medicine, Medical Sciences and Nutrition
University of Aberdeen
Aberdeen Centre for Arthritis and Musculoskeletal Health
Arthritis and Regenerative Medicine Laboratory
Institute of Medical Sciences
Foresterhill, Aberdeen AB25 2ZD
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.
Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.
Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.
External Memberships
Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.
Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.
- Research
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Research Overview
The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.
The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.
The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.
- Publications
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Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis
Arthritis & Rheumatism, vol. 56, no. 2, pp. 489-497Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.22372
Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
Arthritis Research & Therapy, vol. 9, no. 1, pp. 301Contributions to Journals: ArticlesEfficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells
Stem Cells, vol. 24, no. 4, pp. 896-907Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1634/stemcells.2003-0106
Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis
Arthritis & Rheumatism, vol. 54, no. 4, pp. 1209-1221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/ART.21753
Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
Arthritis Research & Therapy, vol. 8, no. 5, pp. R139Contributions to Journals: ArticlesReparative medicine: from tissue engineering to joint surface regeneration
Regenerative Medicine, vol. 1, no. 1, pp. 59-69Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.2217/17460751.1.1.59
Increased Bcl-2/p53 ratio in human osteoarthritic cartilage: a possible role in regulation of chondrocyte metabolism
Annals of the Rheumatic Diseases, vol. 64, no. 2, pp. 217-221Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/ard.2004.022590
Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo
Experimental Cell Research, vol. 287, no. 1, pp. 16-27Contributions to Journals: ArticlesIn vitro growth rate of fibroblast-like synovial cells is reduced by methotrexate treatment
Annals of the Rheumatic Diseases, vol. 62, no. 6, pp. 568-571Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/ard.62.6.568
Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane
Archives of Histology and Cytology, vol. 66, no. 2, pp. 145-153Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1679/aohc.66.145