MD PhD FRCP, Hon Consultant Rheumatologist
Clinical Chair in Experimental Medicine and Rheumatology
- About
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- Email Address
- c.debari@abdn.ac.uk
- Office Address
School of Medicine, Medical Sciences and Nutrition
University of Aberdeen
Aberdeen Centre for Arthritis and Musculoskeletal Health
Arthritis and Regenerative Medicine Laboratory
Institute of Medical Sciences
Foresterhill, Aberdeen AB25 2ZD
United Kingdom
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Professor Cosimo De Bari is a clinically active rheumatologist and a translational scientist with expertise in musculoskeletal regenerative medicine and arthritis pathophysiology. He has a long-standing interest and track record in the study of joint health and disease, with a focus on cell-based therapies for cartilage repair and osteoarthritis.
Cosimo graduated in Medicine (summa cum laude) from the University of Bari (Italy), where he underwent specialist training in Rheumatology. He obtained his PhD from the University of Leuven (Belgium). In 2003 Cosimo moved to King's College London, where in 2005 he was awarded an MRC Clinician Scientist Fellowship. Since 2007 Cosimo holds a clinical chair in Experimental Medicine and Rheumatology (previously Translational Medicine) at the University of Aberdeen.
Cosimo is the founder and director of the Aberdeen Centre for Arthritis and Musculoskeletal Health (awarded “Centre of Excellence in Rheumatology” status by the EULAR), leads the Arthritis and Regenerative Medicine Laboratory, and is deputy director of the Tissue Engineering & Regenerative Therapies Centre Versus Arthritis.
External Memberships
Cosimo has accepted more than 100 invitations to speak at national and international venues, including international conferences, and universities and institutes in Europe and overseas, or to chair sessions and symposia. He takes part in conference organising/program committees such as OARSI.
Cosimo is an Associate Editor for Osteoarthritis and Cartilage and a member of the editorial boards of several journals including Regenerative Medicine. He has served on numerous grant review panels of national and international funding agencies, including MRC, Versus Arthritis, NIHR, NC3R, Vienna Science and Technology Fund, Dutch Arthritis Foundation, California Institute for Regenerative Medicine, and European Commission.
- Research
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Research Overview
The ultimate goal of Professor De Bari's research programme is the development of novel cell-based therapeutic approaches to skeletal repair. His programme consists of two main areas.
The first is centred on the development and validation of "clinically relevant" assays and surrogate measures of the potency of stem cell preparations, to be used as quality controls for efficacy of stem cell therapies in the clinic.
The second area of investigation aims at characterizing the niches of resident stem cells within the joint environment and studying their molecular regulation in vivo in health and diseases such as osteoarthritis and rheumatoid arthritis. Understanding the roles of stem cells in the pathophysiology of joint homeostasis, remodelling and repair in health and disease will be instrumental for the development of novel therapeutic protocols to trigger and enhance intrinsic joint surface repair by targeting resident stem cells, with the ultimate goal to modify disease outcome and restore a functional joint homeostasis.
- Publications
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A regulatory relationship between Tbx1 and FGF signaling during tooth morphogenesis and ameloblast lineage determination
Developmental Biology, vol. 320, no. 1, pp. 39-48Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ydbio.2008.12.001
The large functional spectrum of the heparin-binding cytokines MK and HB-GAM in continuously growing organs: The rodent incisor as a model
Developmental Biology, vol. 320, no. 1, pp. 256-266Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.ydbio.2008.05.530
Stem cells for tooth engineering
European Cells & Materials, vol. 16, no. 1, pp. 1-9Contributions to Journals: ArticlesIdentification of the molecular response of articular cartilage to injury, by microarray screening
Arthritis & Rheumatism, vol. 58, no. 5, pp. 1410-1421Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.23444
Apoptosis in developmental and repair-related human tooth remodeling: a view from the inside
Experimental Cell Research, vol. 314, no. 4, pp. 869-877Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.yexcr.2007.11.001
Cell therapy: a challenge in modern medicine
3rd International Meeting on Medical Engineering and Therapy, pp. 11-17Contributions to Journals: Special IssuesA biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells
Arthritis & Rheumatism, vol. 58, no. 1, pp. 240-250Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.23143
Mesenchymal stem cells in rheumatology: A regenerative approach to joint repair
Clinical Science, vol. 113, no. 8, pp. 339-348Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/CS20070126
Stem cell niches in mammals
Experimental Cell Research, vol. 313, no. 16, pp. 3377-3385Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.yexcr.2007.07.027
Lessons from musculoskeletal stem cell research: The key to successful regenerative medicine development
Arthritis & Rheumatism, vol. 56, no. 3, pp. 714-721Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.22440