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Professor Anne Kiltie

Professor Anne Kiltie
Professor Anne Kiltie
Professor Anne Kiltie

MA DM DSc MRCP(UK) FRCR

Friends of ANCHOR Clinical Chair in Oncology

About
Email Address
anne.kiltie@abdn.ac.uk
Office Address

Room 5.053

School/Department
School of Medicine, Medical Sciences and Nutrition
Google Scholar
Linkedin

Biography

I qualified in medicine from the Universities of Cambridge and Oxford and trained in Clinical Oncology at the Christie Hospital, Manchester, and Cookridge Hospital, Leeds. I undertook my DM at the Paterson Institute, University of Manchester and was a Clinical Research Fellow at ICRF Clare Hall before taking up a Senior Lecturer/Honorary Consultant Clinical Oncologist appointment at the University of Leeds in 2001. I moved to the Department of Oncology, University of Oxford in 2009, and obtained my DSc and personal chair in 2016.

I took up my appointment as Friends of ANCHOR Clinical Chair of Oncology at the University of Aberdeen in June 2021.

My research focusses on exploiting dietary fibre manipulation and its effects on the gut microbiome as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

 

Qualifications

  • DSc Medical Sciences 
    2016 - University of Oxford 
  • DM Medical Sciences 
    1999 - University of Oxford 
  • BM BCh Medicine 
    1988 - University of Oxford 
  • BA Medical Sciences 
    1985 - University of Cambridge 
  • MRCP(UK) General Medicine 
    1992 - Royal College of Physicians of England 
  • FRCR Clinical Oncology 
    1995 - Royal College of Radiologists 
  • MA Medicine 
    1989 - University of Cambridge 
  • MA Medicine 
    1999 - University of Oxford 

Memberships and Affiliations

Internal Memberships

Jul 2021 - present      Member of the Rowett Institute Ethics Panel

Oct 2021 - present     Member of Friends of ANCHOR Research Advisory Group

Oct 2024 - present     Elected member Senatus Academicus

Oct 2024 - present     Member of Honorary Degrees Committee

External Memberships

Apr 2024 - present    Chair, Scottish Radiation Research Forum (ScoRRF)

Jun 2023 - present    Member of RAIDER TrialTranslational Working Group 

Jan 2022 - present    Member of Scientific Review Group BCAN Bladder Cancer Research Innovation Award 2022

Jan 2022 - present    Member of Scottish Radiotherapy Research Forum Committee

Oct 2018 - present     Bladder Cancer Advocacy Network (BCAN) Bladder Cancer Research Network Management Committee

Dec 2017 - present    Member of Editorial Board of European Urology Oncology

Oct 2016 - present     Associate Editor of Bladder Cancer

2014 - present            Grant reviewer for Italian Association for Cancer Research (AIRC)

Sept 2012 - present   British Uro-oncology Group Executive Committee Trustee

Jan 2012 - present     Royal College of Radiologists representative on Advisory Appointments Committees

Latest Publications

  • Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

    Then, C. K., Paillas, S., Moomin, A., Misheva, M. D., Moir, R. A., Hay, S. M., Bremner, D., Roberts (nee Nellany), K. S., Smith, E. E., Heidari, Z., Sescu, D., Wang, X., Suárez-Bonnet, A., Hay, N., Murdoch, S. L., Saito, R., Collie-Duguid, E. S. R., Richardson, S., Priestnall, S. L., Wilson, J. M., Gurumurthy, M., Royle, J. S., Samuel, L. M., Ramsay, G., Vallis, K. A., Foster, K. R., McCullagh, J. S. O., Kiltie, A. E.
    Microbiome, vol. 12, no. 1, 89
    Contributions to Journals: Articles

  • How do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?

    Asim, F., Clarke, L., Donnelly, E., Jamal, F., Piccicacchi, L., Qadir, M., Raja, N., Samadi, C., Then, C. K., Kiltie, A.
    BMJ Oncology, vol. 2, no. 1, e000107
    Contributions to Journals: Review articles

  • Field-cycling imaging in ovarian cancer: a novel technology

    Bhagat, N., Broche, L., Shylasree, T. S., Kiltie, A. E., Bhattacharya, S., Gurumurthy, M.
    International Journal of Gynecological Cancer, vol. 33, no. 8, pp. 1329-1330
    Contributions to Journals: Comments and Debates

  • Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

    Koutros, S., Kiemeney, L. A., Pal Choudhury, P., Milne, R. L., Lopez de Maturana, E., Ye, Y., Joseph, V., Florez-Vargas, O., Dyrskjøt, L., Figueroa, J., Dutta, D., Giles, G. G., Hildebrandt, M. A., Offit, K., Kogevinas, M., Weiderpass, E., McCullough, M. L., Freedman, N. D., Albanes, D., Kooperberg, C., Cortessis, V. K., Karagas, M. R., Johnson, A., Schwenn, M. R., Baris, D., Furberg, H., Bajorin, D. F., Cussenot, O., Cancel-Tassin, G., Benhamou, S., Kraft, P., Porru, S., Carta, A., Bishop, T., Southey, M. C., Matullo, G., Fletcher, T., Kumar, R., Taylor, J. A., Lamy, P., Prip, F., Kalisz, M., Weinstein, S. J., Hengstler, J. G., Selinski, S., Harland, M., Teo, M., Kiltie, A. E., Tardón, A., Serra, C., UROMOL Consortium
    European Urology, vol. 84, no. 1, pp. 127-137
    Contributions to Journals: Articles

  • Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients

    Eaton, S. E., Kaczmarek, J., Mahmood, D., McDiarmid, A. M., Norarfan, A. N., Scott, E. G., Then, C. K., Tsui, H. Y., Kiltie, A. E.
    British Journal of Cancer, vol. 127, pp. 2087–2098
    Contributions to Journals: Review articles

View My Publications

Prizes and Awards

Development Trust Award for Philanthropy and Alumni Engagement, The Principal’s Prizes for Research and Engagement, University of Aberdeen Excellence Awards, Apr 2024

Research

Research Overview

Tumours in the pelvis, including bladder, prostate and colorectal cancer and gynaecological cancers may be treated by surgical removal or organ-preserving radiotherapy-based treatments. Current organ-preservation standard of care for most tumour sites includes addition of radiosensitising chemotherapy to improve tumour control. However, this often comes at the expense of increased radiotherapy-induced side effects to the surrounding normal tissues, including the intestines. Furthermore, such combined treatments are often not tolerated by elderly patients. With the proportion of over 75-year olds set to double by 2050, there is an urgent need to find alternative approaches to radiosensitisation.

Having worked on histone deacetylase inhibitors, which we showed to be effective tumour radiosensitisers without additional acute and late small intestinal toxicity in in vivo models, we are now working to exploit dietary fibre manipulation and the gut microbiota as an ‘endogenous’ means of radiosensitising tumours without increasing radiation toxicity to the surrounding normal tissues including the intestines.

Research Areas

Applied Health Sciences

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Biomedical Sciences

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Nutrition and Health

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Research Specialisms

  • Medicine
  • Food Science
  • Bacteriology
  • Oncology

Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.

Supervision

Supervisees

  • MS POLLY NOCK
  • MISS ANAM WAJID
  • DR NANAK BHAGAT
  • MS MEREL VAN DEN HAAK
  • MR ADAM POTTER

Funding and Grants

  1. Exploiting human microbiota-associated in vivo models for mechanistic studies to understand the benefits of dietary fibre supplementation in patients with prostate cancer. NHS Grampian Charity (£92,422.14) Kiltie AE, 15 Nov 2024 – 31 Oct 2025.
  2. The role of intestinal dendritic cells in mediating tumour and normal tissue responses to dietary fibre manipulation. Friends of ANCHOR Pilot Research Funding (£14,345) AE Kiltie, co-applicants: A Moomin, H Wilson, J Coombes, 1 Aug 2024-31 Jul 2025. RG17583.
  3. Role of intestinal macrophages in the protective effects of dietary fibre supplementation during radiotherapy. Medical Research Scotland PhD Studentship (£126,565.82) AE Kiltie, co-applicants: H Wilson, J Coombes, 1 Oct 2024 – 30 Sept 2028. RG17405.
  4. In gut health not all dietary fibres are equal: diet meets artificial intelligence. RESAS PhD studentship (Anam Wajid; £133,446), J Kyle, AE Kiltie (joint lead supervisors), K Scott, A Ayesh, 1 Jan 2024 to 31 Mar 2027.
  5. Dietary fibre supplementation to delay disease progression in early prostate cancer: preparatory work to develop a feasibility study (DEFINITE study) Friends of ANCHOR (£22,000) AE Kiltie, co-applicants: J Royle, J Kyle, S MacLennan, 1 Oct 2023 – 31 Dec 2024. RG17168.
  6. Feasibility of using National Bowel Screening Programme surplus qFIT samples to investigate the gut microbiota FUTURISTIC study). NHS Grampian Charity (£11,269.44), AE Kiltie, co-applicants: F Din, S McSorley, 1 Oct 2023 – 31 Mar 2025. GCA23249.
  7. Exploiting the gut microbiota and its metabolites in pelvic cancer to improve patient outcomes (PELICAN-23). NHS Grampian Endowment Fund (£130,505.37 plus £30,897.41 = £161,402.78) AE Kiltie, G Ramsay (Co-PI), co-applicants: J Royle, K Dimitropoulos, J Grant, G Horgan, G MacDonald, R McMenimen, M Gurumurthy, L Samuel, 1 Sept 2022 – 30 Sept 2025. ES900/EA4021.
  8. A human volunteer study of the effects of psyllium and inulin on the gut microbiome and metabolites: can we identify responders and non-responders to optimise outcomes for pelvic radiotherapy patients (PIGMent study)? Friends of ANCHOR /University of Aberdeen Development Trust PhD studentship (£168,500) AE Kiltie, co-applicants: A Johnstone, K Scott, A Walker, G Horgan, 1 Oct 2022 – 30 Sept 2026.

Datasets

  • Data from: Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

    Abstract Background Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota, along with clinical evidence of prebiotics enhancing anti-cancer immunity, we hypothesised that dietary fibre and its gut microbiota modification can radiosensitise tumours via secretion of metabolites and/or immunomodulation. We investigated the efficacy of high-fibre diets combined with irradiation in immunoproficient C57BL/6 mice bearing bladder cancer flank allografts. Result Psyllium plus inulin significantly decreased tumour size and delayed tumour growth following irradiation compared to 0.2% cellulose and raised intratumoural CD8+ cells. Post-irradiation, tumour control positively correlated with Lachnospiraceae family abundance. Psyllium plus resistant starch radiosensitised the tumours, positively correlating with Bacteroides genus abundance and increased caecal isoferulic acid levels, associated with a favourable response in terms of tumour control. Psyllium plus inulin mitigated the acute radiation injury caused by 14 Gy. Psyllium plus inulin increased caecal acetate, butyrate and propionate levels, and psyllium alone and psyllium plus resistant starch increased acetate levels. Human gut microbiota profiles at the phylum level were generally more like mouse 0.2% cellulose profiles than high fibre profiles. Conclusion These supplements may be useful in combination with radiotherapy in patients with pelvic malignancy. Video Abstract
    DOI
    10.6084/m9.figshare.c.7234207.v1
    Publisher
    Figshare
    Links
    Date Made Available
    27 December 2024
    Related Research Outputs
    Contributors
    Then, C. K. (Creator), Paillas, S. (Creator), Moomin, A. (Creator), Misheva, M. D. (Creator), Moir, R. A. (Creator), Hay, S. M. (Creator), Bremner, D. (Creator), Roberts (nee Nellany), K. S. (Creator), Smith, E. E. (Creator), Heidari, Z. (Creator), Sescu, D. (Creator), Wang, X. (Creator), Suárez-Bonnet, A. (Creator), Hay, N. (Creator), Murdoch, S. L. (Creator), Saito, R. (Creator), Collie-Duguid, E. S. R. (Creator), Richardson, S. (Creator), Priestnall, S. L. (Creator), Wilson, J. M. (Creator), Gurumurthy, M. (Creator), Royle, J. S. (Creator), Samuel, L. M. (Creator), Ramsay, G. (Creator), Vallis, K. A. (Creator), Foster, K. R. (Creator), McCullagh, J. S. O. (Creator), Kiltie, A. E. (Creator)
View My Datasets on Pure
Teaching

Teaching Responsibilities

ME3013 MBChB SSC2: supervisor

BM4501 BSc Honours project: supervisor

RN5504 Nutrition and Health through the Life Stages: lecture

RN5505 Clinical Nutrition: lecture and seminar

RN5503 Clinical Nutrition for Disease Prevention: lecture

Non-course Teaching Responsibilities

I am a Regent for the MB ChB Regent Scheme.

Publications

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  • Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity

    Then, C. K., Paillas, S., Moomin, A., Misheva, M. D., Moir, R. A., Hay, S. M., Bremner, D., Roberts (nee Nellany), K. S., Smith, E. E., Heidari, Z., Sescu, D., Wang, X., Suárez-Bonnet, A., Hay, N., Murdoch, S. L., Saito, R., Collie-Duguid, E. S. R., Richardson, S., Priestnall, S. L., Wilson, J. M., Gurumurthy, M., Royle, J. S., Samuel, L. M., Ramsay, G., Vallis, K. A., Foster, K. R., McCullagh, J. S. O., Kiltie, A. E.
    Microbiome, vol. 12, no. 1, 89
    Contributions to Journals: Articles

  • How do tumours outside the gastrointestinal tract respond to dietary fibre supplementation?

    Asim, F., Clarke, L., Donnelly, E., Jamal, F., Piccicacchi, L., Qadir, M., Raja, N., Samadi, C., Then, C. K., Kiltie, A.
    BMJ Oncology, vol. 2, no. 1, e000107
    Contributions to Journals: Review articles

  • Field-cycling imaging in ovarian cancer: a novel technology

    Bhagat, N., Broche, L., Shylasree, T. S., Kiltie, A. E., Bhattacharya, S., Gurumurthy, M.
    International Journal of Gynecological Cancer, vol. 33, no. 8, pp. 1329-1330
    Contributions to Journals: Comments and Debates

  • Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

    Koutros, S., Kiemeney, L. A., Pal Choudhury, P., Milne, R. L., Lopez de Maturana, E., Ye, Y., Joseph, V., Florez-Vargas, O., Dyrskjøt, L., Figueroa, J., Dutta, D., Giles, G. G., Hildebrandt, M. A., Offit, K., Kogevinas, M., Weiderpass, E., McCullough, M. L., Freedman, N. D., Albanes, D., Kooperberg, C., Cortessis, V. K., Karagas, M. R., Johnson, A., Schwenn, M. R., Baris, D., Furberg, H., Bajorin, D. F., Cussenot, O., Cancel-Tassin, G., Benhamou, S., Kraft, P., Porru, S., Carta, A., Bishop, T., Southey, M. C., Matullo, G., Fletcher, T., Kumar, R., Taylor, J. A., Lamy, P., Prip, F., Kalisz, M., Weinstein, S. J., Hengstler, J. G., Selinski, S., Harland, M., Teo, M., Kiltie, A. E., Tardón, A., Serra, C., UROMOL Consortium
    European Urology, vol. 84, no. 1, pp. 127-137
    Contributions to Journals: Articles

  • Exploiting dietary fibre and the gut microbiota in pelvic radiotherapy patients

    Eaton, S. E., Kaczmarek, J., Mahmood, D., McDiarmid, A. M., Norarfan, A. N., Scott, E. G., Then, C. K., Tsui, H. Y., Kiltie, A. E.
    British Journal of Cancer, vol. 127, pp. 2087–2098
    Contributions to Journals: Review articles

  • Immunofluorescence microscopy-based detection of ssDNA foci by BrdU in mammalian cells

    Kilgas, S., Kiltie, A. E., Ramadan, K.
    STAR Protocols, vol. 2, no. 4, 100978
    Contributions to Journals: Articles

  • The role of dietary supplements, including biotics, glutamine, polyunsaturated fatty acids and polyphenols, in reducing gastrointestinal side effects in patients undergoing pelvic radiotherapy: A systematic review and meta-analysis

    Bartsch, B., Then, C. K., Harriss, E., Kartsonaki, C., Kiltie, A. E.
    Clinical and Translational Radiation Oncology, vol. 29, pp. 11-19
    Contributions to Journals: Articles

  • Evaluation of Loading Strategies to Improve Tumor Uptake of Gemcitabine in a Murine Orthotopic Bladder Cancer Model Using Ultrasound and Microbubbles

    Ruan, J. L., Browning, R. J., Yildiz, Y. O., Bau, L., Kamila, S., Gray, M. D., Folkes, L., Hampson, A., McHale, A. P., Callan, J. F., Vojnovic, B., Kiltie, A. E., Stride, E.
    Ultrasound in Medicine and Biology, vol. 47, no. 6, pp. 1596-1615
    Contributions to Journals: Articles

  • p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

    Kilgas, S., Singh, A. N., Paillas, S., Then, C. K., Torrecilla, I., Nicholson, J., Browning, L., Vendrell, I., Konietzny, R., Kessler, B. M., Kiltie, A. E., Ramadan, K.
    Cell Reports, vol. 35, no. 8, 109153
    Contributions to Journals: Articles

  • Ultrasound-Mediated Gemcitabine Delivery Reduces the Normal-Tissue Toxicity of Chemoradiation Therapy in a Muscle-Invasive Bladder Cancer Model

    Ruan, J. L., Browning, R. J., Yildiz, Y. O., Gray, M., Bau, L., Kamila, S., Thompson, J., Elliott, A., Smart, S., McHale, A. P., Callan, J. F., Vojnovic, B., Stride, E., Kiltie, A. E.
    International Journal of Radiation Oncology Biology Physics, vol. 109, no. 5, pp. 1472-1482
    Contributions to Journals: Articles

  • SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

    Na, J., Newman, J. A., Then, C. K., Syed, J., Vendrell, I., Torrecilla, I., Ellermann, S., Ramadan, K., Fischer, R., Kiltie, A. E.
    Cell Death and Disease, vol. 12, no. 2, 165
    Contributions to Journals: Articles

  • Greater utility of molecular subtype rather than epithelial-to-mesenchymal transition (EMT) markers for prognosis in high-risk non-muscle-invasive (HGT1) bladder cancer

    Ottley, E. C., Pell, R., Brazier, B., Hollidge, J., Kartsonaki, C., Browning, L., O'Neill, E., Kiltie, A. E.
    Journal of Pathology: Clinical Research, vol. 6, no. 4, pp. 238-251
    Contributions to Journals: Articles

  • Association of Bacteroides acidifaciens relative abundance with high-fibre diet-associated radiosensitisation

    Then, C. K., Paillas, S., Wang, X., Hampson, A., Kiltie, A. E.
    BMC Biology, vol. 18, 102
    Contributions to Journals: Articles

  • The Histone Deacetylase Inhibitor Romidepsin Spares Normal Tissues While Acting as an Effective Radiosensitizer in Bladder Tumors in Vivo

    Paillas, S., Then, C. K., Kilgas, S., Ruan, J. L., Thompson, J., Elliott, A., Smart, S., Kiltie, A. E.
    International Journal of Radiation Oncology Biology Physics, vol. 107, no. 1, pp. 212-221
    Contributions to Journals: Articles

  • EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort: Under the Auspices of the EAU-ESMO Guidelines Committees

    Witjes, J. A., Babjuk, M., Bellmunt, J., Bruins, H. M., De Reijke, T. M., De Santis, M., Gillessen, S., James, N., Maclennan, S., Palou, J., Powles, T., Ribal, M. J., Shariat, S. F., Der Kwast, T. V., Xylinas, E., Agarwal, N., Arends, T., Bamias, A., Birtle, A., Black, P. C., Bochner, B. H., Bolla, M., Boormans, J. L., Bossi, A., Briganti, A., Brummelhuis, I., Burger, M., Castellano, D., Cathomas, R., Chiti, A., Choudhury, A., Compérat, E., Crabb, S., Culine, S., De Bari, B., De Blok, W., J L De Visschere, P., Decaestecker, K., Dimitropoulos, K., Dominguez-Escrig, J. L., Fanti, S., Fonteyne, V., Frydenberg, M., Futterer, J. J., Gakis, G., Geavlete, B., Gontero, P., Grubmüller, B., Hafeez, S., Hansel, D. E., Hartmann, A., Hayne, D., Henry, A. M., Hernandez, V., Herr, H., Herrmann, K., Hoskin, P., Huguet, J., Jereczek-Fossa, B. A., Jones, R., Kamat, A. M., Khoo, V., Kiltie, A. E., Krege, S., Ladoire, S., Lara, P. C., Leliveld, A., Linares-Espinós, E., Løgager, V., Lorch, A., Loriot, Y., Meijer, R., Mir, M. C., Moschini, M., Mostafid, H., Müller, A., Müller, C. R., N'Dow, J., Necchi, A., Neuzillet, Y., Oddens, J. R., Oldenburg, J., Osanto, S., J G Oyen, W., Pacheco-Figueiredo, L., Pappot, H., Patel, M. I., Pieters, B. R., Plass, K., Remzi, M., Retz, M., Richenberg, J., Rink, M., Roghmann, F., Rosenberg, J. E., Rouprêt, M., Rouvière, O., Salembier, C., Salminen, A., Sargos, P., Sengupta, S., Sherif, A., Smeenk, R. J., Smits, A., Stenzl, A., Thalmann, G. N., Tombal, B., Turkbey, B., Lauridsen, S. V., Valdagni, R., Der Heijden, A. G. V., Van Poppel, H., Vartolomei, M. D., Veskimäe, E., Vilaseca, A., Rivera, F. A. V., Wiegel, T., Wiklund, P., Williams, A., Zigeuner, R., Horwich, A., Willemse, P. M.
    European Urology, vol. 77, no. 2, pp. 223-250
    Contributions to Journals: Articles

  • The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8

    Singh, A. N., Oehler, J., Torrecilla, I., Kilgas, S., Li, S., Vaz, B., Guérillon, C., Fielden, J., Hernandez-Carralero, E., Cabrera, E., Tullis, I. D., Meerang, M., Barber, P. R., Freire, R., Parsons, J., Vojnovic, B., Kiltie, A. E., Mailand, N., Ramadan, K.
    EMBO Journal, vol. 38, no. 21, e102361
    Contributions to Journals: Articles

  • MRE11A Isoform Expression Associated with Outcome Following Radiotherapy in Muscle-Invasive Bladder Cancer does not Alter Cell Survival and DNA Double-Strand Break Repair Following Ionising Radiation

    Walker, A. K., Na, J., Browning, L., Humayun-Zakaria, N., Zeegers, M. P., Cheng, K. K., James, N. D., Bryan, R. T., Arnold, R., Kiltie, A. E.
    Bladder Cancer, vol. 5, no. 2, pp. 147-157
    Contributions to Journals: Articles

  • MRE11 as a Predictive Biomarker of Outcome After Radiation Therapy in Bladder Cancer

    Walker, A. K., Karaszi, K., Valentine, H., Strauss, V. Y., Choudhury, A., McGill, S., Wen, K., Brown, M. D., Ramani, V., Bhattarai, S., Teo, M. T., Yang, L., Myers, K. A., Deshmukh, N., Denley, H., Browning, L., Love, S. B., Iyer, G., Clarke, N. W., Hall, E., Huddart, R., James, N. D., Hoskin, P. J., West, C. M., Kiltie, A. E.
    International Journal of Radiation Oncology Biology Physics, vol. 104, no. 4, pp. 809-818
    Contributions to Journals: Articles

  • Mouse Models of Muscle-invasive Bladder Cancer: Key Considerations for Clinical Translation Based on Molecular Subtypes

    Ruan, J. L., Hsu, J. W., Browning, R. J., Stride, E., Yildiz, Y. O., Vojnovic, B., Kiltie, A. E.
    European Urology Oncology, vol. 2, no. 3, pp. 239-247
    Contributions to Journals: Review articles

  • Utility of Bladder-Sparing Therapy vs Radical Cystectomy for Muscle-Invasive Bladder Cancer

    Efstathiou, J. A., Choudhury, A., Kiltie, A. E.
    JAMA Surgery, vol. 154, no. 2, pp. 185-186
    Contributions to Journals: Letters

  • Neoadjuvant treatment for muscle-invasive bladder cancer: The past, the present, and the future

    Hermans, T. J., Voskuilen, C. S., van der Heijden, M. S., Schmitz-Dräger, B. J., Kassouf, W., Seiler, R., Kamat, A. M., Grivas, P., Kiltie, A. E., Black, P. C., van Rhijn, B. W.
    Urologic Oncology: Seminars and Original Investigations, vol. 36, no. 9, pp. 413-422
    Contributions to Journals: Review articles

  • Recommendations for follow-up of muscle-invasive bladder cancer patients: A consensus by the international bladder cancer network

    Zuiverloon, T. C., van Kessel, K. E., Bivalacqua, T. J., Boormans, J. L., Ecke, T. H., Grivas, P. D., Kiltie, A. E., Liedberg, F., Necchi, A., van Rhijn, B. W., Roghmann, F., Sanchez-Carbayo, M., Schmitz-Dräger, B. J., Wezel, F., Kamat, A. M.
    Urologic Oncology: Seminars and Original Investigations, vol. 36, no. 9, pp. 423-431
    Contributions to Journals: Review articles

  • Harnessing citizen science through mobile phone technology to screen for immunohistochemical biomarkers in bladder cancer

    Smittenaar, P., Walker, A. K., McGill, S., Kartsonaki, C., Robinson-Vyas, R. J., McQuillan, J. P., Christie, S., Harris, L., Lawson, J., Henderson, E., Howat, W., Hanby, A., Thomas, G. J., Bhattarai, S., Browning, L., Kiltie, A. E.
    British Journal of Cancer, vol. 119, no. 2, pp. 220-229
    Contributions to Journals: Articles

  • Contemporary Patterns of Multidisciplinary Care in Patients With Muscle-invasive Bladder Cancer

    Harshman, L. C., Tripathi, A., Kaag, M., Efstathiou, J. A., Apolo, A. B., Hoffman-Censits, J. H., Stadler, W. M., Yu, E. Y., Bochner, B. H., Skinner, E. C., Downs, T., Kiltie, A. E., Bajorin, D. F., Guru, K., Shipley, W. U., Steinberg, G. D., Hahn, N. M., Sridhar, S. S.
    Clinical genitourinary cancer, vol. 16, no. 3, pp. 213-218
    Contributions to Journals: Articles

  • High Levels of Patient Satisfaction in Joint Uro-oncology Clinics to Assist Patient Choice in Early Prostate Cancer and Muscle-invasive Bladder Cancer

    Kiltie, A. E., Southby, R., LeMonnier, K., Binnee, J., Niederer, J., Kartsonaki, C., Camilleri, P., Sabharwal, A., Brewster, S., Crew, J., Hamdy, F. C.
    Clinical Oncology, vol. 30, no. 4, pp. e39
    Contributions to Journals: Letters

  • Radiosensitization in vivo by histone deacetylase inhibition with no increase in early normal tissue radiation toxicity

    Groselj, B., Ruan, J. L., Scott, H., Gorrill, J., Nicholson, J., Kelly, J., Anbalagan, S., Thompson, J., Stratford, M. R., Jevons, S. J., Hammond, E. M., Scudamore, C. L., Kerr, M., Kiltie, A. E.
    Molecular Cancer Therapeutics, vol. 17, no. 2, pp. 381-392
    Contributions to Journals: Articles

  • Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset

    Choi, W., Ochoa, A., McConkey, D. J., Aine, M., Höglund, M., Kim, W. Y., Real, F. X., Kiltie, A. E., Milsom, I., Dyrskjøt, L., Lerner, S. P.
    European Urology, vol. 72, no. 3, pp. 354-365
    Contributions to Journals: Review articles

  • No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy

    Walker, A. K., Kartsonaki, C., Collantes, E., Nicholson, J., Gilbert, D. C., Kiltie, A. E.
    British Journal of Cancer, vol. 117, no. 3, pp. 322-325
    Contributions to Journals: Articles

  • The Impact of Histological Variants of Urothelial Carcinoma on Clinical Outcomes Following Trimodality Bladder-sparing Chemoradiation

    Kiltie, A. E., Browning, L.
    European Urology, vol. 72, no. 1, pp. 61-63
    Contributions to Journals: Editorials

  • E3 ligase cIAP2 mediates downregulation of MRE11 and radiosensitization in response to HDAC inhibition in bladder cancer

    Nicholson, J., Jevons, S. J., Groselj, B., Ellermann, S., Konietzny, R., Kerr, M., Kessler, B. M., Kiltie, A. E.
    Cancer Research, vol. 77, no. 11, pp. 3027-3029
    Contributions to Journals: Articles

  • The National Institute for Health and Care Excellence (NICE) Guidance on Bladder Cancer; a Step in the Right Direction?

    Trainor, S., Choudhury, A., Huddart, R., Kiltie, A. E., Kockelbergh, R., Turner, W., Birtle, A., Crabb, S. J.
    Clinical Oncology, vol. 29, no. 6, pp. 344-347
    Contributions to Journals: Editorials

  • Crowdsourcing for translational research: Analysis of biomarker expression using cancer microarrays

    Lawson, J., Robinson-Vyas, R. J., McQuillan, J. P., Paterson, A., Christie, S., Kidza-Griffiths, M., McDuffus, L. A., Moutasim, K. A., Shaw, E. C., Kiltie, A. E., Howat, W. J., Hanby, A. M., Thomas, G. J., Smittenaar, P.
    British Journal of Cancer, vol. 116, no. 2, pp. 237-245
    Contributions to Journals: Articles

  • Biomarkers of Tumour Radiosensitivity and Predicting Benefit from Radiotherapy

    Forker, L. J., Choudhury, A., Kiltie, A. E.
    Clinical Oncology, vol. 27, no. 10, pp. 561-569
    Contributions to Journals: Articles

  • Bladder-sparing strategies for invasive bladder cancer

    Choudhury, A., Huddart, R., Kiltie, A.
    Advances in Bladder Cancer Management. Future Medicine Ltd., pp. 158-173, 16 pages
    Chapters in Books, Reports and Conference Proceedings: Chapters

  • Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of european ancestry

    Figueroa, J. D., Middlebrooks, C. D., Banday, A. R., Ye, Y., Garcia-Closas, M., Chatterjee, N., Koutros, S., Kiemeney, L. A., Rafnar, T., Bishop, T., Furberg, H., Matullo, G., Golka, K., Gago-Dominguez, M., Taylor, J. A., Fletcher, T., Siddiq, A., Cortessis, V. K., Kooperberg, C., Cussenot, O., Benhamou, S., Prescott, J., Porru, S., Dinney, C. P., Malats, N., Baris, D., Purdue, M. P., Jacobs, E. J., Albanes, D., Wang, Z., Chung, C. C., Vermeulen, S. H., Aben, K. K., Galesloot, T. E., Thorleifsson, G., Sulem, P., Stefansson, K., Kiltie, A. E., Harland, M., Teo, M., Offit, K., Vijai, J., Bajorin, D., Kopp, R., Fiorito, G., Guarrera, S., Sacerdote, C., Selinski, S., Hengstler, J. G., Gerullis, H.
    Human Molecular Genetics, vol. 25, no. 6, pp. 1203-1214
    Contributions to Journals: Articles

  • Treatment of Breast and Prostate Cancer by Hypofractionated Radiotherapy: Potential Risks and Benefits

    Ray, K. J., Sibson, N. R., Kiltie, A. E.
    Clinical Oncology, vol. 27, no. 7, pp. 420-426
    Contributions to Journals: Articles

  • High-throughput DNA sequencing identifies novel CtIP (RBBP8) variants in muscle-invasive bladder cancer patients

    Jevons, S. J., Green, A., Lunter, G., Kartsonaki, C., Buck, D., Piazza, P., Kiltie, A. E.
    Bladder Cancer, vol. 1, no. 1, pp. 31-44
    Contributions to Journals: Articles

  • Genome-wide association study yields variants at 20p12.2 that associate with urinary bladder cancer

    Rafnar, T., Sulem, P., Thorleifsson, G., Vermeulen, S. H., Helgason, H., Saemundsdottir, J., Gudjonsson, S. A., Sigurdsson, A., Stacey, S. N., Gudmundsson, J., Johannsdottir, H., Alexiusdottir, K., Petursdottir, V., Nikulasson, S., Geirsson, G., Jonsson, T., Aben, K. K., Grotenhuis, A. J., Verhaegh, G. W., Dudek, A. M., Alfred Witjes, J., van der Heijden, A. G., Vrieling, A., Galesloot, T. E., De Juan, A., Panadero, A., Rivera, F., Hurst, C., Timothy Bishop, D., Sak, S. C., Choudhury, A., Teo, M. T., Arici, C., Carta, A., Toninelli, E., de Verdier, P., Rudnai, P., Gurzau, E., Koppova, K., van der Keur, K. A., Lurkin, I., Goossens, M., Kellen, E., Guarrera, S., Russo, A., Critelli, R., Sacerdote, C., Vineis, P., Krucker, C., Kiltie, A. E.
    Human Molecular Genetics, vol. 23, no. 20, pp. 5545-5557
    Contributions to Journals: Articles

  • Deoxycytidine kinase expression underpins response to gemcitabine in bladder cancer

    Kerr, M., Scott, H. E., Groselj, B., Stratford, M. R., Karaszi, K., Sharma, N. L., Kiltie, A. E.
    Clinical Cancer Research, vol. 20, no. 21, pp. 5435-5445
    Contributions to Journals: Articles

  • Re: Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: A systematic review

    Kiltie, A. E.
    European Urology, vol. 66, no. 3, pp. 597-598
    Contributions to Journals: Comments and Debates

  • Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

    Sharma, A., Sharma, N. L., Lavy, C. B., Kiltie, A. E., Hamdy, F. C., Czernuszka, J.
    Journal of Materials Science, vol. 49, no. 17, pp. 5809-5820
    Contributions to Journals: Review articles

  • Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

    Cazier, J. B., Rao, S. R., McLean, C. M., Walker, A. L., Wright, B. J., Jaeger, E. E., Kartsonaki, C., Marsden, L., Yau, C., Camps, C., Kaisaki, P., Taylor, J., Catto, J. W., Tomlinson, I. P., Kiltie, A. E., Hamdy, F. C., Allan, C., Attar, M., Bell, J., Bentley, D., Broxholme, J., Buck, D., Copley, R., Cornall, R., Donnelly, P., Fiddy, S., Green, A., Gregory, L., Grocock, R., Hatton, E., Holmes, C., Hughes, L., Humburg, P., Humphray, S., Kanapin, A., Kingsbury, Z., Knight, J., Lamble, S., Lise, S., Lonie, L., Lunter, G., Martin, H., Murray, L., McCarthy, D., McVean, G., Pagnamenta, A., Piazza, P., Polanco, G., Ratcliffe, P., Rimmer, A.
    Nature Communications, vol. 5, 3756
    Contributions to Journals: Articles

  • Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer

    Teo, M. T., Dyrskjøt, L., Nsengimana, J., Buchwald, C., Snowden, H., Morgan, J., Jensen, J. B., Knowles, M. A., Taylor, G., Barrett, J. H., Borre, M., ørntoft, T. F., Bishop, D. T., Kiltie, A. E.
    Annals of Oncology, vol. 25, no. 4, pp. 877-883
    Contributions to Journals: Articles

  • Post-transcriptional regulation of MRE11 expression in muscle-invasive bladder tumours

    Martin, R. M., Kerr, M., Teo, M. T., Jevons, S. J., Koritzinsky, M., Wouters, B. G., Bhattarai, S., Kiltie, A. E.
    Oncotarget, vol. 5, no. 4, pp. 993-1003
    Contributions to Journals: Articles

  • Can γH2AX be used to personalise cancer treatment?

    Shah, K., Cornelissen, B., Kiltie, A. E., Vallis, K. A.
    Current molecular medicine, vol. 13, no. 10, pp. 1591-1602
    Contributions to Journals: Review articles

  • Radiosensitisation of bladder cancer cells by panobinostat is modulated by Ku80 expression

    Groselj, B., Kerr, M., Kiltie, A. E.
    Radiotherapy and Oncology, vol. 108, no. 3, pp. 429-433
    Contributions to Journals: Articles

  • The emerging role of histone deacetylase (HDAC) inhibitors in urological cancers

    Sharma, N. L., Groselj, B., Hamdy, F. C., Kiltie, A. E.
    BJU International, vol. 111, no. 4, pp. 537-542
    Contributions to Journals: Review articles

  • Histone deacetylase inhibitors as radiosensitisers: Effects on DNA damage signalling and repair

    Groselj, B., Sharma, N. L., Hamdy, F. C., Kerr, M., Kiltie, A. E.
    British Journal of Cancer, vol. 108, no. 4, pp. 748-754
    Contributions to Journals: Articles

  • Imatinib radiosensitizes bladder cancer by targeting homologous recombination

    Qiao, B., Kerr, M., Groselj, B., Teo, M. T., Knowles, M. A., Bristow, R. G., Phillips, R. M., Kiltie, A. E.
    Cancer Research, vol. 73, no. 5, pp. 1611-1620
    Contributions to Journals: Articles

  • The role of microrna-binding site polymorphisms in DNA repair genes as risk factors for bladder cancer and breast cancer and their impact on radiotherapy outcomes

    Teo, M. T., Landi, D., Taylor, C. F., Elliott, F., Vaslin, L., Cox, D. G., Hall, J., Landi, S., Bishop, D. T., Kiltie, A. E.
    Carcinogenesis, vol. 33, no. 3, pp. 581-586
    Contributions to Journals: Articles
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