BSc (Hons), Molecular and Cellular Biology; PhD, Thrombosis & Haemostasis
Personal Chair
- About
-
- Email Address
- n.j.mutch@abdn.ac.uk
- Telephone Number
- +44 (0)1224 437492
- Office Address
Lab 1.33 01224 437417
Office 5.16 01224 437492
School of Medicine, Medical Sciences and Nutrition,
Institute of Medical Sciences
University of Aberdeen
Foresterhill
Aberdeen
AB25 2ZD
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Biography
Education
University of Aberdeen, Department of Molecular and Cellular Biology and Department of Medince and Therapeutics. Aberdeen, UK. PhD in Haemostasis & Vascular Biology (1997-2000). Supervisor Dr Nuala A Booth. Funded by ACTR.
University of Aberdeen, Aberdeen, UK. BSc (Hons) (1993-1997) in Molecular and Cellular Biology.
Employment
2016: Senior Lecturer, University of Aberdeen, School of Medicine, Medical Sciences and Nutrition. Insitute of Medical Sciences, (IMS).
2011-2016: British Heart Foundation Fellow, Senior Research Fellow, School of Medicine and Dentistry, IMS.
2010-2011: Research Fellow funded by British Heart Foundation, School of Medicine and Dentistry, IMS.
2007-2010: Tenure-track Independent Research Fellow in Cardiovascular Medicine, Department of BIological Sciences, University of Leeds, Leeds, UK.
2004-2006: Postdoctoral research associate, University of Illinois at Urbana-Champaign, Department of Medicine, Champaign, Illinois, USA.
2001-2003: Postdoctoral research fellow, Department of Molecular and Cellular Biology, University of Aberdeen, UK.
Qualifications
- BSc hons Molecular Biology1997 - University of Aberdeen
- PhD Thrombosis & Vascular Biology2001 - University of Aberdeen
Latest Publications
Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Blood Advances, vol. 8, no. 19, pp. 5072–5085.Contributions to Journals: ArticlesStandardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2059-2070Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.005
- [ONLINE] View publication in Scopus
A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma
Journal of Thrombosis and Haemostasis, vol. 22, no. 6, pp. 1758-1771Contributions to Journals: ArticlesFibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3589-3596Contributions to Journals: ArticlesThe Fibrinolysis Renaissance
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3304-3316Contributions to Journals: Articles
- Research
-
Research Areas
Accepting PhDs
I am currently accepting PhDs in Biomedical Sciences.
Please get in touch if you would like to discuss your research ideas further.
Research Specialisms
- Biological Sciences
- Human Biology
- Cardiology
- Cell Biology
- Immunology
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Current Research
POST-DOC
Dr Claire Whyte
BHF funded post-doc (Dec 2015-May 2019). Claire has been in the lab since January 2011 and is on her second BHF-funded project grant. Claire is currently working on the role of platelet-derived plasmiongen in driving local fibrinolysis.
CURRENT PhD STUDENTS
Mohammad Jalal: Start date 01/12/2012; Funded by the Saudi Arabian Government. 4 year PhD.
Paraskevi Untiveros: Start date 01/09/2014; Funded by the Chief Scientist Office. Clinical Fellow 3 year PhD.
Gael Morrow: Start date 12/01/2015; Funded by the British Society of Haemostasis and Thrombosis, British Society of Haematology and Lifeblood. 3 Year PhD.
Maria-Louise Williams: Start date 01/10/16; Funded by the Institute of Medical Sciences, University of Aberdeen. 3 year PhD.
LAB ALLUMNI
Mrs Ausra Lionikiene. Ausra was employed a research technician on my BHF-funded fellowship and studying the biological significance of factor XII. Ausra was an integral member of the team organising the lab, finances and all the personnel.
Funding and Grants
CURRENT GRANTS
1. British Heart Foundation Project Grant PI: NJ Mutch (Dec 2015-Dec 2018) 'Platelet plasminogen as a driver of local fibrinolysis'
2. British Society of Haematology / Lifeblood / British Society of Thrombosis & Haemostasis PhD Studentship PI: NJ Mutch; Co-I CS Whyte (Jan 2015-Jan 2018) 'The impact of thrombus composition on regulation of fibrinolysis under flow'
4. Friends of Anchor PI: Dr Paraskevi Untiveros, Co-I Dr Nicola J Mutch, Dr Henry Watson (Aug 2016-Aug 2017) The role of ABO blood group in thrombosis
5. Chief Scientist Office, Scottish Government Fellow: P Untiveros; Supervisors: NJ Mutch, H Watson ''Influence of Anaemia on Clot Structure'
6. Friends of Anchor PI: NJ Mutch (Apr 2015-Nov 2016) 'A functional role of platelet FXIII-A in clot retraction'
RECENT GRANTS
1. British Heart Foundation Basic Science Fellowship Fellow: NJ Mutch (Mar 2011-Mar 2016 Includes two maternity leaves) 'Characterising the physiological role of factor XII and the contact system'
2. British Heart Foundation Project Grant PI: NJ Mutch; Co-I: RAS Ariëns (Jan 2012-Dec 2015) 'Changes in fibrin clot structure and susceptibility to lysis induced by polyphosphate'
3. Aberdeen Development Trust PhD Studentship PI: NJ Mutch (Oct 2012-Apr 2016) 'The antifibrinolytic function of factor XIII'
4. Chest, Heart and Stroke Scotland PI Isobel Ford Co-I NJ Mutch, MJ McLeod. () Responsiveness to thrombolytic therapy of for Ischaemic stroke
5. British Heart Foundation Project Grant (PG/07/122/23480). PI: NJ Mutch (Jun 2008-Oct 2012) 'Polyphosphate as a physiological surface for contact activation
' - Teaching
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Courses
- MT5524/MT5024 - Molecular Pharmacology
- BDS - Cardiovascular System
- BDS - Endocrinology
Teaching Responsibilities
Course coordinator for BM5003 Cardiovascular Health and Disease
- Publications
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Page 1 of 2 Results 1 to 50 of 81
Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation
Blood Advances, vol. 8, no. 19, pp. 5072–5085.Contributions to Journals: ArticlesStandardization of definition and management for bleeding disorder of unknown cause: communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 22, no. 7, pp. 2059-2070Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2024.03.005
- [ONLINE] View publication in Scopus
A novel method to quantify fibrin–fibrin and fibrin–α2-antiplasmin cross-links in thrombi formed from human trauma patient plasma
Journal of Thrombosis and Haemostasis, vol. 22, no. 6, pp. 1758-1771Contributions to Journals: ArticlesFibrinogenolysis and fibrinolysis in Vaccine-induced Immune Thrombocytopenia and Thrombosis (VITT)
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3589-3596Contributions to Journals: ArticlesThe Fibrinolysis Renaissance
Journal of Thrombosis and Haemostasis, vol. 21, no. 12, pp. 3304-3316Contributions to Journals: ArticlesFibrinolytic pathophysiologies: still the poor cousin of hemostasis?
Journal of Thrombosis and Haemostasis, vol. 21, no. 10, pp. 2645-2647Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2023.08.001
Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial
Journal of Clinical Medicine, vol. 12, no. 18, 5848Contributions to Journals: ArticlesPlatelet factor XIII-A regulates platelet function and promotes clot retraction and stability
Research and Practice in Thrombosis and Haemostasis, vol. 7, no. 5, 100200Contributions to Journals: Articles“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions
Frontiers in cardiovascular medicine, vol. 10, 1146833Contributions to Journals: ArticlesAcute obstetric coagulopathy during postpartum hemorrhage is caused by hyperfibrinolysis and dysfibrinogenemia: an observational cohort study
Journal of Thrombosis and Haemostasis, vol. 21, no. 4, pp. 862-879Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jtha.2022.11.036
- [ONLINE] View publication in Scopus
Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)
Seminars in Thrombosis and Hemostasis, vol. 49, no. 3, pp. 305-313Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1055/s-0042-1758791
Cellular FXIII in Human Macrophage-Derived Foam Cells
International Journal of Molecular Sciences, vol. 24, no. 5, 4802Contributions to Journals: ArticlesLocation, location, location: Fibrin, cells, and fibrinolytic factors in thrombi
Contributions to Journals: Short SurveyAtorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure
Platelets, vol. 34, no. 1, 2206921Contributions to Journals: ArticlesS100A8/A9 drives the formation of procoagulant platelets through GPIbα
Blood, vol. 140, no. 24, pp. 2626-2643Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.2021014966
- [ONLINE] View publication in Scopus
“Going with the flow” in modeling fibrinolysis
Frontiers in cardiovascular medicine, vol. 9, 1054541Contributions to Journals: Review articlesDeterminants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction
JACC: Basic to Translational Science, vol. 7, no. 11, pp. 1069-1082Contributions to Journals: ArticlesCryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial
Critical Care, vol. 26, no. 1, 290Contributions to Journals: ArticlesThe suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1
Journal of Thrombosis and Haemostasis, vol. 20, no. 10, pp. 2394-2406Contributions to Journals: ArticlesBasic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 20, no. 6, pp. 1496-1506Contributions to Journals: ArticlesActivation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles
Journal of Thrombosis and Haemostasis, vol. 20, no. 5, pp. 1223–1235Contributions to Journals: ArticlesThe Efficacy of Fibrinogen Concentrates in Relation to Cryoprecipitate in Restoring Clot Integrity and Stability against Lysis
International Journal of Molecular Sciences, vol. 23, no. 6, 2944Contributions to Journals: ArticlesRemoving plasmin from the equation - Something to chew on ...
Journal of Thrombosis and Haemostasis, vol. 20, no. 2, pp. 280-284Contributions to Journals: EditorialsMonocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation
International Journal of Molecular Sciences, vol. 22, no. 12, 6591Contributions to Journals: ArticlesTrauma-induced coagulopathy
Nature reviews. Disease primers, vol. 7, 30Contributions to Journals: ArticlesA serpin with a finger in many PAI’s: PAI-1’s central function in thromboinflammation and cardiovascular disease
Frontiers in cardiovascular medicine, vol. 8, 653655Contributions to Journals: ArticlesFactor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing
International Journal of Molecular Sciences, vol. 22, no. 6, 3055Contributions to Journals: ArticlesFibrinogen Replacement Therapy for Traumatic Coagulopathy: Does the Fibrinogen Source Matter?
International Journal of Molecular Sciences, vol. 22, no. 4, 2185Contributions to Journals: ArticlesRole of Shear Stress and tPA Concentration in the Fibrinolytic Potential of Thrombi
International Journal of Molecular Sciences, vol. 22, no. 4, 2115Contributions to Journals: ArticlesuPA-mediated plasminogen activation is enhanced by polyphosphate
Haematologica, vol. 106, no. 2, pp. 522-531Contributions to Journals: ArticlesExposure of plasminogen and a novel plasminogen receptor, Plg-RKT, on activated human and murine platelets
Blood, vol. 137, no. 2, pp. 248–257Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.2020007263
- [ONLINE] View publication in Scopus
Physiology of haemostasis: Plasmin-antiplasmin system
Trauma Induced Coagulopathy. Moore, H., Neal, M., Moore, E. (eds.). Springer, pp. 53-74, 22 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-030-53606-0_5
- [ONLINE] View publication in Scopus
Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery
Blood, vol. 136, no. 14, pp. 1685-1697Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1182/blood.2020004818
- [ONLINE] https://ashpublications.org/blood/pages/rights-permissions
- [ONLINE] View publication in Scopus
A new pedigree with thrombomodulin-associated coagulopathy in which delayed fibrinolysis is partially attenuated by co-inherited TAFI deficiency
Journal of Thrombosis and Haemostasis, vol. 18, no. 9, pp. 2209-2214Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/jth.14990
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/15105/1/Westbury_etal_jth_New_pedigree_VOR.pdf
- [ONLINE] View publication in Scopus
Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19
Journal of Thrombosis and Haemostasis, vol. 18, no. 7, pp. 1548-1555Contributions to Journals: ArticlesDefining trauma-induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 18, no. 3, pp. 740-747Contributions to Journals: ArticlesFunctional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation
Haematologica, vol. 105, no. 5Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.3324/haematol.2019.230367
- [ONLINE] Open Access license
Regulation of fibrinolysis by platelets
Platelets. Elsevier, pp. 417-431, 15 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1016/B978-0-12-813456-6.00023-0
- [ONLINE] View publication in Scopus
Let's cross-link: diverse functions of the promiscuous cellular transglutaminase, factor XIII-A
Journal of Thrombosis and Haemostasis, vol. 17, no. 1, pp. 19-30Contributions to Journals: Review articlesAn international study on the feasibility of a standardized combined plasma clot turbidity and lysis assay: Communication from the SSC of the ISTH
Journal of Thrombosis and Haemostasis, vol. 16, no. 5, pp. 1007-1012Contributions to Journals: ArticlesDefective α2antiplasmin cross-linking and thrombus stability in a case of acquired factor XIII deficiency
British Journal of Haematology, vol. 178, no. 5, pp. 794-799Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1111/bjh.14759
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/10464/1/BJH_2017_00164_with_Figures.pdf
Platelet-Mediated Modulation of Fibrinolysis
Seminars in Thrombosis and Hemostasis, vol. 43, no. 2, pp. 115-128Contributions to Journals: Review articlesPolyphosphate co-localizes with factor XII on plateletbound fibrin and augments its plasminogen activator activity
Blood, vol. 128, no. 24, pp. 2834-2845Contributions to Journals: ArticlesPolyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network
Thrombosis and Haemostasis, vol. 116, no. 5, pp. 897-903Contributions to Journals: ArticlesAltered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy
Blood, vol. 128, no. 14, pp. 1879-1883Contributions to Journals: ArticlesNovel aspects of platelet factor XIII function
Thrombosis Research, vol. 141, no. Suppl 2, pp. S17-21Contributions to Journals: Articlespolyphosphate co-localises with FXII on platelet-bound fibrin and markedly augments alpha FXIIa-mediated plasminogen activation
Journal of Thrombosis and Haemostasis, vol. 14, no. Suppl.1, pp. 39Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/jth.13325
Plasmin-antiplasmin system
Trauma Induced Coagulopathy. Gonzalez, E., Moore, H. B., Moore, E. E. (eds.). Springer International Publishing, pp. 31-51, 21 pagesChapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1007/978-3-319-28308-1_3
- [ONLINE] View publication in Scopus
Polyphosphate as a haemostatic modulator
Biochemical Society Transactions, vol. 44, no. 1, pp. 18-24Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1042/BST20150207
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/8200/1/Mutch_NJ_Biochem_Trans_2015.pdf
Harmonisation of D-dimer - A call for action
Thrombosis Research, vol. 137, pp. 219-220Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.thromres.2015.11.031