BSc (Hons), MBChB, PhD, CStat, MD (Hons), FFPHM, DSc, HonFFOM
Clinical Chair in Epidemiology
- About
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- Email Address
- g.j.macfarlane@abdn.ac.uk
- Office Address
- School/Department
- School of Medicine, Medical Sciences and Nutrition
Personal Assistant- Personal Assistant
- Mrs Jisha Babu
Biography
Gary Macfarlane has held the Chair in Epidemiology (Clinical) since 2005 and previously held the same post at The University of Manchester from 1999. He is an Honorary Consultant in the Department of Public Health at NHS Grampian, Deputy Clinical Lead for Chronic Pain at NHS Research Scotland and Director of the Versus Arthritis/Medical Research Council Centre for Musculoskeletal Health and Work. He was Dean of Research Impact and Interdisciplinary Research for the period 2018-2024. He trained in Statistics/ Computing Science and then Medicine at The University of Glasgow before undertaking his PhD at The University of Bristol. He worked at the Division of Epidemiology and Biostatistics at the European Institute of Oncology in Milan before leading a programme of chronic pain research at the Arthritis Research UK Epidemiology Unit at the University of Manchester.
He leads the Epidemiology group at the University of Aberdeen. The clinical research programme focusses on Rheumatic and Musculoskeletal Diseases (RMD) and undertakes research on: mechanisms of disease onset and outcome (observational epidemiology), identifying effective management for RMDs (Clinical trials and evidence synthesis), and designing optimal delivery of care (health services research). He and his research team have particular expertise in common complex conditions (including musculoskeletal pain and fatigue, fibromyalgia, and early osteoarthritis), inflammatory conditions, and rare diseases. The programme also hosts several disease and drug registries: the British Society of Rheumatology Biologics Registers in Ankylosing Spondylitis (BSRBR-AS) and Psoriatic Arthritis (BSR-PsA) and the British Society for Antimicrobial Chemotherapy UK Antimicrobial Registry (UKAR), all of which recruit UK-wide. Professor Macfarlane is a Chartered Statistician of the Royal Statistical Society, a Fellow of the Faculty of Public Health Medicine and an Honorary fellow of the Faculty of Occupational Medicine.
Qualifications
- BSc (Hons) Statistics and Computing Science1985 - University of Glasgow
- MBChB Medicine and Surgery1990 - University of Glasgow
- PhD Epidemiology1993 - University of Bristol
The Epidemiology of Oral Cancer
- MD (Hons) Medicine (Epidemiology)2003 - University of Glasgow
- DSc Medicine2021 - University of Glasgow
- CStat Statistics1999 - Royal Statistical Society
- FFPH Public Health2009 - Faculty of Public Health
- HonFFOM Occupational Medicine2023 - Faculty of Occupational Medicine
I have been awarded Honorary Fellowship of the Faculty of Occupational Medicine
External Memberships
- Health and Safety Executive (UK) Scientific Quality Advisory Group: Member
- British Pain Society Annual Scientific Meeting Organising Committee: Member
- NHS Research Scotland Pain Network: Deputy Chair
- Versus Arthritis Fellowship Committee: Member
- British Society for Rheumatology: Research and Registers Committee
Latest Publications
Childhood maltreatment and chronic ‘all over’ body pain in adulthood: a counterfactual analysis using UK Biobank
PainContributions to Journals: ArticlesRecording of non-musculoskeletal manifestations, comorbidities, and safety outcomes in European spondyloarthritis registries: a survey
Rheumatology Advances in Practice, rkae135Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rap/rkae135
Patients with Axial Spondyloarthritis Reported Willingness to Use Remote Care and Showed High Adherence to Electronic Patient-Reported Outcome Measures: an 18-Month Observational Study
Rheumatology International, vol. 44, no. 10, pp. 2089–2098Contributions to Journals: ArticlesSmoking and alcohol by HPV status in head and neck cancer: A Mendelian Randomization Study
Nature Communications, vol. 15, 7835Contributions to Journals: ArticlesDevelopment and external validation of a head and neck cancer risk prediction model
Head Neck, vol. 46, no. 9, pp. 2261-2273Contributions to Journals: Articles
Prizes and Awards
Sir Alexander Morison Medal from the Royal College of Physicians of Edinburgh
Heberden Medal from the British Society for Rheumatology
- Research
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Research Overview
My major research interests are in the Epidemiology of Rheumatic and Musculoskleletal Disorders (RMD) with a particular focus on common disabling symptoms (chronic pain, and fatigue) inflammatory and non-inflammatory arthritis. I am Director of the Versus Arthritis and MRC Centre for Musculoskeletal Health and Work. I lead several nationwide drug registries. I have current live grant income over £13 million.
Research Specialisms
- Epidemiology
- Medical Statistics
- Medicine
- Environmental and Public Health
Our research specialisms are based on the Higher Education Classification of Subjects (HECoS) which is HESA open data, published under the Creative Commons Attribution 4.0 International licence.
Research programme
You can read about the research programme I lead, including studies underway, research outputs and plain language summaries here: https://www.abdn.ac.uk/iahs/research/epidemiology/research-107.php
Collaborations
Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Health and Work
Professor Macfarlane principal investigator for the Aberdeen spoke of this centre, which is based at the University of Southampton. Coordinated by the University of Southampton, the centre brings together fifteen different academic institutions across the UK, with interest and expertise in rheumatic and musculoskeletal disease, and its relation to occupation, to identify effective and cost-effective ways to minimise the adverse impacts of musculoskeletal disorders in the workplace. The work at the University of Aberdeen is focussed on investigating: media campaigns for low back pain; axial spondyloarthritis; pain management.
European League Against Rheumatism (EULAR) revised guidelines for the management of fibromyalgia
Professor Macfarlane chaired an international group of clinicians, allied health professionals and scientists from 12 countries across Europe, in revising EULAR guidelines for the management of fibromyalgia. Since the original EULAR fibromyalgia guidelines, more than fifty randomised controlled trials have been published concerned with the phramcological or non-pharmacological management of the conditions. The revised guidelines were published, in 2016, in the Annals of the Rheumatic Diseases: http://ard.bmj.com/content/early/2016/07/04/annrheumdis-2016-209724.full
UK-RiME : UK Research in Musculoskeletal Epidemiology
The UK Research in Musculoskeletal Epidemiology (UK-RiME) partnership is a national collaboration between eight epidemiology centres in the United Kingdom including Aberdeen. The partnership seeks to develop a co-ordinated training programme facilitated by exchanges between departments at PhD, post-doctoral, NIHR academic clinical fellow, clinical fellow and international trainee levels. UK-RiME facilitates access to one another’s cohorts and share analytical expertise with each other and the UK musculoskeletal research community.
Funding and Grants
- 2024-29/£1.2m/Versus Arthritis. “PrIOritising early detection of KNEE osteoaRthritis – PIOKNEER
- 2022-25/£999k/ Medical Research Council and Versus Arthritis Advanced Pain Discovery Platform. High Impact Chronic Pain and UK Biobank: presentation, transitions and targets for intervention
- 2022-24/£232k/Chief Scientist’s Office/ Supporting people with musculoskeletal disorders in Scotland to remain in work: adapting the Making it Work™ intervention developed for people with inflammatory arthritis in Canada (Co-Chief Investigator)
- 2021-25/£3,179k/MRC and Versus Arthritis/Consortium Against Pain inEquality (CAPE) - The impact of adverse childhood experiences on chronic pain and responses to treatment (Investigator and Work Package Lead)
- 2021-24/£485k /MRC/ Quantifying the Impact of Work on Paid Employment (Chief Investigator)
- 2021-26/£1,250k/British Society for Antimicrobial Chemotherapy/United Kingdom AntiMicrobial Registry (Co-chief Investigator)
- 2020-26/£2,488k/ NIHR/ NIHR Programme Grant: Development and evaluation of the Digital-My Arm Pain Programme (D-MAPP) for improving painful distal upper limb musculoskeletal disorders (Investigator)
- 2019-26/£2,300k/Medical Research Council & Versus Arthritis Centre of Excellence in Musculoskeletal Health and Work (Chief Investigator Investigator, Aberdeen)
- 2019-25/£1,138k/Versus Arthritis/Developing new models of care for people with fibromyalgia (PACFiND) (Chief Investigator)
- Teaching
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Teaching Responsibilities
Postgraduate (PhD) research students
The Epidemiology group welcomes applications in our research areas of interest.
External courses
Professor Macfarlane established a week-long Intensive Course in Applied Epidemiology (ICAE) at the University of Aberdeen. This course has been run here since 2007, having previously been run for 15 years at the University of Manchester. The course is highly rated by attendees, with attendees from Europe, Asia, the Americas and Australasia. The course is annual and starts on the first Monday in March. For further details and / or to register for the next course please see our ICAE web page.
The Epidemiology Group has also put on shorter courses at external locations including Warsaw and Bucharest and also runs courses focussed on specific clinical disciplines such as "Essentials in Epidemiology for Reproductive Health".
- Publications
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Role of medical history and medication use in the aetiology of upper aerodigestive tract cancers in Europe: the ARCAGE study
Annals of Oncology, vol. 23, no. 4, pp. 1053-1060Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/annonc/mdr335
The epidemiology of multiple somatic symptoms
Journal of Psychosomatic Research, vol. 72, no. 4, pp. 311-317Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.jpsychores.2012.01.009
- [ONLINE] View publication in Scopus
Predicting OA progression to total hip replacement: can we do better than risk factors alone using active shape modelling as an imaging biomarker?
Rheumatology, vol. 51, no. 3, pp. 562-570Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/ker382
- [OPEN ACCESS] http://aura.abdn.ac.uk/bitstream/2164/2790/1/Shape_PCR_study_Rheumatology.pdf
- [ONLINE] View publication in Scopus
Organising a World Congress of Epidemiology (WCE): Reflections and lessons from the XIX WCE, Scotland
Public Health, vol. 126, no. 3, pp. 265-270Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.puhe.2012.01.024
- [ONLINE] View publication in Scopus
Cognitive behavior therapy, exercise, or both for treating chronic widespread pain
JAMA Internal Medicine, vol. 172, no. 1, pp. 48-57Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1001/archinternmed.2011.555
The prevalence and management of low back pain across adulthood: Results from a population-based cross-sectional study (the MUSICIAN study)
Pain, vol. 153, no. 1, pp. 27-32Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pain.2011.08.005
Back pain
75th Annual Scientific Meeting of the American-College-of-Rheumatology/46th Annual Scientific Meeting of the Association-of-Rheumatology-Health-Professionals, pp. S345-S346Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1002/art.33310
Maternal and perinatal risk factors and childhood cancer
Society for Social Medicine 55th Annual Scientific MeetingContributions to Conferences: PostersPopulation attributable risk of tobacco and alcohol for upper aerodigestive tract cancer
Oral Oncology, vol. 47, no. 8, pp. 725-731Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.oraloncology.2011.05.004
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium
PLoS Genetics, vol. 7, no. 3, e1001333Contributions to Journals: ArticlesLife-course influences on chronic pain in adults
Chronic Pain Epidemiology: From Aetiology to Public Health. Oxford University Press (OUP)Chapters in Books, Reports and Conference Proceedings: Chapters- [ONLINE] DOI: https://doi.org/10.1093/acprof:oso/9780199235766.003.0015
- [ONLINE] View publication in Scopus
Hypothalamic-Pituitary-Adrenal Axis Response to Mental Stress Predicts Chronic Widespread Pain Onset: Results from the SPICE Study
Arthritis & Rheumatism, vol. 62, no. S10, pp. 649Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1002/art.30166
Fatigue: A principal contributor to impaired quality of life in ANCA-associated vasculitis
Rheumatology, vol. 49, no. 7, pp. 1383-1390Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/keq098
Few clinical parameters mark out anti-TNF use among patients with ankylosing spondylitis: Data from the Scotland and Ireland registry for ankylosing spondylitis (SIRAS)
Clinical and Experimental Rheumatology, vol. 28, no. 4, pp. 621Contributions to Journals: AbstractsFibromyalgia (FM) is not a clinical characteristic of ANCA-Associated Vasculitis (AAV) in Northern Scotland
APMIS, vol. 117, no. s127, pp. 161Contributions to Journals: Abstracts- [ONLINE] DOI: https://doi.org/10.1111/j.1600-0463.2009.02504.x
Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality (vol 48, pg 74, 2009): corrigendum
Rheumatology, vol. 48, no. 4, pp. 459Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/kep033
Musculoskeletal pain is associated with a long-term increased risk of cancer and cardiovascular-related mortality
Rheumatology, vol. 48, no. 1, pp. 74-77Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/ken424
Unexplained orofacial pain - Is an early diagnosis possible?
British Dental Journal, vol. 205, no. 3Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1038/sj.bdj.2008.585
- [ONLINE] View publication in Scopus
Active exercise, education, and cognitive behavioral therapy for persistent disabling low back pain: a randomized controlled trial
Spine, vol. 32, no. 15, pp. 1578-1585Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1097/BRS.0b013e318074f890
Cerebral emboli as a potential cause of Alzheimer's disease and vascular dementia: case-control study
British Medical Journal, vol. 332, pp. 1119-1124Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1136/bmj.38814.696493.AE
Managing low back pain presenting to primary care: where do we go from here?
Pain, vol. 122, no. 3, pp. 219-222Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pain.2006.03.013
Predicting persistent disabling low back pain in general practice: a prospective cohort study
The British Journal of General Practice, vol. 56, no. 526, pp. 334-41Contributions to Journals: ArticlesPredictors of persistent neck pain after whiplash injury
Emergency Medicine Journal, vol. 23, no. 3, pp. 195-201Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1136/emj.2005.027102
Does physical trauma lead to an increase in the risk of new onset widespread pain?
Annals of the Rheumatic Diseases, vol. 65, no. 3, pp. 391-393Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/ard.2005.037531
Predicting New Onset of Widespread Pain Following a Motor Vehicle Collision
Journal of Rheumatology, vol. 33, no. 5, pp. 968-974Contributions to Journals: EditorialsThe epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors?
International Journal of Epidemiology, vol. 35, pp. 468-476Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1093/ije/dyi265
Who Will Develop Chronic Pain and Why? The Epidemiological Evidence
Proceedings of the 11th World Congress on Pain, pp. 529-541, 12 pagesChapters in Books, Reports and Conference Proceedings: ChaptersComment on Hendriks et al.: prognostic factors for poor recovery in acute whiplash patients. Pain 2005;114:408-416
Pain, vol. 119, no. 1-3, pp. 247-248Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pain.2005.09.012
Long-term mortality amongst Gulf War Veterans: is there a relationship with experiences during deployment and subsequent morbidity?
British Medical Journal, vol. 34, no. 6, pp. 1403-1408Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1093/IJE/DYI205
Onset of neck pain after a motor vehicle accident: a case-control study
Journal of Rheumatology, vol. 32, no. 8, pp. 1576-83Contributions to Journals: ArticlesEpidemiology of low back pain in children and adolescents
Archives of Disease in Childhood, vol. 90, no. 3, pp. 312-316Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1136/adc.2004.056812
Is musculoskeletal pain more common now than 40 years ago? : two population-based cross-sectional studies
RheumatologyContributions to Journals: EditorialsPrimary care consultation predictors in men and women: a cohort study
The British Journal of General Practice, vol. 55, pp. 108-113Contributions to Journals: EditorialsAn excess of widespread pain among South Asians: are low levels of vitamin D implicated?
Annals of the Rheumatic Diseases, vol. 64, pp. 1217-1219Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1136/ard.2004.032656
Association between pain in the hip region and radiographic changes of osteoarthritis: results from a population-based study
Rheumatology, vol. 44, pp. 337-341Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/keh458
Chronic Widespread Pain and Fibromyalgia: Should Reports of Increased Mortality Influence Management
Current Rheumatology Reports, vol. 7, pp. 339-341Contributions to Journals: EditorialsDefining hip pain for population studies
Annals of the Rheumatic Diseases, vol. 64, pp. 95-98Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1136/ard.2003.018788
Development and validation of the Manchester oro-facial pain disability scale.
Community Dentistry and Oral Epidemiology, vol. 33, pp. 141-149Contributions to Journals: ArticlesDo strong opioids have a role in the early management of back pain? Recommendations from a European expert panel
Current Medical Research and Opinion, vol. 21, no. 11, pp. 1819-1828Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1185/030079905X65303
Epidemiology of Pain in Older Persons
British Journal of Anaesthesia, vol. 35Contributions to Journals: EditorialsLooking back: development in our understanding of the occurrence, aetiology and prognosis of chronic pain 1954-2004
Rheumatology, vol. 44, no. 4, pp. 23-26Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1093/rheumatology/kei057
Poor sleep and depression are independently associated with a reduced pain threshold.Results of a population based study
Pain, vol. 115, pp. 316-321Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1016/j.pain.2005.03.009
Parental pain is not associated with pain in the child: a population based study
Annals of the Rheumatic Diseases, vol. 63, no. 9, pp. 1152-1154Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1136/ard.2003.014670
Can one predict the likely specific orofacial pain syndrome from a self-completed questionnaire?
Pain, vol. 111, pp. 270-277Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.pain.2004.07.002
DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma
Cancer Letters, vol. 209, no. 2, pp. 207-213Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1016/j.canlet.2003.12.018
Childhood experience and health care in adulthood
British Journal of Clinical Psychology, vol. 185, pp. 134-139Contributions to Journals: EditorialsMechanical injury and psychosocial factors in the work place predict the onset of widespread body pain: a two-year prospective study among cohorts of newly employed workers
Arthritis & Rheumatism, vol. 50, no. 5, pp. 1655-1664Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1002/art.20258
Psychosocial and illness related predictors of consultation rates in primary care - a cohort study
Psychological Medicine, vol. 34, no. 4, pp. 719-728Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1017/S0033291703001223
The Cheshire Foot Pain and Disability Survey: a population survey assessing prevalence and associations
Pain, vol. 110, pp. 378-384Contributions to Journals: Editorials- [ONLINE] DOI: https://doi.org/10.1016/j.pain.2004.04.019
Occurrence of Raynaud's phenomenon in children ages 12-15 years: prevalence and association with other common symptoms
Arthritis & Rheumatism, vol. 48, no. 12, pp. 3518-3521Contributions to Journals: Articles- [ONLINE] DOI: https://doi.org/10.1002/art.11340